Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Food Allergy and Type 2 Immunity
7:40 pm - 8:25 pm
"The History of Food Allergy"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Regulation of Allergic Inflammation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Food Allergy Genetics and Epidemiology
9:00 am - 9:20 am
"Food Allergy Genetics: A Perspective on Identifying Risk and Tailoring Therapy"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"The Public Health Impact of Food Allergy: Prevalence, Severity, Disparities, and Access"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Fatal Anaphylaxis: Bad Luck or Something We Can Predict?"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Biological Mechanisms Impacting Health Disparities in Allergic Disease"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Atopic Disease in Inborn Errors of Immunity"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Genetic Disorders and Traits in Severe Allergic Inflammatory Responses"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Peanut Sensitization is Common in School-Aged Children from Honduras: Relevance of CCDs but Not Major Peanut Component Allergens"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Leveraging the Genetics of Mixed Ancestry in Food Allergy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Type 2 Immunity
7:30 pm - 7:50 pm
"Allergen-Specific Inhibitors of Systemic Anaphylaxis"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
"iNKT Cell Stimulation Leads to the Production of Gut Peanut-Specific Immunoglobulin A Through a Type 2 Conventional Dendritic Cell-Dependent Pathway"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Pathophysiology of FPIES"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"IgE Produced in Food Allergy is Dependent Upon IL-4 Derived from T Follicular Regulatory Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Innate Immune Mechanisms Regulating Type-2 Immunity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Early Introduction and Tolerance
9:00 am - 9:20 am
"The Role of Detergent in Eosinophilic Esophagitis"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Keeping Up with the Neighbors: Understanding Local Control of Epidermal Stem Cell Behaviors with Intravital Imaging"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Can Tolerance be Restored Through Early Treatment of Allergic Infants and Toddlers?"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Are There Long-Term Consequences of Asymptomatic Food Sensitization?"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Loss-of-Function Variants in Transforming Growth Factor Beta (TGFb) and Allergic Disease"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Targeting the Skin for Allergy Prevention"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Neutralizing IgG4 Antibodies are a Biomarker of Sustained Efficacy After Peanut Oral Immunotherapy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Susceptibility to Oral Anaphylaxis is a Heritable Trait in Mice"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Sensitization, Skin and Gut
7:30 pm - 7:50 pm
"Gut Epithelial Cells as Participants in Allergy"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
"Plant Defense Compounds Control a Neuro-Immune Circuit in Allergic Sensitization"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Mechanisms for Initiation of Food Allergy by Skin Pre-Disposed to Atopic Dermatitis"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Effects of IFNy on IL-10+B Cell Protection Against Eosinophilic Esophagitis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"B Cell Repertoires and Phenotypes in Food Allergy and Oral Immunotherapy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Environmental Drivers of Sensitization and Reactivity
9:00 am - 9:20 am
"Role of Allergen-Specific B Cell in Cow’s Milk-OIT-Induced Desensitization, Remission, and Natural Outgrowth"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Bacterial Metabolites Regulate Allergic Responses to Food"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Diet and Microbiota Drivers for the B Cell Repertoire"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Food Allergy From a Transcriptomic Lens"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Early Life Imprinting of Intestinal Tolerance"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Dietary Antigens in Oral Tolerance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"IL-1ß is Necessary for Indoor Dust-Mediated Airway Sensitization to Peanut"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Human Colon as a Source of IgE in Food-Sensitized Patients."
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
T Cells in IgE and Non-IgE-Mediated Food Allergies
7:30 pm - 7:50 pm
"T Cell Responses in Alpha-Gal Syndrome"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Metabolomics of Food Allergy and Immunotherapy"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"DOCK8 and STAT3 Cooperate to Restrain IgE-Inducing T Follicular Helper Cells"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Immunologic Phenotypes of Food Allergic Diseases"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Gamma Delta T cell-IL-3 Axis Controls the Responsiveness of Sensory Neurons to Allergens"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Immunotherapy Outcomes and Mechanisms
9:00 am - 9:20 am
"Shining a Light on Early Determinants of Food Allergy: Systems Biology of Early Atopy (SunBeam)"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Immune Modulation and the Potential for Remission After Peanut Sublingual Immunotherapy"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Preventing Food Allergy: Moving from Efficacy to Effectiveness"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Biologics in Food Allergy: A Jump Start"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Epitope Endgame: Atomic Structure of IgE Epitopes"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Targeting T Cells to Treat Food Allergy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Immunomodulatory Metabolites Differ Over Time and Between Desensitization Outcomes in Children on Peanut Oral Immunotherapy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Non-Canonical Role of T Follicular Helper Cells in the Maintenance of Peripheral Tolerance"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mast Cells, Basophils and Mechanisms of Reactivity
7:30 pm - 7:40 pm
"Mast Cell-Intrinsic TGF-b Signaling Modulates Mast Cell Effector Function and Allergic Responses"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
"Mast Cells and their Progenitors in Allergic Lung Inflammation"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Pro-Resolving Roles for Basophils and Monocyte-Derived Macrophages in IgE-Mediated Skin Allergy."
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"IgG Antibodies Regulate the Pro-Inflammatory Program of IgE: Allergen-Activated Mast Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
