Intersection of Basic and Translational Research to Understand Fragile X and ASDs

May 11 - 12, 2024

Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Fragile X and Autism-Related Disorders GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The Gordon Research Seminar on Fragile X and Autism-Related Disorders is a unique forum for graduate students, post-docs, and medical trainees to present and exchange new data and cutting edge ideas. The focus of this meeting is to showcase outstanding research by early career scientists using basic, translational, and/or clinical approaches to understand Fragile X Syndrome and/or other autism spectrum disorders. Through this meeting, we will bring together early stage scientists from multiple fields to discuss innovations in ASD research with the goal of fostering new ideas and collaborations. This meeting will provide a highly interactive platform to promote the exchange of ideas and protocols, scientific networking, collaborations and mentorship.

Related Meeting

This GRS will be held in conjunction with the "Fragile X and Autism-Related Disorders" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm	Molecular Pathogenesis of FXS and ASD Discussion Leader:
3:15 pm - 3:25 pm	"Molecular Consequences Driving Neurological Deficits Caused by Changes in MeCP2 Levels"
3:25 pm - 3:30 pm	Discussion
3:30 pm - 3:40 pm	"Fmr1-/y and Syngap+/- Mouse Models Exhibit Divergent Translation Environments and Deficits of Synaptic Plasticity"
3:40 pm - 3:45 pm	Discussion
3:45 pm - 3:55 pm	"The Role of Astrocyte BMP Signaling in Fragile X Syndrome Model Mice"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Advances in Genetics and Functional Genomics and Behavior and Circuit Dysfunction in FXS and ASD Discussion Leaders: and
5:30 pm - 5:40 pm	Introduction by Discussion Leader
5:40 pm - 5:50 pm	"Identifying Genetic Modifiers of Seizures in Fragile X Syndrome Through Whole Genome Sequencing and Functional Testing"
5:50 pm - 5:55 pm	Discussion
5:55 pm - 6:05 pm	"Development of an Ovine Model of Fragile X Syndrome for Biomarker Discovery and Therapeutic Testing"
6:05 pm - 6:10 pm	Discussion
6:10 pm - 6:20 pm	"Heterozygosity for Neurodevelopmental Disorder-Associated TRIO Variants Leads to both Shared and Distinct Deficits in Behavior, Neuronal Development, and Synaptic Transmission in Mice"
6:20 pm - 6:25 pm	Discussion
6:25 pm - 6:35 pm	"Altered Physiology of Primary Visual Cortex in Fragile X Syndrome Revealed by Field Potential Recordings"
6:35 pm - 6:40 pm	Discussion
6:40 pm - 6:50 pm	"Neocortical Excitation/Inhibition Imbalance During Early Development Leads to Permanent Socio-Behavioral, Transcriptomic and Connectivity Alterations"
6:50 pm - 6:55 pm	Discussion
6:55 pm - 7:05 pm	"Visual Discrimination in FXS: Insights from Behavior and EEG"
7:05 pm - 7:10 pm	Discussion
7:10 pm - 7:30 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Body-Brain Interactions in FXS and ASD and Advances in Therapeutic Strategies for FXS and ASD Discussion Leaders: and
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:20 am	"Impaired Baseline and Induction Kinetics of the Cellular Stress Response in Rett Syndrome"
9:20 am - 9:25 am	Discussion
9:25 am - 9:35 am	"Effects of Nf1 on Sleep Behavior are Mediated through Starvation and SARM1 Dependent NAD+ Metabolism"
9:35 am - 9:40 am	Discussion
9:40 am - 9:50 am	"Examining the Role of Specific NMDA Receptor Subunits in Cortical Circuit Dysfunction in Fragile X Syndrome"
9:50 am - 9:55 am	Discussion
9:55 am - 10:05 am	"Results from a Double-Blind, Randomized, Placebo-Control Trial of Lovastatin and Minocycline in Fragile X Syndrome"
10:05 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Negr1: A New Possible Convergent Hub for Autistic Spectrum Disorders"
10:20 am - 10:25 am	Discussion
10:25 am - 10:35 am	"A Combination of Multi-Electrode Array (MEA) and Live Mouse Tracker (LMT) as a Versatile Drug Screening Platform for Fragile X Syndrome"
10:35 am - 10:40 am	Discussion
10:40 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Panel Discussion Careers in Biomedical Sciences Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Careers in Biomedical Sciences
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

David L. Nelson, Ph.D.

Research reported in this publication was supported by the National Institutes of Health under Award Number 1R13HD115300-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Fragile X and Autism-Related Disorders

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