Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanobiology From Molecules to Cells
7:40 pm - 8:20 pm
"Tumor Cells Lack Rigidity Sensors and Are Mechanosensitive"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mech(n)anobiology of Dendritic Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"How Cancers Exploit Mechanical Weakness in the Stroma"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Using Integrin Structure to Devise Therapeutic Interventions
9:00 am - 9:20 am
"New Structural Insights into Integrin Signaling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structure-Guided Design of Novel Integrin Antagonists"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Single Molecule FRET Measurement Reveals Integrin Activation Trajectory"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Understanding Integrin Therapeutics Using cryoEM"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Pleiotrophin's Interaction With aM I Domain is Activation State Dependent"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Identification of a Lead Compound to Disrupt the Heterodimer Stability of ITGAV and ITGB5"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Imaging Dynamics of Cell-ECM interaction and Signaling
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Substitute Fascin for Fbronectin – Anchorage-Independent Assembly of Adhesion-like Structures Promoting Proliferation Signals in Cancer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Geometric and Mechanical Constraints on Tissue Morphogenesis by the Extracellular Matrix"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Differential Activation and Mesoscale Organization of Integrin Nanoclusters in Focal Adhesions"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"The Molecular Dynamics of Single Integrin a5ß1 Heterodimers in Living Zebrafish Embryos"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Different Types of Direct Talin-Actin Binding Play Specific Roles in Cell-ECM Adhesion During Mammalian Development"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Tools and Approaches to Study Mechanotransduction
9:00 am - 9:20 am
"Identifying Context-specific, Tension-dependent Protein Complexes Within Focal Adhesions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Probing the Mechanobiology of Wound Healing and Disease: Tools to Detect and Manipulate Fibronectin-integrin Interactions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Cell-matrix Adhesion and the Cell-cycle"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"The Mechanics of Epithelial Monolayers: Buckling, Curling, and Tearing"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Visualizing Mechanotransduction through Actin Filaments"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"The Interplay Among Force, Focal Adhesions, and YAP"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"YAP/Rigidity and Apoptosis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane and Receptor Trafficking
7:30 pm - 7:50 pm
"Turning over Active and Delivering New - Integrin Traffic and Cell Migration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Extracellular Vesicles: What Does Membrane Trafficking Have to do with It"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Tissue Fluidification in Breast Cancer Progression"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Altered Metabolism Coordinates Small Extracellular Vesicle Production and Invasive Behavior During Metastatic Seeding of Breast Cancer"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Dissecting avß6 Internalization and Trafficking"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Matrix Receptors in Fibrosis and Disease
9:00 am - 9:20 am
"SNED1: a Novel ECM Protein at the Intersection of Cancer and Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Integrin Signaling in Epithelial Cell Injury and Repair"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"The Collagen Receptor Discoidin Domain Receptor 1 Regulates Mitochondrial Oxidative Stress in Kidney Injury"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Cancer Cell Response to Isolation Stress Leads to Secretion of a Fibronectin-enriched Niche that Supports Tumor Initiation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Interrogating Basement Membrane Regulation and Dynamics in the Kidney"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Pregnancy-associated Maternal Antibodies Against ß3 Integrins Cause Endothelial Cell Damage and Disrupt Sprouting Angiogenesis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Influence of JAK2V617F Mutation on the N-glycosylation Profile of a2 and ß1 Integrins in the Megakaryocyte and Platelet Lineages"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Matrix Receptors in Host-Tumor Interaction
7:30 pm - 7:50 pm
"Blood Vessel Control of Cancer Cells – New Ways for Old Roads"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Extracellular Matrix Supports Cancer Cell Growth Under Amino Acid Starvation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Targeting the Metastatic Niche"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Integrin-Mediated TGF-Beta Activation in Tumor Immune Evasion"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cell-ECM Receptors in Cancer Cell Migration and Invasion
9:00 am - 9:20 am
"Mechanosensitive Actin Dynamics in Cancer Cell Invasion"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanosensing Governs Metabolism and Metastasis of Pancreatic Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Integrin a3ß1 Regulates the Tumor Cell Secretome to Promote a Pro-Tumorigenic Microenvironment"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"FAK and Extracellular Matrix – Making Connections in Ovarian Cancer"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Extracellular Matrix Mechanics Regulates Stem Cell Fate by Altering Nuclear Architecture"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Mechanical Regulation of Mevalonate Pathway Enzyme Synthesis via Integrin and Rac1 Signaling"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Collective Amoeboid Migration: How to Move With Integrins but no Extracellular Matrix"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Fibronectin From Structure to Function
7:30 pm - 8:10 pm
"The Not-so-Simple Process of Fibronectin Matrix Assembly"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Tensin3 Interaction With Talin Drives the Formation of Fibronectin-Associated Fibrillar Adhesions"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Fibroblasts Deposit Membranous Tracks That Steer Cancer Cell Migration"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Mechanosenssing and matrix homeostasis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure