Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: ECM Adhesion and Stem Cell Fate |
| Discussion Leader: Charles Streuli (University of Manchester, United Kingdom) |
7:40 pm - 8:20 pm | Fiona Watt (Kings College London, United Kingdom) "Regulation of Epidermal Stem Cell Fate by Cell-Cell and Cell-ECM Adhesion" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Penney Gilbert (University of Toronto, Canada) "Adhesion, Mechanics, and Muscle Stem Cells" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Sara Wickstrom (Max Planck Institute for Biology of Aging, Germany) "Regulation of Stem Cell Quiescence by Cell-Matrix Interaction" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | From Molecules to Adhesions: A Biophysical Perspective |
| Discussion Leader: Alexander Bershadsky (Mechanobiology Institute, Singapore / Weizmann Institute of Science, Israel) |
9:00 am - 9:20 am | Alexander Dunn (Stanford University, USA) "Nanoscale Architecture of Force Transmission at Integrin Adhesions" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Cheng Zhu (Georgia Institute of Technology, USA) "Force-Dependent Cross Modulation of Integrin Activation" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | David Calderwood (Yale University, USA) "Control of Integrin Signaling by Activator and Inhibitor Networks" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Matthew Paszek (Cornell University, USA) "Glycocalyx and Force Regulation of Integrin Signaling" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Frederic Lagarrigue (University of California, San Diego, USA) "Visualizing an Integrin Activation Complex in Living Cells" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Rishita Changede (Mechanobiology Institute, Singapore) "Integrin Clusters of 100nm Form Early Adhesions and Depend on Talin" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Mechanics, Integrins, and Adhesion Signaling |
| Discussion Leader: Martin Humphries (University of Manchester, United Kingdom) |
6:00 pm - 6:20 pm | Corinne Albiges-Rizo (Albert Bonniot Institute, CNRS, INSERM, France) "Integrin Signaling in Mechanotransduction" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:45 pm | Tobias Zech (University of Liverpool, United Kingdom) "N-WASP/WIP Mediated Matrix Adhesion Site Maturation Drives 3D Cancer Cell Migration Through Direct Force Coupling to the Nucleus" |
6:45 pm - 6:55 pm | Discussion |
6:55 pm - 7:15 pm | Senthil Muthuswamy (University Health Network, University of Toronto, Canada) "Basement Membrane Assembly During 3D Morphogenesis: A Role for Rotating Epithelial Structures" |
7:15 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Martin Schwartz (Yale School of Medicine, USA) "Fibronectin as a Modulator of Vascular Inflammation and Atherosclerosis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Adhesion Dynamics |
| Discussion Leader: Jim Norman (Beatson Institute for Cancer Research, United Kingdom) |
9:00 am - 9:25 am | James Casanova (University of Virginia Health Sciences, USA) "Regulation of Integrin Internalization and Recycling" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Patrick Caswell (Wellcome Trust Centre for Cell-Matrix Research, United Kingdom) "Integrin Trafficking Reprograms the Actin Cytoskeleton for Migration in 3D-Matrix" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:50 am | Mridu Acharya (Benaroya Research Institute, USA) "Alpha(v) Integrins Engage Autophagy Components to Regulate Immune Receptor Trafficking and Signaling" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Anne Straube (University of Warwick, United Kingdom) "Microtubule-Based Transport in the Regulation of Focal Adhesions and Podosomes" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Mark Morgan (Institute of Translational Medicine, University of Liverpool, United Kingdom) "Syndecan-4 Controls Integrin Trafficking to Regulate the Biochemical and Biomechanical Properties of the Extracellular Microenvironment" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Philippe Chavrier (Institut Curie, France) "Mechanism of Matrix Metalloproteinase Secretion During Breast Tumor Cell Invasion" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Adhesion Dynamics and Cell Phenotype |
| Discussion Leader: Jean Schwarzbauer (Princeton University, USA) |
6:00 pm - 6:20 pm | Donald Gullberg (University of Bergen, Norway) "Collagen-Binding Integrin Receptors: Static Links or Indicators of Connective Tissue Dynamics" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Diane Barber (University of California, San Francisco, USA) "pH Sensors Regulating Motility and Adhesion Dynamics" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Suresh Alahari (Louisiana State University, USA) "Nischarin Regulates Breast
Cancer Progression Through the AMPK-mTOR Pathway" |
7:15 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Nicholas Brown (University of Cambridge, United Kingdom) "The Integrin-Cytoskeletal Link: Subcomplex Dynamics and Stoichiometry" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Reciprocal Interplay Between the ECM and Tissue Phenotype |
| Discussion Leader: Rebecca Wells (University of Pennsylvania, USA) |
9:00 am - 9:20 am | Thomas Barker (Georgia Institute of Technology / Emory University, USA) "Fibronectin and Lung Fibrosis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Mercedes Costell (University of Valencia, Spain) "Alpha5 Beta1 Integrin Adhesion to Fibronectin: The Synergy Site Function In Vivo" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Scott Holley (Yale University, USA) "Fibronectin in Zebra Fish Development" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Matthias Lutolf (Ecole Polytechnique Federale de Lausanne, Switzerland) "Bioengineering Approaches to Guide Stem Cell-Based Organogenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Alexandra Naba (Massachusetts Institute of Technology, USA) "Dissecting the
Contributions of the Extracellular Matrix to Tumor Progression and Metastasis
Using Proteomics" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Gertraud Orend (INSERM University of Strasbourg, France) "Use of Genetic Models to Unravel Tumorigenic Signaling by Tenascin-C" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | ECM, Signaling, and Adhesion in Context |
| Discussion Leader: Mark Ginsberg (University of California, San Diego, USA) |
6:00 pm - 6:20 pm | Ellen Van Obberghen-Schilling (University of Nice, France) "Oncofetal Fibronectin in the Tumor Microenvironment" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:45 pm | Whitney Longmate (Albany Medical College, USA) "Cross-Suppression of Epidermal Integrin a3β1 by a9β1 Regulates the Paracrine-Mediated Resolution of Wound Angiogenesis" |
6:45 pm - 6:55 pm | Discussion |
6:55 pm - 7:15 pm | Lina Dagnino (University of Western Ontario, Canada) "Role of Integrin-Linked Kinase in Epidermal Integrity and Barrier Function" |
7:15 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Kevin Janes (University of Virginia, USA) "Cell-to-Cell Heterogeneities Caused by Adhesion and ECM-Resident Ligands in Breast Cancer" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Adhesion and Signaling in Tissue Development and Homeostasis |
| Discussion Leader: Reinhard Faessler (Max Planck Institute of Biochemistry, Germany) |
9:00 am - 9:20 am | Nasreen Akhtar (University of Sheffield, United Kingdom) "Integrins and Rho GTPases in Mammary Gland Development" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | J. Matthew Barnes (University of California, San Francisco, USA) "A Glycocalyx-Integrin Mechano Switch Promotes Glioma Aggression" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:20 am | Coffee Break |
10:20 am - 10:40 am | Roy Zent (Vanderbilt Medical Center, USA) "Integrins and the Kidney" |
10:40 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Shaohua Li (Rutgers University, Robert Wood Johnson Medical School, USA) "Integrins and Dystroglycan Compensate Each Other to Mediate Basement Membrane Assembly and Epiblast Morphogenesis" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Jianfeng Chen (Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China) "Regulatory T Cell Depletion in the Gut Cased by Integrin β7 Deficiency Exacerbates DSS Colitis by Evoking Aberrant Innate Immunity" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:20 pm | Dean Sheppard (University of California, San Francisco, USA) "Targeting Integrins to Treat Organ Fibrosis, Tissue Edema and Auto-Immunity" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Adhesion and Signaling in Disease |
| Discussion Leader: Johanna Ivaska (University of Turku, Finland) |
6:00 pm - 6:20 pm | Richard Assoian (University of Pennsylvania, USA) "How Arteries Stiffen, How Cells Respond, and Why It Matters" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Judith Varner (University of California, San Diego, USA) "Innate Immune Cell Integrins Control Tumor Immune Suppression" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | David Schlaepfer (University of California, San Diego, USA) "FAK in Cancer: Mechanistic Findings and Clinical Applications" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Simon Goodman (Merck KGaA, Germany) "Therapeutic Application of Drugs Aimed at Integrins: Intensive Concentration with a Detached Attitude" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |