| SUNDAY |
| 2:00-9:00 pm | Arrival and Check-in |
| 4:30-6:00 pm | Welcome Reception |
| 6:00 pm | Dinner |
| 7:30-7:35 pm | Welcome |
| 7:30 - 9:30 pm | Glycoprotein Biosynthesis and Quality Control |
| Chair: Phillips W. Robbins (Boston University) |
| 7:35-7:40 pm | Introduction |
| 7:40-8:10 pm | Armando Parodi (Buenos Aires, Argentina)
"Domain organization and conformation recognition pattern of an ER Glucosyltransferase" |
| 8:10-8:40 pm | Anant Menon (Univ. Wisconsin, Madison)
"Signal-mediated ER retention and degradation of the GPI transamidase subunit Gaa1" |
| 8:40-9:00 pm | Mark Lehrman (Univ. Texas Southwestern Med. Center)
"Control of Lipid-linked Oligosaccharide Synthesis by the Unfolded Protein Response" |
| 9:00-9:15 pm | William J. Lennarz (State Univ. New York, Stony Brook)
"The Degradation of Misfolded Glycoproteins" |
| 9:15-9:30 pm | James C. Jamieson (Univ. of Manitoba)
"3D Reconstruction of Lipoprotein-containing Structures at the ER-cisGolgi Interface of Rat Hepatocytes"
|
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Conference Photo |
| 9:00 am - 12:30 pm | Glycoconjugates in Development and Cell Signaling |
| Chair: Pamela Stanley (Albert Einstein College of Medicine) |
| 9:00-9:05 pm | Introduction |
| 9:05-9:35 am | Paul Martin (Univ. California - San Diego)
"Roles for Galgt2 in neuromuscular development and muscular dystrophy" |
| 9:35-10:05 am | Pamela Stanley (Albert Einstein College of Medicine)
"Protein O-Fucosyltransferase 1 is an Essential Component of Notch Signaling Pathways" |
| 10:05-10:20 am | Michiko Fukuda (Burnham Institute)
"Involvement of alpha-mannosidase IIx in an alternate N-glycan processing pathway" |
| 10:20-10:35 am | Joseph Hernandez (UCLA School of Medicine)
"CD43 Expression Modulates Galectin-1 Mediated Death of T cells: Association with CD7 May Form Pro-death Complex" |
| 10:35-11:00 am | COFFEE BREAK |
| 11:00-11:30 am | Gerald Hart (The Johns Hopkins University Medical School)
"O-Linked N-Acetylglucosamine is a Metabolite Sensor that Modulates Signaling Pathways,
Transcription and Responses to Stress" |
| 11:30-12:00 am | Scott Selleck (Arizona Cancer Center)
"Shaping morphogen gradients with Glypican" |
| 12:00-12:15 pm | Vivianne Otto (Swiss Fed. Inst. Tech.(ETH)/Univ. of OK Health Sciences Center)
"Specific Glycan Structures are Required for the Ability of Soluble ICAM-1 to Induce MIP-2 Production in Mouse Astrocytes" |
| 12:15-12:30 pm | E. Tian (NIDDK, NIH)
"Mucin-type O-glycosylation is Required for Early Mandibular Development in vitro" |
| 12:30 pm | Lunch |
| 4:30-6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Genetic Disorders in Glycoconjugate Biosynthesis |
| Chair: James Paulson (Scripps Research Institute) |
| 7:30-7:35 pm | Introduction |
| 7:35-8:05 pm | Tamao Endo (Tokyo Metropolitan Institute of Gerontology)
"Defective glycosylation in congenital muscular dystrophy" |
| 8:05-8:20 pm | John F. Cipollo (Boston Univ.)
"The Patterns of PNGase F released N-glycans of C. elegans Larval stages" |
| 8:20-8:35 pm | Patricia Berninsone (Boston University)
"The pleiotropic srf mutants in C. elegans: a link between expression of surface
glycoconjugates and intercellular signaling during development" |
| 8:35-9:05 pm | Hudson Freeze (Burnham Institute)
"Congenital Disorders of Glycosylation....The View from Space..." |
| 9:05-9:20 pm | Tongzhong Ju (Univ. of Oklahoma Health Sciences Center)
"Cosmc is a Molecular Chaperone Required for Core 1 O-glycan Expression: Subcellular Localization of Cosmc and Core 1β3-Gal-T" |
| 9:20-9:30 pm | Laura Sturla (Univ. of Genova)
"Differential Terminal Fucosylation of N-linked Glycans Versus Protein O-Fucosylation in Leukocyte Adhesion Deficiency Type II (CDGIIc)" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Glycoconjugate Biosynthesis |
| Chair: Gerald Hart (The Johns Hopkins University Medical School) |
| 9:00-9:05 am | Introduction |
| 9:05-9:35 am | Henrik Clausen (University of Copenhagen)
"Control of Mucin-Type O-Glycosylation" |
| 9:35-10:05 am | Naoyuki Taniguchi (Osaka University Medical School)
"Deficiency of FUT 8 in mice leads to high mortality" |
| 10:05-10:20 am | Robert Haltiwanger (State Univ. of New York at Stony Brook)
"Analysis of enzymes involved in protein O-fucosylation" |
| 10:20-10:35 am | Jan Hofsteenge (Friedrich Miescher Inst.)
"Protein C-Mannosylation and O-Fucosylation" |
| 10:35-11:00 am | COFFEE BREAK |
| 11:00-11:30 am | Jeff Esko (Univ. California - San Diego)
"Endothelial Cell Heparan Sulfate and Inflammation" |
| 11:30-12:00 am | John Lowe (Univ. Michigan)
"The biology and biochemistry of fucosylation" |
| 12:00-12:15 pm | Nathan Sharon (Weizmann Institute, Israel)
"Biases and Complex Patterns in the Residues Flanking Protein N-glycosylation Sites" |
| 12:15-12:30 pm | Christopher M. West (Univ. of Florida College of Medicine)
"Specificity of a UDP-Galactose:Fucoside α1,3Galactosyltransferase that Modifies Skp1 in the Cytoplasm of Dictyostelium" |
| 12:30 pm | Lunch |
| 4:00-6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Molecular Interactions of Proteins and Carbohydrates |
| Chair: William J. Lennarz (State Univ. New York, Stony Brook) |
| 7:30-7:35 pm | Introduction |
| 7:35-8:05pm | Jacques Baenziger (Washington University School of Medicine)
"Clearance of glycoproteins: Some unexpected answers" |
| 8:05-8:35 pm | Nancy Dahms (Medical College of Wisconsin)
"Carbohydrate Recognition by the Mannose 6-Phosphate Receptors" |
| 8:35-9:05 pm | Pradman Qasba (NIH)
"Conformational changes in beta-1,4-galactosyltransferases: Relevance to enzymatic function and biological consequences" |
| 9:05-9:20 pm | Anne Leppänen (Univ. of Oklahoma Health Sciences Center)
"Binding of L-selectin to Model Glycosulfopeptides From PSGL-1 Requires Tyrosine Sulfation and Core-2 Branched O-Glycan" |
| 9:20-9:30 pm | David Live (Univ. of Minnesota)
"Structure and Dynamics of a Cell Surface Mucin Motif" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:35 am | Chemical Approaches to Glycobiology |
| Chair: Y.C. Lee (The Johns Hopkins University) |
| 9:00-9:05 am | Introduction |
| 9:05-9:30 am | Geert-Jan Boons (University of Georgia/CCRC)
"Synthesis and Proinflammatory Effects of Peptidoglycan and Lipopolysaccharide Derivatives" |
| 9:30-10:00 am | Peter H. Seeberger (MIT)
"Carbohydrate Arrays Enabled by Automated Oligosaccharide Synthesis" |
| 10:00-10:25 am | Laura Kiessling (University of Wisconsin-Madison)
"Modulating Immune Responses with Multivalent Carbohydrate Ligands" |
| 10:25-10:35 am | Jillian R. Brown (Univ. California-San Diego)
"Synthetic Glycosides Inhibit Sialyl Lewis X-Mediated Tumor Growth" |
| 10:35-10:55 am | COFFEE BREAK |
| 10:55 am - 12:30 pm | Cancer Glycobiology |
| Chair: Sen-itiroh Hakomori (Pacific Northwest Research Institute) |
| 10:55-11:00 am | Introduction |
| 11:00-11:25 am | Tatsuro Irimura (University of Tokyo)
"Carbohydrate Recognition in Invasion and Metastasis" |
| 11:25-11:50 am | Ajit Varki (Univ. California - San Diego)
"Role of Selectins and Mucins in Cancer Metastasis and Trousseau's Syndrome" |
| 11:50-12:15 pm | Reiji Kannagi (Aichi Cancer Center Research Institute, Nagoya)
"Transcriptional induction of selectin ligand expression in cancer" |
| 12:15-12:30 pm | Michael Pierce (Univ. of Georgia/CCRC)
"Changes in Sulfation of N-Glycans of β1 Integrin During Colon Cancer Progression" |
| 12:30 pm | Lunch |
| 4:30-6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Glycoconjugates and Carbohydrate Binding Proteins in Innate Immunity |
| Chair: Nathan Sharon (Weizmann Institute, Israel) |
| 7:30-7:35 pm | Introduction |
| 7:35-8:05 pm | Jamey Marth (Univ. California - San Diego)
"Glycan genetics and autoimmune disease" |
| 8:05-8:35 pm | Minoru Fukuda (Burnham Institute)
"Natural killer (NK) cells attack tumor cells in a carbohydrate dependent manner" |
| 8:35-8:55 pm | Daan van Aalten (Univ. of Dundee)
"Siglecs & Chi-lectins - structures from the human innate immune system" |
| 8:55-9:15 pm | Linda Baum (UCLA School of Medicine)
"Galectin-1 influence on T cell survival, immune responsiveness and tumor immunoediting" |
| 9:15-9:30 pm | Gerardo R. Vasta (University of Maryland Biotechnology Institute)
"F-lectins: A family of Fucose-binding Animal Lectins with a Characteristic Sequence Motif and Structural Fold"
|
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:30 am | Neurobiology of Glycoconjugates |
| Chair: Mary Catherine Glick (Children's Hospital of Philadelphia) |
| 9:00-9:05 am | Introduction |
| 9:05-9:35 am | Ron Schnaar (Johns Hopkins Univ.)
"Gangliosides as cell-cell recognition ligands and signal transducers in nerve cells" |
| 9:35-10:05 am | Melitta Schachner (University of Hamburg)
"Carbohydrate-mediated interactions between neural cells" |
| 10:05-10:20 am | Daniel E. Michele (Univ. of Iowa)
"Post-translational Processing and Functional Disruption of Dystroglycan in Congenital Muscular Dystrophy with Developmental Brain Abnormalities"
|
| 10:20-10:30 am | Shinobu Katazume-Kawaguchi (Riken Institute)
"Characterization of α2,6-sialyltransferase Cleavage by Alzheimer's Beta-secretase (BACE1) and Following Processing by Aminopeptidase" |
| 10:30-10:40 am | Karen Colley (Univ. of Illinois College of Medicine)
"The Molecular Basis for NCAM Recognition by the Polysialyltransferases, PST and STX" |
| 10:40-10:55 am | COFFEE BREAK |
| 10:55 am - 12:30 pm | Genomics, Proteomics and the Era of Glycomics |
| Chair: John T. Gallagher (Paterson Institute for Cancer Research, Manchester, UK) |
| 10:55-11:00 am | Introduction |
| 11:00-11:30 am | Jun Hirabayashi (Teikyo University)
"Structural Glycomics: MSn or Lectinn?" |
| 11:30-12:00 am | Kurt Drickamer (University of Oxford)
"Combining genomic and structural perspectives on carbohydrate recognition" |
| 12:00-12:15 pm | Anne Dell (Imperial College of Science)
"Applications of MS to Glycomics and Glyco-proteomics" |
| 12:15-12:30 pm | Kay-Hooi Khoo (Academia Sinica, Taipei, Taiwan)
"MALDI-MS Profiling and CID MS/MS Sequencing of Complex Glycans for Facile Implementation of Glycomics"
|
| 12:30 pm | Lunch |
| 4:30-6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Microbial and Parasite Glycobiology |
| Chair: Anne Dell (Imperial College of Science) |
| 7:30-7:35 pm | Introduction |
| 7:35-8:00 pm | Tamara Doering (Washington Univ. School of Med.)
"A yeast goes under cover: Capsule synthesis in Cryptococcus neoformans" |
| 8:00-8:25 pm | Chris Raetz (Duke University Medical Center)
"Biosynthesis of outer membrane glycolipids in Gram-negative bacteria" |
| 8:25-8:50 pm | Mike Ferguson (Univ. of Dundee)
"GPI pathway inhibitors as trypanocidal agents" |
| 8:50-9:15 pm | Markus Aebi (Swiss Federal Institute of Technology (ETH), Zurich)
"N-linked protein glycosylation, from eukaryotes to bacteria " |
| 9:15-9:30 pm | Paul Messner (Boltzmann-Institut für Molekulare Nanotechnologie, Univ. für Bodenkultur)
"Novel Aspects of S-layer protein Glycosylation" |
| 9:30-9:45 pm | BUSINESS MEETING |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
