Deciphering the Mechanisms and Functions of Chromatin Organization in Eukaryotic Genomes

The 3-dimensional organization of eukaryotic genomes within the nucleus has emerged as an important aspect of many cellular processes. Delineation of its regulation has led to insights into normal physiology and diseases. Technological advancements have allowed researchers to interrogate higher-order chromatin structures at unprecedented resolutions and in distinct biological contexts. We now understand that interplay between diverse pathways regulate the nuclear organization in different cell types. While great strides have been made in the past decade, the underlying molecular mechanism that controls genome architecture remains to be fully understood. The 2023 conference on Genome Architecture in Cell Fate and Disease: “Deciphering the mechanisms of chromatin organization in eukaryotic genomes” is the fourth meeting of this series that aims to promote discussion in the field of 3D genome organization. Specific focus will be placed on epigenetic mechanisms, regulation during development, chromatin dysfunction in disease, and technology development.