SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Glycan diversity: biochemistry, regulation and enzymology |
| Discussion Leader: Robert Haltiwanger (Stonybrook University) |
7:40 pm - 8:04 pm | Jeff Esko (U California, San Diego)
"Degrading Heparan Sulfate"
|
8:04 pm - 8:11 pm | Discussion |
8:11 pm - 8:21 pm | Poster Talk: Yanzhuang Wang (U Michigan)
"Golgi cisternal stacking is required for accurate glycosylation"
|
8:21 pm - 8:26 pm | Discussion |
8:26 pm - 8:50 pm | Henrik Clausen (U Copenhagen)
"Functional glycomics using Zinc Finger nuclease engineered human cell lines"
|
8:50 pm - 8:57 pm | Discussion |
8:57 pm - 9:21 pm | Steve Withers (U British Columbia)
"Chemistry and glycobiology: a rewarding relationship" |
9:21 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:50 am | Glycosylation and Quality Control |
| Discussion Leaders: Reid Gilmore (U Mass Med School) and Karen Colley (U Ill Collge of Med)
|
9:00 am - 9:05 am | Introduction: Reid Gilmore (U Mass Med School) and Karen Colley (U Ill Collge of Med) |
9:05 am - 9:28 am | Reid Gilmore (U Mass Med School)
"The role of oligosaccharyltransferase isoforms in mammalian cells"
|
9:28 am - 9:35 am | Discussion |
9:35 am - 9:58 am | Stuart Moore (INSERM, Paris)
"Glycosylation and quality control: a view from the trash can"
|
9:58 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Group Photo / Coffee Break |
10:35 am - 10:45 am | Poster Talk: Cecilia D'Alessio (Foundacion Instituto Leloir)
"Structure of the MRH domain of glucosidase II, a key enzyme in glycoprotein folding quality control"
|
10:45 am - 10:50 am | Discussion |
10:50 am - 12:30 pm | Glycomics |
| Discussion Leader: Stuart Haslam (Imperial College) |
10:50 am - 10:55 am | Introduction: Stuart Haslam (Imperial College) |
10:55 am - 11:18 am | Carlito Lebrilla (U California, Davis)
"Rapid throughput Glycome and Glycoproteome analysis and its implications to Glycobiology"
|
11:18 am - 11:25 am | Discussion |
11:25 am - 11:48 am | Kay-Hooi Khoo (Academia Sinica)
"Sulfoglycomics: Technical development and applications to immune cells"
|
11:48 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Poster Talk: Rodrigo Ortiz-Meoz (Harvard Medical School)
"Identification of Novel Cellular Targets of O-GlcNAc Transferase" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Poster Talk: Vanessa Dehennaut (CNRS)
"O-GlcNAcylation, a novel regulator of cell signaling and cell cycle"
|
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structure and Biochemistry |
| Discussion Leader: Steve Withers (U British Columbia) |
7:30 pm - 7:35 pm | Introduction: Steve Withers (U British Columbia) |
7:35 pm - 7:57 pm | Kaspar Locher (ETH, Zurich)
"Structure and reaction mechanism of bacterial oligosaccharyltransferase"
|
7:57 pm - 8:03 pm | Discussion |
8:03 pm - 8:13 pm | Poster Talk: Shunsuke Matsumoto (Kyoto University)
"Crystal structure of an archaeal oligosaccharyltransferase"
|
8:13 pm - 8:18 pm | Discussion |
8:18 pm - 8:40 pm | Koichi Kato (National Institutes of Natural Sciences, Okazaki)
"Molecular and structural basis for N-glycan-dependent determination of glycoprotein fates in cells"
|
8:40 pm - 8:46 pm | Discussion |
8:46 pm - 8:56 pm | Poster Talk: David Rose (U Waterloo)
"Structural analysis of α-glucosidase I"
|
8:56 pm - 9:01 pm | Discussion |
9:01 pm - 9:24 pm | Karen Colley (U Ill Coll of Medicine)
"Structural basis for protein-specific polysialylation"
|
9:24 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:50 am | Chemistry |
| Discussion Leader: Geert-Jan Boons (U Georgia) |
9:00 am - 9:05 am | Introduction: Geert-Jan Boons (U Georgia) |
9:05 am - 9:28 am | Carolyn Bertozzi (U California, Berkeley)
"Imaging glycans in microbes" |
9:28 am - 9:35 am | Discussion |
9:35 am - 9:58 am | Sabine Flitsch (Univ of Manchester)
"Investigation of glycoenzyme activity using glycoarrays"
|
9:58 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:45 am | Poster Talk: Leslie Revoredo (Case Western Reserve)
"Independently profiling the function of the catalytic and lectin domains of the UDP: GalNAc Polypeptide α-N-Acetylgalactosaminyltransferases (ppGalNAc-Ts) via novel glycopeptide substrates"
|
10:45 am - 10:50 am | Discussion |
10:50 am - 12:30 pm | Glycobiology of Viruses |
| Discussion Leader: James Paulson (Scripps Res Inst) |
10:50 am - 10:55 am | Introduction: James Paulson (Scripps Res Inst) |
10:55 am - 11:18 am | Thierry Hennet (University of Zurich)
"Giant virus glycosylation"
|
11:18 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Poster Talk: Michela Tonetti (U Genova)
"Structural characterization of the N-linked glycans associated to the capsid protein of the giant DNA virus PBCV-1"
|
11:35 am - 11:40 am | Discussion |
11:40 am - 12:02 pm | Yoshihiro Kawaoka (University of Tokyo, U Wisconsin, Madison)
"Pandemic influenza"
|
12:02 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Poster Talk: Helen Blanchard (Griffith University)
"Rotavirus recognition of, and interactions with, sialic acid-containing receptors"
|
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Parasite & Microbial Glycobiology |
| Discussion Leader: Chris West (U Oklahoma Coll of Med) |
7:30 pm - 7:35 pm | Introduction: Chris West (U Oklahoma Coll of Med) |
7:35 pm - 7:57 pm | Tamara Doering (Washington U Med Sch)
"Polysaccharide capsule synthesis in the pathogenic yeast Cryptococcus neoformans"
|
7:57 pm - 8:03 pm | Discussion |
8:03 pm - 8:25 pm | Michael Ferguson (University of Dundee)
"Sugar nucleotide metabolism in Trypanosoma brucei"
|
8:25 pm - 8:31 pm | Discussion |
8:31 pm - 8:54 pm | Sonja-Varena Albers (Max Planck Institute)
"N-glycosylation in crenarchaea"
|
8:54 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Poster Talk: Michel Riviere (U of Toulouse France)
"O-mannosylation of bacterial proteins is crucial for virulence of Myco-bacterium tuberculosis"
|
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Poster Talk: Julia Anzengruber (U Natural Res & Life Sci, Austria)
"Evidence of species-wide general O-glycosylation of extracellular proteins in Lactobacillus buchneri"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:50 am | Glycoconjugate biosynthesis and catabolism |
| Discussion Leader: Jeff Esko (U California, San Diego) |
9:00 am - 9:05 am | Introduction: Jeff Esko (U California, San Diego) |
9:05 am - 9:28 am | Robert Linhardt (Rensselaer Polytech Institute)
"Proteoglycan biochemistry, synthesis, and analysis"
|
9:28 am - 9:35 am | Discussion |
9:35 am - 9:58 am | Harry Brumer (Univ of British Columbia)
"CAZymology of the human gut microbiome"
|
9:58 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:45 am | Poster Talk: Ding Xu (U California, San Diego)
"Heparan Sulfate-Dependent Oligomerization of the Receptor for Advanced Glycation End Products (RAGE) is Essential for Signal Transduction" |
10:45 am - 10:50 am | Discussion |
10:50 am - 12:30 pm | Epigenetic regulation and glycan diversity |
| Discussion Leader: John A. Hanover (NIDDK) |
10:50 am - 10:55 am | Introduction: John A. Hanover (NIDDK) |
10:55 am - 11:18 am | Kelth Vosseller (Drexel College of Medicine)
"O-GlcNAc signaling as metabolic sensor; implications in disease"
|
11:18 am - 11:25 am | Discussion |
11:25 am - 11:48 am | Tetsuya Okajima (Nagoya Univ School of Medicine)
"Biochemical and biological analysis of O-GlcNAc modification of extracellular proteins"
|
11:48 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Poster Talk: Francesco Rao (U of Dundee)
"The human O-GlcNAcase C-terminal domain is a pseudo histone acetyltransferase"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Poster Talk: Frederic Bard (Inst Mol Cell Biol, Singapore)
