Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Interdisciplinary Glycobiology
Cross-cutting topics from leading glycobiologists.
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Glycans that Regulate Cell Fate Decisions in Mammals"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"The Iron-y of the Lipoprotein Receptor, Syndecan-1"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Precisely Heterogeneous - The Biogenesis of N-Linked Protein Glycosylation"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycans in Niche Communities and Innate Immunity
Glycan mediators of cell-cell and cell-biome interactions, innate immune responses, and regulated glycosylation of immune cells and tissues.
9:00 am - 9:05 am
Introduction by Discussion Leader: Glycans in Niche Communities
9:05 am - 9:30 am
"Gene-Microbiota Interactions Contribute to the Pathogenesis
of Inflammatory Bowel Disease"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"The Destruction of Host Glycoconjugates by Microbial
Commensals and Pathogens"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"PglC, a Short Bacterial Phospho-Glycosyltransferase with Tunable Specificity"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader: Innate Immunity
10:55 am - 11:20 am
"Glycan Modulation of Pathogen-Phagocyte
Interactions"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Siglec Ligands in Human Airway Inflammation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Upregulation of Self-Associated Molecular Patterns and Siglec Receptors on T Cells Facilitate Cancer Immune Evasion"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Alteration in Mucin Glycosylation and Bacterial Colonization During Colitis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycosylation and Signaling
Nucleocytoplasmic glycosylation and the role of cell surface signaling receptors in regulating glycan expression.
7:30 pm - 7:55 pm
"Nutrient Regulation of Transcription and Signaling
by O-GlcNAcylation: A Fundamental Mechanism of Glucose Toxicity in Diabetes"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Extracellular Heparan Sulfate in Hedgehog Morphogen
Processing and Function"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Cis-Prenyltranferase: From Polyprenols to Human
Glycosylation Disorders"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"ADP-Ribosylation in the Innate Immune Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"N-Glycosylation Regulates Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Activation and Signaling"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Glycobiology of HIV, Evolution, and Development
Glycan modulation of HIV virus antigenicity, evolutionary pressures on glycan diversity, and developmental roles for glycan elaboration.
9:00 am - 9:05 am
Introduction by Discussion Leader: HIV Glycobiology
9:05 am - 9:30 am
"The HIV Glycan Shield and Immunogen Design"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Antibody Glycosylation as a Key Predictor of
Protective Humoral Immunity Against Infection"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Toxoplasma gondii Has Distinct Nucleocytosolic and Secretory O-Fucosylation Pathways"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader: Evolutionary and Developmental Glycobiology
10:55 am - 11:20 am
"Ecology and Evolution of Glycans"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Regulation of BMP Signaling by Drosophila NGLY1"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"New Insights into Host Adaptation of Yersinia pestis "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Plasmodium Short N-Glycans Are Critical for Parasite Survival and Development"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Leveraging Glycoscience for Developing Therapeutics
Leveraging glycoknowledge to design therapeutics and to understand human disease or disease model pathophysiology.
7:30 pm - 7:55 pm
"Targeting Siglecs to Modulate Immune Cell Responses"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Novel Pharmacophores for Glycosidase Inhibition"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Chasing the Structure of Oncofetal Chondroitin
Sulfate"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Targeting Sialic Acid-Mediated Interactions to Reverse Cancer-Associated Immune Suppression"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Effects of a Novel Inhibitor of N-Linked Glycosylation, NGI-1, on Influenza Immunogenicity"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular and Molecular Pathways for Glycoprotein Trafficking and the Glycobiology of Microbes and Parasites
Molecular and cellular pathways that modulate glycosylation and glycoprotein trafficking as well as glycans produced by microbes, and parasites, and the host glycofactors that modulate pathogenicity.
9:00 am - 9:05 am
Introduction by Discussion Leader: Glycoprotein Trafficking
9:05 am - 9:30 am
"Toward Curing NGLY1-Deficiency"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Galectin Secretion Directed by the Cellular
Glycosylation State and Controlled by Autophagy"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"GRASP55 Senses Energy Deprivation Through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader: Microbes and Parasites
10:55 am - 11:20 am
"Novel Bio-Conversions and Nucleotide Sugar
Transport Mechanisms in Trypanosomatid Parasites"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Multiple Roles for Campylobacter Glycoconjugates"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Understanding the Glycocalyx of the Infectious Trypanosoma brucei Metacyclic Forms"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Biochemical and Evolutionary Characterization of the GNA Gene Family in Apicomplexa"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Structural Biology of Glycogene Products
Motif specific glycosylation and protein structural determination of important glycoenzymes and complexes.
7:30 pm - 7:55 pm
"Structural Insights into Sulfation-Dependent Self-Glycan
Recognition by the Human Immune-Inhibitory Receptor Siglec-8"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Commonalities and Differences Among Membrane-Embedded Processive Glycosyltransferases"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Structural Basis of GlcNAc Transferase Substrate
Specificity"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Structural Studies of Bacterial Oligosaccharyltransferase PglB"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Glycosylation Associated with O2 -Sensing Modulates the F-Box Combining Site in Dictyostelium Skp1"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Omics, Informatics, and the Pathobiochemistry of Glycosylation Diseases
Advances in omics, integrated omics, bioinformatics for glycobiology and the impact of altered glycosylation for human disorders of glycosylation.
9:00 am - 9:05 am
Introduction by Discussion Leader: Omics and Informatics
9:05 am - 9:30 am
"High Sensitivity Glycomics: Windows to Glycan
Function"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Glycomics, Personal Profiling and Prediabetes"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Analyzing Glycans and Glycogenes with Web Resources: RINGS, FlyGlycoDB and GlyTouCan"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader: Glycosylation Diseases
10:55 am - 11:20 am
"Whoa Man: Regulating Functional O-Mannosylation"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Glycosphingolipid Expression in a New Animal Model of Fabry Disease"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Deletion of B3GLCT Disrupts Craniofacial, Skeletal, and Cardiac Development in Mice"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Insights into Neuromuscular Pathogenesis of CDGs Using a Novel PMM2 Zebrafish Mutant"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycobiology of Neural Function and Disease
Glycan functions in neural development, neurophysiology, and neural disease.
7:30 pm - 7:55 pm
"Cerebrospinal Fluid-Based Signaling in the
Mammalian Brain"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"The Role of Polysialic Acid in Myelin Repair"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Mechanisms Regulating Sialylation and Its Effect on Neural Transmission in Drosophila "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"GPI-Anchor Synthesis Deficiency Caused by Homozygous Splice-Variants in Human ARV1"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Nutrient-Driven O-GlcNAc Cycling Impacts Neurodevelopmental Timing and Metabolism"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure