Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Molecular Mechanisms of FXS and Neurodevelopmental Disorders
Discussion Leader: Nisha Raj (Emory University, USA)
3:15 pm - 3:20 pm
Opening Remarks
3:20 pm - 3:35 pm
Anmol Nagpal (McGill University, Canada)
"The Impact Knockout Mouse Model Suggests a Role for eIF2a-Dependent Translation in Autism Spectrum Disorders"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
Arielle Valdez (Emory University, USA)
"Role of CDH1-APC as a Regulator of FMRP and Protein Synthesis at the Synapse"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Cellular and Synaptic Mechanisms of FXS and Neurodevelopmental Disorders
Discussion Leader: Benjamin Auerbach (State University of New York at Buffalo, USA)
5:30 pm - 5:45 pm
Katherine Bonnycastle (University of Edinburgh, United Kingdom)
"Synaptic Vesicle Recycling Defects in Models of Fragile X Syndrome"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Vineet Arora (Instituto de Neurociencias de Alicante, CSIC-UMH, Spain)
"Grik4 Over-Expression Underlies Altered Synaptic Gain and Enhances Basal Activation of Amygdala Circuits"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Laura Oliveira (Centre for Discovery Brain Sciences, University of Edinburgh, United Kingdom)
"Axon Initial Segment Morphology Regulates Cellular Excitability in Rodent Models of Fragile X Syndrome"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Xiaoqin Zhan (University of Calgary, Canada)
"Regulation of Mossy Fiber-Granule Cell Synaptic Plasticity by a Novel FMRP-Cav3.1 Calcium Channel Association"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Yeri Song (University of Pennsylvania, USA)
"Altered Ionotropic Receptor Maturation in the Impaired Auditory Critical Periods of Fmr1 Knockout Mice"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Elizabeth McCullagh (University of Colorado Anschutz Medical Campus, USA)
"Alterations to the Auditory Brainstem in Fragile X Syndrome"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Network Function in FXS and Neurodevelopmental Disorders
Discussion Leader: Adam Jackson (University of Edinburgh, United Kingdom)
9:00 am - 9:15 am
Naveen Nagarajan (University of Utah, USA)
"Corticostriatal Circuit Defects in Hoxb8 Mutant Mouse Model of Repetitive Behaviors"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Tanya Weerakkody (Stanford University, USA)
"Prefrontal Network and Axonal Hypoactivity in a Maternal Immune Activation Model of Autism Spectrum Disorder"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Eliana Weisz (Perelman School of Medicine, University of Pennsylvania, USA)
"Drosophila FMRP Modulates Energy Metabolism and Mitochondrial Function"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Rachel Rahn (Washington University in St. Louis, USA)
"Towards Evaluating Connectivity in Models of Neurodevelopmental Disease: An Optical Imaging Pipeline for Functional Connectivity Analysis Across Development in the Mouse Cortex"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Teresa Wen (University of California, Riverside, USA)
"Developmental Changes in EEG Correlates of Auditory Hypersensitivity in a Fragile X Syndrome Mouse Model"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Benjamin Auerbach (State University of New York at Buffalo, USA)
"Sound Hypersensitivity and Auditory Circuit Disruption in a Rat Model of Fragile X"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Translational Advances in FXS and Neurodevelopmental Disorders / Mentorship Component: Recent Technical and Conceptual Advances
Discussion Leader: Sam Booker (University of Edinburgh, United Kingdom)
1:30 pm - 1:45 pm
Jonathan Lovelace (University of California, Riverside, USA)
"Pharmacological Rescue of Translation-Relevant EEG Phenotypes in a Mouse Model of Fragile X Syndrome"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Lauren Schmitt (Cincinnati Children's Hospital Medical Center, USA)
"A Novel EEG Approach to Understanding Expressive Language Deficits in Fragile-X Syndrome"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:30 pm
Panel Discussion
Recent Technical and Conceptual Advances Within the FXS and NDD Fields and Ramifications on Clinical Aspects
Peter Kind (University of Edinburgh, United Kingdom)
Laura Mamounas (National Institute of Neurological Disorders and Stroke, NIH, USA)
Emily Osterweil (University of Edinburgh, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
