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Fibronectin, Integrins and Related Molecules

Gordon Research Conference

Extracellular Matrix and Integrins: Regulation of Cell and Tissue Function

May 5 - 10, 2019

Chairs

and

Vice Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The 2019 Gordon Research Conference on “Fibronectin, Integrins and Related Molecules” will be held May 5th-10th at the Il Ciocco Hotel and Resort, Lucca (Barga), Italy. This is the premier international conference for academic, government and industry scientists interested in understanding how integrins and the extracellular matrix regulate virtually every aspect of cell and tissue function. The program reflects the interdisciplinary nature of the integrin and extracellular matrix field, spanning different areas of biology from inflammation to mechanobiology, cell migration, stem cells, development, and cancer. The meeting will showcase cutting-edge new technological advances in imaging, modelling, biosensors and single molecule techniques and feature paradigm shifts linked to metabolism, basement membranes and stem cell niches, receptor trafficking and structural biology. It will highlight exciting unpublished data and stimulate active discussion among all participants. It will include 5-10 short talks selected from abstracts and four poster sessions. Graduate students and postdoctoral fellows are encouraged to apply to the associated Gordon Research Seminar (GRS).

Related Meeting

This GRC will be held in conjunction with the "Fibronectin, Integrins and Related Molecules" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Making Sense of Focal Adhesions Discussion Leader:
7:40 pm - 8:20 pm	"Genetics and Cell Biology of Focal Adhesion Proteins"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Nanoscale Architecture of the Integrin-Based Adhesion Complexes and Cortical Actin Cytoskeleton in Embryonic Stem Cells"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"In Vivo Adhesive Structures in Drosophila to Gain Insight into the Function of Adhesion Components"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Integrin Binding Proteins Discussion Leader:
9:00 am - 9:20 am	"Kindlin's Structure and Function"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Regulation of Integrin Bidirectional Signaling by Distinct Modular Interactions"
9:50 am - 10:00 am	Discussion
10:00 am - 10:15 am	Selected from Poster Abstracts: "Force Tuning Through Regulation of Clathrin-Dependent Integrin Endocytosis"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Distinct Adhesion Complexes and Integrin Associated Proteins"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	Selected from Poster Abstracts: "Unraveling the Mechanisms Enabling ECM Sensing at Filopodia Tips"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	Selected from Poster Abstracts: "Fever Promotes T-Cell Trafficking via a Thermal Sensory Hsp90-α4 Integrin Pathway"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizers: and
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Inflammation and Homeostasis Discussion Leader:
6:00 pm - 6:20 pm	"β2 Integrin Regulation"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Integrin Signaling Regulates Insulin-Stimulated Metabolism"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Role of Integrins in Regulatory T Cell Biology"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Biomechanical Regulation of Morphogenesis and Tissue Homeostasis by Cell-Matrix Adhesion"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Mechanisms and Mechanics of Integrin ECM Connections Discussion Leader:
9:00 am - 9:20 am	"Structural Characterization of Integrins by Single-Particle EM"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Exploring How Fibronectin-Binding Integrins upon Initiating Adhesion Sense Mechanical Load and Signal Other Integrins to Strengthen Cell Adhesion"
9:50 am - 10:00 am	Discussion
10:00 am - 10:15 am	Selected from Poster Abstracts: "Leukocyte Integrin Activation Reduces Tumor Progression by Reprogramming Tumor-Associated Macrophages and Is a Novel Therapeutic Strategy"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Tuning Force Transduction in Amoeboid Migration"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Exploring the Substrate Dependence of Integrin-Mediated Mechanotransduction"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Selected from Poster Abstracts: "Integrins Control Basal-Cell Positioning and YAP Activity at Tumor Margins to Initiate Invasion"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Selected from Poster Abstracts: "Alpha(v) Integrins and Autophagy Proteins Regulate Immune Signaling Through Intracellular Trafficking Event"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Integrin Delivery and Adhesion Structures Discussion Leader:
6:00 pm - 6:20 pm	"Mechanistic Details of Integrin and Other Cell Adhesion Molecules Trafficking Through the Endo-Lysosomal Network"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Frustrated Endocytosis in Cell Migration and Mechanotransduction"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Structural Biology of Cell Shape Formation"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	Selected from Poster Abstracts: "The Nuclear Import Machinery Captures Endosomes to Drive Depletion of Nuclear G-Actin and SRF/MRTF Gene Expression"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	Selected from Poster Abstracts: "Control of Vascular Permeability via β1-Integrin"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cell-ECM Interfaces Discussion Leader:
9:00 am - 9:20 am	"Integrin Associated Proteins Regulate Metastatic Dissemination Through Alterations to the Tumor Microenvironment"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Structural Mechanism of Laminin Recognition by Integrins"
9:50 am - 10:00 am	Discussion
10:00 am - 10:15 am	Selected from Poster Abstracts: "Extracellular Matrix Components HAPLN1, Lumican and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Matrix Microenvironment Mediated Drug Resistance in Cancer"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	"The Multifaceted Functions of Fibronectin in Tumor Tissue"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Selected from Poster Abstracts: "Extracellular Matrix Mechanical Cues Regulate Lipid Metabolism Through Lipin-1 and SREBP"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Selected from Poster Abstracts: "Biochemical Elucidation of the Bipartite Binding Site of Laminin for Integrins"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Tools and Models for Deciphering Forces Discussion Leader:
6:00 pm - 6:20 pm	"Probes for Integrin Force Imaging"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Mechanotransduction and Mechanoadaptation at the Nucleocytoskeletal Interface"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Deciphering the Talin Code Using Structural Mechanobiology"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	Selected from Poster Abstracts: "Force-Independent Association of the Mechanosensors Talin and Vinculin"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	Selected from Poster Abstracts: "Rap1 Binding and a Lipid-Dependent Helix in Talin F1 Domain Promote Integrin Activation in Tandem"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm	Integrating Force and Function Discussion Leader:
9:00 am - 9:20 am	"Cell-Basement Membrane Interactions During Collective Cell Migration"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Mechanical Communication Between Cells and the Matrix"
9:50 am - 10:00 am	Discussion
10:00 am - 10:15 am	Selected from Poster Abstracts: "Fibronectin-Mediated Inter-Tissue Adhesion Predisposes the Neural Tube to Spina Bifida"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Definition of the Adhesome by Proximity Biotinylation"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Mechanobiology of Extracellular Matrix in Healthy and Diseased Tissues"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Selected from Poster Abstracts: "αv-Class Integrins Mediate Cell Adhesion to Fibronectin Exclusively Through Binding to the RGD Motif"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Selected from Poster Abstracts: "Microtubule Function in the Mechanosensitive Regulation of Cell Migration"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Keynote Session: New Molecules in Adhesion Dynamics Discussion Leader:
6:00 pm - 6:40 pm	"A Novel Milieu Molecule for TGF-β Required for Microglia Function"
6:40 pm - 6:50 pm	Discussion
6:50 pm - 7:05 pm	Selected from Poster Abstracts: "Integrin α3β1 Regulates the Keratinocyte Secretome and Promotes Epidermal Tumor Growth Through Paracrine Stimulation of the Tumor Microenvironment"
7:05 pm - 7:10 pm	Discussion
7:10 pm - 7:25 pm	Selected from Poster Abstracts: "Activation of Integrins by Ligands Through Binding to an Allosteric Site"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Integrin Dynamics and Adhesion"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by (1R13AR075407-01) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Conference History Fibronectin, Integrins and Related Molecules (GRS)

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