Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Molecular Characteristics of FXS and ASDs
Discussion Leader: Sameer Bajikar (Baylor College of Medicine, United States)
3:15 pm - 3:25 pm
Nisha Raj (Emory University, United States)
"Mapping the Developmental Nascent Proteome and Identifying Causal Protein Networks in FXS and Autism Related Disorders"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
Kagistia Hana Utami (Nanyang Technological University, Singapore)
"Identifying Genetic modifiers of FMR1 Silencing in Human FXS Neural Cells"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Ummi Ciptasari (Radboudumc & Donders Institute for Brain, Cognition, and Behaviour, The Netherlands)
"Modelling ARID1B-Deficiency in Coffin-Siris Syndrome Using Human iPSC-derived Excitatory Neurons"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Synaptic Dysfunctions and Adaptations in FXS and ASDs
Discussion Leader: Sam Booker (University of Edinburgh, United Kingdom)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 5:50 pm
Francesco Longo (University of Gothenburg - Sahlgrenska Academy, Sweden)
"Cell Type-Specific Disruption of Cortico-Striatal Circuitry Drives Repetitive Patterns of Behaviour in Fragile X Syndrome Model Mice"
5:50 pm - 5:55 pm
Discussion
5:55 pm - 6:05 pm
Shashank Ojha (The Hebrew University of Jerusalem, Israel)
"Nitric Oxide as a Novel Therapeutic Target for Autism Spectrum Disorder (ASD): Focus on Cntnap2 (Caspr-2) Mouse Model"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:20 pm
Kartik Pradeepan (Western University; Robarts Research Institute, Canada)
"Modeling From Single Cell Electrophysiology to Neuronal Network Interactions in Human Induced Pluripotent Stem Cell Derived Rett Syndrome and Isogenic Controls"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:35 pm
Vineet Arora (The Scripps Research Institute-Florida, United States)
"The Autism Risk Gene Syngap1 Assembles Cortical Circuits by Regulating Intrinsic Membrane Excitability"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Gemma Molinaro (UT Southwestestern Medical Center, United States)
"Sex-Specific, mGlu5 Receptor-Dependent Dysfunction of Sensory Neocortical Circuits in a Mouse Model of Autism-Spectrum Disorder, Caused by Deletion of PTEN"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Noah Moore Stypidou (University of Edinburgh, United Kingdom)
"Juvenile Fmr1-Knockout Rats Show Enhanced Feature Encoding in the Cortex"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Behaviour and Circuit Differences in FXS and ASDs
Talks in this session will focus on how mutations that cause FXS and ASDs affect circuitry and networks in the brain, and how these changes manifest in altered behaviours.
Discussion Leader: Ilse Gantois (McGill University, Canada)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
Sarah Giachetti (University of Edinburgh, United Kingdom)
"Assessing Gene Transfer in a Mouse Model of SYNGAP1 Haploinsufficiency Associated Disorder"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Hayley Drozd (Indiana University School of Medicine, United States)
"Social Behavioral Deficits in Preclinical Neurofibromatosis Type 1: Awake-behaving Corticoaccumbal Recordings and Optogenetic Rescue"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Sameer Bajikar (Baylor College of Medicine, United States)
"GDF11 Expression Level Modulates Neurological Behavior and is Regulated by MeCP2"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Sam Post (University of California, Riverside, United States)
"Multimodal Temporal Pattern Discrimination in Awake-Behaving Mice"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Katilynne Croom (University of California, Riverside, United States)
"Auditory Temporal Processing Across Development in Two Different Mouse Models of Autism"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
Andrew Holley (UT Southwestern Medical Center, United States)
"Deletion of Autism-Related Genes in the Auditory Brainstem Contributes to Sound-Driven Cortical EEG Abnormalities and Can Be Prevented by Low-Level Expression"
10:35 am - 10:40 am
Discussion
10:40 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Alternative Models for Fragile X and ASDs / Panel Discussion: Career Development
Discussion Leader: Troy McDiarmid (University of Washington, United States)
1:30 pm - 1:40 pm
Lexis Kepler (University of British Columbia/Djavad Mowafaghian Centre for Brain Health, Canada)
"Rapid Assessment of the Temporal Function and Phenotypic Reversibility of Neurodevelopmental Disorder Risk Genes Using Auxin-Inducible Degradation in C. elegans "
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Brooke Latour (Radboudumc, The Netherlands)
"Modelling Koolen-de Vries Syndrome in Cerebral Organoids"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:30 pm
Panel Discussion
Career Development
Kimberly Huber (University of Texas Southwestern Medical Center, United States)
Tracy King (National Institutes of Health, United States)
Mustafa Sahin (Boston Children's Hospital, United States)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
