I. Sunday PM
January 31 | Fibronectin Matrix Assembly and Signaling |
Jean Schwarzbauer, Chair
- Jean Schwarzbauer (Princeton) - Fibronectin assembly and transmembrane signaling
- Martin Humphries (Manchester) - Structure/function of the FN heparin binding region
- Denise Hocking (U. Rochester) - Excess deposition of fibronectin and collagen in pulmonary fibrosis (short talk)
- Bill Kaelin (Dana Farber) - Fibronectin matrix and tumor suppressor function
- Jamie MacLeod (Cornell) - FN-C, a cartilage-specific alternatively spliced form of FN (short talk)
II. Monday AM
February 1 | Cooperative Signaling by Integrins and Associated Receptors |
Ken Yamada, Chair
- Ken Yamada (NIDR/NIH) - Regulation of Integrin signaling complexes
- Martin Schwartz (Scripps) - Integrins, oncogenes and growth control
- Martin Hemler (Dana Farber) - Signaling complexes formed by integrins and TM4SF proteins
- Ann Woods (U. Ala.) - Integrins and syndecans
- Laird Bloom (MIT) - Heparin binding activity in FN (short talk)
| Optional Afternoon Workshop | NIH Informal Workshop (2-4 pm) |
- Zakir Bengali - SRA of the Pathobiochemistry Study Section
- Suresh Mohla - Program Officer, Cancer Biology Program, National Cancer Institute
These veterans of the Grants Review Branch (Bengali) and the NCI Extramural Program (Mohla) will make short presentations and answer questions. They will also be available for informal consultation throughout the Conference.
| Afternoon Poster Session I (4:30-6:00 pm) |
| III. Monday PM | Keynote Presentation |
- Tony Pawson (Toronto) - Receptors and modular signaling proteins in cellular interactions
IV. Tuesday AM
February 2 | Integrin Activation and Signaling |
Mark Ginsberg, Chair
- Mark Ginsberg (Scripps) - Cytoplasmic domains and integrin activation
- Timothy Springer (Harvard) - Extracellular β-propeller modules
- Erkki Ruoslahti (Burnham Instit.) - R-ras and an Eph/R-ras pathway regulating integrin activity
- Tom Daniel (Vanderbilt) - Ephs, integrin activation and vascular patterning
- Jun-Lin Guan (Cornell) - Regulation of cell cycle apoptosis by FAK and Pyk2 (short talk)
| Optional Afternoon Workshop | Biotechnology and Therapeutics |
Sarah Bodary (Genentech), Organizer
- Martine Gaillard (Hoecsht Marion Roussel) - Prevention of bone resorption and osteoporosis in animal models by OARAs: new nonpeptidic ligands of the alpha V beta 3 vitronectin receptor
- Sarah Bodary (Genentech) - From proteins to small molecules -- LFA-1 antagonists as anti-inflammatory therapeutics
- Marvin Garavoy (XOMA) - Does antibody-targeting of LFA-1 alter expression of the immunologically-mediated disease, Psoriasis?
- Douglas Cerretti (Immunex) - TNF-alpha antagonism: from the TNF-alpha converting enzyme (TACE/ADAM 17) to Enbrel (soluble TNF receptor)
- Roy Lobb (Biogen) - VLA-4 antagonists: current status
| Afternoon Poster Session II (4:30-6:00 pm) |
| V. Tuesday PM | Integrin activation and signaling (continued) |
Eric Brown, Chair
- Eric Brown (Wash. U.) - Reversible integrin activation and inactivation
- Shokat Dedhar (UBC) - ILK and integrin signaling
- David Schlaepfer (Scripps) - Connections between growth factors, FAK, and cell migration
- Lucia Languino (Yale) - Role of p27kip1 in integrin modulation of cell proliferation
VI. Wednesday AM
February 3 | Adhesion and Disease |
Jeff Bergelson, Chair
- Jeff Bergelson (CHOP/Penn) - Integrins and viral infection: echo and adenovirus
- Jean-Louis Mege (U. Marseilles) - Pathogenesis of rickettsiae
- Claire Doerschuk (Harvard) - Role of β-2 integrins in host defense
- Avi Kupfer (Nat'l Jewish Hosp.) - Formation of 3-D segregated SMACs during T cell activation (short talk)
- Steve Teitelbaum (Wash. U.) - Osteoclast αVβ3: controlling osteoporosis
| Optional Afternoon Workshop | Genetic Approaches: Animal Models |
Arnoud Sonnenberg (NKI), Organizer
- Arnoud Sonnenberg (NKI) - Genetic analysis of integrin splice variants in mice
- Ben Williams (Univ. Illinois) - Integrin and integrin-linked kinase function during C. elegans muscle development
- Amanda Littlewood-Evans (Friedrich-Miescher Inst.) - Inner ear sensory hair loss, neuronal apoptosis and balance defects in integrin alpha-8-deficient mice
- Maria l. Valencik (Mayo Clinic) - Transgenic expression of a dominant negative integrin in the heart reveals a critical role for integrin regulation in cardiac function
- Joy Yang (Johns Hopkins Univ.) - Using chimeric analysis to study the role of alpha-4 beta-1 integrin in mouse embryonic development
- Elisabeth Georges-Labouesse (Univ. Strasbourg) - Overlapping functions of alpha-3 and alpha-6 integrins during mouse development
- Michael DiPersio (Albany Medical College) - Use of conditionally-immortalized keratinocytes from alpha-3 deficient mice to study integrin-dependent mechanisms of matrix organization
| Afternoon Poster Session III (4:30-6:00 pm) |
| VII. Wednesday PM | ECM and Survival |
Zena Werb, Chair
- Dusko Ilic (UCSF) - FAK, FRNK and anchorage-dependent survival
- Monique Arpin (Curie Inst.) - Role of ezrin, a membrane-cytoskeleton linker, in adhesion-dependent epithelial cell survival
- Zena Werb (UCSF) - Matrix, proteolysis and survival
- Paola DeFilippi (U. Torino) - Integrin activation of EGF-R: role in adhesion-dependent survival (short talk)
VIII. Thursday AM
February 4 | Signaling from the Cytoskeleton |
Mary Beckerle, Chair
- Anna Huttenlocher (Univ. Ill.) - Regulation of migration by integrins
- Mary Beckerle (Univ. Utah) - Roles of integrin-associated protein complexes in cell motility
- Josephine Adams (Univ. College London) - Organization of cytoskeleton by fascin and GTPases in response to thrombospondin (short talk)
- David Critchley (Univ. Leicester) - Studies on talin and paxillin and focal adhesion assembly (short talk)
- Deborah Black (Stony Brook) - The Yersinia tyrosine phosphatase targets focal adhesion on host cells (short talk)
- Diane Barber (UCSF) - Rho, Na+/H exchange and the cytoskeleton
| Afternoon Poster Session IV (4:30-6:00 pm) |
| IX. Thursday PM | ECM, Integrins and Development |
Richard Hynes, Chair
- Richard Hynes (MIT) - Insights from genetic targeting of adhesion molecules
- Susan Fisher (UCSF) - Trophoblast and "pseudo-vasculogenesis"
- Dean Sheppard (UCSF) - Role of TGF β
lactivation in integrin-mediated regulation of tissue inflammation and fibrosis
- Humphrey Gardner (Scripps) - New phenotypes for integrins α1 and α2 subunit knockouts (short talk)
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