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Glycobiology

Gordon Research Conference

Biological Roles of Glycans as Major Building Blocks of Life

March 12 - 17, 2023

Chairs

and

Vice Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Glycobiology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Glycobiology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Interdisciplinary Glycobiology: Biological Functions of Major Glycosylation Pathways Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:15 pm	"Antithrombin-Heparan Sulfate Revisited"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:50 pm	"Nutrient Regulation of Gene Expression by O-GlcNAcylation: Roles in Chronic Diseases of Aging."
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:25 pm	"Brain Glycosylation: So Much to Still Learn!"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Glycoconjugate Biosynthesis, Trafficking and Signaling Discussion Leaders: and
9:00 am - 9:25 am	"Localization and Novel Functions of Enzymes for GPI Biosynthesis"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	"Honoring Monosaccharide Heritage, Diversity, and Inclusion"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Roles of O-fucose and O-glucose for the Effective Transport of DLK1 to the Cell Surface"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Glycoengineering Strategies to Tune Extracellular Vesicle Secretion and Functional Properties"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Glycosylation Regulates Pluripotent Stem Cell Status and Signaling"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"A Genetic Dissection Approach to Functional Glycomics"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Navigating Tools to Induce Glycome Manipulations of CAR-T Cell Therapy in Diffuse Large B Cell Lymphoma"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Identification and Functional Characterization of a Novel T-cell Ligand for the Siglec-7 Immune Checkpoint Receptor"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Pathomechanisms of Glycosylation Disorders Discussion Leader:
7:30 pm - 7:55 pm	"Immune Thrombocytopenia: The Role of Glycans Contributing to a Never-Ending Enigma"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	"Towards Finding a Cure for NGLY1 Deficiency"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	"OGT-XLID: A Congenital Disorder of Intracellular Glycosylation"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"O-GlcNAc Transferase Contributes to Sex-Specific Placental Deregulation in Gestational Diabetes"
9:10 pm - 9:15 pm	Discussion
9:25 pm - 9:35 pm	"An Extra ECM-Binding Matriglycan on Dystroglycan"
9:35 pm - 9:40 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cell Communities, Pathogens, and Viruses Discussion Leaders: and
9:00 am - 9:25 am	"The Fungal Pathogen Cryptococcus neoformans: Filling Gaps in the Cell Wall"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	"Degradation of Host Mucin Glycoproteins in the Pathogenesis of Inflammatory Bowel Disease"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Structural Insights into the Unique Substrate Recognition Mode of the Toxoplasma gondii Mucin-Type O-glycosyltransferase TgGalNAc-T3"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Role of Novel Carbohydrate-Binding Modules of 1,2-a-L-fucosidase (AfcA) in Mucin O-glycan Breakdown by Bifidobacterium bifidum"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Viral-Host Interactions: From Glycomics to Function"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Under the Coat: Effects of Natural Variations on the Structure, Dynamics, Evasion and Glycan Binding of SARS-CoV-2 S"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Impact of the C-Type Lectin Receptor DCIR on Immunopathology in the Brain During Viral Neuroinfection"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"The Infectious Salmon Anaemia Virus Sialic Acid 4-O-acetyl Esterase Extensively Prunes Target Cell Surfaces in Infected Hosts"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Glycoimmunology Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	"Immune Control Through Receptor Glycosylation and Dysregulation by Autoantibodies"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Exploiting Siglecs as Glyco-Immune Checkpoints"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Glycosylation-Engineering of CAR-T Cells"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Glycoimmune Landscapes in T Cell-Mediated Autoimmunity"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"The Human Milk Oligosaccharide 3’Sialyllactose Promotes Inflammation Resolution and Reduces Atherosclerosis Development in Mice"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Evolution, Development and Neural Functions Discussion Leaders: and
9:00 am - 9:25 am	"A “Hotspot" in Human Evolution and Disease"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	"Elucidating the Molecular Mechanisms of Proteoglycan Functions Using the Drosophila Model"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Discovery, Occurrence, and Functions of Sialic Acid-Specific Sulfotransferases"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Evolution of H3N2 Influenza Virus for the Adaptation to Human Airway Glycome"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"N-Acetylglucosamine Promotes Immunosenescence and is a Potential Therapeutic for Myelin Repair and Neurodegeneration in Multiple Sclerosis"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"A Role for GPI-Anchor Biosynthesis in Sleep Regulation"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Effects of Genetic and Environmental Factors on the Expression of Polysialic Acid from the View Points of Mental Disorders"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Cerebrovascular Glycocalyx Degeneration During Aging and Neurodegenerative Disease Promotes Blood-Brain Barrier Dysfunction and Brain Bleeds"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Glycans in Pathobiology Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	"Multimodal Spatial Mapping of N-linked Glycosylation of Infiltrating Immune Clusters in Tumor Tissue Microenvironments"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Upregulation of ST6GAL1 Sialyltransferase Promotes Early Stages in Pancreatic Cancer Development"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Glycoprotein Regulators Critical to Human Disease and Virus Infection Uncovered Through Genetic Screens"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Cholesterol Dependent Cytolysin Toxins use Carbohydrates as Cellular Receptors"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Integrated in vivo Functional Screens and Multi-Omics Analyses Identify a2,3-sialylation as Essential for Melanoma Survival"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Glycoinformatics and Emerging Technologies for Glycoscience Discussion Leaders: and
9:00 am - 9:25 am	"Tracking the Diversity and Similarities Across Bacterial Glycoproteomes Using Unsupervised Bioinformatic Approaches"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	"T-cell Immunoglobulin and Mucin Domain-Containing Protein (TIM) Glycoproteomic Landscape and Structural Dynamics Enabled by Mucinase SmE"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"The MSFragger Glyco Software Suite in FragPipe: A Growing Toolkit for Glycoproteomics Analysis"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Deciphering Glycoprofiles Through A.I.- Informed Lectin Profiles"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Simultaneous Improvement and Harmonization of Multimodal Glyco-Analysis Technologies for Medical Demands"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Cell-specific Bioorthogonal Tagging of Glycoproteins. - EMBO Young Investigator lecture"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Glycan and RNA Sequencing for Profiling the Distinct Cellular Glyco-States in Single Cells"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Breast Milk Antibodies to Microbial Glycoconjugates"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Multitude of Glycan Structures, Glycosylation Enzymes and Pathways Discussion Leader:
7:30 pm - 7:55 pm	"Matriglycan: Function and Mechanism of Elongation via LARGE1"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	"Measuring and Analyzing Input-Output Responses in Glycobiological Systems"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Structural Study Reveals How Heparan Sulfate Copolymerase EXT1-2 Enforces the strict [GlcA-GlcNAc]_n Disaccharide Repeat"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Mechanism of Antibody-Specific Deglycosylation and Immune Evasion by Streptococcal IgG-Specific Endoglycosidases"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Global View of Domain-Specific O-Man Glycosylations and Specificities of Three Distinct Biosynthetic Pathways"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Transcription Factors HNF1A, HNF4A and FOXA2 Regulate Protein N-Glycosylation in Hepatic Cells"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by National Institute of Dental & Craniofacial Research of the National Institutes of Health under Award Number R13DE032572. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This award is co-funded by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the National Center for Advancing Translational Sciences (NCATS).

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