Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Lessons Learned Using Genetic Biocontrol Interventions
Discussion Leaders: Anthony James (University of California, Irvine, United States) and Nikolay Kandul (University of California, San Diego, United States)
7:40 pm - 8:00 pm
Kelly Matzen (Oxitec Ltd, United Kingdom)
"Friendly™ insects: self-limiting male deployments delivering targeted biocontrol of invasive pests"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Jérémy Bouyer (Cirad, Réunion)
"Use of the boosted sterile insect technique to control invasive Aedes mosquitoes in Europe"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Bradley White (Verily, United States)
"Debug at 9 Years: Successes, Failures and Lessons Learned from the release of 100s of Millions of Mosquitoes"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
LEE CHING NG (NATIONAL ENVIRONMENT AGENCY, ENVIRONMENTAL HEALTH INSTITUTE, Singapore)
"Cation Modulation of δ ENaC"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gene Drives, Genetics and Genetic Engineering
Discussion Leaders: Philippos Papathanos (Hebrew University of Jerusalem, Israel) and Andrea Crisanti (Imperial College, United Kingdom)
9:00 am - 9:15 am
Andrea (Andie) Smidler (UCSD, United States)
"Ifegenia and pgSIT in Anopheles gambiae: novel daughter-killing, genetic sexing, and male sterilization systems for scalable, non-driving, vector control"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Craig Montell (University of California, Santa Barbara, United States)
"Controlling Aedes aegypti population and how they sense people"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Brian Tarimo (Ifakara Health Institute (IHI), Tanzania)
"Development of gene editing tools in major African malaria vectors to better understand their biology and application as a control intervention/tool."
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Eric Marois (Institut National de la Recherche Médicale, France)
"Maleness-Associated Transgenes for the Control of Aedes albopictus "
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Conor McMeniman (Johns Hopkins University, United States)
"Optimized Genetic Tools to Decode and Manipulate Mosquito Chemosensory Biology"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
George Christophides (Imperial College London, United Kingdom)
"Recoded Mosquito Midgut Immunity and Gene Drive for Malaria Elimination in Africa"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Federica Bernardini (IMPERIAL COLLEGE LONDON, United Kingdom)
"Expanding the Toolkit for Genetic Biocontrol of the Malaria Mosquito Anopheles Gambiae"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Zach Adelman (Texas A&M University, United States)
"Leveraging DNA repair for scarless transgene removal"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Joanna Tannous (Oak Ridge National Laboratory, United States)
"Developing safeguarding CRISPR-Cas9 gene drive in the plant pathogenic fungus, Sphaerulina musiva, to mitigate Populus diseases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Chelsea Smartt (University of Florida, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Manipulating Microbiomes to Affect Host Phenotypes and Control Populations
Discussion Leaders: Scott O'Neill (World Mosquito Program , France) and M. Renee Bellinger (United States Geological Survey, United States)
6:00 pm - 6:15 pm
Iliano Coutinho-Abreu (University of California San Diego, United States)
"Manipulating the human skin microbiome to prevent mosquito bites and pathogen transmission"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:35 pm
Stephen Dobson (MosquitoMate, Inc, United States)
"The Pesticidal Use of Wolbachia Against Medically Important Mosquitoes in the USA"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Jason Rasgon (Penn State University, United States)
"Novel anti-virals and mosquitocidals from mosquito-associated fungi"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Seth Bordenstein (Pennsylvania State University, United States)
"Modifying the Sperm Epigenome Aids a Maternally-Inherited Symbiont (Wolbachia )"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
Kirsten Pelz-Stelinski (University of Florida, United States)
"Mtigating Candidatus Liberibacter asiaticus transmission using genetic biocontrol"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Engineered Technologies for Genetic Biocontrol
Discussion Leaders: Luke Alphey (University of York, United Kingdom) and Nikolai Windbichler (Imperial College London, United Kingdom)
9:00 am - 9:15 am
Robyn Raban (University of California, San Diego, United States)
"Innovative Strategies for Sustainable Vector Control"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Kevin Myles (Texas A&M University, United States)
"Unlocking the Pathogenic Potential of Arthropod-borne Viruses for Genetic Biocontrol"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Monika Gulia-Nuss (University of Nevada Reno, United States)
"Progress Towards Germline Transformation of Ticks"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Ioanna Morianou (Imperial College London, Italy)
"Pre-empting gene drive resistance by characterising its evolutionary space and dynamics of spread"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Stephanie Gamez (Agragene, United States)
"pgSIT: An Improved Sterile Insect Technique for Insect Biocontrol"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Célia Lutrat (CNRS, France)
"Genetic Sexing Strains for Aedes SIT are expected to allow large savings in control programmes"
11:25 am - 11:30 am
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Social and Regulatory Science on Genetic Biocontrol
Discussion Leaders: Brinda Dass (FNIH, United States) and Samantha O’Loughlin (Imperial College London, United Kingdom)
6:00 pm - 6:15 pm
Isabelle Coche (Outreach Network for Gene Drive Research, Portugal)
"International Governance of Gene Drive Research: Reconciling Divergent Priorities to Create an Enabling Environment for Innovation"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:35 pm
Sarah Hartley (University of Exeter, United Kingdom)
"Social science on risk assessment for genetic biocontrol"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Jason Delborne (North Carolina State University, United States)
"Stakeholder Engagement for Genetic Biocontrol"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Ana Kormos (University of California Davis, United States)
"Stakeholder Engagement for the Application of Gene Drives"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
Charles Mugoya (Target Malaria, Uganda)
"Regulatory issues around the Target Malaria's planned work with non-gene drive genetically modified Mosquitoes"
7:35 pm - 7:40 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Manipulating Sex Determination for Genetic Biocontrol
Discussion Leaders: Max Scott (North Carolina State University, United States) and Jake Tu (Department of Biochemistry, Virginia Tech, United States)
9:00 am - 9:15 am
Junru Liu (University of California, San Diego, United States)
"Engineering Repressible Female-Specific Lethality for Insect Population Biocontrol"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Kevin Esvelt (Massachusetts Institute of Technology, United States)
"Y-linked editing and drive efficiency in rodents"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Tony Nolan (Liverpool School of Tropical Medicine, United Kingdom)
"Developing gene drives for population suppression of the malaria vector Anopheles funestus "
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Eveline Verhulst (Wageningen University & Research, The Netherlands)
"Insights from the Sex Determination Mechanism of the Model Parasitoid, Nasonia vitripennis , and their Application for Biocontrol."
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Angela Meccariello (Imperial College London, United Kingdom)
"Making males: from medfly biology to medfly control"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Scott Geib (USDA-ARS, United States)
"Developing biocontrol tools for Tephritids"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Yael Arien (The Hebrew University of Jerusalem, Israel)
"Developing a novel sex ratio distortion system in Anopheles gambiae"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Marc Schetelig (Justus-Liebig-University Giessen, Germany)
"Generic markers and temperature-sensitive lethal systems for insect pest control"
12:05 pm - 12:10 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Modeling for Genetic Biocontrol
Discussion Leaders: Austin Burt (Imperial College London, United Kingdom) and Florence Debarre (Sorbonne Universite, France)
6:00 pm - 6:15 pm
John Marshall (University of California, Berkeley, United States)
"Close-kin mark-recapture methods to estimate demographic parameters of mosquitoes and implications for control"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:35 pm
Prashanth Selvaraj (Bill and Melinda Gates Foundation, United States)
"Target product profiles for replacement drives and biocontrol using EMOD Malaria, an agent-based mathematical model of malaria transmission"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Hector M. Sanchez C. (University of California, Berkeley, United States)
"Constrained Optimization and Machine Learning Techniques applied to the Identification of Operational Ranges and Spatial Surveillance of Genetic Constructs in Mosquito Control Mathematical Modelling"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Jaline Gerardin (Northwestern University, United States)
"Modeling Malaria Interventions to Inform Policy"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
Katie Willis (Imperial College London, United Kingdom)
"Developing Strategies for Efficient Localisable Genetic Biocontrol"
7:35 pm - 7:40 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Elucidating Vector-Pathogen Interactions with an Aim to Engineer Anti-Pathogen Effectors
Discussion Leaders: George Dimopoulos (Johns Hopkins Bloomberg School of Public Health, United States) and Karine Le Roch (University Of California, Riverside, United States)
9:00 am - 9:15 am
CHUNHONG CHEN (National Health Research Institutes, Taiwan)
"Harnessing Gene Functions in Dengue Infection: Exploring Gene Drive as a Promising Genetic Control Strategy"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Yuemei Dong (Johns Hopkins School of Public Health, United States)
"Curbing vector-borne diseases: Versatile combinations of genetic modifications for pathogen suppression in the mosquitoes"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Prasad Paradkar (CSIRO- Australian Centre for Disease Preparedness, Australia)
"Making Mosquitoes Resistant to Virus Transmission."
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Bryony Bonning (University of Florida, United States)
"Gut Binding Peptide-mediated Identification of Insect and Pathogen Binding Domains."
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Eric Calvo (National Institutes of Health, United States)
"Arthropod salivary proteins as modulators of vertebrate vascular biology and pathogen transmission"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Shirley Luckhart (University of Idaho, United States)
"Feeding them information: regulation of parasite transmission by host genetics and allergic inflammation in malaria."
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Claudia Rückert (University of Nevada, Reno, United States)
"New genetic tools to study Culex mosquito-virus interactions"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Rebeca Carballar (University of California Irvine, United States)
"Mosquito population modification and the malaria eradication agenda"
12:05 pm - 12:10 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Population Genetics, Ecology, Field Work, and Monitoring
Discussion Leaders: Gordana Rašic (QIMR Berghofer Medical Research Institute, Australia) and Hervé Bossin (Institut Louis Malardé, French Polynesia)
6:00 pm - 6:15 pm
Gabriel Carrasco-Escobar (UPCH, Peru)
"The use of drones for mosquito surveillance and control"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:35 pm
Mariangela Bonizzoni (University of Pavia, Italy)
"Patterns of evolution in invasive arboviral vectors: from genomics to physiology"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Adam Vorsino (USFWS, United States)
"Island and Islet Specific Populations of Aedes albopictus Across the Pacific."
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Abdoulaye Diabate (Institut de Recherche en Sciences de la Sante (IRSS) / Sya Innovation Center, Burkina Faso)
"Field Preparedness for the Implementation of Gene Drive in Africa"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
Fredros Okumu (Ifakara Health Institute, Tanzania)
"Considerations for monitoring GM Mosquitoes in Africa"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Greg Lanzaro (University of California, Davis, United States)
"Field Trial Design for Evaluation of an Anopheline Mosquito Population Modification Strategy Employing a Low Threshold Gene Drive"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure