| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Fragile X Syndrome: Discoveries and New Approaches |
| Discussion Leader: Michael Tranfaglia (FRAXA Research Foundation, USA) |
| 3:45 pm - 3:50 pm | Introduction by Discussion Leader |
| 3:50 pm - 4:20 pm | Peter Kind (University of Edinburgh, United Kingdom)
"Fragile X Syndrome: Discoveries and New Approaches" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | The Genetic and Physiological Basis of ASDs |
| Discussion Leader: Ilse Gantois (McGill University, Canada) |
| 7:30 pm - 7:50 pm | Weirui Guo (University of Texas Southwestern Medical Center, USA)
"Mechanisms of mGluR5 Dysfunction in a Fragile X Syndrome Mouse Model" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Giselle Fernandes (National Center for Biological Sciences, India)
"mGluR-Dependent Plasticity in the Amygdala and Fragile X Syndrome" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Rachel Sare (National Institute of Mental Health, NIH, USA)
"Long-Term Effects of Chronic Sleep Restriction on Behavior in Fmr1 KO Mice" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Margaret King (Geisinger Health System, USA)
"Heritable Quantitative Traits and Implications for the Study of Phenotypic Heterogeneity in Fragile X Syndrome" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Identification and Investigation of New Therapeutic Targets |
| Discussion Leader: Margaret King (Geisinger Health System, USA) |
| 9:00 am - 9:20 am | Ellen Hoffman (Yale University, USA)
"High-Throughput Drug Discovery in Zebrafish Models of Autism Risk Genes" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Dawn Lammert (State University of New York Upstate Medical University, USA)
"RELN Mutations Identified in Autism Spectrum Patients Cause a Protein Biosynthetic Defect" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Amit Modgil (Tufts University, USA)
"Neurosteroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Elizabeth Berry-Kravis (Rush University Medical Center, USA)
"An Update on Fragile X Clinical Trials" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Translating Basic Research into the Clinic |
| A panel of experts composed of academic investigators, clinicians and funding agencies will be discussing recent progress and difficulties of taking basic research into the clinic. |
| Discussion Leader: Sally Till (University of Edinburgh, United Kingdom) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Translating Basic Research into the Clinic" |
|
- Elizabeth Berry-Kravis (Rush University Medical Center, USA)
- Christina Gross (Cincinnati Children's Hospital Medical Center, USA)
- Laura Mamounas (National Institute of Neurological Disorders and Stroke, NIH, USA)
- Paul Wang (Autism Speaks, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
