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Food Allergy

Gordon Research Conference

Regulation of Food Tolerance

November 13 - 18, 2022

Chairs Cecilia Berin and Hans Oettgen

Vice Chairs Stephanie C. Eisenbarth and Simon P. Hogan

Residence Inn at Oxnard River Ridge

2101 West Vineyard Ave

Oxnard, California, United States

Venue and Travel Information

Conference Description

The 2022 Food Allergy Gordon Conference will focus on emerging science in food allergy obtained from mouse models, human immunology, and clinical trials. This conference will highlight advances in our understanding of immune mechanisms of allergy and tolerance to foods. Novel areas of concentration include key systems that interact with and shape immunity, including microbiome, the nervous system, and the neuroendocrine system. We will also highlight science supporting emerging treatment approaches for food allergy.

Related Meeting

This GRC will be held in conjunction with the "Food Allergy" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Environmental Exposures and Food Allergy Discussion Leader: Corinne Keet (University of North Carolina, Chapel Hill, United States)
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:30 pm	Kari Nadeau (Stanford University, United States) "Climate Change and Health: Problem and Solution Based Research Approaches"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	Richard Locksley (University of California, San Francisco; HHMI, United States) "Innate Allergy"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Early Life Immune Development, Microbiome and Immune Regulation Discussion Leaders: Joan Cook-Mills (Indiana University School of Medicine, United States)
9:00 am - 9:25 am	Kirsi Jarvinen-Seppo (University of Rochester Medical Center, United States) "How Might the Infant Immune System Have Developed Before the Allergy Epidemic?"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	Michiko Oyoshi (Massachusetts General Hospital / Harvard University, United States) "Maternal Regulation of Neonatal Food Tolerance"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	Harald Renz (Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics Philipps University Ma, Germany) "The Impact of Microbial Exposure on Allergy Prevention"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	Talal Chatila (Boston Children's Hospital / Harvard Medical School, United States) "Immune Regulatory Checkpoints in the Evolution of Food Allergy"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	Rima Rachid (Boston Children's Hospital, United States) "Microbial Therapeutics for the Treatment of Food Allergy"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:25 pm	Gislaine Martins (Cedars Sinai Medical Center, United States) "A Role for Blimp1 in Intestinal Mucosa Regulatory T Cell Function"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Corinne Keet (University of North Carolina, Chapel Hill, United States) and Stephanie Eisenbarth (Yale University School of Medicine, United States)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Novel Technologies and Mechanisms in Food Allergy Discussion Leader: Stephen Galli (Stanford University School of Medicine, United States)
7:30 pm - 7:55 pm	Sindy Tang (Stanford University, United States) "Microfluidic Methods for Food Allergy Diagnostics"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	Duncan Morgan (Massachusetts Institute of Technology, United States) "Utility of TCR Sequencing in Allergy"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	Hirohito Kita (Mayo Clinic Arizona, United States) "T Follicular Helper Cells in Food Allergy"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Basic to Translational Advances in IgE Biology Discussion Leader: Wendy Davidson (National Institute of Allergy and Infectious Diseases, NIH, United States)
9:00 am - 9:25 am	Duane Wesemann (Brigham and Women's Hospital / Harvard Medical School, United States) "Understanding IgE Responses"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	Robert Anthony (Harvard Medical School/Massachusetts General Hospital, United States) "Glycan Regulation of IgE"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	Maria Curotto de Lafaille (Icahn School of Medicine at Mount Sinai, United States) "B Cell Memory in Food Allergy"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	Jamie Orengo (Regeneron Pharmaceuticals, United States) "Maintenance of Long-Lived IgE"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	Stephen Quake (Stanford University, United States) "Single Cell Genomics and Allergies"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:25 pm	Scott Boyd (Stanford University School of Medicine, United States) "Human B Cell and Antibody Responses in Food Allergy Immunotherapy"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Antigen Receptors Discussion Leader: Maria Curotto de Lafaille (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 7:55 pm	Wayne Shreffler (Massachusetts General Hospital / Harvard Medical School, United States) "T Cells in Food Allergy"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	Bjoern Peters (La Jolla Institute forImmunology, United States) "T Cell Epitope Recognition in Allergy"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	Derek Croote (IgGenix, United States) "Unbiased Human IgE Antibody Discovery Yields High-Affinity Antibodies Against Numerous Diverse Allergens"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Neuroimmunology of Allergic Disease Discussion Leader: Sarita Patil (Massachusetts General Hospital / Harvard Medical School, United States)
9:00 am - 9:25 am	Esther Borges Florsheim (Arizona State University, United States) "Allergic Defenses to Food"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	Isaac Chiu (Harvard Medical School, United States) "Neuronal Regulation of Gut Epithelial Cells and Barrier Function in Inflammation"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	Caroline Sokol (Massachusetts General Hospital, United States) "Neuro-Immune Circuits Driving Allergic Sensitization"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	Milena Bogunovic (University of Massachusetts Medical School, United States) "Macrophages and Enteric Nervous System Remodeling by Intestinal Inflammation"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	Sebastien Talbot (Universite de Montreal, Canada) "Nociceptor Neurons Drive B Cells Activity"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm	IgG Antibodies and Protection from Food Allergy Discussion Leader: Lisa Wheatley (National Institute of Allergy and Infectious Diseases, NIH, United States)
7:30 pm - 7:55 pm	Sarita Patil (Massachusetts General Hospital / Harvard Medical School, United States) "Antibody Mediated Protection in IgE Mediated Food Allergy"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	Alexandra Santos (King's College London, United Kingdom) "Dissecting Allergen-Specific Antibody Function in Food Allergy"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	Hugh Sampson (Icahn School of Medicine at Mount Sinai, United States) "What Does Epitope-Specific Antibody Profiling Teach Us About the Immune Response to Food Allergens?"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Sensing at Mucosal Sites Discussion Leader: Patricia Fulkerson (National Institute of Allergy and Infectious Diseases, NIH, United States)
9:00 am - 9:25 am	Raif Geha (Boston Children's Hospital / Harvard University, United States) "Mechanisms of Aggravation of Food Anaphylaxis in Atopic Dermatitis by S. aureus Skin Colonization"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	Noah Palm (Yale School of Medicine, United States) "Mapping Uncharted Landscapes of Host-Microbiota Connectivity"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	DeBroski Herbert (University of Pennsylvania, United States) "Distinct Roles for Interleukin 33 Depending on Cellular Source"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	Andrew Wang (Yale University, United States) "Understanding How Modern Xenobiotics Act as Allergic Adjuvants"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	Thomas Platts-Mills (University of Virginia, United States) "Beyond the Original Syndrome: Alpha-gal and Cardiovascular Disease"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Future Directions in Basic and Clinical Food Allergy Research Discussion Leader: Wayne Shreffler (Massachusetts General Hospital / Harvard Medical School, United States)
7:30 pm - 8:00 pm	Alkis Togias (National Institute of Allergy and Infectious Diseases, NIH, United States) "NIAID-Supported Research in Food Allergy: Present and Future"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Erika von Mutius (Dr. von Hauner Children´s Hospital Munich, Helmholtz Center Munich, Germany) "Environmental Influences on Asthma and Allergy Development"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Bruce Bochner (Northwestern University, United States) "Siglec-8 on Eosinophils and Mast Cells: From Discovery to Clinical Trials"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Supported by a Grant From Pfizer Inc.

Food Allergy Research and Education

Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R13AI164747. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Food Allergy (GRS)

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