Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Interdisciplinary Glycosciences
Three lectures addressing tools and future perspectives.
Discussion Leader: Henrik Clausen (University of Copenhagen, Denmark)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
James Dennis (Lunenfeld Tanenbaum Research Institute / Mount Sinai Hospital, Canada)
"Genetic Code Asymmetry Supports Diversity Through Experimentation with Posttranslational Modifications"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Sabine Flitsch (University of Manchester, United Kingdom)
"Discovery and Analysis of New Glycoenzyme Activities"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Catharina Steentoft (Copenhagen Center for Glycomics, University of Copenhagen, Denmark)
"Targeting Cancer Associated O-Glycosylation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Building Glycan Complexity: Structural Insights
Discussion Leader: Robert Haltiwanger (University of Georgia, USA)
9:00 am - 9:20 am
Taroh Kinoshita (Research Institute for Microbial Diseases, Osaka University, Japan)
"Interactions Between GPI-Anchor Biosynthesis and Glycosphingolipid Biosynthesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Marcelo Guerin (CIC bioGUNE, Spain)
"Structural Basis of Glycogen Biosynthesis Regulation in Bacteria"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kaspar Locher (ETH Zurich, Switzerland)
"Structural Insight into Eukaryotic Oligosaccharyltransferase"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Simon Newstead (University of Oxford, United Kingdom)
"Structural Basis of Nucleotide Sugar Transport Across the Golgi Membrane"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Daniel Kolarich (Institute for Glycomics, Griffith University, Australia)
"Clinical Glycome Deep-Sequencing to Decipher the Glyco-Language of Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Arun Everest-Dass (Institute for Glycomics, Griffith University, Australia)
"Spatial Glycan Localization of the Mammalian Brain Using MALDI Imaging"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Lara Mahal (New York University, USA) and Sabine Flitsch (University of Manchester, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycans and Tools
Discussion Leader: Thomas Peters (University of Lubeck, Germany)
6:00 pm - 6:20 pm
Jeffrey Gildersleeve (National Cancer Institute, NIH, USA)
"Immunological Development of Antibodies to Carbohydrates"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Geert-Jan Boons (Utrecht University, The Netherlands)
"Chemical Ways to Complex Glycans"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Peng Wu (The Scripps Research Institute, USA)
"Explore the Promiscuity of Glycosylation Enzymes to Boost the Efficacy of Cancer Immunotherapy"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Alvaro Mallagaray (University of Lübeck, Germany)
"NMR Experiments Identify Allosteric Networks and a Posttranslational Modification in a Human Norovirus Coat Protein"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular Processes Controlled by Glycans and Lectins
Discussion Leader: Mark von Itzstein (Griffith University, Australia)
9:00 am - 9:20 am
Anne Imberty (Centre de Recherches sur les Macromolécules Végétales (CERMAV), CNRS, Université Grenoble Alpes, France)
"Recombinant and Engineered Lectins for Research and Diagnostics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ludger Johannes (Institut Curie, France)
"Lectin-Driven and Glycosphingolipid-Dependent Construction of Endocytic Pits"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ajit Varki (University of California, San Diego, USA)
"Sialobiology Is Intimately Involved in the Majority of Human Infectious Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Joseph Zaia (Boston University Medical Campus, USA)
"Assigning Proteoglycan Site-Specific Glycosylation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Hans Bakker (Hannover Medical School, Germany)
"The Role of C -Mannosylation in Protein Folding and Stability"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Matt Whorton (Oregon Heath and Science University, USA)
"Structural Basis for Mammalian Nucleotide Sugar Transport"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Dynamic Protein Modification by O -GlcNAcylation
Discussion Leader: Nicolle Packer (Macquarie University / Institute for Glycomics, Griffith University, Australia)
6:00 pm - 6:20 pm
Gerald Hart (University of Georgia, USA)
"Nutrient Regulation of Gene Expression and Cell Signaling"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Christina Woo (Harvard University, USA)
"Mapping and Manipulating O -GlcNAc During Immunoactivation"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
David Vocadlo (Simon Fraser University, Canada)
"Chemical Biology Approaches for Studying O -GlcNAc"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Tai-Ping Sun (Duke University, USA)
"Regulation of Nuclear Transcription Factors by a Novel Interplay Between Posttranslational O-Fucosylation and O-GlcNAcylation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycosyltransferases and Glycobioinformatics
Discussion Leader: Anne Harduin-Lepers (CNRS, France)
9:00 am - 9:20 am
Robert Haltiwanger (University of Georgia, USA)
"Identification and Characterization of Two Novel Protein O -Glucosyltransferases"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ramón Hurtado Guerrero (University of Zaragoza, Spain)
"Molecular Basis of GalNAc-Ts Substrate Specificity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Cristina De Castro (University of Naples Federico II, Italy)
"Glycosylation in Giant Viruses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kiyoko Aoki-Kinoshita (Soka University, Japan)
"Omics Data Integration Efforts Leading to Applications in Medicine, Energy, Nutrition and the Environment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Frédérique Lisacek (SIB Swiss Institute of Bioinformatics, Switzerland)
"Glyco(proteo)mics Goes Visual, Interactive and Analytical"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Elisa Fadda (Maynooth University, Ireland)
"Sequence-to-Structure Dependence of Isolated IgG Fc Complex Biantennary N-Glycans: A Molecular Dynamics Study"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Weiqian Cao (Fudan University, China)
"Highly Efficient and Precise Glycoproteomic Analysis with Intelligent Technology"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycans in Oncodevelopment
Discussion Leader: Tobias Lange (University Medical Center Hamburg-Eppendorf, Germany)
6:00 pm - 6:20 pm
Lara Mahal (New York University, USA)
"Regulation of Glycosylation Related Enzymes in Tumor Biology"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Nora Heisterkamp (Beckman Research Institute, City of Hope, USA)
"Galectins: What Is Their Message from the Bone Marrow Microenvironment to Leukemia Cells?"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Salome Pinho (Institute of Molecular Pathology and Immunology, University of Porto, Portugal)
"Glycosylation at the Interface of Inflammation and Cancer: Mechanisms and Clinical Implications"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Shoko Nishihara (Soka University, Japan)
"O-GlcNAc Inhibits FGF4 Signaling via Inhibition of PKC-Zeta Phosphorylation to Maintain Naïve State in Mouse Embryonic Stem Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Glycans in Ontodevelopment and Immunology
Discussion Leader: Soerge Kelm (University of Bremen, Germany)
9:00 am - 9:20 am
Yvette Van Kooyk (Amsterdam University Medical Center (AmsterdamUMC), The Netherlands)
"Glycan Recognition by Myeloid Cells in the Tumor Microenvironment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lars Nitschke (Friedrich-Alexander University Erlangen-Nürnberg, Germany)
"The Role of Siglecs and Sialic Acids in the Regulation of Immune Cell Functions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Gabriel Rabinovich (Institute of Biology and Experimental Medicine, CONICET / University of Buenos Aires, Argentina)
"Shaping the Immune Landscape by Galectin-Driven Regulatory Circuits: Therapeutic Opportunities in Cancer, Autoimmunity and Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Markus Abeln (Hannover Medical School, Germany)
"Sialic Acid Is the Fetal Line of Defense Against Maternal Complement Attack"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michael Tiemeyer (University of Georgia, USA)
"Drosophila melanogaster : A Model to Study Glycosylation Disorders"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Katrine Schjoldager (University of Copenhagen, Denmark)
"Naturally Occurring O-Glycans Regulate Activity and Stability of Peptide Hormones"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Ten Feizi (Imperial College London, United Kingdom)
"Glycan Markers of Human Stem Cells Assigned with Beam Search Arrays"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Biotechnological Perspectives
Discussion Leader: Vlad Panin (Texas A&M University, USA)
6:00 pm - 6:20 pm
Nico Callewaert (VIB / Ghent University, Belgium)
"GlycoLiverProfile: The First Diagnostic Glycomics Biomarker Reaches the Clinic. A 15-Year Journey"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Paul DeAngelis (University of Oklahoma Health Sciences Center, USA)
"Glycosaminoglycan Engineering: Chemoenzymatic Synthesis of Heparosan- and Hyaluronan-Based Polymers"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Donald Jarvis (University of Wyoming, USA)
"Glycoengineering in the Baculovirus-Insect Cell System"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Herta Steinkellner (University of Natural Resources and Life Sciences, Vienna (BOKU), Austria)
"Plant Based Glycan Engineering and Functional Activities of IgE and IgA Antibodies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure