Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Interdisciplinary Glycobiology
Cross-cutting topics from leading glycobiologists.
Discussion Leader: Kelly Ten Hagen (National Institutes of Health, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Pamela Stanley (Albert Einstein College of Medicine, USA)
"Glycans that Regulate Cell Fate Decisions in Mammals"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Jeffrey Esko (University of California, San Diego, USA)
"The Iron-y of the Lipoprotein Receptor, Syndecan-1"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Markus Aebi (ETH Zurich, Switzerland)
"Precisely Heterogeneous - The Biogenesis of N-Linked Protein Glycosylation"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycans in Niche Communities and Innate Immunity
Glycan mediators of cell-cell and cell-biome interactions, innate immune responses, and regulated glycosylation of immune cells and tissues.
Discussion Leaders: Anne Imberty (CERMAV, CNRS, France) and Fikri Avci (University of Georgia, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader: Glycans in Niche Communities
9:05 am - 9:30 am
Hiutung Chu (California Institute of Technology, USA)
"Gene-Microbiota Interactions Contribute to the Pathogenesis
of Inflammatory Bowel Disease"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Alisdair Boraston (University of Victoria, Canada)
"The Destruction of Host Glycoconjugates by Microbial
Commensals and Pathogens"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Mario Feldman (Washington University School of Medicine, USA)
"PglC, a Short Bacterial Phospho-Glycosyltransferase with Tunable Specificity"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader: Innate Immunity
10:55 am - 11:20 am
Victor Nizet (University of California, San Diego, USA)
"Glycan Modulation of Pathogen-Phagocyte
Interactions"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Ronald Schnaar (Johns Hopkins School of Medicine, USA)
"Siglec Ligands in Human Airway Inflammation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Michal Stanczak (University Hospital Basel, Switzerland)
"Upregulation of Self-Associated Molecular Patterns and Siglec Receptors on T Cells Facilitate Cancer Immune Evasion"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Lubor Borsig (University of Zurich, Switzerland)
"Alteration in Mucin Glycosylation and Bacterial Colonization During Colitis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Karen Colley (University of Illinois at Chicago, USA) and Nicolle Packer (Macquarie University, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycosylation and Signaling
Nucleocytoplasmic glycosylation and the role of cell surface signaling receptors in regulating glycan expression.
Discussion Leader: John Hanover (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
7:30 pm - 7:55 pm
Gerald Hart (Johns Hopkins School of Medicine, USA)
"Nutrient Regulation of Transcription and Signaling
by O-GlcNAcylation: A Fundamental Mechanism of Glucose Toxicity in Diabetes"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Kay Grobe (University of Muenster, Germany)
"Extracellular Heparan Sulfate in Hedgehog Morphogen
Processing and Function"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
William Sessa (Yale University, USA)
"Cis-Prenyltranferase: From Polyprenols to Human
Glycosylation Disorders"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Casey Daniels (National Institutes of Health, USA)
"ADP-Ribosylation in the Innate Immune Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kevin Chandler (Boston University, USA)
"N-Glycosylation Regulates Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Activation and Signaling"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Glycobiology of HIV, Evolution, and Development
Glycan modulation of HIV virus antigenicity, evolutionary pressures on glycan diversity, and developmental roles for glycan elaboration.
Discussion Leaders: Thierry Hennet (University of Zurich, Switzerland) and Robert Haltiwanger (University of Georgia, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader: HIV Glycobiology
9:05 am - 9:30 am
Max Crispin (University of Oxford, United Kingdom)
"The HIV Glycan Shield and Immunogen Design"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Galit Alter (Ragon Institute, Harvard Medical School, USA)
"Antibody Glycosylation as a Key Predictor of
Protective Humoral Immunity Against Infection"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Giulia Bandini (Boston University, USA)
"Toxoplasma gondii Has Distinct Nucleocytosolic and Secretory O-Fucosylation Pathways"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader: Evolutionary and Developmental Glycobiology
10:55 am - 11:20 am
Pascal Gagneux (University of California, San Diego, USA)
"Ecology and Evolution of Glycans"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Hamed Jafar-Nejad (Baylor College of Medicine, USA)
"Regulation of BMP Signaling by Drosophila NGLY1"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Naazneen Khan (University of California, San Diego, USA)
"New Insights into Host Adaptation of Yersinia pestis "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Joao Rodrigues (Instituto de Medicina Molecular, Portugal)
"Plasmodium Short N-Glycans Are Critical for Parasite Survival and Development"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Leveraging Glycoscience for Developing Therapeutics
Leveraging glycoknowledge to design therapeutics and to understand human disease or disease model pathophysiology.
Discussion Leader: Michael Pierce (University of Georgia, USA)
7:30 pm - 7:55 pm
James Paulson (The Scripps Research Institute, USA)
"Targeting Siglecs to Modulate Immune Cell Responses"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Stephen Withers (University of British Columbia, Canada)
"Novel Pharmacophores for Glycosidase Inhibition"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Thomas Clausen (University of Copenhagen, Denmark)
"Chasing the Structure of Oncofetal Chondroitin
Sulfate"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Heinz Laubli (University Hospital Basel, Switzerland)
"Targeting Sialic Acid-Mediated Interactions to Reverse Cancer-Associated Immune Suppression"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Irina Alymova (Centers for Disease Control and Prevention, USA)
"Effects of a Novel Inhibitor of N-Linked Glycosylation, NGI-1, on Influenza Immunogenicity"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular and Molecular Pathways for Glycoprotein Trafficking and the Glycobiology of Microbes and Parasites
Molecular and cellular pathways that modulate glycosylation and glycoprotein trafficking as well as glycans produced by microbes, and parasites, and the host glycofactors that modulate pathogenicity.
Discussion Leaders: Richard Steet (University of Georgia, USA) and Richard Cummings (Beth Israel Deaconess Medical Center, Harvard Medical School, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader: Glycoprotein Trafficking
9:05 am - 9:30 am
Tadashi Suzuki (RIKEN Global Research Cluster, Japan)
"Toward Curing NGLY1-Deficiency"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Hans Wandall (University of Copenhagen, Denmark)
"Galectin Secretion Directed by the Cellular
Glycosylation State and Controlled by Autophagy"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Yanzhuang Wang (University of Michigan, USA)
"GRASP55 Senses Energy Deprivation Through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader: Microbes and Parasites
10:55 am - 11:20 am
Michael A. Ferguson (University of Dundee, United Kingdom)
"Novel Bio-Conversions and Nucleotide Sugar
Transport Mechanisms in Trypanosomatid Parasites"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Christine Szymanski (Complex Carbohydrate Research Center, University of Georgia, USA)
"Multiple Roles for Campylobacter Glycoconjugates"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Aitor Casas-Sanchez (Liverpool School of Tropical Medicine, United Kingdom)
"Understanding the Glycocalyx of the Infectious Trypanosoma brucei Metacyclic Forms"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Marta Cova (ISGlobal, Spain)
"Biochemical and Evolutionary Characterization of the GNA Gene Family in Apicomplexa"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Structural Biology of Glycogene Products
Motif specific glycosylation and protein structural determination of important glycoenzymes and complexes.
Discussion Leader: Karen Colley (University of Illinois at Chicago, USA)
7:30 pm - 7:55 pm
Mario Schubert (University of Salzburg, Austria)
"Structural Insights into Sulfation-Dependent Self-Glycan
Recognition by the Human Immune-Inhibitory Receptor Siglec-8"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Jochen Zimmer (University of Virginia School of Medicine, USA)
"Commonalities and Differences Among Membrane-Embedded Processive Glycosyltransferases"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Kelley Moremen (University of Georgia, USA)
"Structural Basis of GlcNAc Transferase Substrate
Specificity"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Maja Napiorkowska (ETH Zurich, Switzerland)
"Structural Studies of Bacterial Oligosaccharyltransferase PglB"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Christopher West (University of Georgia, USA)
"Glycosylation Associated with O2 -Sensing Modulates the F-Box Combining Site in Dictyostelium Skp1"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Omics, Informatics, and the Pathobiochemistry of Glycosylation Diseases
Advances in omics, integrated omics, bioinformatics for glycobiology and the impact of altered glycosylation for human disorders of glycosylation.
Discussion Leaders: Nicolle Packer (Macquarie University, Australia) and Linda Baum (University of California, Los Angeles, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader: Omics and Informatics
9:05 am - 9:30 am
Anne Dell (Imperial College London, United Kingdom)
"High Sensitivity Glycomics: Windows to Glycan
Function"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Michael Snyder (Stanford University, USA)
"Glycomics, Personal Profiling and Prediabetes"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Kiyoko Aoki-Kinoshita (Soka University, Japan)
"Analyzing Glycans and Glycogenes with Web Resources: RINGS, FlyGlycoDB and GlyTouCan"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader: Glycosylation Diseases
10:55 am - 11:20 am
Lance Wells (University of Georgia, USA)
"Whoa Man: Regulating Functional O-Mannosylation"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Nancy Dahms (Medical College of Wisconsin, USA)
"Glycosphingolipid Expression in a New Animal Model of Fabry Disease"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Bernadette Holdener (Stony Brook University, USA)
"Deletion of B3GLCT Disrupts Craniofacial, Skeletal, and Cardiac Development in Mice"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Elsenoor Klaver (University of Georgia, USA)
"Insights into Neuromuscular Pathogenesis of CDGs Using a Novel PMM2 Zebrafish Mutant"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycobiology of Neural Function and Disease
Glycan functions in neural development, neurophysiology, and neural disease.
Discussion Leader: Rita Gerardy-Schahn (Institute for Cellular Chemistry, Hannover Medical School, Germany)
7:30 pm - 7:55 pm
Maria Lehtinen (Boston Children's Hospital, USA)
"Cerebrospinal Fluid-Based Signaling in the
Mammalian Brain"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Herbert Hildebrandt (Hannover Medical School, Germany)
"The Role of Polysialic Acid in Myelin Repair"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Vlad Panin (Texas A&M University, USA)
"Mechanisms Regulating Sialylation and Its Effect on Neural Transmission in Drosophila "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Mariska Davids (National Institutes of Health, USA)
"GPI-Anchor Synthesis Deficiency Caused by Homozygous Splice-Variants in Human ARV1"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Stephanie Olivier-Van Stichelen (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Nutrient-Driven O-GlcNAc Cycling Impacts Neurodevelopmental Timing and Metabolism"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure