Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Glycans and Evolution |
| Discussion Leader: Markus Aebi (ETH Zurich, Switzerland) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 8:10 pm | Steven Ball (University of Lille, France) "From Evil to Redemption: Turning an
Intracellular Pathogen's Glycogen Metabolism Effectors into the Major Drivers
of Plastid Endosymbiosis" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Pascal Gagneux (University of California, San Diego, USA) "Convergent Glycan Evolution - Patterns in the
Glycan Jungle?" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Ajit Varki (University of California, San Diego, USA) "Human-Specific Evolution of Sialic Acids and
Siglecs" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Glycobiology of Prokaryotes and Unicellular Organisms |
| Discussion Leader: Richard Cummings (Emory University School of Medicine, USA) |
9:00 am - 9:25 am | Barbara Imperiali (Massachusetts Institute of Technology, USA) "Pathways and Processes of Prokaryotic N-Linked
Glycosylation" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:50 am | Giulia Bandini (Boston University, USA) "Glycoproteins with Fucosylated O-Glycans Are Present in a Structure Associated with the Nuclear Membrane of Toxoplasma gondii" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:20 am | Elizabeth Hartland (University of Melbourne, Australia) "A Surprising Glycosylation
Prevents Cell Death During E. coli Infection" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Malcolm McConville (University of Melbourne, Australia) "Dissecting Unusual Glycosylation Pathways in Microbial Pathogens" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Itamar Yadid (Migal - Galilee Research Institute, Israel) "A Lectin Based Screen for the Identification of Genes Relevant to Bacterial Biosynthesis of Glycosphingolipids" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Rita Gerardy-Schahn (Hannover Medical School, Institute for Cellular Chemistry, Germany) "Linkage Specificity Determinants of Bacterial Capsule Polymerases" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Glycobiology of the Microbiota |
| Discussion Leader: Rita Gerardy-Schahn (Hannover Medical School, Institute for Cellular Chemistry, Germany) |
6:00 pm - 6:25 pm | Christine Szymanski (University of Alberta, Canada) "Interactions
Between Campylobacter jejuni and the Gut Microbiome" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Harry Gilbert (University of Newcastle, United Kingdom) "Glycan Utilization by
the Human Distal Gut Microbiota" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Yen-Lin Huang (University of Zurich, Switzerland) "Sialic Acid Promotes Overgrowth of Intestinal E. coli and Intestinal Inflammation" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Lars Bode (University of California, San Diego, USA) "Human Milk Oligosaccharides
as Direct and Indirect Primers for the Infant Microbiome" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Glycobiology of Plants, Flies and Worms |
| Discussion Leader: Michael Tiemeyer (University of Georgia, USA) |
9:00 am - 9:25 am | Henrik Scheller (Lawrence Berkeley National Laboratory, USA) "Nucleotide Sugar Transporters in Plants and Their Role in
Glycan Biosynthesis" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:50 am | Els Van Damme (Ghent University, Belgium) "Lectin Domains at the Frontiers of Plant Defense" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:20 am | Kelly Ten Hagen (National Institutes of Health, USA) "Protein O-Glycosylation in
Developmentally Regulated Secretion" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Hannes Buelow (Albert Einstein College of Medicine, USA) "Heparan Sulfate Modification Patterns in
Development and Disease" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Joseph Yost (University of Utah, USA) "HSPGs in Cardiovascular Development" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Anne Harduin-Lepers (CNRS, France) "Integrative View of a 2,3-Sialyltransferases (ST3Gal) Molecular and Functional Evolution in Deuterostomes: Significance of Lineage Specific Losses" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Glycobiology: A Molecular View |
| Discussion Leader: Karen Colley (University of Illinois, Chicago, USA) |
6:00 pm - 6:25 pm | Gideon Davies (University of York, United Kingdom) "Diverse Strategies for the Degradation of
Mannosides" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Kelley Moremen (University of Georgia, USA) "Structural
Basis for Substrate Specificity Among N-Glycan (GH47) Processing
Alpha-Mannosidases" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Camilo Perez (ETH Zürich, Switzerland) "Mechanism of Lipid-Linked Oligosaccharide Flipping by the ABC Exporter PglK" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:40 pm | Katie Doores (King's College London, United Kingdom) "HIV Envelope Glycosylation and Broadly Neutralizing Antibody Recognition." |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Christa Litschko (Institute for Cellular Chemistry, Germany) "The Capsule Polymerase CslB of Neisseria meningitidis Serogroup L Catalyses the Formation of Glycosidic Bonds and the Transfer of GlcNAc-1-Phosphate" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biosynthesis of Carbohydrates; Carbohydrates in Disease |
| Discussion Leader: John Hanover (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) |
9:00 am - 9:25 am | Hans Bakker (Hannover Medical School, Germany) "From Identification of the C-Mannosyltransferase
Gene to Function of C-Mannosylation" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Sabine Strahl (University of Heidelberg, Germany) "Protein O-Mannosylation: Cadherins and Beyond" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Hans Wandall (University of Copenhagen, Denmark) "Molecular Dissection of Glycan Function by Simple Cells and Simplified Tissues" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Taroh Kinoshita (Osaka University Research Institute for Microbial Disease, Japan) "Shedding of Cripto-1 by
PGAP6, a Membrane-Bound, GPI-Specific Phospholipase A2" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Michelle Dookwah (University of Georgia, USA) "Cell-Specific Glycomic and Signaling Alterations Associated with Human Ganglioside Deficiency" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Michael Pierce (University of Georgia, USA) "A Unique, Protein-Specific N-Glycan with High
Sensitivity and Specificity for Pancreatic Cancer" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Carbohydrate-Binding Proteins |
| Discussion Leader: Anne Imberty (CERMAV-CNRS, Grenoble, France) |
6:00 pm - 6:25 pm | Takashi Angata (Academia Sinica, Taiwan) "Siglec-14:
From Molecular Evolution to Disease Susceptibility" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Gabriel Rabinovich (Laboratorio de Inmunopatologia, Argentina) "Integrating Immune
and Vascular Signaling Programs Through Galectin-Glycan Interactions" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:35 pm | Felix Randow (MRC Laboratory of Molecular Biology, United Kingdom) "Galectins as Danger Receptors for Cellular
Damage and Pathogen Invasion" |
7:35 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Birte Svensson (Technical University of Denmark, Denmark) "Surface Binding Sites (SBS) in Carbohydrate-Active Enzymes" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Glycobiology of Biopharmaceuticals and Vaccines |
| Discussion Leader: Irma Van Die (VU University Medical Center Amsterdam, The Netherlands) |
9:00 am - 9:25 am | Richard Cummings (Emory University School of Medicine, USA) "Glycans As Antigens and Modulators of Immunity" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Francesco Berti (Novartis Vaccines and Diagnostics, Italy) "In vitro Synthesized Capsular Polysaccharides: Towards a
Novel Strategy for Production of Glycoconjugate Vaccines Against Neisseria
meningitidis Infections" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 10:55 am | Sabina Gerber (GlycoVaxyn AG, Switzerland) "A Novel Bioconjugate Vaccine to Prevent Staphylococcus aureus Infection" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:15 am | Fabrizio Chiodo (Leiden University Medical Center, The Netherlands) "On the Dual Antigen/Adjuvant Role of Haemophilus influenzae Synthetic Polysaccharides in Carbohydrate-Based Vaccines" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Kuo-I Lin (Academia Sinica, Taiwan) "Vaccination with Monoglycosylated Hemagglutinin Induced Cross-Strain Immunity Against Influenza Virus Infections" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Susanna Fleurkens (ETH Zurich, Switzerland) "Glycoengineering in Insect Cells to Produce Carbohydrate-Based Vaccines Against Haemonchus contortus" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Irma Van Die (VU University Medical Center Amsterdam, The Netherlands) "Immunomodulation by Glycans of the Whipworm Trichuris suis: Implications for Multiple Sclerosis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Analytical Tools and Big Data |
| Discussion Leader: Nicolle Packer (Macquarie University, Australia) |
6:00 pm - 6:25 pm | Bernard Henrissat (CNRS, France) "The Power of Glycogenomics (How Carbohydrate-Active Enzymes Link
Glycobiology to Genomics)" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Manfred Wuhrer (Vrije University Amsterdam, The Netherlands) "Mass Spectrometry for
Revealing Disease-Associated Glycosylation Changes" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:35 pm | William York (University of Georgia, USA) "A Major Challenge of Glycoinformatics: Resolving
the Significance of Incomplete Analytical Information" |
7:35 pm - 7:45 pm | Discussion |
7:45 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |