SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Evolutionary and Developmental Glycobiology |
7:35 pm - 7:40 pm | Discussion Leader: Pamela Stanley (Albert Einstein College of Medicine)
Introduction |
7:40 pm - 8:03 pm | Ajit Varki (University of California, San Diego)
"Multiple differences in sialobiology between humans and great apes" |
8:03 pm - 8:08 pm | Discussion |
8:08 pm - 8:31 pm | Yu Yamaguchi (Burnham Institute for Medical Research)
"Genetic dissection of the role of heparan sulfate in mammalian development" |
8:31 pm - 8:36 pm | Discussion |
8:36 pm - 8:59 pm | Jan Hofsteenge (Friedrich Miescher Institute for Biomedical Research)
"The enzymes synthesizing the protein-linked disaccharide Glc-Fuc-O- are important for normal development" |
8:59 pm - 9:04 pm | Discussion |
9:04 pm - 9:17 pm | Poster Talk: Carolina Caffaro (Boston University)
"Functional redundancy of nucleotide-sugar transporters in C. elegans" |
9:17 pm - 9:30 pm | Poster Talk: Kelley Ten Hagen (NIH)
"A UDP-GalNAc:Polypeptide N-acetylgalactosaminyltransferase is required for epithelial tube formation" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Glycobiology of Microbes and Parasites |
9:00 am - 9:05 am | Discussion Leader: Anant Menon (Weill Medical College of Cornell University)
Introduction |
9:05 am - 9:28 am | Malcolm McConville (University of Melbourne)
"Biosynthesis and function of new and old glycosylation pathways in protozoan parasites" |
9:28 am - 9:33 am | Discussion |
9:33 am - 9:56 am | Susan Logan (National Research Institute of Canada)
"Flagellar glycosylation systems of bacteria - novel therapeutic targets and novel therapeutic products" |
9:56 am - 10:01 am | Discussion |
10:01 am - 10:16 am | Poster Talk: John Samuelson (Boston University)
"Positive selection for Asn-linked glycosylation in eukaryotes with N-glycan-associated quality control of protein folding and negative selection for N-glycans in apicoplexa" |
10:16 am - 10:30 am | Poster Talk: Ten Feizi (Imperial College London)
"New insights into microbe-host interactions using microarrays of lipid-linked oligosaccharides" |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Noorjahan Panjwani (Tufts University School of Medicine)
"Role of mannose-mediated adherence in cytopathogenic mechanisms of Acanthamoeba" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Lora Hooper (University of Texas-Southwestern)
"An intestinal C-type lectin with direct bactericidal activity" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Poster Talk: Peter Delputte (University of Ghent)
"Porcine Arterivirus internalization in macrophages is mediated by sialic acid-dependent virus attachment to the macrophage-specific receptor sialoadhesin" |
12:15 pm - 12:30 pm | Poster Talk: Christopher West (University of Oklahoma Health Sciences Center)
"Dependence of O2-sensing in Dictyostelium on cytoplasmic prolyl hydroxylation and glycosylation" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Glycobiology of Cancer |
7:30 pm - 7:35 pm | Discussion Leader: Michael Pierce (University of Georgia-CCRC)
Introduction |
7:35 pm - 7:59 pm | Jim Dennis (Samuel Lunenfeld Research Institute)
"Control of tumor invasion and growth by N-glycan processing" |
7:59 pm - 8:04 pm | Discussion |
8:04 pm - 8:28 pm | Pauline Rudd (Oxford University)
"Potential cancer biomarkers revealed by new strategies for glycan analysis" |
8:28 pm - 8:33 pm | Discussion |
8:33 pm - 8:57 pm | Jeff Esko (University of California, San Diego)
"Endothelial heparan sulfate and tumor angiogenesis" |
8:57 pm - 9:02 pm | Discussion |
9:02 pm - 9:16 pm | Poster Talk: Karen Abbott (University of Georgia-CCRC)
"Identification of glycoproteins from breast cancer cells that express a specific class of N-linked glycans associated with invasiveness" |
9:16 pm - 9:30 pm | Poster Talk: Sumana Datta (Texas A&M University)
"Heparan sulfate modification enzymes and Sonic Hedgehog signaling in prostate" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biosynthesis of Glycoconjugates |
