Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Early Development, Organogenesis and Evolution
Discussion Leaders: David Ornitz (Washington University in St. Louis, United States) and Linda Dalecka (First Faculty of Medicine, Charles University, Czech Republic)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
Suzanne Mansour (University of Utah, United States)
"FGF Signaling in Inner Ear Development and Function"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
Didier Stainier (Max Planck Institute for Heart and Lung Research, Germany)
"Genetic Robustness in Signaling Pathways"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Vincent Harley (Hudson Institute of Medical Research, Australia)
"A Novel FGF9 Variant Reveals a Role for Dimerization in Sex Determination"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Musculoskeletal and Craniofacial Roles
Discussion Leaders: Amy Merrill (University of Southern California, United States) and Maria Iavazzo (TELETHON INSTITUTE OF GENETICS AND MEDICINE, Italy)
9:00 am - 9:20 am
David Ornitz (Washington University in St. Louis, United States)
"FGF Signaling in Skeletal Homeostasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Audrey Nickle (University of Southern California, United States)
"Mechanisms of Craniosynostosis in Bent Bone Dysplasia Syndrome"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Laurence Legeai-Mallet (Institut Imagine-Inserm U1163-Université de Paris, France)
"Activating FGFR3 Mutant Causes Hypochondroplasia with Fragile Bones Showing a Novel Pathological Defect in Cortical Bone in Mice"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Marit Aure (NIH, United States)
"Fibroblast Growth Factor Receptor 1 and 2 is Essential for Development and Differentiation in Salivary Glands"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Timothy Saunders (University of Warwick, United Kingdom)
"The Role of FGFR in Heart and Skeletal Muscle Morphogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Isaac Campos (The University of Alabama at Birmingham, United States)
"The Role of Fibroblast Growth Factor Receptor 4 in Physiologic Cardiac Hypertrophy"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Abigail Tucker (King's College London, United Kingdom)
"Fgfs And Integration of The Developing Ear: Coordinating Development To Make An Ear Drum"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kylie Heitman (University of Alabama at Birmingham, United States)
"Skeletal Muscle is a Novel Source of FGF23 in Mouse Models of Chronic Kidney Disease and Skeletal Muscle Atrophy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Chiara Francavilla (University of Manchester, United Kingdom) and Amy Merrill (University of Southern California, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interaction of FGFs with Other Signaling Pathways
Discussion Leaders: Saverio Bellusci (Justus Liebig University Giessen, Germany) and Luca Ferrarese (ETH Zürich, Switzerland)
6:00 pm - 6:20 pm
Joshua Brickman (Copenhagen University, Denmark)
"Enhancer Regulation by FGF/ERK in Pluripotent Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Juan Fons (king's college london, United Kingdom)
"Understanding Syndromic Microtia: FGFs in the Interphase Between Muscle and Cartilage"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Igor Stagljar (University of Toronto, Canada)
"Receptor Tyrosine Kinase-Interactomes, Drug Actions and Genome-Informed Medicine"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Amy Merrill (University of Southern California, United States)
"FGF Signalling in Cranial Joint Development"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Xuanyu Min (Columbia University Department of Ophthalmology, United States)
"Reciprocal Interactions Mediated by FGF and Wnt Signaling Coordinate the Growth of the Optic Cup and Lens"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Stem Cells, Tissue Regeneration and Repair
Discussion Leaders: Joshua Brickman (Copenhagen University, Denmark)
9:00 am - 9:20 am
Denise Al Alam (Lundquist Institute for Biomedical Innovation, United States)
"FGF Signaling in Lung Development and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sabine Werner (ETH Zurich, Switzerland)
"FGF Signaling in Epithelial Injury and Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
David Enshell-Seijffers (BAR-ILAN University, Israel)
"Fgf Signaling in the Mesenchymal Niche of the Hair Follicle Regulates Stem Cell Quiescence and Regeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Saverio Bellusci (Justus Liebig University Giessen, Germany)
"Role of FGFR2b Signaling in Alveolar Epithelial Cells During Homeostasis, Regeneration and Repair"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Helen Makarenkova (The Scripps Research Institute, United States)
"Role of FGF10 in an Evolutionary Conserved Population of Ionocytes"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Stijn De Langhe (Mayo Clinic in Rochester, Minnesota, United States)
"Niche-Mediated Repair of Airways via Fgf10 is Directed in a Position Dependent Manner"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Structural Biology of FGFs and Novel Technologies
Discussion Leaders: Richard Grose (Queen Mary University of London, United Kingdom) and Qiaoying Wang (Queen Mary University of London, United Kingdom)
6:00 pm - 6:20 pm
Chiara Francavilla (University of Manchester, United Kingdom)
"FGFR Functional Selectivity in Breast Cancer Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Christina Schuh (Brickman lab, Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Denmark)
"Novel Genetic Tools To Probe Enhancer Regulation By Fgf/Erk In Pluripotent Stem Cells"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Moosa Mohammadi (Oujiang Laboratory, Wenzhou, China, United States)
"An Asymmetric FGF Receptor Tyrosine Kinase Dimer Mediates A-loop Tyrosine Trans-Phosphorylation and Signaling"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Tarja Kinnunen (University of Huddersfield, United Kingdom)
"The Synergistic Roles Of Klothos in Increased Longevity and Healthy Lifespan in the Nematode C. elegans"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
FGFs in Cancer: Mechanism, Progression and Therapy
Discussion Leaders: Denise Al Alam (Lundquist Institute for Biomedical Innovation, United States) and Yongjun Yin (Washington University in St. Louis, United States)
9:00 am - 9:20 am
Richard Grose (Queen Mary University of London, United Kingdom)
"Therapeutic Targeting of FGFR Signaling in Pancreatic Adenocarcinoma"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Harriet Ferguson (University of Manchester, United Kingdom)
"A Multi-Omics Approach to Understand FGFR2b and EGFR Functional Crosstalk and RSK2-Dependent Signalling in Breast Cancer Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Fen Wang (Texas A&M University, United States)
"FGF Signaling in Cancer Cell Metabolism"
10:05 am - 10:15 am
Discussion
10:25 am - 10:35 am
Camille Viaut (Institut Imagine, France)
"Role(s) Of FGFR3 During Axial Skeleton In Two Fgfr3 Mouse Models"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Florian Siebzehnrubl (Cardiff University, United Kingdom)
"Functions of FGF Receptor Signaling on Cancer Stem Cells in Glioblastoma"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Sunday Oladipupo (Lilly Research Laboratories, United States)
"FGF9 Induces Angiogenesis Mediated by Mesenchymal Cell FGFR1/3 Dependent Mechanisms"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Kel Vin Woo (Washington University in St. Louis, United States)
"Protective Role of Smooth Muscle FGF Signaling in Hypoxia-Induced Pulmonary Hypertension"
12:30 pm - 12:40 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Metabolic Homeostasis and Endocrine Functions
Discussion Leaders: Sabine Werner (ETH Zurich, Switzerland) and Camille Viaut (Institut Imagine, France)
6:00 pm - 6:20 pm
Jarrad Scarlett (University of Washington, Seattle, United States)
"Targeting the Brain to Treat Diabetes: Lessons and Insights from Fibroblast Growth Factor 1 (FGF1)"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Michaela Bosakova (Institute of Animal Physiology and Genetics CAS, Czech Republic)
"Endoplasmic Reticulum (ER) Stress Disrupts FGF Siignaling Via Altered Processing of FGF Receptors"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Carmine Settembre (Tigem (Telethon Institute of Genetics and Medicine), Italy)
"Regulation of Selective Autophagy by FGF Signaling"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Nelly Pitteloud (Centre Hospitalier Universitaire Vaudois, Switzerland)
"Decreased FGF Signaling in Human Reproduction"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Joanne Watson (University of Manchester, United Kingdom)
"Spatially Resolved Phosphoproteomics Reveals Fibroblast Growth Factor Receptor Recycling-Driven Regulation of Autophagy and Survival"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
FGFs in Development and Disease of the Nervous System
Discussion Leaders: Suzanne Mansour (University of Utah, United States) and Arun Lingampally (Justus Liebig University Giessen, CPI, Germany)
9:00 am - 9:20 am
Xin Zhang (Columbia University, United States)
"Abelson Kinases Regulate FGF Signaling in Lens Vesicle Closure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Giada Vanacore (University of East Anglia, United Kingdom)
"FGF18 is Involved in Postnatal Ventricular-Subventricular Zone (V-SVZ) Neurogenesis"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Martin Berghoff (University of Giessen, Germany)
"FGF Signaling in Myelination and Multiple Sclerosis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Neoklis Makrides (Columbia University, United States)
"FGF Signaling Potentiates Müller Glia for Retinal Regeneration"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Dalit Sela-Donenfeld (The Hebrew University, Israel)
"FGF3 Promotes the Development of Hindbrain Boundaries as NPSCs via Interacting With Their ECM"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Carlos Abascal Sherwell Sánchez (King´s College London, United Kingdom)
"Characterising the FGF Signaling Pathway in the Postnatal Pituitary Stem Cell Compartment"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Raj Ladher (National Centre for Biological Sciences, India)
"FGF Triggers Cytoskeletal Remodelling During the Morphogenesis of the Cochlea"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intracellular-Acting and Non-Canonical FGFs
Discussion Leaders: Xin Zhang (Columbia University, United States) and Mira Gökyildirim (University Medicine Rostock / Clinic for Paediatrics and Adolescent Medicine, Germany)
6:00 pm - 6:20 pm
Laura Capolupo (EPFL, Switzerland)
"Sphingolipids Control Dermal Fibroblast Heterogeneity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Franziska Mewes (Hanover Medical School, Germany)
"Evaluation of the Therapeutic Potential of FGF-2HMW and FGF-2LMW in an In Vitro Model of Parkinson’s Disease"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Mattia Malvezzi (Weill Cornell Medical College, United States)
"Investigating Non-Canonical FGFs Using Proximity-Labeling Proteomics"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Martyna Biadun (University of Wroclaw, Poland)
"FGF Homologous Factors are Secreted Proteins That Induce Signaling in Cells Expressing FGF Receptors"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Martyna Sochacka (University of Wroclaw, Poland)
"Protein-Protein Interactions of FGF12 - An Indication of a Novel Intracellular Function"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure