Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The State of Food Allergy Research and Lessons from Other Immunology Research
To facilitate discussion about the current state of food allergy research and how we define the most pressing unmet needs we will juxtapose a talk on emerging therapies in food allergy and their mechanistic underpinnings with one focused on another clinical immunological disease.
Discussion Leader: Gideon Lack (King's College London, United Kingdom)
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:40 pm
Cezmi Akdis (Swiss Institute of Allergy and Asthma Research, Switzerland)
"Epithelial Barrier Hypothesis for the Development of Allergic and Other Inflammatory Diseases"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:25 pm
Ramnik Xavier (Massachusetts General Hospital / Broad Institute of MIT and Harvard, USA)
"Immune Modulation in IBD: A History of Basic Science Leading Clinical Transformations"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innate and Adaptive Th2 Immunity in Neurodevelopment, Oncology and Autoimmunity
Discussion Leader: Stephen Galli (Stanford University School of Medicine, USA)
9:00 am - 9:20 am
Steven Ziegler (Benaroya Research Institute, USA)
"Role of TSLP in Oncology"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Anna Molofsky (University of California, San Francisco, USA)
"IL-33 in Neurodevelopment"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Shiv Pillai (Massachusetts General Hospital / Harvard University, USA)
"IL-4+ BATF+ T Follicular Helper Cells in IgG4-RD"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Deepak Rao (Brigham and Women's Hospital / Harvard Medical School, USA)
"Peripheral and Follicular Helper T Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jessica Strid (Imperial College London, United Kingdom)
"Role of IgE in Tumor Immunology"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Thomas Platts-Mills (University of Virginia, USA)
"Galactose-a-1,3-Galactose Specific IgE Antibody"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Cecilia Berin (Icahn School of Medicine at Mount Sinai, USA) and Stephanie Eisenbarth (Yale University School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lessons from Vaccinology for the Development of Rational Interventions in Food Allergy
Discussion Leader: Steven Ziegler (Benaroya Research Institute, USA)
7:30 pm - 7:40 pm
Alyssa Mitson-Salazar (Yale University, USA)
"Investigating Regulatory T Cell Control of Allergic Gut Inflammation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
Bali Pulendran (Stanford University, USA)
"Systems Vaccinology"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Supinda Bunyavanich (Icahn School of Medicine at Mount Sinai, USA)
"Transcriptomic Insights on Food Allergy"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Pattraporn Satitsuksanoa (Swiss Institute of Allergy and Asthma Research, Switzerland)
"B Cells Responses in Allergic Children During Oral Immunotherapy in Comparison to Natural Tolerance"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Eicosanoid Dysregulation and Pathogenic Th2 Immunity
Discussion Leader: Joshua Boyce (Harvard Medical School, USA)
9:00 am - 9:20 am
Amit Awasthi (Translational Health Science and Technology Institute, India)
"Regulation of IL-9 Expression in T Helper Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lisa Cameron (Western University, Canada)
"CRTh2 Regulation and Role in Th2 Cells and Type 2 Inflammatory Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Mark Rochman (Cincinnati Children's Hospital Medical Center, USA)
"The Epithelial Unit in Eosinophilic Esophagitis and Food Allergy"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Tanya Laidlaw (Brigham and Women's Hospital / Harvard Medical School, USA)
"Eicosanoid Dysregulation in AERD"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Takahisa Murata (The University of Tokyo, Japan)
"PGDM as a Specific Maker of Food Allergy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Christoph Schlapbach (University Hospital of Bern, University of Bern, Switzerland)
"PPAR-Gamma+ CD4 Th2 Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurosensory Pathways Relevant to Aversive Food Responses
Discussion Leader: Cezmi Akdis (Swiss Institute of Allergy and Asthma Research, Switzerland)
7:30 pm - 7:40 pm
Duncan Morgan (Massachusetts Institute of Technology, USA)
"Single-Cell RNA Sequencing Identifies Metabolic Characteristics of T Cells in Eosinophilic Esophagitis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
Ivan de Araujo (Icahn School of Medicine at Mount Sinai, USA)
"Gut-Brain Axis and Potential Relevance to Food Allergy"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Esther Florsheim (Yale University, USA)
"IgE Dependent Taste Preference"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Nicolas Gaudenzio (INSERM / University of Toulouse, France)
"House Dust Mites Activate Nociceptor-Mast Cell Clusters to Drive Type 2 Skin Inflammation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Caroline Sokol (Massachusetts General Hospital, USA)
"Cutaneous Neuroimmune Interactions Control the Initiation of the Allergic Immune Response"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation and Maintenance of Type 2 Immunity: Adaptive
Discussion Leader: Richard Insel (Janssen Pharmaceuticals, USA)
9:00 am - 9:20 am
Manel Jordana (McMaster University, Canada)
"Long-Lived IgE Memory"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Talal Chatila (Boston Children's Hospital / Harvard Medical School, USA)
"IL-4 Signaling and Allergen-Specific T Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Christopher Love (Massachusetts Institute of Technology, USA)
"Allergen-Specific T Cell Phenotype Diversity"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mubeccel Akdis (Swiss Institute of Allergy and Asthma Research, Switzerland)
"B Cell Regulation in Milk Allergy in Response to OIT"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jamie Orengo (Regeneron Pharmaceuticals, USA)
"Novel Approaches to Treating Allergic Disorders with Monoclonal Antibodies"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Alexandra Santos (King's College London, United Kingdom)
"Risk Assessment Using Basophil Activation to Differentiate Reaction Severity and Threshold During Oral Peanut Challenges in the LEAP Studies"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Justine Calise (Benaroya Research Institute at Virginia Mason, USA)
"Optimal TH2A Effector Function Requires Local Epithelial Cytokine Signaling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation and Maintenance of Type 2 Immunity: Innate
Discussion Leader: Zuhair Ballas (University of Iowa, USA)
7:30 pm - 7:50 pm
Alexander Scheffold (Christian-Albrechts Universität zu Kiel, Germany)
"Antigen-Specific Regulation of Mucosal Tolerance Versus Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jean-Philippe Girard (CNRS / Université de Toulouse, France)
"IL-33 in Mucosal Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Patrick Brennan (Brigham and Women's Hospital / Harvard Medical School, USA)
"iNKT Cells and Enteral Lipid Antigens"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Simon Hogan (University of Michigan, USA)
"Unknown Intestinal Epithelial Immunological Responses and Food Allergen Sampling"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Food Allergy Risk Determinants
Discussion Leader: Corinne Keet (Johns Hopkins School of Medicine, USA)
9:00 am - 9:20 am
Kirsi Jarvinen-Seppo (University of Rochester Medical Center, USA)
"Breast Milk as an Immune Modulator"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kirsten Perrett (Murdoch Children's Research Institute, Australia)
"Food Allergy Risk Factors and Prevention"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stephanie Eisenbarth (Yale University School of Medicine, USA)
"IgA, Microbiome and Food Allergy Risk"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Sarita Patil (Massachusetts General Hospital / Harvard Medical School, USA)
"The IgEhi Endophenotype in Peanut Oral Immunotherapy"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
Rasika Mathias (Johns Hopkins University, USA)
"The MALT1 Locus and Progression of Allergic Immunity"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Caroline Roduit (University Children's Hospital Zurich, Switzerland)
"Atopic Dermatitis Phenotypes in Childhood and the Development of Other Allergic Diseases"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Eric Wambre (Benaroya Research Institute, USA)
"Baseline Characteristics of Peanut-Allergic Individuals During the Dupilumab as Adjunct to AR101 Clinical Trial"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Food Allergy Prevention: Clinical Science and Best Practice
Discussion Leader: Kari Nadeau (Stanford University, USA)
7:30 pm - 7:40 pm
Despina Karalis (Geisel School of Medicine, Dartmouth College, USA)
"Perinatal Factors and Food Allergy Development in Early Childhood"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
George du Toit (King's College London / Guy's and St Thomas' NHS Foundation Trust, United Kingdom)
"Oral Tolerance as Food Allergy Prevention"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Graham Roberts (University of Southampton, United Kingdom)
"Translating LEAP into Public Health"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Helen Brough (King's College London / Guy's and St Thomas' NHS Foundation Trust, United Kingdom)
"Limitations of Oral Tolerance and Approaches Targeting the Skin"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure