Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Interdisciplinary Glycosciences
Three lectures addressing tools and future perspectives.
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Genetic Code Asymmetry Supports Diversity Through Experimentation with Posttranslational Modifications"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Discovery and Analysis of New Glycoenzyme Activities"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Targeting Cancer Associated O-Glycosylation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Building Glycan Complexity: Structural Insights
9:00 am - 9:20 am
"Interactions Between GPI-Anchor Biosynthesis and Glycosphingolipid Biosynthesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structural Basis of Glycogen Biosynthesis Regulation in Bacteria"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Structural Insight into Eukaryotic Oligosaccharyltransferase"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structural Basis of Nucleotide Sugar Transport Across the Golgi Membrane"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Clinical Glycome Deep-Sequencing to Decipher the Glyco-Language of Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Spatial Glycan Localization of the Mammalian Brain Using MALDI Imaging"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Immunological Development of Antibodies to Carbohydrates"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Chemical Ways to Complex Glycans"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Explore the Promiscuity of Glycosylation Enzymes to Boost the Efficacy of Cancer Immunotherapy"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"NMR Experiments Identify Allosteric Networks and a Posttranslational Modification in a Human Norovirus Coat Protein"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular Processes Controlled by Glycans and Lectins
9:00 am - 9:20 am
"Recombinant and Engineered Lectins for Research and Diagnostics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Lectin-Driven and Glycosphingolipid-Dependent Construction of Endocytic Pits"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Sialobiology Is Intimately Involved in the Majority of Human Infectious Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Assigning Proteoglycan Site-Specific Glycosylation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Role of C -Mannosylation in Protein Folding and Stability"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Structural Basis for Mammalian Nucleotide Sugar Transport"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Dynamic Protein Modification by O -GlcNAcylation
6:00 pm - 6:20 pm
"Nutrient Regulation of Gene Expression and Cell Signaling"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Mapping and Manipulating O -GlcNAc During Immunoactivation"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Chemical Biology Approaches for Studying O -GlcNAc"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Regulation of Nuclear Transcription Factors by a Novel Interplay Between Posttranslational O-Fucosylation and O-GlcNAcylation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycosyltransferases and Glycobioinformatics
9:00 am - 9:20 am
"Identification and Characterization of Two Novel Protein O -Glucosyltransferases"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Molecular Basis of GalNAc-Ts Substrate Specificity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Glycosylation in Giant Viruses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Omics Data Integration Efforts Leading to Applications in Medicine, Energy, Nutrition and the Environment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Glyco(proteo)mics Goes Visual, Interactive and Analytical"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Sequence-to-Structure Dependence of Isolated IgG Fc Complex Biantennary N-Glycans: A Molecular Dynamics Study"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Highly Efficient and Precise Glycoproteomic Analysis with Intelligent Technology"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycans in Oncodevelopment
6:00 pm - 6:20 pm
"Regulation of Glycosylation Related Enzymes in Tumor Biology"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Galectins: What Is Their Message from the Bone Marrow Microenvironment to Leukemia Cells?"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Glycosylation at the Interface of Inflammation and Cancer: Mechanisms and Clinical Implications"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"O-GlcNAc Inhibits FGF4 Signaling via Inhibition of PKC-Zeta Phosphorylation to Maintain Naïve State in Mouse Embryonic Stem Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Glycans in Ontodevelopment and Immunology
9:00 am - 9:20 am
"Glycan Recognition by Myeloid Cells in the Tumor Microenvironment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Role of Siglecs and Sialic Acids in the Regulation of Immune Cell Functions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Shaping the Immune Landscape by Galectin-Driven Regulatory Circuits: Therapeutic Opportunities in Cancer, Autoimmunity and Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Sialic Acid Is the Fetal Line of Defense Against Maternal Complement Attack"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Drosophila melanogaster : A Model to Study Glycosylation Disorders"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Naturally Occurring O-Glycans Regulate Activity and Stability of Peptide Hormones"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Glycan Markers of Human Stem Cells Assigned with Beam Search Arrays"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Biotechnological Perspectives
6:00 pm - 6:20 pm
"GlycoLiverProfile: The First Diagnostic Glycomics Biomarker Reaches the Clinic. A 15-Year Journey"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Glycosaminoglycan Engineering: Chemoenzymatic Synthesis of Heparosan- and Hyaluronan-Based Polymers"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Glycoengineering in the Baculovirus-Insect Cell System"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Plant Based Glycan Engineering and Functional Activities of IgE and IgA Antibodies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure