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Glycolipid and Sphingolipid Biology

Gordon Research Conference

January 11 - 16, 1998
Chair Sarah Spiegel
Vice Chair Guido Tettamanti
Four Points Sheraton / Holiday Inn Express
1050 Schooner Drive
Ventura, California, United States
 Venue and Travel Information

Conference Program

Sunday Evening 7:30-9:30 PM

Membrane Dynamics and Organization of Glyco(sphingo)lipids.

Discussion leaders: Dr. Sen-itiroh Hakomori and Dr. Richard Anderson
  • Dr. Sen-itiroh Hakomori: Glycosphingolipid Microdomain in Cell Adhesions, Coupled with Signaling
  • Dr. Richard Anderson: The Caveolae Membrane System
  • Dr. Sandro Sonnino: Relationships Between the Chemical and Physico-Chemical Properties of Gangliosides and the Formation of Ganglioside-Enriched Membrane Domains
  • Dr.Yukaka Sanai: Association of Src-Family Tyrosine Kinase Lyn with Gangloside GD3 in Rat Brain
  • Dr. Deborah Brown: Organization of Sphingolipids, Cholesterol, and Proteins in Detergent-Resistant Membrane Domains

Monday Morning 8:30-12:30 AM

Trafficking, Transport, Sorting, and Subcellular Localization of Glyco(sphingo)lipids.

Discussion leaders: Dr. Guido Tettamanti and Dr. Richard Pagano
  • Dr. Guido Tettamanti: Introduction
  • Dr. Richard Pagano: Intracellular Transport and Metabolism of Sphingolipid Analogs
  • Dr. Gerrit van Meer: Glycosphingolipid Sorting in Epithelial Cells, Roles for Membrane Domains and Multidrug Transporters
  • Dr. Yoshio Hirabayashi: Biological Function of Glycolipids: Lessons from Glycolipid-Deficient Mutants
  • Dr. William Young: Soluble Glycosyltransferases
  • Dr. Laura Riboni: Sphingolipid Metabolites in Neural Growth and Differentiation
  • Dr. Tony Futerman: Regulatory Roles for Glycolipids and Sphingolipids in Neuronal Growth

Poster Presentations: 4:00 - 6:00

Discussion leader: Dr. Donald Marcus
  • Dr. Erich Gulbins: Function of the Acidic Sphingomyelinase in Cellular Signaling and Internalization Processes

Monday Evening 7:30-9:30 PM

Enzymes, Cofactors and Genes Controlling Glyco(sphingo)lipid Metabolism.

Discussion leaders: Dr. Konrad Sandhoff and Dr. Shimon Gatt
  • Dr. Konrad Sandhoff: Glycolipid Enzymology at Membrane Surface
  • Dr. Shimon Gatt: Application of Fluorescent Sphingolipids to the Study of Normal and Pathological Metabolism
  • Dr. Wendy Campana: Prosaposin and Prosaptides: Novel Neurotrophic and Myelinotrophic Factors
  • Dr. Masaki Saito: Molecular Cloning and Characterization of Human Ganglioside GM3 Synthase (Sialyltransferase-l: SAT-1)
  • Dr. Robert Yu: Regulation of Ganglioside Biosynthesis

Tuesday Morning 8:30-12:30 AM

Gene Targeting Approaches to Glyco(sphingo)lipid Biology.

Discussion leaders: Dr. Kunihiko Suzuki and Dr. Wilhelm Stoffel
  • Dr. Kunihiko Suzuki: Introduction
  • Dr. Wilhelm Stoffel: Glycosphingolipids, Pacemakers of a New Approach to Molecular Membrane Biology
  • Dr. Richard Proia: Genetic Manipulaffon of Ganglioside Synthesis and Degradation Pathways: Implications for Function and Therapeutics
  • Dr. Edward Schuchman: New Insights into Acid Sphingomyelinases and Acid Ceramidase: Lessons from Knock-Out Mice and Other Model Systems
  • Dr. Koichi Furakawa: Genetic Modification of Glycosphingolipids in Experimental Animals
  • Dr. Hong Liu: Identification of Genes Associated with Neuro2a Differentiation Induced by the Expression of GD3 Synthase
  • Dr. Jin-ichi Inokuchi: A New Approach for Improvement of Synaptic Function and Memory Deficits by Up-regulating Ganglioside Biosynthesis with L-threo-PDMP

Poster Presentations: 4:00 - 6:00

Discussion leader: Dr. Subhash Basu
  • Dr. Masaru Taniguchi: Recognition of Glycolipids by NKT Cells

Tuesday Evening 7:30-9:30 PM

Medical and Immunotherapeutic Aspects of Glyco(sphingo)lipids.

Discussion leaders: Dr. Alfred Merrill and Dr. Stephan Ladisch
  • Dr. Alfred Merrill: Sphingolipids in the Prevention and Treatment of Cancer
  • Dr. Stephan Ladisch: Tumor Ganglioside Shedding: Biological Consequences and Therapeutic Strategies
  • Dr. Philip Livingston: Ganglioside Vaccines Against Cancer: From the Laboratory to Phase III Clinical Trials
  • Dr. Takao Taki: Glyco-Replica Peptides which Mimic Functional Roles in Cell Adhesion
  • Dr. Pam Fredman: The Potential Role of Sulfatide in Immunological Disease Processes

Wednesday Morning 8:30-12:30 AM

Sphingolipids Metabolites: Regulation of Cell Growth, Stress and Apoptosis.

Discussion leaders: Dr. Yussuf Hannun and Dr. Sarah Spiegel
  • Dr. Yussuf Hannun: Ceramide and the Eukaryotic Stress Response
  • Dr. Sarah Spiegel: Dual Functions of Sphingosine 1-Phosphate
  • Dr. Lina Obeid: Sphingolipids as Mediators of Cell Cycle Arrest, Cellular Senescence, and Apoptosis
  • Dr. Thierry Levade: Role of Sphingomyelin Hydrolysis in Regulation of Cell Growth
  • Dr. Gerhild van Echten: Organization and Regulation of Sphingolipid Biosynthesis: Studies with Synthetic Sphingolipid Analogs
  • Dr. Jonathan Tilly: Lipid-Signaling Pathways in Chemotherapy-Induced Germ Cell Apoptosis
  • Dr. Yasuyuki Igarashi: Sphingosine 1-Phosphate as an Intercellular Messenger Released from Activated Platelets, Conceivably Playing a Variety of Physiological and Pathophysiological Roles in Blood Vessels

Poster Presentations: 4:00 - 6:00

Discussion leader: Dr. Roger Laine

Wednesday Evening 7:30-9:30 PM

Sphingolipid Metabolism in Yeast and Mammalian Cells.

Discussion leaders: Dr. Robert Dickson and Dr. Suzanne Mandala
  • Dr. Robert Dickson: The Role of Sphingolipid Signaling During Saccharomyces Cerevisiae Stress Responses
  • Dr. Suzanne Mandala: Sphingolipid Metabolites and Stress Response in Yeast
  • Dr. James Shayman: Characterization of 1-O-Ceramide Synthase, A Novel Phospholipase A2
  • Dr. Manjo Basu: Hydrophobic Nature of the Mammalian Ceramide Glycanases
  • Dr. Julie Saba: Isolation of Sphingosine Phosphate Lyase from Saccharomyces Cerevisiae

Thursday Morning 8:30-12:30 AM

Transmembrane Signaling I: Sphingolipids Metabolites.

Discussion leaders: Dr. Richard Kolesnick and Glyn Dawson
  • Dr. Richard Kolesnick: Endothelial Apoptosis and Disease
  • Dr. Glyn Dawson: Regulation of Ceramide Catabolism and Apoptosis
  • Dr. Guido Kroemer: Cerarnide-Induced Apoptosis: Implication of Mitochondria
  • Dr. Jorge Moscat: Control of Proliferation and Survivat Through the Atypicat PKC Pathways
  • Dr. Martin Kronke: Activation of Acidic and Neutrat Sphingomyelinases by TNF Receptor-Associated Proteins
  • Dr. Josef Pfeilschifter: Identification of Ceramide Targets
  • Dr. Roberto Testi: Lipid and Glycolipid Mediators of Fas-Induced Apoptosis

    Thursday Evening 7:30-9:30 PM

    Glycolipid Signaling, Recognition and Adhesion.

    Discussion leaders: Dr. Yoshitaka Nagai and Dr. Robert Ledeen
    • Dr. Yoshitaka Nagai: Introduction
    • Dr. Robert Ledeen: Nuclear Gangliosides and Neuronat Differentiation
    • Dr. Clifford Lingwood: Globotriaosyl Ceramide Provides a Conduit from the Cell Surface to the Nucleus
    • Dr. Ronald Schnaar: Ganglioside Recognition by Myelin-Associated Glycoprotein

    • Contributors

    Sincere thanks are extended to the following for their generous support:

    Mizutani Foundation
    Mitsubishi Kasei Corporation
    Sankyo Company, Inc.
    FIDIA Company
    Agmen, Inc.
    Hoffmann-La Roche
    Merck Research Laboratories
    National Science Foundation
    Glaxo Wellcome, Inc.

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