MONDAY |
8:30 am | Structure-function of nectins and integrins |
| Discussion Leader: Kenneth Yamada |
| Jean Schwarzbauer
"Mutational analysis of fibronectin" |
| Robert Burgeson
"Functions of kallinin (epiligrin)" |
| Joseph Loftus
"Ligand binding domains of integrins" |
7:00 pm | Three-dimensional structure of nectins |
| Discussion Leader: Michael Mosesson |
| Harold Erickson
"Crystallographic structures" |
| Iain Campbell
"Solution structures of fibronectin modules" |
| Kathyrn Ely
"Ligand-mimetic antibodies" |
| Mattia Rocco
"Assembling the moduli: a low-resolution model of fibronectin" |
TUESDAY |
9:00 am | Matrix regulation of growth and function |
| Discussion Leader: Erkki Ruoslahti |
| Mary Beckerle
"Zyxin, zinc fingers at the junction" |
| Eugene Marcantonio
"Extracellular and transmembrane association of integrin α and β subunits" |
| Martin Schwartz
"Regulation of intracellular calcium by integrins" |
2:00 pm | Workshop: Biotechnology |
| Chairs: Michael Pierschbacher, David Phillips and Michael Gallatin |
7:00 pm | Integrins as intracellular receptors |
| Discussion Leader: Martin Hemler |
| Eric Brown
"Integrin associated protein" |
| Alan Horwitz
"Mutational analysis of cytoplasmic domains" |
| Filippo Giancotti
"Molecular analysis of the α6β4 integrin" |
WEDNESDAY |
9:00 am | Biological integration of adhesive signals |
| Discussion Leader: Louis Reichardt |
| Ralph Isberg
"Invasin and β1 integrin chain determinants necessary for efficient bacterial internalization by mammalian cells" |
| Caroline Damsky
"Genetic approaches to integrin function in differentiation and invasion" |
| Dave Cheresh
"Molecular signalling and integrin-mediated cell migration" |
7:00 pm | Integrin antagonists |
| Discussion Leader: Deane Mosher |
| Jack Lawler
"The structure, function and evolution of the thrombospondin genes" |
| Kathryn Crossin
"Cytotactin - a matrix protein with adhesive and counter-adhesive domains" |
THURSDAY |
9:00 am | Molecular genetic analysis of nectins and integrins |
| Discussion Leader: Richard Hynes |
| Doug Dean
"α4β1 and VCAM-1 in development" |
| Dianne Fristrom
"Drosophila integrins" |
| Edward Hedgecock
"Extracellular matrix in C. Elegans" |
2:00 pm | Workshop: Novel integrins and variants |
| Chairs: Vito Quaranta and Dean Sheppard |
7:00 pm | Keynote Talk |
| Henry Bourne
"Signaling specificity of G proteins" |
FRIDAY |
9:00 am | Modulation of integrin function |
| Discussion Leader: Sanford Shattil |
| Tom Parsons
"Tyrosine kinases" |
| Leslie Parise
"Dynamic regulation of integrin αIIb-β3" |
| Carl Figdor
"Modulation of β1 and β2 integrins" |