9:00 am - 9:05 am | Discussion Leaders: Carlos Hirschberg and Phillips Robbins (Boston University Goldman School of Dental Medicine)
Introduction |
9:05 am - 9:28 am | Ariel Orellana (Andres Bello University)
"Nucleotide sugar transporters and their role in quality control in the endoplasmic reticulum" |
9:28 am - 9:33 am | Discussion |
9:33 am - 9:56 am | Debra Mohnen (University of Georgia-CCRC)
"Studies on the synthesis of the plant cell wall pectic polysaccharide homogalacturonan identify a gene family of proven and putative galacturonosyltransferases involved in pectin and xylan synthesis" |
9:56 am - 10:01 am | Discussion |
10:01 am - 10:16 am | Poster Talk: Weihan Zhao (University of Illinois at Chicago)
"CMP-sialic acid transporter trafficking and Golgi localization" |
10:16 am - 10:30 am | Poster Talk: Sumana Sanyal (Weill Medical College of Cornell University)
"Reconstitution of glycolipid flip-flop in the pathway of protein N-glycosylation in the ER reveals a role for specific proteins but not Rft1p" |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Paul Weigel (University of Oklahoma Health Sciences Center)
"Mechanisms of biosynthesis by the Class I hyaluronan synthases - novel nonclassical glycosyltransferases" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Jacques Baenziger (Washington University School of Medicine)
"Changes in glycoprotein hormone glycosylation modulate in vivo function" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Poster Talk: Sara Olson (University of California, San Diego)
"Identification of novel chondroitin proteoglycans in C. elegans" |
12:15 pm - 12:30 pm | Poster Talk: Thierry Hennet (University of Zurich)
"Biological and medical significance of collagen glycosylation" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Quality Control in Glycoconjugate Biosynthesis |
7:30 pm - 7:35 pm | Discussion Leader: William Lennarz (Stony Brook)
Introduction |
7:35 pm - 7:59 pm | Robert Haltiwanger (Stony Brook)
"Role of O-glycosylation in quality control of cysteine-knot motif folding" |
7:59 pm - 8:04 pm | Discussion |
8:04 pm - 8:28 pm | Minoru Fukuda (Burnham Institute for Medical Research)
"The i-extension enzyme and Large collaborate in functional glycosylation of alpha-dystroglycan" |
8:28 pm - 8:33 pm | Discussion |
8:33 pm - 8:57 pm | Richard Cummings (Emory University)
"Glycoprotein biosynthesis: Cosmc chaperone and mutational disruption of O-glycosylation" |
8:57 pm - 9:02 pm | Discussion |
9:02 pm - 9:16 pm | Poster Talk: Paola Deprez (ETH Zurich)
"Mechanism of ER glucosidase II trimming in yeast and mammals" |
9:16 pm - 9:30 pm | Poster Talk: Jurgen Roth (University of Zurich)
"EDEM1 reveals a novel quality control vesicular transport pathway out of the endoplasmic reticulum" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Glycomics and Structure |
9:00 am - 9:05 am | Discussion Leader: Anne Dell (Imperial College London)
Introduction |
9:05 am - 9:28 am | Kelley Moremen (University of Georgia-CCRC)
"Glycome analysis during differentiation of murine embryonic stem cells" |
9:28 am - 9:33 am | Discussion |
9:33 am - 9:56 am | Lara Mahal (University of Texas at Austin)
"Exploring the Cellular Glycome via Microarrays" |
9:56 am - 10:01 am | Discussion |
10:01 am - 10:16 am | Poster Talk: Songming Chen (Van Andel Research Institute)
"Multiplexed analysis of glycan variation on native proteins captured by antibody microarrays" |
10:16 am - 10:30 am | Poster Talk: Daan Van Aalten (University of Dundee)
"Molecular mechanisms of O-GlcNAcase and its inhibitors" |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Minoru Kanehisa (Kyoto University)
"Deciphering biosynthetic codes of glycans and other biological molecules" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Timothy Fritz (NIH)
"Structural insights into mucin-type glycosylation initiation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Poster Talk: Marcus Aebi (ETH-Zurich)
"Galectins in the mushroom Coprinopsis cinerea - from structure to defense" |
12:15 pm - 12:30 pm | Poster Talk: Marina Zhuravleva (NIH)
"Structure determination of two N-terminal domains of human myeloid cell inhibitory receptor Siglec-5: An insight into receptor specificity" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Glycoimmunology |
7:30 pm - 7:35 pm | Discussion Leader: James Paulson (Scripps Research Institute)
Introduction |
7:35 pm - 7:59 pm | Paul Crocker (University of Dundee)
"Role of sialoadhesin in fine-tuning immune responses" |
7:59 pm - 8:04 pm | Discussion |
8:04 pm - 8:28 pm | Hermann Ziltener (University of British Columbia)
"New aspects of selectin ligand PSGL-1 in the development and trafficking of T cells" |
8:28 pm - 8:33 pm | Discussion |
8:33 pm - 8:57 pm | Linda Baum (UCLA School of Medicine)
"Galectin-control of innate and adaptive immune responses" |
8:57 pm - 9:02 pm | Discussion |
9:02 pm - 9:16 pm | Poster Talk: Karen Snapp (University of Illinois at Chicago)
"Structural requirements for the adhesion and invasion of Anaplasma phagocytophilum to human and mouse P-selectin Glycoprotein Ligand-1" |
9:16 pm - 9:30 pm | Poster Talk: Pam Grewal (University of California, San Diego)
"ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Glyconeurobiology |
9:00 am - 9:05 am | Discussion Leader: Michael Tiemeyer (University of Georgia-CCRC)
Introduction |
9:05 am - 9:28 am | Huaiyu Hu (SUNY-Upstate Medical University)
"Mechanisms of abnormal cell migration in POMGnT1 knockout brain" |
9:28 am - 9:33 am | Discussion |
9:33 am - 9:56 am | David Van Vactor (Harvard Medical School)
"Synaptic signaling downstream of the heparan sulfate proteoglycans Syndecan and Dallylike" |
9:56 am - 10:01 am | Discussion |
10:01 am - 10:16 am | Poster Talk: Sarah Baas (University of Georgia/CCRC)
"A new mutation that alters tissue-specific expression of N-linked glycans in the Drosophila embryo" |
10:16 am - 10:30 am | Poster Talk: Hans Bakker (Hannover Medical School)
"A new glycosyltransferase regulating protein with chaperone activity from Drosophila melanogaster" |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Ronald Schnaar (Johns Hopkins School of Medicine)
"Sialoglycans in axon stability and regeneration" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Chihiro Sato (Nagoya University)
"A short-term regulation of polysialic acid expression in microglia" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Poster Talk: Vlad Panin (Texas A&M University)
"Sialyltransferase in required for the development of the central nervous system in Drosophila" |
12:15 pm - 12:30 pm | Poster Talk: Kiyohiko Angata (Burnham Institute for Medical Research)
"Polysialic acid regulates cell migration and differentiation of neural precursors in developing and the adult brain" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Glycobiology of Disease |
7:30 pm - 7:35 pm | Discussion Leader: Jerry Hart (Johns Hopkins School of Medicine)
Introduction |
7:35 pm - 7:59 pm | Michael Demetriou (University of California, Irvine)
"Genetic and metabolic regulation of autoimmunity via the N-glycan and hexosamine pathways" |
7:59 pm - 8:04 pm | Discussion |
8:04 pm - 8:28 pm | Lance Wells (University of Georgia-CCRC)
"Aberrant O-glycosylation and disease" |
8:28 pm - 8:33 pm | Discussion |
8:33 pm - 8:57 pm | Jeffrey Ravetch (Rockefeller)
"Modulation of IgG effector functions by regulated glycosylation" |
8:57 pm - 9:02 pm | Discussion |
9:02 pm - 9:16 pm | Poster Talk: Kazuaki Ohtsubo (University of California, San Diego/HHMI)
"Dietary and genetic control of pancreatic beta cell glucose transporter glycosylation promotes insulin secretion in suppressing the pathogenesis of type 2 diabetes" |
9:16 pm - 9:30 pm | Poster Talk: Hudson Freeze (Burham Institute for Medical Research)
"Updates and new perspectives on Congenital Disorders of Glycosylation" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |