Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Engineering and Utilizing Glycans
3:15 pm - 3:25 pm
"GlycoDelete: Engineering of Protein Production Systems to Drastically Reduce Glycan Heterogeneity of Biopharmaceuticals"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
"Engineering Antibody-Sialidase Conjugates for Targeted Removal of Sialic Acids on the Cancer Cell Glycocalyx"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
"A Cell-Free Platform for Point-of-Care Production of Glycoprotein Therapeutics and Bioconjugate Vaccines"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Exploring and Understanding the Complexity of the Glycome
5:30 pm - 5:40 pm
"In Vivo Monitoring, Analysis and Modeling of Monoclonal Antibody N-Glycosylation Kinetics in CHO Cells"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Site-Specific Control of Protein Glycosylation by Rapid Discovery of Unique Glycosyltransferase Activities"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"CGE-LIF as a Novel Approach for the Analysis of Glycosphingolipid-Derived Glycans"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Better Together: Relative Retention Time Plus Spectral Matching Improves Automated Glycan Characterisation Using PGC-nLC-IT-ESI-MSMS"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Colorectal Cancer Cell Lines Reveal Striking Isomeric Diversity of the Human Cancer O-Glycome"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Structural Studies of ER-Based Glycosyltransferases"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"O-Acetylation of Sialoglycans: The Role of the Acetyl-CoA Transporter AT-1"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Translating the Cancer Glyco-Code with Genome-Wide CRISPR Screens"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Glycans in Health and Disease
9:00 am - 9:10 am
"Glycosyltransferase ST6Gal-I Promotes the Epithelial to Mesenchymal Transition Through the Sialylation of EGFR and Increases Pancreatic Cancer Metastasis"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Probing the Dynamic Role of Fucose in Our Gut-Microbiome Homeostasis via a Chemical Biology Approach"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Sox2 Drives ST6Gal-I Expression and Activity to Promote a CSC Phenotype in Ovarian Cancer"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"TMEM165: A New Key Player in Golgi Glycosylation and Cellular Mn2+ Homeostasis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Influenza Hemagglutinins H2, H5, H6, and H11 Are Not Targets of Pulmonary Surfactant Protein D: Structural Prediction and Confirmation of N-Glycan Sub-Type as a Pathogenic Factor in Influenza"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Identification of 9-O-Acetyl-N-Acetylneuraminic Acid (Neu5,9Ac2) as Main O-Acetylated Sialic Acid Species of GD2 in Breast Cancer Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Targeting Antibiotics via Carbohydrate Probes Against Pseudomonas aeruginosa Biofilm"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"MAGT1-CDG vs. XMEN: Two Faces of the Same Glycosylation Disorder?"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
1:30 pm - 2:30 pm
Panel Discussion
Career Mentoring
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes