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Food Allergy

Gordon Research Conference

Mechanisms, Prevention of, and Emerging Therapies for Food Allergy

January 7 - 12, 2018

Chair Kari C. Nadeau

Vice Chair Gideon Lack

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

As the importance of food allergy is gaining global awareness, this first Gordon Research Conference on Food Allergy will uniquely focus on food-allergen-specific immune function in health and disease. In the past 15 years, more than 9,500 articles have been published in food allergy. Nonetheless, these developments have yet to change the standard of clinical care for food allergy — complete avoidance of the allergenic food. The pressing need for effective therapies for food allergy can only be met by developing a deeper and more comprehensive understanding of immune mechanisms. We aim to amplify the increasing momentum of research advances in food allergy with this new GRC focused specifically on its basic and translational aspects from diverse disciplinary perspectives.

Leading researchers from around the world with expertise in immunology, molecular and cell biology, and computational biology who are interested in understanding healthy and food-allergic immune function will be featured, including those who study emerging problems such as the role of the microbiome in food allergy, and the mechanisms of desensitization achieved through emerging therapies such as oral immunotherapy. This five-day international scientific conference encouraging free discussion — often of unpublished research — aims to provide cross-fertilization and collaboration among researchers in relevant fields, and will help to develop and integrate this rapidly evolving field.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Global Impact of Food Allergy Discussion Leaders: Zuhair Ballas (University of Iowa, USA) and Dale Umetsu (Genentech, USA)
7:40 pm - 7:55 pm	Opening Remarks
7:55 pm - 8:10 pm	Introduction by Discussion Leader
8:10 pm - 8:20 pm	Robert Wood (Johns Hopkins University School of Medicine, USA) "Exciting New Therapies"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:35 pm	Daniel Rotrosen (National Institute of Allergy and Infectious Diseases, NIH, USA) "NIAID's Strategic Approach to Food Allergy Research"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:50 pm	Michael Levin (University of Cape Town / Red Cross War Memorial Children's Hospital, South Africa) "Alpha Gal in Rural African Subjects"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	Katie Allen (Murdoch Children's Research Institute, Australia) "The Five Ds of Food Allergy Prevention – Is There More to the Food Allergy Epidemic than Diet Alone"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Marc Rothenberg (Cincinnati Children's Hospital Medical Center, USA) "Deciphering the Immunological, Molecular and Genetic Components of the Food Allergy Disorder Eosinophilic Esophagitis"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Food Allergy vs Tolerance: Understanding the Balance Discussion Leaders: Hugh Sampson (Icahn School of Medicine at Mount Sinai, USA) and Alkis Togias (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:20 am	Gideon Lack (King's College London, United Kingdom) "Lessons We Have Learned from Early Childhood Exposure to Peanut"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Carlos Camargo (Massachusetts General Hospital / Harvard University, USA) "Epidemiological Evidence for the Atopic March"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Antonella Muraro (Food Allergy Referral Center, Padua General University Hospital, Italy) "Optimizing Translation Research and Implementation of Best Practice of Care for Food Allergy"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Carla Davis (Texas Children's Hospital / Baylor College of Medicine, USA) "Prevention of Symptoms with Oral Immunotherapy: What Is the Dose Threshold?"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	Ruby Pawankar (Nippon Medical School, Japan) "The Microbiome and Changing Patterns of Food Allergies in Asia"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	Donald Leung (National Jewish Health, USA) "The Role of Staphylococcus aureus in Food Allergy"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	Anuradha Ray (University of Pittsburgh School of Medicine, USA) "Mitochondrial Control of Immune Tolerance to Allergens"
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Ruslan Medzhitov (Yale School of Medicine, USA) "Food Surveillance by the Immune System"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Michiko Oyoshi (Boston Children's Hospital / Harvard Medical School, USA) "Induction of Neonatal Tolerance Through Breast Milk"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizers: Rosemarie Dekruyff (Stanford University, USA) and Cathryn Nagler (The University of Chicago, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Role of T Cells in Food Allergy Discussion Leader: Talal Chatila (Boston Children's Hospital / Harvard Medical School, USA)
7:30 pm - 7:45 pm	Willi Born (National Jewish Health, USA) "Pre-Immune Influence of Gamma Delta T Cells on B Lymphocytes and Antibodies"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Erik Wambre (Benaroya Research Institute, USA) "Deconvoluting Heterogeneity in the CD4+ T Cell Responses to Food Allergen"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Lars Poulsen (University of Copenhagen, Denmark) "Mapping Epitope Targets of T Cells in Food Allergy"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Pamela Guerrerio (National Institute of Allergy and Infectious Diseases, NIH, USA) "Investigation of Peanut-Specific T Effector and T Regulatory Cells in Children Allergic and Tolerant to Peanut"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Anne Singh (University of Wisconsin-Madison School of Medicine and Public Health, USA) "Regulatory T Cells in Food Allergy"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Immunological Mechanisms of Food Allergy: From Skin to Gut Discussion Leaders: Marshall Plaut (National Institute of Allergy and Infectious Diseases, NIH, USA) and Marsha Wills-Karp (Johns Hopkins Bloomberg School of Public Health, USA)
9:00 am - 9:10 am	Gerald Nepom (Benaroya Research Institute, USA) "In Pursuit of Immune Tolerance: Perspectives from the Immune Tolerance Network"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	Corinne Keet (Johns Hopkins School of Medicine, USA) "Practical Aspects of Early Peanut Introduction: Who Needs to Be Screened and How?"
9:25 am - 9:30 am	Discussion
9:30 am - 9:50 am	David Artis (Weill Cornell Medicine, USA) "Immune Regulation at Barrier Surfaces"
9:50 am - 9:55 am	Discussion
9:55 am - 10:15 am	Steven Ziegler (Benaroya Research Institute, USA) "Regulation of Type-2 Immunity and Inflammation"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	Cathryn Nagler (The University of Chicago, USA) "Regulation of Allergic Responses to Food by Commensal Bacteria"
11:10 am - 11:20 am	Discussion
11:20 am - 11:30 am	Gregory Sonnenberg (Weill Cornell Medicine, USA) "Innate Lymphoid Cell (ILC) Regulation of Host-Microbe Interactions"
11:30 am - 11:35 am	Discussion
11:35 am - 11:45 am	Ruchi Gupta (Ann & Robert H. Lurie Children's Hospital of Chicago / Northwestern University School of Medicine, USA) "Early Diet and Environment's Impact on Microbiome and the Development of Allergies"
11:45 am - 11:50 am	Discussion
11:50 am - 12:00 pm	Daniel Mucida (The Rockefeller University, USA) "Tissue Adaptation: Implications for Gut Immunity and Tolerance"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:15 pm	Kathy McCoy (University of Calgary, Canada) "The Interplay Between the Gut Microbiota and Food Allergy"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Protein and Peptide Chemistry Involved in Food Allergy Discussion Leader: Holden Maecker (Stanford University School of Medicine, USA)
7:30 pm - 7:45 pm	Introduction by Discussion Leader: Probing the Immune Response in Food Allergy Using CyTOF
7:45 pm - 7:55 pm	Veronique Schulten (La Jolla Institute for Allergy and Immunology, USA) "Mapping Epitope Targets of T Cells in Food Allergy"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Michael Angelo (Stanford University School of Medicine, USA) "Highly Multiplexed Analysis of Resident and Inflammatory Immune Cell Populations Using Multiplexed Ion Beam Imaging"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Melanie Neeland (Murdoch Children's Research Institute, Australia) "Early Life Innate Immune Signatures of Persistent Food Allergy"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Anna Pomes (INDOOR Biotechnologies, Inc., USA) "Food Allergens: A Molecular Perspective"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Philip Johnson (University of Nebraska-Lincoln, USA) "Using Proteomics to Investigate Allergen Epithelial Transport and Subsequent Sensitization and Elicitation"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Ronald Rabin (U.S. Food and Drug Administration, USA) "Mass Spectrometry to Complement Standardization of Complex Allergenic Extracts"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Magnus Borres (Uppsala University, Sweden) "The Role of 2S Albumins in Food Allergy"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Role of B Cells and Immunoglobulins in Food Allergy Discussion Leaders: Wesley Burks (University of North Carolina School of Medicine, USA), Marcella Ruddy (Regeneron Pharmaceuticals, Inc., USA) and Wendy Davidson (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:20 am	Mubeccel Akdis (Swiss Institute of Allergy and Asthma Research, Switzerland) "Induction and Breaking of Allergen Tolerance, Role of T and B Regulatory Cells"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Duane Wesemann (Brigham and Women's Hospital / Harvard Medical School, USA) "Regulation of IgE B Cells"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Thomas Platts-Mills (University of Virginia, USA) "Can Specific IgE and IgG4 Responses Help to Explain the Increases in Food Allergy?"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	Scott Boyd (Stanford University School of Medicine, USA) "Analysis of B Cell Repertoires in Peanut Allergy"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Wayne Shreffler (Massachusetts General Hospital / Harvard Medical School, USA) "Analysis of Antigen-Specific Repertoire in Relation to Peanut Allergy Phenotypes"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Theodore Jardetzky (Stanford University, USA) "Inhibition of IgE: Receptor Interactions and Signaling"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Maria Curotto de Lafaille (New York University School of Medicine, USA) "IgG1 Memory Cells Keep the Memory of IgE Responses"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Motohiro Ebisawa (Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Japan) "The Roles of IgE in Food Allergy"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Yu Kawakami (La Jolla Institute for Allergy and Immunology, USA) "Inhibitors of Histamine Releasing Factor Mitigate Anaphylactic Symptoms of Food Allergy in the Mouse Model"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	The Roles of Basophils, Eosinophils, and Mast Cells in Food Allergy Discussion Leader: Hans Oettgen (Boston Children's Hospital / Harvard Medical School, USA)
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 7:55 pm	Stephen Galli (Stanford University School of Medicine, USA) "Deciphering the Roles of Mast Cells Versus Basophils in Food Allergy and Anaphylaxis"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Donald MacGlashan (The Johns Hopkins University School of Medicine, USA) "Terminating Mediator Release from Human Basophils and Mast Cells"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Bruce Bochner (Northwestern University, USA) "Novel Strategies to Prevent Mast Cell Activation in Anaphylaxis"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Melanie Dispenza (Northwestern University, USA) "Two Doses of Ibrutinib Abrogates Skin Test Responses and Basophil Activation in Food Allergic Adults"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Yui-Hsi Wang (Sanofi, USA) "IL-4 Signaling and IL-9-Producing Mucosal Mast Cells in Food Allergy"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Manuel Leyva Castillo (Boston Children's Hospital, USA) "Skin Mechanical Injury Promotes ILC2-Dependent Intestinal Mast Cell Expansion"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Role of the Epithelium in Allergic Disease Discussion Leader: Rosemarie Dekruyff (Stanford University, USA)
9:00 am - 9:20 am	Cezmi Akdis (Swiss Institute of Allergy and Asthma Research, Switzerland) "Role of Epithelial Barrier and Allergic Diseases"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Simon Hogan (Cincinnati Children's Hospital Medical Center, USA) "Intestinal Epithelial Allergen Sampling and Food Allergy"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Moshe Biton (Broad Institute of Harvard and MIT / Massachusetts General Hospital, USA) "Crosstalk Between Intestinal Stem Cells and Immune Cells Modulate Epithelial Cell Fate"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	Marsha Wills-Karp (Johns Hopkins Bloomberg School of Public Health, USA) "Regulation of IL-33 by Dectin-1"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	Cecilia Berin (Icahn School of Medicine at Mount Sinai, USA) "Mechanisms of Sensitization and Tolerance to Foods Through the Skin"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	Stephanie Eisenbarth (Yale University School of Medicine, USA) "What a Rare Immunodeficiency Can Teach Us About the Immunological Mechanisms of Food Allergy"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	Mark Davis (Stanford University School of Medicine, USA) "Immune Dysregulation in Humans and Mice"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Esther Florsheim (Yale University, USA) "How to Avoid Allergens? Characterizing the Neuroimmune Mechanisms of Food Aversion"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Kelly Orgel (University of North Carolina at Chapel Hill, USA) "Features of CC027/GeniUnc, an Orally Reacting Peanut Allergy Model"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Johanna Smeekens (University of North Carolina at Chapel Hill, USA) "Adjuvant-Free Intragastric Sensitization to Peanut in CC027/GeniUnc Mice"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Phenotypes and Endotypes in Food Allergy Discussion Leader: Antonella Muraro (Food Allergy Referral Center, Padua General University Hospital, Italy)
7:30 pm - 8:00 pm	George Yancopoulos (Regeneron Pharmaceuticals, Inc., USA) "IL-13/IL-4 in Allergic Inflammatory Diseases"
8:00 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Jonathan Spergel (Children's Hospital of Philadelphia, USA) "Food Allergies: Phenotypes: IgE or Not? Endotypes: Anaphylaxis or Not?"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Rudolf Valenta (Medical University of Vienna, Austria) "Molecular Allergology in Diagnosis, Treatment and Prevention of Food Allergy"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	R. Sharon Chinthrajah (Stanford University School of Medicine, USA) "Mechanistic Clues to What Makes Oral Immunotherapy Work"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	James Baker (Food Allergy Research and Education (FARE), USA) "Mucosal Immune Redirection in Food Allergy"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by 1R13AI136365-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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