Sunday Feb. 2

• Afternoon - Registration
• 6:00 - 7:30 p.m. - DINNER
• 7:30 - 7:45 p.m. - Announcements and Program Overview

Methods & Structural Biology of Glycoconjugates

• Anne Dell & Steve Homans - Discussion Leaders
• 7:45 - 8:15 p.m. - Dr. Anne Dell, "The Q-TOF: A new ultra-high sensitivety mass spectrometer for biopolymer sequencing"
• 8:15 - 8:30 p.m. - Drs. Vernon N. Reinhold, Bruce B. Reinhold, Branch Moody, Steven A. Porcelli & Michael B. Brenner, "Structural characterization of glycosylated and non-peptide antigens: is the presentation paradigm different?"
• 8:30 - 8:45 p.m. - Drs. Steffen Goletz, F.-G. Hanisch & U. Karsten, "Sequencing strategy for the localization of O-glycosylation sites of MUC1"
• 8:45 - 9:00 p.m. - Dr. Jim Naismith, "High resolution crystal structures of con-A carbohydrate complexes"
• 9:00 - 9:30 p.m. - Dr. Jesus Jimenez-Barbero, "Applications of NMR spectroscopy to the study of protein/carbohydrate interactions"

Monday Feb. 3

Biosynthesis & Metabolism

• Robert Haltiwanger & Pamela Stanley - Discussion Leaders
• 9:00 - 9:30 a.m. - Dr. Shuichi Tsuji, "What controls the biosynthesis of polysialic acid"
• 9:30 - 9:45 a.m. - Drs. Lisa K. Kreppel & Gerald W. Hart, "O-GlcNAc transferase: a novel, highly conserved enzyme"
• 9:45 - 10:00 a.m. - Drs. Robert Haltiwanger, R. Scartozzi and G. Philipsberg, "Modulation of O-GlcNAc levels on proteins in cells"
• 10:00 - 10:30 a.m. - Dr. Rita Gerardy-Schahn, "Searching for PSA: a new strategy to clone factors along the biosynthetic pathway of complex carbohydrates"
• 10:30 - 10:45 a.m. - Coffee Break
• 10:45 - 11:15 a.m. - Dr. Claudia Abeijon, "Nucleotide sugar transporters in mammals and yeast"
• 11:15 - 11:30 a.m. - Drs. Joachim Krieg, Wolfgang Glasner, Anna Vicentini, Marie-Agnes Doucey, Andreas Loffler, Daniel Hess & Jan Hofsteenge, "C-mannosylation of human ribonuclease 2"
• 11:30 - 11:45 - Dr. Toshisuke Kawasaki, "Cloning and functional expression of a novel glucuronyltransferase involved in the biosynthesis of HNK-1 carbohydrate epitope"
• 11:45 - Noon - Dr. Yang Wang, Reed Harris & Michael Spellman - "Purification and molecular cloning of an O-fucosyltransferase, EGF-domain O-fucosylation"
• Noon - 12:30 p.m. - Dr. Pamela Stanley, "New molecules involved in glycosylation in mammals identified in CHO mutants"
• 12:30 - 1:30 p.m. - LUNCH
• AFTERNOON FREE
• 4:30 - 6:00 p.m. - POSTER SESSION
• 6:00 - 7:30 p.m. - DINNER

Mucins & Proteoglycans

• Bob Hill & Vince Hascall - Discussion Leaders
• 7:30 - 8:00 p.m. - Dr. Anna Plaas, "Characterization of non-reducing terminal residues on chondroitin sulfate: implications for chain polymerization and sulfation"
• 8:00 - 8:30 p.m. - Dr. Bob Linhardt, "Heparin structure and activities mediated through its interactions with proteins"
• 8:30 - 9:00 p.m. - Dr. James R. Gum, "The structure and expression of gastrointestinal mucins"
• 9:00 - 9:30 p.m. - Dr. Robert Hill, "Submaxillary mucin structure and assembly"

Tuesday Feb. 4

N-Glycans: Biosynthesis & Functions

• Harry Schachter & Annette Herscovics - Discussion Leaders
• 9:00 - 9:30 a.m. - Dr. Annette Herscovics, "Structure and function of alpha mannosidases involved in N-glycan processing"
• 9:30 - 9:45 a.m. - Drs. Robert Campbell, Jenny Tan, Harry Schacter, Brad Bendiak & Jamey Marth, "Targeted inactivation of the murine UDP-GlcNAc:alpha-6-D-Mannoside ß-1,2-N-acetylglucosaminyltransferase II gene"
• 9:45 - 10:00 a.m. - Dr. Naoyuki Taniguchi, "Bisecting GlcNAc structures act as negative sorting signals for cell surface glycoproteins in Forskolin treated rat hepatoma cells"
• 10:00 - 10:30 a. m. - Dr. Hudson Freeze, "Mannose and protein N-glycosylation: low tech therapy?"
• 10:30 - 11:00 a.m. - Coffee Break
• 11:00 - 11:15 a.m. - Drs. Irma Van Die, Hans Bakker & Dirk H. Van Den Eijnden, "The ß1--»4 galactosyltransferase family: glycosytransferases with a different UDP-sugar specificity"
• 11:15 - 11:30 a.m. - Drs. Tadashi Suzuki, Ken Kitajima, Yasufumi Emori, Yasuo Inoue & Sadako Inoue, "Site-specific de-N-glycosylation of glycoproteins"
• 11:30 - 11:45 a.m. - Drs. A. K. Sarkar, K. S. Rostand, R. K. Jain, K. L. Matta & J. D. Esko, "Fucosylation of disaccharide precursors of sialyl Lewis X inhibits selectin-mediated cell adhesion"
• 11:45 - Noon - Drs. Bruce A Macher, Loc Vo, Marie Marcinko & Stephanie Lee, "Structure-function analysis of human alpha 1,3 fucosyltransferase: amino acids involved in acceptor substrate specificity"
• Noon - 12:30 p.m. - Dr. Markus Aebi, "The highly conserved STT3 protein is a component of the oligosaccharyltransferase complex"
• 12:30 - 1:30 p.m. - LUNCH
• AFTERNOON FREE
• 3:30 - 4:30 p.m. - Dr. Zakir Bengali, "The NIH grants process and the concerns of the glycobiology community"
• 4:30 - 6:00 p.m. - POSTER SESSION
• 6:00 - 7:30 p.m. - DINNER

Bacterial and Eukaryotic Glycolipids

• Chris Raetz & Sen Hakomori - Discussion Leaders
• 7:30 - 7:50 p.m. - - Dr. Sen-itiroh Hakomori, "Glycosphingolipids in signaling and adhesion: overview and a few examples"
• 7:50 - 8:10 p.m. - Drs. Karl-Anders Karlsson, Halina Miller-Podraza,, Susann Teneberg & Jonas Angström, "Structural characterization of polyglycosylceramides in relation to binding by Helicobacter pylori and by Escherichia coli heat-labile toxin"
• 8:10 - 8:30 p.m - Dr. Ronald L. Schnaar, "Sialoglycococonjugate recognition by myelin-associated glycoprotein and related I-type lectins: Structural specificity and functional implications"
• 8:30 - 9:00 p.m - - Dr. Chris Raetz, "Lipid A biosynthesis: a target for antibacterial drugs"
• 9:00 - 9:15 p.m - - Dr. A. Valvano, "Molecular and biochemical characterization of genes involved in the biosynthesis of the Escherichia coli inner core lipopolysaccharide"
• 9:15 - 9:30 p.m. - Dr. K. F. Johnson, "N. gonorrhoeae 1gt A gene encodes a polyglycosyltransferase"

Wednesday Feb. 5

Sialic Acids

• Ajit Varki & Rick Troy - Discussion Leaders
• 9:00 - 9:25 a.m. - Dr. Yasou Inoue, "KDN: occurrence and oncodevelopmental glycotypes"
• 9:25 - 9:40 a.m. - Dr. Ken Kitajima, "Olgosialic acid-containing glycoproteins occur in vertebrates more frequently than recognized until now: their distribution, biosynthesis and function"
• 9:40 - 9:55 a. m. - Drs. Minoru Fukuda, Kiyohiko Angata, Edgar Ong & Jun Nagayama, "Developmental regulation of polysialic acid synthesis directed by two polysialyltransferases, PST and STX"
• 9:55 - 10:15 a.m. - Coffee Break
• 10:15 - 10:30 a.m. - Drs. Jiyan Ma, Roy Qian, Francisco M. Rausa, III & Karen J. Colley, "Two alpha2,6-sialyltransferase isoforms differ in catalytic activity, localization and proteolytic processing"
• 10:30 - 10:45 a.m. - Dr. Jamey Marth, "Investigation of ST6Gal 1 gene function in mutant mice"
• 10:45 - 11:00 a.m. - Dr. Gary Taylor, "The sialidase superfamily: structures, functions and therapeutic potential"
• 11:15 - 11:30 a.m. - Dr. Yu-Teh Li, "Specificity, cloning and expression of a NeuAcalpha2,3 gal-specific sialidase, sialidase L"
• 11:30 - 11:45 a.m. - Dr. Carolyn R. Bertozzi, "Engineering cell surface chemistry and recognition using the pathways for oligosaccharide biosynthesis"
• 11:45 - Noon - Drs. Song Yu, Nathan J. Wardrip, Yasushi Shimoda & Jerry L. Hedrick, "N-glycans are required for the binding activity of the cortical granule lectin"
• Noon - 12:30 p.m. - Dr. Ajit Varki, "Biosynthesis and turnover of the O-acetyl and N-acetyl groups of sialic acids"
• 12:30 - 1:30 p.m. - LUNCH
• AFTERNOON FREE
• 4:30 - 6:00 p.m. - POSTER SESSION
• 6:00 - 7:30 p.m. - DINNER

GPI-Anchors & Parasite Glycosylation

• Anant Menon & Peter Orlean - Discussion Leaders
• 7:30 - 8:00 p.m. - Dr. Anant Menon, "Intracellular transport of GPIs"
• 8:00 - 8:30 p.m. - Dr. Andreas Conzelmann, "Yeast mutants deficient in the addition of complete GPI anchors to proteins"
• 8:30 - 8:45 p.m. - Drs. Peter Gerold, Saba Berhe, Jürgen Kimmel, Sola Ogun, Livia Vivas, Anthony Holder, Nicole Freiberg & Ralph T. Schwarz, "Glycosyl-phosphatidylinositols in Plasmodia"
• 8:45 - 9:15 p.m. - Dr. Peter Orlean, "Conserved genes required for GPI anchoring"
• 9:15 - 9:30 p.m. - Drs. Kuo-yuan Hwa, Alvaro Acosta-Serrano, George Quellhorst, Sharon Krag & Paul T. Englund, "A genetic approach to protein glycosylation in Trypanosoma brucei"

Thursday Feb. 6

Glycobiology of Protozoans & Parasites

• Sam Turco & Richard Cummings - Discussion Leaders

• 9:00 - 9:15 a.m. - Election Balloting for 1999 Gordon Conf. Vice Chair
• 9:15 - 9:45 a.m. - Dr. Richard Cummings, "Schistosomiasis and other helminthic infections: fucosylation and antigenicity"
• 9:45 - 10:15 a.m. - Dr. Peter Overath, "Protein modification by phosphoglycans in Leishmania"
• 10:15 - 10:45 a.m. - Coffee Break
• 10:45 - 11:15 a.m. - Dr. Armando Parodi, "Probing the quality control of glycoprotein folding in Trypanosoma cruzi"
• 11:15 - 11:30 - Dr. Kay-Hooi Khoo, Delphi Chatterjee, John Caulfield & Anne Dell, "Structural mapping of the glycans of Shistosomal egg antigens"
• 11:30 - 11:45 - Drs. A. Vandersall-Nairn, K. O'Brien, R. K. Merkle, T. N. Oeltmann & K. W. Moreman, "Cloning and expression of the acid alpha-mannosidase of Trypanosoma cruzi"
• 11:45 - 12:15 p.m. - Dr. Sam Turco, "Golgi GDP-mannose uptake requires Leishmania LPG2: a member of a eukaryotic family of putative nucleotide-sugar transporters"
• 12:15 - 12:30 p.m. - Drs. Christopher M. West, P. Teng-umnuay, Emil Kozarov & Michael Bubb, "Characterization of a cytolic glycosylation pathway in the cellular slime mold Dictyostelium discoideum"
• 12:30 - 1:30 p.m. - LUNCH
• AFTERNOON FREE
• 4:30 - 6:00 p.m. - POSTER SESSION
• 6:00 - 7:30 p.m. - DINNER

Glycobiology In Development & Disease

• Jacques Baenziger & Bill Lennarz - Discussion Leaders
• 7:30 - 7:45 p.m. - Election Results/Business Meeting
• 7:45 - 8:15 p.m. - Dr. John Lowe, "Fucosyltransferase-mutant mice disclose collaborative roles for fuc-TIU and fuc-TVII in selectin ligand synthesis"
• 8:15 - 8:30 p.m. - Dr. Motonori Hoshi, "Structure and biological activity of the main saccharide chain in the acrosome reaction-inducing substance of the starfish, Asterias amurensis"
• 8:30 - 8:45 p.m. - Drs. P. M. Simon, P. Goode, D. Piskorska, J. McCauley, R. Barthelson, D. Zopf & E. McGuire, "Multivalent glycoconjugates as inhibitors of pathogenetic bacterial adherence"
• 8:45 - 9:00 p.m. - Dr. Jacques Baenziger, "GalNAc-4-sulfate receptor"
• 9:00 - 9:30 p.m. - Dr. Brian J. Popko, "Myelin without galactolipids"

Friday Feb. 7

• BREAKFAST