| 7:30-8:30 am | BREAKFAST |
| 8:30-9:00 am | CONFERENCE PHOTOGRAPH SESSSION |
| GLYCOSYLATION IN PROTEIN FOLDING
Chair: John Bergeron |
| 9:00-9:30 am | David Williams - University of Toronto, Toronto, Canada
Calnexin, Calreticulin And The Folding Of Glycoproteins Within the Endoplasmic Reticulum |
| 9:30-9:45 am | Stefana M. Petrescu, Norica Nichita, Andrei J. Petrescu, Frances M. Platt, Mark R. Wormald, Raymond A. Dwek - Romanian Academy, Bucharest, Romania
Folding And Activity Of The Metalloenzyme Tyrosinase Is Regulated By Calnexin And Calreticulin |
| 9:45-10:15 am | Armando J. Parodi - Fundacion Campomar, Buenos Aires, Argentina
What Schizosaccharomyces Pombe Mutants Reveal About The Quality Control Of Glycoprotein Folding |
| 10:15-10:30 am | Susana Silberstein, Gabriel Schlenstedt, Pam A. Silver, and Reid Gilmore -University of Massachusetts Medical School, Worcester, MA
A Role For The Dnaj Homologue Scj1p In Folding Of Hypoglycosylated Proteins In The Yeast Endoplasmic Reticulum |
| 10:30-10:45 am | Christopher M. West, Patana Teng-umnuay, Sharon Compton, and Hanke van der Wel - University of Florida, Gainesville, FL
Evidence That A Cytoplasmic/Nuclear Protein Involved In Ubiquitination Is Modified By A Novel Cytoplasmic Glycosylation Pathway |
| 10:45-11:00 am | COFFEE BREAK |
| GLYCOSYLATION IN INTRACELLULAR TRAFFICKING
Chair: Stuart Kornfeld |
| 11:00-11:30 am | William M. Canfield - University of Oklahoma, Oklahoma City, OK
Molecular Characterization Of The Mannose 6-Phosphate Dependent Lysosomal Enzyme Trafficking Pathway |
| 11:30-11:45 am | G. Sahagian, J. Cuozzo, K. Tao, J. Warner, M. Cygler and J. Mort - Tufts University School of Medicine, Boston, MA
Common Lysine-based Structure for Mannose Phosphorylation of Lysosomal Proteins |
| 11:45-12:00 pm | Rosalind Kornfeld, Ming Bao, Kevin Brewer, Carolyn Noll, and William M. Canfield - Washington University, St-Louis, MO, & others
Molecular Cloning and Functional Expression of Human N-acetylglucosamine-1-phosphodiester a-N-acetylglucosaminidase |
| 12:00-12:30 pm | Nancy Dahms - Medical College of Wisconsin, Milwaukee, WI
Insight Into Lysosomal Enzyme Targeting From The Crystal Structure Of The Mannose 6-Phosphate Receptors |
| 12:30-1:30 pm | LUNCH |
| 1:30-3:30 pm | AFTERNOON FREE |
| 3:30-4:30 pm | GENOMICS WORKSHOP |
| 4:30-6:00 pm | POSTER SESSION |
| 6:00-7:30 pm | DINNER |
| YEAST GLYCOCONJUGATES
Chairs: Howard Bussey and Peter Orlean |
| 7:30-8:00 pm | Stephan te Heesen - Federal Institute of Technology, Zürich, Switzerland
New Aspects in the Biosynthesis of N-linked Sugars at the Endoplasmic Reticulum of Yeast |
| 8:00-8:15 pm | Olga Castro, Ling Yun Chen, Armando J. Parodi, and Claudia Abeijon - Boston University Goldman School of Dental Medicine, Boston, MA, & others
UDP-Glucose Transport Into The Endoplasmic Reticulum Of S. Cerevisiae: In Vivo And In Vitro Evidence. |
| 8:15-8:30 pm | Steve Grimme, Chris Taron, Erin Gaynor, Guillaume Montdésert, Steve Reed, Scott Emr, and Peter Orlean - University of Illinois at Urbana-Champaign, & others
New Yeast Genes Involved In Late Stages In Biosynthesis And Modification Of The GPI Anchor Precursor |
| 8:30-8:45 pm | Sabine Strahl-Bolsinger, T. Willer, V. Girrbach, M. Gentzsch and W. Tanner - University of Regensburg, Regensburg, Germany
Protein O-Glycosylation: The Evolutionarily Conserved PMT Gene Family. |
| 8:45-9:00 pm | John F. Cipollo, Neta Dean, and Robert B. Trimble - Albany School of Public Health, Albany, NY
Study Of N-Linked Oligosaccharides In The Saccharomyces Cerevisiae Dalg11 Mutant: Synthesis And Processing Of The Cytosolicly-Truncated Man4GlcNAc2-PP-Dol. |
| 9:00-9:30 pm | Frans Klis - University of Amsterdam, Amsterdam, The Netherlands
Compensatory Changes In The Molecular Architecture Of The Cell Wall In Response To Cell Wall Defects In Saccharomyces Cerevisiae |
| 9:30-9:45 pm | Yasunori Chiba, Satoshi Yoshida, Yoshifumi Jigami and Makoto Takeuchi. - Kirin Brewery Co., Yokohama, Japan, & others
Construction Of The Mammalian Glycosylation System In Saccharomyces Cerevisiae - Production Of High-Mannose And Hybrid-Type Sugar Chains In The Yeast |
| 7:30-8:30 am | BREAKFAST |
| EXTRACELLULAR CARBOHYDRATE RECEPTORS
Chairs: Karen Colley and Jerry Hart |
| 9:00-9:30 am | E.Yvonne Jones - University of Oxford, Oxford, U.K.
Structural Basis Of Sialic Acid Recognition In The Siglec Family |
| 9:30-9:45 am | Stephanie Wragg and Kurt Drickamer - University of Oxford, Oxford, U.K.
Identification of Amino Acid Residues That Determine pH Dependence of Ligand Binding to the Asialoglycoprotein Receptor During Endocytosis |
| 9:45-10:00 am | Terry Kay Epperson, Viswanath Ramachandran, Kamala D. Patel, Rodger P. McEver and Richard D. Cummings - Oklahoma Health Sciences Center, OK
Noncovalent Dimerization of P-Selectin Glycoprotein Ligand-1 and Minimal Determinants for Binding to P-Selectin |
| 10:00-10:15 am | Lesley G. Ellies, Shigeru Tsuboi, Bronislawa Petryniak, John B. Lowe, Minoru Fukuda, and Jamey D. Marth - University of California, San Diego, CA, & others
Core 2 O-Glycans Differentially Regulate Selectin Ligand Formation |
| 10:15-10:45 am | Marilynn E. Etzler - University of California, Davis, CA
Studies On The Role Of A Nod Factor Binding Lectin/Apyrase In The Rhizobium-Legume Symbiosis |
| 10:45-11:15 am | COFFEE BREAK |
| 11:15-11:30 am | Loc H. Vo and Jerry L. Hedrick - University of California, Davis, CA
Identification Of Oligosaccharides Involved In Sperm-Egg Envelope Binding In Xenopus Laevis. |
| 11:30-11:45 am | J.-K. Lee, M. Pang, J. Schnee, L. Baum, K. Moremen, and Michael Pierce - University of Georgia, Athens, & others
Human Homologs Of The Xenopus Oocyte Lectin Show Unique Tissue Expression And Are Members Of A Novel Lectin Family.
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| 11:45-12:15 pm | Jacques U. Baenziger - Washington University School of Medicine, St. Louis, MO
The Role of the Man/GalNAc-4-SO4 Receptor in Reproduction |
| 12:30-1:30 pm | LUNCH |
| 1:30-4:30 pm | AFTERNOON FREE |
| 4:30-6:00 pm | POSTER SESSION |
| 6:00-7:30 pm | DINNER |
| GLYCOCONJUGATES IN IMMUNE FUNCTION
Chair: David Williams |
| 7:30-8:00 pm | Robert Modlin - University of California, Los Angeles, CA
CD1 Presentation Of Microbial Lipoglycan and Lipid Antigens To T Cells |
| 8:00-8:30 pm | Linda Baum - University of California, Los Angeles, CA
Galectin-1 Induced T Cell Apoptosis: A Novel Cell Death Pathway |
| 8:30-8:45 pm | Marisa Galvan, M. Fukuda and L. Baum - UCLA, Los Angeles, CA, & others
The Role of Core 2 GnT Expression in Galectin-1 Apoptosis |
| 8:45-9:00 pm | Daniel Chui, Gayathri Sellakumar, Kurt W. Marek, Mark Sutton-Smith, Anne Dell, and Jamey D. Marth - University of California, San Diego, CA, & others
Genetic Linkage of Carbohydrate Alterations with the Formation of Autoimmune Disease
|
| 7:30-8:30 am | BREAKFAST |
| GLYCOCONJUGATES IN DEVELOPMENT
Chairs: Richard Cummings and Harry Schachter |
| 9:00-9:30 am | Jamey Marth - University of California, San Diego, CA
N- and O-Glycan Physiology Revealed by Targeted Gene Ablation |
| 9:30-10:00 am | Richard L. Proia - National Institutes of Health, Bethesda, MD
Genetic Disruption of the Natural History of Glycosphingolipids |
| 10:00-10:15 am | Robert S. Haltiwanger, Daniel J. Moloney and Li Shao - State University of NewYork at Stony Brook, NY
O-linked Fucose and O-linked Glucose Modifications of the Epidermal Growth Factor-like Modules of Notch in Chinese Hamster Ovary Cells. |
| 10:15-10:30 am | Martin Charron, Nancy L. Shaper, and Joel H. Shaper - John Hopkins University, Baltimore, MD
A 457 Genomic Fragment Containing an Ets-Core Binding Motif is Sufficient for Expression of Murine Beta-4-Galactosyltransferase-I in Late Pachytene Spermatocytes and Round Spermatids. |
| 10:30-10:45 am | Hsun-Hua Chou, Hiromu Takematsu, Sandra Diaz, Jane Iber, Elizabeth Nickerson, Kerry Wright, Elaine A. Muchmore, David L. Nelson, Stephen T. Warren and Ajit Varki - University of California, San Diego, CA, & others
Humans are Knockout Primates for CMP-sialic Acid Hydroxylase: implications for Human Evolution |
| 10:45-11:15 am | COFFEE BREAK |
| 11:15-11:45 am | John B. Lowe - University of Michigan, Ann Arbor, MI
Developmental Consequences of GDP-Fucose Deficiency in FX-Null Mice |
| 11:45 am | BUSINESS MEETING -Vice Chair Election Balloting for 2001 |
| 12:30-1:30 pm | LUNCH |
| 1:30-4:30 pm | AFTERNOON FREE |
| 4:30-6:00 pm | POSTER SESSION |
| 6:00-7:30 pm | DINNER |
| GLYCOLIPIDS AND PROTEOGLYCANS - FUNCTIONAL ASPECTS
Chair: Carlos Hirschberg |
| 7:30-8:00 pm | David Carey - Pennsylvania State College of Medicine, Danville, PA
Structure and Function Of Membrane Proteoglycans In The Developing Nervous System |
| 8:00-8:15 pm | Xiaomei Bai, Ge Wei, Anjana Sinha, and Jeffrey D. Esko - University of California, San Diego, CA
Animal Cell Mutants Altered in GlcA Transferase and Glycosaminoglycan Biosynthesis |
| 8:15-8:45 pm | John T. Gallagher - Christie Hospital, Manchester, U.K.
Sequence Analysis of Heparan Sulphate |
| 8:45-9:00 pm | Hong Liu and Shuichi Tsuji - Institute of Physical and Chemical Research, Wako, Japan
Isolation Of 10 Differentially Expressed Cdnas In Differentiated Neuro2a Cells Induced Through Controlled Expression Of The GD3 Synthase Gene |
| 9:00-9:30 pm | Konrad Sandhoff - Der Rheinischen Friedrich Wilhelms Universität, Bonn, Germany
Glycosphingolipid Activator Proteins And The Topology of Lysosomal Digestion |
| 7:30-8:30 am | BREAKFAST |
| MICROBIAL GLYCOCONJUGATES
Chair: Anne Dell |
| 9:00-9:30 am | Sam Turco - University of Kentucky, Lexington, KY
The Lipophosphoglycan Of Leishmania Parasites |
| 9:30-9:45 am | Haslam Stuart M., Morris H.R., and Dell A. - Imperial College of Science, London, U.K.
Parasitic filarial nematode N-glycans. |
| 9:45-10:15 am | Dean Crick - Colorado State University, Fort Collins, CO
Cell Wall Biogenesis in Mycobacterium Tuberculosis, a Central Role of Polyprenyl Phosphates |
| 10:15-10:30 am | Tamara L. Doering and Ulf Sommer - Cornell University, New York, NY
Capsule Biosynthesis In The Pathogenic Fungus Cryptococcus Neoformans |
| 10:30-10:45 am | Kwame Nyame, Anne M. Leppanen and Richard D. Cummings - University of Oklahoma, OK
Generation of Antibodies to LDN and LDNF in Schistosoma mansoni infected Animals and Humans |
| 10:45-11:15 am | COFFEE BREAK |
| 11:15-11:30 am | Irma van Die, Frans Kooyman, Lonneke Vervelde, Angelique van Tetering, Richard D. Cummings and Veronique Gomord - Vrije University, Amsterdam, The Netherlands
N-Glycans Of Parasitic Helminths Contribute To The Host Ige Response Upon Infection |
| 11:30-11:45 pm | Vernon Reinhold, Walter Muhlecker, Bruce Reinhold, Song Ye, Peter Rice, and Daniel Stein - University of Hampshire, & others
Structural Characterization of Neisseria gonorrhoeae LOSN-glycans of parasitic helminths contribute to the host IgE response upon infection |
| 11:45 pm | BUSINESS MEETING: Election Results |
| 12:30-1:30 pm | LUNCH |
| 1:30-4:30 pm | AFTERNOON FREE |
| 4:30-6:00 pm | POSTER SESSION |
| 6:00-7:30 pm | DINNER |
| GLYCOSYLATION DISEASES AND THERAPY
Chair: Ajit Varki |
| 7:30-8:00 pm | Ken Lloyd - Memorial Sloan-Kettering Cancer Center, New York, NY
Towards The Development Of Carbohydrate-Based Cancer Vaccines |
| 8:00-8:30 pm | David Zopf - Neose Pharmaceuticals, Horsham, PA
Development and Production of Oligosaccharide Drugs |
| 8:30-8:45 pm | Michela Tonetti, Laura Sturla, Angela Bisso, Davide Zanardi, Antonio De Flora and Amos Etzioni - University of Genova, Genova, Italy
Time-Dependent Normalization Of Defective Slex Expression And GDP-D-Mannose 4,6 Dehydratase (GMD) Activity In Long-Term Culture Of Lymphocytes From A LAD II Patients |
| 8:45-9:00 pm | M.C. (Susy) Glick, A.D. Rhim, V. Kothari, A. Liu, J.N. Weiser, and T.F. Scanlin - The Children's Hospital of Philadelphia, PA
Terminal Fucosylation and Sialylation in Cystic Fibrosis (CF) |
| 9:00-9:15 pm | Thierry Hennet, Timo Imbach, Patricie Burda, Peter Kuhnert, Markus Aebi, and Eric G. Berger - University of Zürich, Switzerland, & others
A Mutation in the Human Ortholog of the Saccharomyces Cerevisiae alg6 Gene Causes Carbohydrate-Deficient Glycoprotein Syndrome Type-Ic |
| 9:15-9:30 pm | Hudson Freeze, Soohyun Kim , Geetha Srikrishna , Darshini Mehta , Simon Murch , Kay Dryhurst - The Burnham Institute, La Jolla, CA, & others
New Enzymatic Defects And Therapy For Carbohydrate Deficient Glycoprotein Syndrome. |
