SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff & Chair |
7:35 pm - 9:30 pm | Structural Glycobiology - Enzymes and Receptors |
| Discussion Leader: Carlos Hirschberg (Boston University School of Dental Medicine) |
7:35 pm - 7:40 pm | Carlos Hirschberg (Boston University School of Dental Medicine) "Introduction" |
7:40 pm - 8:03 pm | Nancy M. Dahms (Medical College of Wisconsin) "Lysosomal enzyme recognition and the P-type lectins" |
8:03 pm - 8:08 pm | Discussion |
8:08 pm - 8:18 pm | Poster Talk: Xiaoqiang Wang (Noble Foundation, Oklahoma) "Structural basis of glycosylation of small molecules" |
8:18 pm - 8:22 pm | Discussion |
8:22 pm - 8:44 pm | David R. Rose (University of Toronto) "Mapping the substrate binding subsites of Golgi Mannosidase II and implications for inhibitor development" |
8:44 pm - 8:49 pm | Discussion |
8:49 pm - 8:59 pm | Poster Talk: Binghe Wang (Georgia State University) "Going after the ‘sweet spot’ in selecting aptamers for glycoproteins" |
8:59 pm - 9:03 pm | Discussion |
9:03 pm - 9:25 pm | Jian Liu (University of North Carolina) "Engineering the sulfotransferases to modify heparan sulfate" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:00 pm | Refreshments |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | Mechanisms of Glycosylation I |
| Discussion Leaders: John Hanover (NIH) and Kelly Ten Hagen (NIH) |
9:00 am - 9:05 am | Kelly Ten Hagen (NIH) "Introduction" |
9:05 am - 9:27 am | Anant K. Menon (Cornell Medical College) "Lipid flipping and protein N-glycosylation" |
9:27 am - 9:32 am | Discussion |
9:32 am - 9:55 am | Markus Aebi (Swiss Federal Institute of Technology) "Some novel aspects of N-linked protein glycosylation in the ER" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Group Photo / Coffee Break |
10:30 am - 10:40 am | Poster Talk: Julio J. Caramelo (Buenos Aires) "The interplay between the diverse activities of calreticulin" |
10:40 am - 10:45 am | Discussion |
10:45 am - 10:55 am | Poster Talk: Christian Thiel (University Children’s Hospital Heidelberg) "A mouse model for Congenital Disorder of Glycosylation Ia" |
10:55 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Mechanisms of Glycosylation II |
| Discussion Leader: Jacques Baenziger (Washington University) |
11:00 am - 11:05 am | Jacques Baenziger (Washington University) "Introduction" |
11:05 am - 11:27 am | Thierry Hennet (Zurich) "Collagen glycosylation" |
11:27 am - 11:32 am | Discussion |
11:32 am - 11:55 am | Stuart Kornfeld (Washington University) "New insights into UDP-GlcNAc:lysosomal enzyme N-acetyglucosamine-1-phosphotransferase from mouse models" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Poster Talk: Heather R. Flanagan-Steet (CCRC, University of Georgia) "Investigation of the cartilage morphogenesis defects in Mucolipidosis-II zebrafish" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk: Francois J.C. Foulquier (University of Lille 1/CNRS) "Link between Golgi pH homeostasis and glycosylation: contribution of CDG-II patients" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (Poster Chair: Kelley W. Moremen, Univ. of Georgia) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Infectious Disease - Eukaryotes |
| Discussion Leader: Richard D. Cummings (Emory) |
7:30 pm - 7:35 pm | Richard D. Cummings (Emory) "Introduction" |
7:35 pm - 7:58 pm | James Stevens (Center for Disease Control) "Receptor interactions of seasonal and pandemic potential influenza viruses" |
7:58 pm - 8:03 pm | Discussion |
8:03 pm - 8:27 pm | Michael A. Ferguson (Dundee) "Novel aspects of African trypanosome oligosaccharyl- and glycosyl-transferases" |
8:27 pm - 8:32 pm | Discussion |
8:32 pm - 8:55 pm | Steve Beverley (Washington University) "Synthesis of GDP-D-Ara(pyranose) by a novel bifunctional enzyme and its role in Leishmania biology and parasitism" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Poster Talk: John C. Samuelson (Boston University School of Dental Medicine) "Evidence for a ‘wattle and daub’ model of the cyst wall of Entamoeba" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Poster Talk: Alexander Titz (ETH Zurich) "Identification of a member of a novel galactosyltransferase family unravels the molecular basis of the nematotoxicity of fungal galectin CGL2" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:00 pm | Poster Session I / Refreshments |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | Immune & Vascular Glycobiology I |
| Discussion Leader: Jim C. Paulson (Scripps) |
9:00 am - 9:05 am | Jim C. Paulson (Scripps) "Introduction" |
9:05 am - 9:27 am | Lijun Xia (Oklahoma Medical Research Foundation) "Endothelial cell mucin-type O-glycans control establishment and maintenance of distinct blood and lymphatic vessel systems" |
9:27 am - 9:32 am | Discussion |
9:32 am - 9:55 am | John B. Lowe (Genentech) "Notch-Notch ligand interactions, Notch signaling and Notch glycosylation in the immune system" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Poster Talk: Lindsay Steirer (Washington University School of Medicine) "The mannose/GalNAc-4-SO4 receptor and asialoglycoprotein receptor regulate steroid hormone production during sexual reproduction and pregnancy" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Poster Talk: Hans H. Wandall (University of Copenhagen) "Megakaryocytes package and deliver Golgi-associated glycosyltransferases into platelet granules enabling extra-cellular glycosylation" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 12:30 pm | Immune & Vascular Glycobiology II |
| Discussion Leader: Jim C. Paulson (Scripps) |
11:00 am - 11:05 am | Jim C. Paulson (Scripps) "Introduction" |
11:05 am - 11:27 am | Gabriel Rabinovich (Buenos Aires) "Galectins at the crossroads of tolerance and inflammation: lessons from experimental models in vivo" |
11:27 am - 11:32 am | Discussion |
11:32 am - 11:55 am | Yvette van Kooyk (Vrije University) "Dendritic cell C-type lectins modulators of immune responses" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Poster Talk: Sachiko Sato (Research Centre for Infectious Diseases, Quebec) "Galectin-1 facilitates HIV-1 infection by stabilizing virion adhesion to susceptible cells" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk: Jin-ichi Inokuchi (Tohoku Pharmaceutical University) "Distinct ganglioside-species specific dependencies between CD4+ and CD8+ T cells in the TCR-mediated activation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Optional Excursion TBA |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cancer & Cell Regulation |
| Discussion Leader: Jim Dennis (University of Toronto) |
7:30 pm - 7:35 pm | Jim Dennis (University of Toronto) "Introduction" |
7:35 pm - 7:58 pm | Melanie A. Simpson (University of Nebraska) "Glucuronidation in prostate cancer: hyaluronan accumulation versus androgen inactivation" |
7:58 pm - 8:03 pm | Discussion |
8:03 pm - 8:27 pm | Steven D. Rosen (UCSF) "The Sulfs in Cancer" |
8:27 pm - 8:32 pm | Discussion |
8:32 pm - 8:55 pm | Tatsuro Irimura (University of Tokyo) "MUC21/Epiglycanin: the oldest cancer-associated mucin rediscovered" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Poster Talk: Kathryn E. Wellen (University of Pennsylvania) "Hexosamine pathway activity regulates glutamine metabolism" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Poster Talk: Fionnuala M. Morrish (Fred Hutchinson Cancer Research Center) "Oncogene regulation of substrate supply alters O-GlcNAc modification of proteins during cell cycle entry" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:00 pm | Poster Session I / Refreshments |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | Developmental Glycobiology I |
| Discussion Leader: Robert S. Haltiwanger (Stony Brook) |
9:00 am - 9:05 am | Bob Haltiwanger (Stony Brook) "Introduction" |
9:05 am - 9:27 am | Hamed Jafar-Nejad (University of Texas Health Sciences Center) "Regulation of Notch signaling by the glycosyltransferase Rumi" |
9:27 am - 9:32 am | Discussion |
9:32 am - 9:55 am | Kenji Matsuno (Tokyo University of Science) "The monosaccharide O-fucose modification of Notch contributes to its signaling activity" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Poster Talk: Ellen K. LeMosy (Medical College of Georgia) "The continuing saga of Pipe and glycosaminoglycans in Drosophila embryonic axis patterning: new input from biochemical and functional approaches" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Poster Talk: Tabea Dierker (University of Muenster) "New functions of heparan sulfate in Hedgehog signaling" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 12:30 pm | Developmental Glycobiology II |
| Discussion Leader: Jeffrey Esko (UCSD) |
11:00 am - 11:05 am | Jeffrey Esko (UCSD) "Introduction" |
11:05 am - 11:27 am | Hiroshi Nakato (University of Minnesota) "Heparan sulfate proteoglycans in gradients and niche" |
11:27 am - 11:32 am | Discussion |
11:32 am - 11:42 am | Poster Talk: Hideyuki Takeuchi (Stony Brook) "Novel specificity of a glycosyltransferase, Rumi, required for Notch signaling" |
11:42 am - 11:47 am | Discussion |
11:47 am - 12:10 pm | Pamela Stanley (Albert Einstein) "O-fucose glycans of Notch in T cell development" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk: Rebecca Baldwin (Paterson Institute for Cancer Research, UK) "Heparan Sulphate epitopes can be used to fractionate defined lineages during embryonic stem cell differentiation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (Poster Chair: Kelley W. Moremen, Univ. of Georgia) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structural Glycobiology - Glycans & Glycomics |
| Discussion Leader: Anne Dell (Imperial College) |
7:30 pm - 7:35 pm | Anne Dell (Imperial College) "Introduction" |
7:35 pm - 8:03 pm | Xi Chen (UC Davis) "Ligand specificity studies of Siglecs using combinatorial chemoenzymatically synthesized sialosides" |
7:58 pm - 8:03 pm | Discussion |
8:03 pm - 8:27 pm | Heather Desaire (University of Kansas) "New methods of glycopeptide analysis for profiling HIV envelope glycoproteins" |
8:27 pm - 8:32 pm | Discussion |
8:32 pm - 8:55 pm | Lance Wells (CCRC, University of Georgia) "Glycomic approaches for the analysis of embryonic Stem cells" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Poster Talk: Kevin Canis (Imperial College London) "Towards a comprehensive glycan map of Von Willebrand Factor" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Poster Talk: Josef Voglmeir (Manchester) "Glycosyltransferases and their application on peptide arrays" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:00 pm | Poster Session II / Refreshments |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | Infectious Disease - Prokaryotes |
| Discussion Leader: Phillips Robbins (Boston University School of Dental Medicine) |
9:00 am - 9:05 am | Phillips Robbins (Boston University School of Dental Medicine) "Introduction" |
9:05 am - 9:27 am | Geert-Jan Boons (CCRC, University of Georgia) "Click chemistry and glycoscience" |
9:27 am - 9:32 am | Discussion |
9:32 am - 9:55 am | Mario F. Feldman (Alberta) "Extreme substrate promiscuity of a bacterial oligosaccharyltransferase involved in protein-O-linked glycosylation" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Poster Talk: Ian C. Schoenhofen (National Research Council, Ottawa) "Biosynthesis of a sialic acid mimic, legionaminic acid, using enzymes from Campylobacter jejuni" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Poster Talk: Dennis M. Whitfield (National Research Council, Ottawa) "Development of new glycosylation methodologies for the synthesis of archaeal derived glycolipid adjuvants" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 12:30 pm | Metabolic Regulation |
| Discussion Leader: Gerald W. Hart (Johns Hopkins School of Medicine) |
11:00 am - 11:05 am | Gerald W. Hart (Johns Hopkins School of Medicine) "Introduction" |
11:05 am - 11:28 am | Xiaoyong Yang (Yale University School of Medicine) "O-GlcNAc: A sweet metabolic switch" |
11:28 am - 11:33 am | Discussion |
11:33 am - 11:55 am | Natasha Zachara (Johns Hopkins University School of Medicine) "The sweet nature of the cellular stress response" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Poster Talk: Salil K. Ghosh (NIDDK) "Altered O-GlcNAc cycling impacts nucleotide sugar metabolism, macronutrient storage and expression of C-type lectins" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk: Line M. Gronning-Wang (University of Oslo) "The nuclear receptor LXR is O-GlcNAc modified in response to glucose" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Optional Excursion TBA |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Nerve and Muscle Glycobiology |
| Discussion Leader: Linda Baum (UCLA) |
7:30 pm - 7:35 pm | Linda Baum (UCLA) "Introduction" |
7:35 pm - 7:58 pm | Karen J. Colley (Illinois) "Requirements for protein specific polysialylation" |
7:58 pm - 8:03 pm | Discussion |
8:03 pm - 8:26 pm | J. Michael Pierce (University of Georgia) "A tale of two sisters" |
8:26 pm - 8:31 pm | Discussion |
8:31 pm - 8:55 pm | Paul T. Martin (Ohio State) "Cmah is a genetic modifier of disease progression in mdx mice" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Poster Talk: Gregory R. Moe (Children’s Hospital Oakland Research Institute) "Acquisition of exogenous polysialic acid containing de-N-acetyl sialic acid by cancer cells produces large increases in surface expressed and intracellular de-N-acetyl sialic acid-modified antigens" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Poster Talk: Sander I. van Kasteren (University of Dundee) "Glyconanoparticles for the early detection of brain disease" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:00 pm | Poster Session II / Refreshments |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |