Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Extracellular Matrix in Tissue Function
Discussion Leader: Charles Streuli (University of Manchester, United Kingdom)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:40 pm
Billy Hudson (Vanderbilt University, USA)
"Evolutionary Dawn of the Extracellular Matrix and Epithelial Tissues"
8:40 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
How Signals from the Matrix Control Cell Fate
Discussion Leader: Ambra Pozzi (Vanderbilt University School of Medicine, USA)
9:00 am - 9:20 am
Alfred Nordheim (University of Tuebingen, Germany)
"Matrix Control of Liver Fibrosis"
9:20 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: Kate Herum (University of California, San Diego, USA)
"Mechanical Regulation of Fibroblast Pro-Fibrotic Phenotypes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Qing-Jun Meng (University of Manchester, United Kingdom)
"ECM-Dependent Circadian Clocks"
10:20 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Florian Bentzinger (University of Sherbrooke, Canada)
"Impaired Adhesion to the Stem Cell Niche ECM Affects the Regenerative Capacity of Aged Skeletal Muscle"
11:30 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Therapeutic Targeting of Integrins In Vivo "
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Johanna Ivaska (University of Turku, Finland) and Ambra Pozzi (Vanderbilt University School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Matrix Architecture and Cell Function
Discussion Leader: Christine-Maria Horejs (Karolinska Institutet, Sweden)
7:30 pm - 7:50 pm
Michael Sherratt (University of Manchester, United Kingdom)
"Matrix Architecture in Ageing"
7:50 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Selected from Poster Abstracts: Rishita Changede (Mechanobiology Institute, National University of Singapore, Singapore)
"Nanoclusters Are Building Blocks of Cell-Matrix Adhesions"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Christopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
"Unveiling Adhesion Regulation Mechanisms Using Engineered Microenvironments"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Ambika Kurbet (Institute for Stem Cell Biology and Regenerative Medicine, India)
"Sterile Inflammation Enhances EMC Degradation in Integrin β1 KO Embryonic Skin"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanotransduction
Discussion Leader: Andrew Chisholm (Wellcome Trust, United Kingdom)
9:00 am - 9:20 am
Medhavi Vishwakarma (Max Planck Institute for Intelligent Systems, Germany)
"Mechanotransduction in Collective Cell Migration"
9:20 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: John Lamar (Albany Medical College, USA)
"Integrin/Src-Mediated YAP/TAZ Activation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jing Yang (University of California, San Diego, USA)
"Regulation of EMT and Tumour Metastasis by Matrix Stiffness"
10:20 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Valerie Weaver (University of California, San Francisco, USA)
"Mechanisms of Cancer Metastasis"
11:30 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Selected from Poster Abstracts: Jose De Pereda (Institute for Molecular and Celular Biology of Cancer (CSIC-USAL), Spain)
"Interaction Between Integrin a6b4 and BPAG1e"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Selected from Poster Abstracts: Coert Margadant (Sanquin Research, The Netherlands)
"A Novel Complex Regulating Integrin Sorting to Recycling Endosomes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Extracellular Matrix and Stem Cells
Discussion Leader: Petra Gross (Journal of Cell Science, United Kingdom)
7:30 pm - 7:50 pm
Charles ffrench-Constant (University of Edinburgh, United Kingdom)
"The Matrix in Neuronal Stem Cells and Fate"
7:50 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Selected from Poster Abstracts: Johanna Englund (Institute of Biotechnology, University of Helsinki, Finland)
"BM Laminins Regulate Stemness by Guiding Asymmetric Cell Division"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Andres Garcia (Georgia Institute of Technology, USA)
"Engineering Synthetic ECMs for Stem Cells"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Gregory Goreczny (SUNY Upstate Medical University, USA)
"Hic-5 Promotes Mammary Tumor Progression Through Remodeling of the Extracellular Matrix"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Adhesion in Cancer
Discussion Leader: Bruce Rogers (Morphic Therapeutic, USA)
9:00 am - 9:20 am
Clare Isacke (Breast Cancer Now Research Centre, United Kingdom)
"Novel Metastasis Modulators Involving Stromal ECM"
9:20 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: Joseph Juan (Genentech, USA)
"Inhibiting Integrin α5β1 Modulates Matrix Formation in the Tumor"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Chris Madsen (Lund University, Sweden)
"ECM Remodelling During Cancer Progression and Metastasis"
10:20 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
John Marshall (Barts Cancer Institute, Queen Mary University of London, United Kingdom)
"Integrins as Cancer Therapeutic Targets"
11:30 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Jennifer Elisseeff (Johns Hopkins University, USA)
"Immunology of ECM-Derived Biomaterials in Regeneration and Cancer"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell Migration
Discussion Leader: Tobias Zech (University of Liverpool, United Kingdom)
7:30 pm - 7:50 pm
Ambra Pozzi (Vanderbilt University School of Medicine, USA)
"Talin Regulates Discoidin Domain Receptor1-Mediated Cell Junctions"
7:50 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Selected from Poster Abstracts: Guillaume Jacquemet (University of Turku, Finland)
"Myosin-X Filopodia and Cancer Cell Invasion"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Nils Gauthier (IFOM - The FIRC Institute of Molecular Oncology, Italy)
"Cell Migration in Fibrous Microenvironments"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Nisha Mohd Rafiq (Mechanobiology Institute, Singapore)
"ARF1-Induced Myosin II Suppresion of Podosomes"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Integrin Trafficking
Discussion Leader: Johanna Ivaska (University of Turku, Finland)
9:00 am - 9:20 am
Ludger Johannes (Institut Curie, France)
"Endocytic Uptake and Retrograde Trafficking of Focal Adhesion Proteins"
9:20 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: Stephanie Kermorgant (Barts Cancer Institute, Queen Mary University of London, United Kingdom)
"Co-Trafficking of Beta 1-Integrin and c-Met Promote Cancer Cell Survival"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ralph Boettcher (Max Planck Institute of Biochemistry, Germany)
"Analyzing Integrin Trafficking and Its Role for Integrin Function and Stability"
10:20 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
David Lyden (Weill Cornell Medicine, USA)
"Exosomes and Metastasis"
11:30 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Jim Norman (Beatson Institute, University of Glasgow, United Kingdom)
"Integrins and Trafficking"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: How the Adhesome Works
Discussion Leader: Roy Zent (Vanderbilt University Medical Center, USA)
7:30 pm - 7:40 pm
Ben Goult (University of Kent, United Kingdom)
"Talin as a Mechanosensitive Signaling Platform"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Roland Thuenauer (University of Freiburg, Germany)
"Unraveling Integrin Sorting in Epithelial Cells by Synchronizing Integrin Trafficking"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:50 pm
Mark Ginsberg (University of California, San Diego, USA)
"Deconvoluting the Adhesome"
8:50 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure