Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Making Sense of Focal Adhesions
Discussion Leader: Rachel Lennon (Wellcome Trust Centre for Cell-Matrix Research, United Kingdom)
7:40 pm - 8:20 pm
Reinhard Faessler (Max Planck Institute of Biochemistry, Germany)
"Genetics and Cell Biology of Focal Adhesion Proteins"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Pakorn Kanchanawong (National University of Singapore, Singapore)
"Nanoscale Architecture of the Integrin-Based Adhesion Complexes and Cortical Actin Cytoskeleton in Embryonic Stem Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Nicholas Brown (University of Cambridge, United Kingdom)
"In Vivo Adhesive Structures in Drosophila to Gain Insight into the Function of Adhesion Components"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Integrin Binding Proteins
Discussion Leader: Bernhard Wehrle-Haller (University of Geneva, Switzerland)
9:00 am - 9:20 am
Cong Yu (Southern University of Science and Technology, China)
"Kindlin's Structure and Function"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jun Qin (Cleveland Clinic, USA)
"Regulation of Integrin Bidirectional Signaling by Distinct Modular Interactions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Selected from Poster Abstracts: Corinne Albiges-Rizo (Institute for Advanced Biosciences, Université Grenoble / CNRS, INSERM, France)
"Force Tuning Through Regulation of Clathrin-Dependent Integrin Endocytosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Arnoud Sonnenberg (Netherlands Cancer Institute, The Netherlands)
"Distinct Adhesion Complexes and Integrin Associated Proteins"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts: Guillaume Jacquemet (University of Turku, Finland)
"Unraveling the Mechanisms Enabling ECM Sensing at Filopodia Tips"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Jianfeng Chen (Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China)
"Fever Promotes T-Cell Trafficking via a Thermal Sensory Hsp90-α4 Integrin Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Ambra Pozzi (Vanderbilt University School of Medicine, USA) and Johanna Ivaska (University of Turku, Finland)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Inflammation and Homeostasis
Discussion Leader: Ambra Pozzi (Vanderbilt University School of Medicine, USA)
6:00 pm - 6:20 pm
Klaus Ley (La Jolla Institute for Immunology, USA)
"β2 Integrin Regulation"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
David Wasserman (Vanderbilt University, USA)
"Integrin Signaling Regulates Insulin-Stimulated Metabolism"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
John Chang (University of California, San Diego, USA)
"Role of Integrins in Regulatory T Cell Biology"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Guy Tanentzapf (University of British Columbia, Canada)
"Biomechanical Regulation of Morphogenesis and Tissue Homeostasis by Cell-Matrix Adhesion"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms and Mechanics of Integrin ECM Connections
Discussion Leader: Madeleine Oudin (Tufts University, USA)
9:00 am - 9:20 am
Thomas Walz (Rockefeller University, USA)
"Structural Characterization of Integrins by Single-Particle EM"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Nico Strohmeyer (ETH Zurich, Switzerland)
"Exploring How Fibronectin-Binding Integrins upon Initiating Adhesion Sense Mechanical Load and Signal Other Integrins to Strengthen Cell Adhesion"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Selected from Poster Abstracts: Vineet Gupta (Rush University Medical Center, USA)
"Leukocyte Integrin Activation Reduces Tumor Progression by Reprogramming Tumor-Associated Macrophages and Is a Novel Therapeutic Strategy"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Michael Sixt (Institute of Science and Technology Austria, Austria)
"Tuning Force Transduction in Amoeboid Migration"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Pere Roca-Cusachs (Universitat de Barcelona, Spain)
"Exploring the Substrate Dependence of Integrin-Mediated Mechanotransduction"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Antoine Khalil (University Medical Center Utrecht, The Netherlands)
"Integrins Control Basal-Cell Positioning and YAP Activity at Tumor Margins to Initiate Invasion"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Mridu Acharya (Seattle Children's Research Institute, Benaroya Research Institute, USA)
"Alpha(v) Integrins and Autophagy Proteins Regulate Immune Signaling Through Intracellular Trafficking Event"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Integrin Delivery and Adhesion Structures
Discussion Leader: Guido Serini (Candiolo Cancer Institute (FPO-IRCCS), Italy)
6:00 pm - 6:20 pm
Peter Cullen (University of Bristol, United Kingdom)
"Mechanistic Details of Integrin and Other Cell Adhesion Molecules Trafficking Through the Endo-Lysosomal Network"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Guillaume Montagnac (Institut Gustave Roussy, France)
"Frustrated Endocytosis in Cell Migration and Mechanotransduction"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Naoko Mizuno (Max Planck Institute of Biochemistry, Germany)
"Structural Biology of Cell Shape Formation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Selected from Poster Abstracts: Sergi Marco (The Beatson Institute, United Kingdom)
"The Nuclear Import Machinery Captures Endosomes to Drive Depletion of Nuclear G-Actin and SRF/MRTF Gene Expression"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Selected from Poster Abstracts: Pipsa Saharinen (University of Helsinki, Finland)
"Control of Vascular Permeability via β1-Integrin"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-ECM Interfaces
Discussion Leader: Corinne Albiges-Rizo (Institute for Advanced Biosciences, Université Grenoble / CNRS, INSERM, France)
9:00 am - 9:20 am
Val Brunton (Edinburgh Cancer Research Centre, United Kingdom)
"Integrin Associated Proteins Regulate Metastatic Dissemination Through Alterations to the Tumor Microenvironment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Junichi Takagi (Institute for Protein Research, Osaka University, Japan)
"Structural Mechanism of Laminin Recognition by Integrins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Selected from Poster Abstracts: Katherine Long (King's College London, United Kingdom)
"Extracellular Matrix Components HAPLN1, Lumican and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Taru Muranen (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Matrix Microenvironment Mediated Drug Resistance in Cancer"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Ellen Van Obberghen-Schilling (Université Côte d'Azur, France)
"The Multifaceted Functions of Fibronectin in Tumor Tissue"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Sirio Dupont (University of Padua, Italy)
"Extracellular Matrix Mechanical Cues Regulate Lipid Metabolism Through Lipin-1 and SREBP"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Yukimasa Taniguchi (Osaka University, Japan)
"Biochemical Elucidation of the Bipartite Binding Site of Laminin for Integrins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tools and Models for Deciphering Forces
Discussion Leader: Vinay Swaminathan (Lund University, Sweden)
6:00 pm - 6:20 pm
Khalid Salaita (Emory University, USA)
"Probes for Integrin Force Imaging"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Sara Wickstrom (University of Helsinki, Finland)
"Mechanotransduction and Mechanoadaptation at the Nucleocytoskeletal Interface"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Ben Goult (University of Kent, United Kingdom)
"Deciphering the Talin Code Using Structural Mechanobiology"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Selected from Poster Abstracts: Paul Atherton (University of Manchester, United Kingdom)
"Force-Independent Association of the Mechanosensors Talin and Vinculin"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Selected from Poster Abstracts: Alexandre Gingras (University of California, San Diego, USA)
"Rap1 Binding and a Lipid-Dependent Helix in Talin F1 Domain Promote Integrin Activation in Tandem"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Integrating Force and Function
Discussion Leader: Jim Norman (Beatson Institute, University of Glasgow, United Kingdom)
9:00 am - 9:20 am
Sally Horne-Badovinac (University of Chicago, USA)
"Cell-Basement Membrane Interactions During Collective Cell Migration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Cynthia Reinhart-King (Vanderbilt University, USA)
"Mechanical Communication Between Cells and the Matrix"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Selected from Poster Abstracts: Scott Holley (Yale University, USA)
"Fibronectin-Mediated Inter-Tissue Adhesion Predisposes the Neural Tube to Spina Bifida"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Martin Humphries (University of Manchester, United Kingdom)
"Definition of the Adhesome by Proximity Biotinylation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Viola Vogel (ETH Zurich, Switzerland)
"Mechanobiology of Extracellular Matrix in Healthy and Diseased Tissues"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Mercedes Costell (University of Valencia, Spain)
"αv-Class Integrins Mediate Cell Adhesion to Fibronectin Exclusively Through Binding to the RGD Motif"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Sandrine Etienne-Manneville (Institut Pasteur, CNRS, France)
"Microtubule Function in the Mechanosensitive Regulation of Cell Migration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: New Molecules in Adhesion Dynamics
Discussion Leader: Mark Ginsberg (University of California, San Diego, USA)
6:00 pm - 6:40 pm
Timothy Springer (Boston Children's Hospital / Harvard Medical School, USA)
"A Novel Milieu Molecule for TGF-β Required for Microglia Function"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Selected from Poster Abstracts: Michael DiPersio (Albany Medical College, USA)
"Integrin α3β1 Regulates the Keratinocyte Secretome and Promotes Epidermal Tumor Growth Through Paracrine Stimulation of the Tumor Microenvironment"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Selected from Poster Abstracts: Yoshikazu Takada (UC Davis School of Medicine, USA)
"Activation of Integrins by Ligands Through Binding to an Allosteric Site"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
David Calderwood (Yale University, USA)
"Integrin Dynamics and Adhesion"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
