| Sunday, March 4th |
| Afternoon | REGISTRATION |
| 6.00-7.30 pm | DINNER |
| 7.30-7.45 pm | WELCOME |
| I. NEW FRONTIERS IN GLYCOBIOLOGY |
| Discussion Leader: Gerald Hart, John Hopkins Medical School |
| 7.45-8.15 pm | Alan Diekman
Carbohydrate Epitopes in Immuno-Contraceptive Development |
| 8.15-8.45 pm | Neil Olszewski, University of Minnesota, USA
Protein O-GlcNacylation regulates hormone responses of plants |
| 8.45-9.15 pm | Herman Spaink, Leiden University, The Netherlands
The function of chitin oligosaccharides in plant and animal development. |
| Monday, March 5th |
| 7.30-8.30 am | BREAKFAST |
| 8.30-9.00 am | CONFERENCE PHOTOGRAPH SESSION |
| II. STRUCTURAL GLYCOBIOLOGY |
| Discussion Leaders: Kurt Drickamer, Oxford University, UK
Steven Homans, Leeds University, UK |
| 9.00-9.15 am | Overview |
| 9.15-9.45 am | James Rini, University of Toronto, Canada
X-Ray crystal structure of rabbit N-acetylglucosaminyltransferase I: enzyme mechanism and a new protein superfamily |
| 9.45-10.15 am | Erhard Hohenester, Imperial College, UK
Laminin G-like domains in basement membrane proteins: calcium-dependent lectins with specificity for alpha-dystroglycan |
| 10.15-10.30 am | Nathan Zaccai, University of Oxford, UK
Structure-based drug design studies on sialoadhesin, a member of the siglec family
|
| 10.30-11.00 am | COFFEE BREAK |
| 11.00-11.15 am | Christina Shaeffer, Universitat fur Bodenkultur, Austria
Complete analysis of the glycosylation and molecular cloning of the sbsE gene from the surface layer (S-layer) glycoprotein of Bacillus stearothermophilus NRS 2004/3a |
| 11.15-11.45 pm | Stefan Knight, Uppsala Biomedical Centre, Sweden
Structural aspects of assembly and carbohydrate recognition in pilus-mediated bacterial adhesion. |
| 11.45-12.15 pm | Steven Matthews, Imperial College of Science, UK
Carbohydrate recognition by papG from uropathogenic E.coli |
| 12.15- 12.30 pm | Catherine Cooper, Proteome Systems Ltd., Australia
GlycoSuiteDB: a new curated database of glycoprotein-dervied glycan structures.
|
| 12.30-1.30 pm | LUNCH |
| 1.30-4.30 pm | AFTERNOON FREE |
| 4.30-6.00 pm | POSTER SESSION |
| 6.00-7.30 pm | DINNER |
| III. GLYCOSYLTRANFERASES |
| Discussion Leaders: Henrik Clausen, University of Copenhagen
Karen Colley, University of Illinois, Chicago |
| 7.30-8.00 pm | Minoru Fukuda, Burnham Institute, USA
Structural diversity of oligosaccharides that provide functional diversity. |
| 8.00-8.15 pm | Shinobu Kitazume-Kawaguchi, RIKEN Institute, Japan
ST6Gal I cleavage occurs at different sites in various cell types. |
| 8.15-8.45 pm | Taroh Kinoshita, Osaka University, Japan
Biosynthesis of GPI anchors |
| 8.45-9.00 pm | Sabine Strahl, University of Regensburg, Germany
The evolutionarily conserved protein O-mannosyltransferase (PMT).
|
| 9.00-9.30 pm | Robert Haltiwanger, State University of New York at Stony Brook
Fringe is an O-fucose specific ß1,3 N-acetylglucosaminyltransferase |
| Tuesday, March 6th |
| 7.30-8.30 am | BREAKFAST |
| IV. GENE KNOCKOUTS |
| Discussion Leaders: Brian Popko, University of North Carolina, USA
Pamela Stanley, Albert Einstein College of Medicine, USA |
| 9.00-9.15 am | ANNOUNCEMENTS |
| 9.15-9.30 am | Overview |
| 9.30-10.00 am | Hisashi Narimatsu, Soka University, Tokyo, Japan
Analysis of Fut9-knockout mouse. |
| 10.00-10.30 am | James Dennis, University of Toronto, Canada
Mgat5-modified glycans regulate signaling via focal adhesions and T cell receptors. |
| 10.30 -10.45 | Pam Grewal, University of Nottingham, UK
Murine muscular dystrophy phenotype caused by a glycosyltransferase mutation of the dystrophin associated glycoprotein complex. |
| 10.45-11.15 am | COFFEE BREAK |
| 11.15-11.45 am | Jamey Marth, University of California San Diego, USA
Approaching an understanding of mammalian glycan function in vivo. |
| 11.45-12.00 am | Niall O'Donnell, University of California San Diego, USA
Using conditional mutagenesis to investigate the mechanism by which the O-GlcNAc transferase is essential for embryogenesis and cell viability.
|
| 12.00-12.15 pm | Ruediger Horstkorte, Free University of Berlin, Germany
Lack of sialylation causes embryonic lethality in mice. |
| 12.15-12.30 pm | Catherine Merry, Christie Research Centre, Manchester, UK
The molecular phenotype of heparan sulphate in the Hs2st-/-mutant mouse. |
| 12.30-1.30 pm | LUNCH |
| 1.30-4.30 pm | AFTERNOON FREE |
| 4.30-6.00 pm | POSTER SESSION |
| 6.00-7.30 pm | DINNER |
| V. SIGLECS |
| Discussion Leaders: Paul Crocker, University of Dundee, UK
Ronald Schnaar, John Hopkins University, Baltimore |
| 7.30-7.45 pm | Overview |
| 7.45-8.15 pm | Roberto Biassoni, Istituto Scientifico Tumori IST, Genova, Italy
Functional and molecular characterization of p75/AIRM1 (Siglec-7), a CD33 homologue |
| 8.15-8.30pm | Yasuhiro Hashimoto, RIKEN Institute, Japan
Identification of a novel subset of rat macrophages that expresses unmasked forms of sialoadhesin in a high level.
|
| 8.30-8.45pm | Hiromu Takematsu, Kyoto University, Japan
Targeted disruption of the CMP-NeuAc hydroxylase gene. |
| 8.45-9.00pm | Ronald Schnaar, Johns Hopkins University, USA
Ligands and functions of the brain siglec, myelin-associated glycoprotein. |
| 9.00-9.30pm | Ajit Varki, University of California, San Diego, USA
Siglecs in humans and apes |
| Wednesday, March 7th |
| 7.30-8.30 am | BREAKFAST |
| VI. GLYCO-IMMUNOLOGY |
| Discussion Leaders: Linda Baum, University of California, Los Angeles
Richard Cummings, University of Oklahoma |
| 8.30-9.00 am | BUSINESS MEETING |
| 9.00-9.15 am | Overview |
| 9.15-9.45 am | Donald Harn, University of Harvard, Boston
Induction of Type 2 and anti-inflammatory immune responses by helminth expressed carbohydrates |
| 9.45-10.00 am | Kwame Nyame, University of Oklahoma, USA
Expression, localization and antibody responses to LacdiNAc, fucosylated LacdiNAc and LewisX anigenes of Schistosoma mansoni. |
| 10.00-10.15 am | Stephan Hinderlich, Free University of Berlin, Germany
Regulation and modulation of cell surface sialylation. |
| 10.15-10.45 am | Francoise Poirier, INSERM, France
Galectin null mutant mice |
| 10.45-11.15 am | COFFEE BREAK |
| 11.15-11.30 am | Nobuyoshi Hiraoka, The Burnham Institute, USA
Two distinct O-glycan core structures that form L-selectin ligands. |
| 11.30-11.45 am | Marcus Sperandio, University of Virginia, USA
Absence of L-selectin-dependent and reduction of P-and E-selectin-dependent leukocyte rolling in core 2 beta-1,6-N-GlcNAc transferase deficient mice in inflamed cremaster muscle venules. |
| 11.45-12.00pm | Kerstin Luhn, University of Muenster, Germany
The defective gene in leukocyte adhesion deficiency II codes for a GDP-fucose transporter. |
| 12.00-12.30 pm | Mitchell Kronenberg, La Jolla Institute for Allergy & Immunology, San Diego
How T lymphocytes recognize carbohydrates |
| 12.30-1.30 pm | LUNCH |
| 1.30-4.30 pm | AFTERNOON FREE |
| 4.30-6.00 pm | POSTER SESSION |
| 6.00-7.30 pm | DINNER |
| VII. PROTEOGLYCANS, GROWTH
AND DEVELOPMENT |
| Discussion Leaders:
John Gallagher, University of Manchester, UK
Jeffrey Esko, University of California, San Diego |
| 7.30-7.45 pm | Jeffrey Esko, University of California, San Diego
Enzyme interactions in heparan sulfate biosynthesis |
| 7.45-8.00 pm | Ram Sasisekharan, MIT, USA
Direct isolation and sequencing of specific protein-binding glycosaminoglycans on a chip. |
| 8.00-8.30 pm | Scott Selleck, University of Arizona, USA
Proteoglycans in growth control and synapse assembly |
| 8.30-8.45 pm | Ten Feizi, Imperial College, UK
Toward defining the developmentally-regulated heparan sulphate antigen, 10E4, which appears at the earliest stage of the prion disease, scrapie. |
| 8.45-9.00 pm | Christian Goetting, Heart and Diabetes Centre, Bad Oeynhausen, Germany
Xylosyltransferase: a novel protein family in the heparan sulfate biosynthesis. |
| 9.00-9.30 pm | Peter Seeberger, Massachusetts Institute of Technology, USA
Automated Synthesis of Oligosacharides and Glycosaminoglycans |
| Thursday, March 8th |
| 7.30-8.30 am | BREAKFAST |
| 8.30-9.15 am | TRIBUTE TO ANDRE VERBERT |
| Chairs: Harry Schachter, Hospital for Sick Children, Canada
Jean-Claude Michalski, Lille University, France |
| VIII. GLYCOBIOLOGY AND DISEASE |
| Discussion Leaders: Inka Brockhausen, Queen's University, Canada
Gary Jacob, Synergy Institute, New Jersey, USA |
| 9.15-9.30 am | Overview |
| 9.30-10.00 am | David Bundle, University of Alberta, Canada
Starfish Takes Sting Out of Shiga Toxins: Design, Synthesis and Mode of Action of Tailored Multivalent Carbohydrate Ligands |
| 10.00-10.15 am | Roger Chammas, Medical School at University of Sao Paulo, Brazil
Disialogangliosides modulate integrin dependent melanocyte migration. |
| 10.15-10.30 am | Jillian Brown, University of California San Diego, USA
Disaccharide primers: inhibition of sialyl Lewis X-mediated tumor cell adhesion. |
| 10.30-11.00 am | COFFEE BREAK |
| 11.00-11.30 am | Joy Burchell, Guy's Hospital, London, UK
Mechanisms underlying the aberrant O-linked glycosylation seen in breast carcinomas |
| 11.30-12.00 pm | Fran Platt, University of Oxford, UK
Substrate reduction therapy for the glycosphingolipidoses |
| 12.00-12.30 pm | BUSINESS MEETING |
| 12.30-1.30 pm | LUNCH |
| 1.30-4.30 pm | AFTERNOON FREE |
| 4.30-6.00 pm | POSTER SESSION |
| 6.00-7.30 pm | DINNER |
| IX. GLYCOBIOLOGY IN THE POST GENOMICS ERA |
| Discussion Leaders: Carolyn Bertozzi, University of California, Berkeley
James Paulson, Scripps Research Institute, La Jolla |
| 7.30-7.40 pm | James Paulson, Overview |
| 7.40-8.00 pm | Kurt Drickamer, University of Oxford, UK
A genomic view of carbohydrate-recognition domains |
| 8.00-8.30 pm | Carolyn Bertozzi, University of California, Berkeley
Unnatural substrate-based selection of human glycosylation mutants |
| 8.30-9.00 pm | Tony Cass, Imperial College, UK
Applications of Molecular Arrays in Glycobiology |
| 9.00-9.30 pm | Richard Cummings, University of Oklahoma, USA
Sweet Worms: Glycosyltransferases, Development and Immunity |
| Friday, March 9th |
| 7.30-8.30 am | BREAKFAST |
| DEPARTURE |
