| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Integrin Structure & activation |
| Session Chair: Robert C. Liddington, Burnham Institute |
| David Calderwood, Yale University School of Medicine
"Control of integrin-talin interactions regulates integrin activation" |
| Timothy A. Springer, Harvard Medical School
"Transduction of conformational change in integrins across membranes" |
| Tina Izard, St. Jude Children's Research Hospital
"Dynamic Alterations in Vinculin Structure Relay Integrin Signals" |
| Short Talk: Robert C. Liddington, Burnham Institute |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell-matrix contacts and signaling |
| Session Chair: Martin Humphries, University of Manchester |
| Tatsuo Kinashi, Kyoto University
"Regulation of integrin-mediated adhesion and migration by Rap1 and RAPL" |
| Renata Pasqualini, University of Texas M.D. Anderson Cancer Center
"Functional signaling pathways in vascular, stromal, and tumor cells revealed by targeting integrin cytoplasmic domains" |
| Pier Carlo Marchisio, San Raffaele Scientific Institute DIBIT
"Organization of a novel podosome" |
| 11:15 am | Photo |
| Nellie Kieffer, University of Luxembourg
"Functional role of talin in integrin αIIβ3 mediated cell adhesion" |
| Short Talk: Ivanmatteo De Curtis, San Raffaele Scientific Institute DIBIT |
| Martin Humphries, University of Manchester
"Integrin signaling pathways controlling focal adhesions and cell migration" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1. First Authors (A-G) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Integrin Membrane interactions |
| Session Chair: Filippo Giancotti, Sloan-Kettering Memorial Cancer Institute |
| Martin E. Hemler, Dana Farber Cancer Institute
"Modulation of integrin-dependent functions by tetraspanin proteins" |
| Harold Chapman, University of California San Francisco
"Regulation of β1 integrin function by the urokinase receptor" |
| William G. Stetler-Stevenson, National Cancer Institute, N.I.H.
"TIMP-2 mediated inhibition of angiogenesis through alpha3beta1 & regulation of Shp1 association with alpha3beta1" |
| Short Talk: Chuanyue Wu, University of Pittsburg |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Integrins in morphogenesis |
| Session Chair: Caroline Damsky, University of California, San Francisco |
| Jordan Kreidberg, Harvard Medical School
"Integrins in epithelial morphogenesis" |
| Douglas E. DeSimone, University of Virginia
"Fibronectin Matrix and the Regulation of Directed Cell Movements in Morphogenesis" |
| Federico Bussolino, University of Torino
"Class 3 semaphorin regulation of vascular morphogenesis through integrin inhibition" |
| Vincenzo Cirulli, University of California, San Diego
"Adhesive and migratory cues in the developing pancreatic epithelium" |
| Paola DeFilippi, University of Torino
"P130Cas and p140Cap in mammary epithelial cell organization" |
| Short Talk: Julia L. Mills, University of British Columbia |
| Short Talk: Miguel Del Pozo, Cardiovascular Research National Center (CNIC) |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Informal/Optional discussion on Integrin Therapeutics |
| Roy Lobb, Albor Biologics Inc. (Chair and Moderator) |
| Jefferson Tilley, Hoffmann-La Roche Inc.
"Discovery of alpha4 integrin small molecule antagonists" |
| Ted Yednock, Elan Pharmaceuticals
"Clinical update on Tysabri, a humanized antibody to alpha 4 integrin, for the treatment of multiple sclerosis and Crohn's disease" |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cell Migration |
| Session Chair: Anna Huttenlocher, University of Wisconsin Madison |
| Mike Sheetz, Columbia University
"Forces on Integrins Activate Tyrosine Kinase Substrates Locally and Signal Globally" |
| Alex Kolodkin, Johns Hopkins University School of Medicine
"Molecular mechanisms of neuronal growth cone guidance" |
| Short Talk: Charles ffrench-Constant, University of Cambridge |
| Anne Huttenlocher, University of Wisconsin Madison
"Calpain regulation during cell migration" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling in disease |
| Session Chair: Jean Schwarzbauer, Princeton University |
| Fiona Watt, London Research Institute/CR-UK
"Role of cell adhesion molecules in regulating the stem cell compartment of normal epidermis and epidermal tumours" |
| Richard Hynes, Massachusetts Institute of Technology
"Pathological consequences of mutations in adhesion genes" |
| David Cheresh, The Scripps Research Institute
"Physiological Consequences of Vascular Cell Adhesion Mechanisms" |
| Erkki Ruoslahti, Burnham Institute
"Regulation of anoikis by the Bit1-Groucho pathway" |
| Short Talk: Steve Nishimura, University of California San Francisco |
| Short Talk: Staffan Stromblad |
| Short Talk: Elizabeth Luna, University of Massachusetts |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 2:00 pm - 4:00 pm | Informal/Optional session for new investigators to discuss funding opportunities at the N.I.H. & strategies for initiating a successful career |
| Dr. Neeraja Sathyamoorthy, Program Officer, National Cancer Institute |
| 4:00 pm - 6:00 pm | Poster Session 2. First Authors (H-N) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Speaker |
| Atsushi Miyawaki, RIKEN Institute
"Novel approaches to visualizing protein function in living cells" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Matrix assembly |
| Session Chair: Kenneth M. Yamada, N.I.D.C.R., N.I.H. |
| Peter D. Yurchenco, Robert Wood Johnson Medical School
"Role of laminin assembly and apoptosis in the polarization of embryonic epithelia" |
| Kevin P. Campbell, University of Iowa Carver College of Medicine
"Functional domains required for dystroglycan-dependent basement membrane Interactions" |
| Jean E. Schwarzbauer, Princeton University
"Fibronectin matrix assembly in three dimensions" |
| Martin A. Schwartz, University of Virginia
"Extracellular matrix remodeling and integrin signaling in the endothelial response to fluid shear stress" |
| Short Talk: Ghada Kurban, McGill University |
| Short Talk: Johanna Ivaska, University of Turku |
| Short Talk: Kenneth M. Yamada, N.I.D.C.R., N.I.H. |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 2:00 pm | Informal/Optional roundtable to discuss Cell Migration Consortium |
| Robert C. Liddington, Burnham Institute (Organizer) |
| 4:00 pm - 6:00 pm | Poster Session 3. First Authors (N-Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Effectors & regulators |
| Session Chair: Dean Sheppard, University of California, San Francisco |
| Richard A. Anderson, University of Wisconsin School of Medicine
"Phosphoinositides at Focal Adhesions Key Mediators of Integrin Function" |
| Mary C. Beckerle, University of Utah
"New roles for LIM proteins in integrin signaling" |
| Mark H. Ginsberg, University of California, San Diego
"Connecting Integrins to Tumor Cell Growth and Nutrient Signaling" |
| Dean Sheppard, University of California, San Francisco
"Role of integrin-linked spermine/spermidine acetyltransferase in accelerated cell migration" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
