Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Extracellular Matrix and the Stem Cell Niche
Discussion Leader: Guillaume Jacquemet (University of Turku, Finland)
3:15 pm - 3:45 pm
Fiona Watt (King's College London, United Kingdom)
"The Role of the Extracellular Matrix in Regulating Stem Cell Fate"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Cells Getting Stuck In: Adhesion Structure, Dynamics and Signalling
Discussion Leaders: Ambra Pozzi (Vanderbilt University School of Medicine, USA) and Nico Strohmeyer (ETH Zurich, Switzerland)
5:30 pm - 5:45 pm
Megan Chastney (University of Manchester, United Kingdom)
"Definition of the Adhesome by Proximity-Biotinylation: Effects of Force"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Leandro Moretti (University of Virginia, USA)
"Fibronectin Exhibits Mechanical Memory"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Sarah Keary (ICFO - The Institute of Photonic Sciences, Spain)
"Super-Resolution Microscopy Reveals Nano-Hubs of Spatially Segregated Proteins Within Focal Adhesions"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Bo Shen (University of Texas Southwestern Medical Center, USA)
"Integrin Alpha11 Is an Osteolectin Receptor and Is Required for the Maintenance of Adult Skeletal Bone Mass"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Madeleine Moore (Cancer Research UK Beatson Institute, United Kingdom)
"The Translation Initiation Factor, eIF4A2 Controls ECM Production and Fibrosis in Hepatic Senescence"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Maximilian Huber (ETH Zürich, Switzerland)
"Quantification of Cell Adhesion Modulation During Mitosis Using Single-Cell Force Spectroscopy"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cells on the Move: Migration and the Matrix
Discussion Leaders: Johanna Ivaska (University of Turku, Finland) and Katherine Long (King's College London, United Kingdom)
9:00 am - 9:15 am
Marjaana Ojalill (University of Turku, Finland)
"Cancer Associated Fibroblasts Modulate Cancer Cell Invasion Through Extracellular Matrix"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Ana Rosa Saez Ibanez (IMBIM, Uppsala University, Sweden)
"Erbb3 Receptor Tyrosine Kinase Drives Recycling of β1-Integrin in Cooperation with GGA3 and Rabaptin5"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Roxanne Glazier (Emory University, USA)
"DNA Nanotechnology Reveals that Podosomes Apply Piconewton Integrin Tension on Fluid Substrates"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Alana Cowell (University of Kent, United Kingdom)
"Talin Rod Domain-Containing Protein 1 (TLNRD1) Is a Novel Actin-Bundling Protein that Localises to the Tips of Filopodia"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Paulina Moreno Layseca (Turku Centre for Biotechnology, Finland)
"Swiprosin1 Links Rab21-Containing Vesicles with the Actin Cytoskeleton to Drive Integrin Endocytosis in Breast Cancer Cells"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Allison Drain (University of California, San Francisco, USA)
"Inflammation Promotes Tumor Aggression by Stimulating Collagen Crosslinking and Stromal Stiffening"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Getting Ahead in Science: Scientific Integrity, Publishing and Career Progression
A panel discussion focusing on three topics: 1. Career - is an academic career possible without a "high-impact" paper? 2. Integrity - how do you ensure scientific integrity in an increasingly pressurized, rush-to-publish, environment? 3. Publishing - does science require publishers anymore?
Discussion Leader: Jim Norman (Beatson Institute, University of Glasgow, United Kingdom)
1:30 pm - 2:30 pm
Panel Discussion
Career Progression, Scientific Integrity and Publishing
Roy Zent (Vanderbilt University Medical Center, USA)
Fiona Watt (King's College London, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes