Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Early Embryogenesis: The Origin of the Germline
Discussion Leader: Ian Chambers (University of Edinburgh, United Kingdom)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Magdalena Zernicka-Goetz (University of Cambridge, United Kingdom)
"Building the Mammalian Embryo In Vivo and In Vitro "
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Takashi Hiiragi (European Molecular Biology Laboratory (EMBL), Germany)
"Self-Organization in Mouse Development"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Jianping Fu (University of Michigan, Ann Arbor, USA)
"Synthetic Human Embryo-Like Structures: A New Paradigm for Human Embryology"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Regulation of the Germline
Discussion Leader: Josephine Bowles (The University of Queensland, Australia)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
Selected from Poster Abstracts: Walfred Tang (University of Cambridge, United Kingdom)
"A Critical but Divergent Role of PRDM14 in Human Primordial Germ Cell Fate Revealed by Inducible Degrons"
9:15 am - 9:20 am
Discussion
9:20 am - 9:45 am
Martin Matzuk (Baylor College of Medicine, USA)
"Targeting Spermatogenesis for Male Contraception"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Selected from Poster Abstracts: Julia Spindel (The Babraham Institute, University of Cambridge / MRC Cambridge Stem Cell Institute, United Kingdom)
"The Role and Regulation of UHRF1 During Mammalian Embryogenesis"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:05 am
Wei Li (Institute of Zoology, Chinese Academy of Sciences, China)
"Deciphering Allelic Imbalance and Its Role in Reproduction"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Man Zhang (University of Edinburgh, United Kingdom)
"Otx2 Heterozygosity Enables ESRRB to Induce PGC Differentiation Without Cytokines"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Peter Koopman (The University of Queensland, Australia)
"Molecular Pathways of Mammalian Sex Determination"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
General Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Female Germline Development
Discussion Leader: Lei Lei (University of Michigan, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Ji Wu (Shanghai Jiao Tong University, China)
"Epigenetic Regulation Mechanism in Differentiation of Female Germline Stem Cells"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Evelyn Telfer (University of Edinburgh, United Kingdom)
"Growing Old Human Oocytes and Making New Ones In Vitro "
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Cai-Xia Yang (Northeast Agricultural University, China)
"Functional Investigation of Long Noncoding RNAs on Porcine Oocyte Maturation and Early Embryo Development"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Single Cell Analyses of Germ Cell Development
Discussion Leader: Blanche Capel (Duke University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Fuchou Tang (Peking University, China)
"Decoding the Gene Regulation Network of Human Germline Cells by Single Cell Functional Genomics Approach"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Kikue Tachibana (IMBA - Institute of Molecular Biotechnology, Austrian Academy of Sciences, Austria)
"New Insights into the Causes of the Maternal Age Effect"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Selected from Poster Abstracts: Tsotne Chitiashvili (University of California, Los Angeles, USA)
"Human Primordial Germ Cells Recapitulate X Chromosome Dynamics of Human Pre-Implantation Embryos"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
Sue Hammoud (University of Michigan, USA)
"The Power of One: Single Cell Sequencing Identifies an Unexpected Somatic Cell Progenitor"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Brian Hermann (University of Texas at San Antonio, USA)
"Identifying Spermatogonial Stem Cells and Their Regulatory Framework with Single-Cell Transcriptomics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:15 pm
General Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
Environmental Impacts on the Germline
Discussion Leader: Patricia Hunt (Washington State University, USA)
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:30 pm
Qi Chen (University of California, Riverside, USA)
"Sperm RNA Code: How Many More Secrets in Programming Offspring Phenotypes?"