"Encoding the glycome: the role of Golgi organization" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Immunology and Cancer |
| Discussion Leader: Michael Pierce (U Georgia) |
7:30 pm - 7:35 pm | Introduction: Michael Pierce (U Georgia) |
7:35 pm - 7:57 pm | Richard Cummings (Emory Sch of Med)
"Tn and SialylTn Antigens in Human Cancer: Genetic Regulation and Contributions to Cancer Phenotypes"
|
7:57 pm - 8:03 pm | Discussion |
8:03 pm - 8:25 pm | Kevin Campbell (U of Iowa Sch of Med)
"Genetics and Glycobiology of Dystroglycanopathies"
|
8:25 pm - 8:31 pm | Discussion |
8:31 pm - 8:54 pm | Dennis Kasper (Harvard)
"Revising our understanding of the role of carbohydrates in immunity"
|
8:54 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Poster Talk: Francis Jacob (University Hospital, Basel)
"The glycosphingolipid P1 expressed on ovarian cancer cells shows correlated A4GALT expression and matches with novel Exon2a genotype"
|
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Poster Talk: Yuko Naito-Matsui (Kyoto U)
"Regulation of immune system by the activation-dependent alteration of sialic acid species in lymphocytes"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:50 am | Host-microbe interactions |
| Discussion Leader: Richard Cummings (Emory Sch Med) |
9:00 am - 9:05 am | Introduction: Richard Cummings (Emory Sch Med) |
9:05 am - 9:28 am | Lora Hooper (UT Southwestern)
"Lectin-mediated immune defense of the intestine"
|
9:28 am - 9:35 am | Discussion |
9:35 am - 9:58 am | Jonathan Hodgkin (Oxford)
"Glycosylation and bacterial infection in the nematode C. elegans"
|
9:58 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:45 am | Poster Talk: Therese Wohlschlager (ETH, Zurich)
"Methylated glycans as targets of Tectonin: a nematotoxic fungal lectin of novel specificity"
|
10:45 am - 10:50 am | Discussion |
10:50 am - 12:30 pm | Genetic Disorders and Vertebrate Pathology |
| Discussion Leader: Hudson Freeze (Sanford Burnham) |
10:50 am - 10:55 am | Introduction: Hudson Freeze (Sanford Burnham) |
10:55 am - 11:18 am | Gordon Lauc (U of Zagreb)
"Genes affecting N-glycosylation of human proteins show pleiotropy with autoimmune diseases, cancer, diabetes and neuropsychiatric disorders"
|
11:18 am - 11:25 am | Discussion |
11:25 am - 11:48 am | Peter Roach (Indiana School of Medicine)
"Glycogen Metabolism and Lafora Disease"
|
11:48 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Poster Talk: Onno Holleboom (U Amsterdam)
"Genetic defects in protein glycosylation as cause of dyslipidemia" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Poster Talk: Lianchun Wang (U Georgia)
"Heparan sulfate is required for prostate cancer initiation and progression"
|
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetic Disorders and Development |
| Discussion Leader: Lance Wells (U Georgia) |
7:30 pm - 7:35 pm | Introduction: Lance Wells (U Georgia) |
7:35 pm - 7:57 pm | Francois Foulquier (University of Lille)
"Contribution of CDG-II to the understanding of the molecular mechanisms of N-linked protein glycosylation"
|
7:57 pm - 8:03 pm | Discussion |
8:03 pm - 8:13 pm | Poster Talk: Duy Tran (NIDCR, NIH)
"Real time imaging of dynamic secretory events to define the role of protein O-glycosylation in regulated secretion"
|
8:13 pm - 8:18 pm | Discussion |
8:18 pm - 8:28 pm | Poster Talk: Flavio Schwarz (U California San Diego)
"Modulation of innate immune responses in the central nervous system by Siglec-11 and Siglec-16"
|
8:28 pm - 8:33 pm | Discussion |
8:33 pm - 8:55 pm | Linda Baum (UCLA)
"O-glycans as master switches to regulate leukocyte migration, function and survival"
|
8:55 pm - 9:01 pm | Discussion |
9:01 pm - 9:23 pm | Richard Steet (U Georgia)
"Elucidating ML-II Pathogenesis and GlcNAc-1-Phosphotransferase Function Using Zebrafish"
|
9:23 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |