Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Matrix Adhesion and Cancer Invasion
Discussion Leader: Johanna Ivaska (University of Turku, Finland)
3:45 pm - 4:05 pm
Tobias Zech (University of Liverpool, United Kingdom)
"Matrix Adhesion Site Composition Regulates Nuclear-Force-Coupling to Drive Polarised Cell Migration"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Sarah Palmer (Cancer Research UK Beatson Institute, United Kingdom)
"A Proteomic Approach to Identify Endosomal Cargoes Controlling Cancer Invasiveness"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Migration - Dissecting the Key Players
Discussion Leader: Roy Zent (Vanderbilt University Medical Center, USA)
7:30 pm - 7:45 pm
Nisha Mohd Rafiq (Mechanobiology Institute, Singapore)
"Myosin II-Dependent Suppression of Podosomes by an ARNO-ARF1 Signaling Axis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Gregory Goreczny (SUNY Upstate Medical University, USA)
"Hic-5 Promotes Mammary Tumor Progression Through Remodeling of the Extracellular Matrix"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jennifer Allen (University of Manchester, United Kingdom)
"Integrin-Driven Invasion in Ovarian Cancer"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Louisiane Perrin (Temple University, USA)
"Role of Soluble Cues in Extracellular Matrix Degradation During Cancer Metastasis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Mary-Kate Hayward (Barts Cancer Institute, Queen Mary University of London, United Kingdom)
"Functional Significance of Integrin avb6 and Fibronectin in DCIS-Myoepithelial Cells: Role in Progression to Invasion"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Nicolas Rabas (Cancer Research UK Beatson Institute, United Kingdom)
"Glutaminolysis: A New Pro-Invasive Role"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
ECM Dynamics and Cell Phenotype
Discussion Leader: Charles Streuli (University of Manchester, United Kingdom)
9:00 am - 9:15 am
Maqsood Ahmed (University of Edinburgh, United Kingdom)
"Extracellular Matrix in the Developing Ventral Midbrain"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Amanda Haage (University of British Columbia, Canada)
"Modulation of Integrin-Based Cell-Matrix Adhesion via Talin Autoinhibition Regulates Cell Behavior and Migration In Vivo "
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Ambika Kurbet (Institute for Stem Cell Biology and Regenerative Medicine, India)
"Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Natasha Boel (Rhodes University, South Africa)
"Investigating the Mechanism of Fibronectin Turnover: Identifying a Role for LRP1 and Hsp90"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Sophie Smolders (Hasselt University, Belgium)
"Age-Specific Function of Alpha5Beta1 Integrin in Microglial Migration During Early Colonization of the Developing Mouse Cortex"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
David Novo (Cancer Research UK Beatson Institute, United Kingdom)
"Microvesicle-Mediated Mutant p53 Gain-of-Function in Cancer and Stromal Cells"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Keynote Session: Plasticity of Cell-Matrix Interactions
Discussion Leader: Christine-Maria Horejs (Karolinska Institutet, Sweden)
1:30 pm - 2:10 pm
Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Plasticity of Cell-Matrix Interactions: Lessons from Solving Controversy"
2:10 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