4:30 pm - 4:40 pm
Discussion
4:40 pm - 5:05 pm
Adam Watkins (University of Nottingham, United Kingdom)
"Dads, Diet and Disease: The Paternal Programming of Offspring Health"
5:05 pm - 5:15 pm
Discussion
5:15 pm - 5:40 pm
Michael Skinner (Washington State University, USA)
"Environmental Impacts on the Epigenetic Transgenerational Inheritance of Sperm Epimutations and Their Developmental Origins"
5:40 pm - 5:50 pm
Discussion
5:50 pm - 6:00 pm
General Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spermatogonial Stem Cells and Their Niche
Discussion Leader: Jon Oatley (Washington State University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
Selected from Poster Abstracts: Robin Friedman (Ohana Biosciences, USA)
"Widespread Haploid-Biased Gene Expression in Mammalian Spermatogenesis Associated with Frequent Selective Sweeps and Evolutionary Conflict"
9:15 am - 9:20 am
Discussion
9:20 am - 9:45 am
Bradley Cairns (University of Utah, USA)
"The Human Testis Transcriptional Cell Atlas"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Selected from Poster Abstracts: Julien Legrand (Monash University, Australia)
"Role of the RNA Helicase DDX5 in Spermatogonial Maintenance and Function"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Xin Chen (Johns Hopkins University, USA)
"Asymmetry from Symmetry or Symmetry from Asymmetry?"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Aya Uchida (The University of Tokyo, Japan)
"Non-Cell Autonomous Regionalization of Sertoli Valve Niche in the Terminal Segment of the Seminiferous Tubules of Mouse Testes"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Jan-Bernd Stukenborg (Karolinska Institutet, Sweden)
"Male Germ Stem Cells, Their Niche and Potential In Vitro "
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: Cameron Berry (Stanford University, USA)
"Developmentally Regulated Differential Cleavage of Transcript 3' Ends Controls a Switch in Proteins Expressed as Male Germline Cells Transition from Proliferation to Differentiation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Epigenetic Programming of Germline Development
Discussion Leader: Amander Clark (University of California, Los Angeles, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Mitinori Saitou (Kyoto University, Japan)
"Mechanism and Reconstitution In Vitro of Human Germ Cell Development"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Makoto Tachibana (Graduate School of Frontier Biosciences, Osaka University, Japan)
"Epigenetic Regulation of Spermatogonial Development by Histone Demethylation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Patrick Western (Hudson Institute of Medical Research, Australia)
"Germline Epigenetics: Polycomb Regulated Investment in Offspring Futures"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Technological Advances in Germ Cell Research
Discussion Leader: Susana Chuva de Sousa Lopes (Leiden University Medical Center, The Netherlands)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
Selected from Poster Abstracts: Swati Sharma (Centre for Reproductive Medicine and Andrology, University of Münster, Germany)
"Testes-on-Chip Model for In Vitro Primate Spermatogenesis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:45 am
Irina Larina (Baylor College of Medicine, USA)
"Regulation of Gametes and Preimplantation Embryos by Oviduct Environment: What Can We Learn from In Vivo Imaging"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Selected from Poster Abstracts: Magdalena Wagner (Karolinska Institutet, Sweden)
"Characterization of Human Ovarian Tissue Cells"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Goro Yoshizaki (Tokyo University of Marine Science and Technology, Japan)
"Germ Cell Transplantation in Fish: Current Status and Future Prospects"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Daisylyn Senna Tan (The University of Hong Kong, Hong Kong SAR China)
"Elucidating the Mechanism for High Performance Cell Fate Reprogramming by an Artificially Evolved POU Factor"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Masahito Ikawa (Osaka University, Japan)
"CRISPR/Cas9 Mediated Genome Editing and Its Application for the Study of Fertilization"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: Kanako Ikami (University of Michigan, USA)
"Branched Germline Cysts Formation and Fragmentation in Mouse Gametogenesis"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Natural and Induced Mutations in the Germline
Discussion Leader: John McCarrey (University of Texas at San Antonio, USA)
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:30 pm
Itai Yanai (New York University Langone Health, USA)
"Widespread Transcriptional Scanning in Testes Modulates Gene Evolution Rates"
4:30 pm - 4:40 pm
Discussion
4:40 pm - 5:05 pm
Anne Goriely (University of Oxford, United Kingdom)
"Selfish Testes, New Mutations and Human Disease"
5:05 pm - 5:15 pm
Discussion
5:15 pm - 5:40 pm
Jacob Mueller (University of Michigan Medical School, USA)
"A Mus Lineage-Specific Gene Family Is Essential for Male Fertility and Equalized Sex Ratio"
5:40 pm - 5:50 pm
Discussion
5:50 pm - 6:00 pm
General Discussion
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure