| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcoming comments |
| 7:35 pm - 7:45 pm | Guido Tettamanti University of Milan
Introductory thoughts from the Chair of the 2000 Glycolipid and Sphingolipid Gordon Conference |
| 7:45 pm - 9:30 pm | Biophysical aspects of glyco(sphingo)lipids |
| Session Chair: Tony Futerman Weizmann Institute of Science |
| 7:45 pm - 8:00 pm | Chair's Overview |
| 8:00 pm - 8:30 pm | Erwin London SUNY at Stony Brook
The organization of sphingolipid-cholesterol rafts |
| 8:30 pm - 9:00 pm | Paavo Kinnunen University of Helsinki
Sphingomyelin and ceramide - possible biophysical foundations
of their mechanisms of action |
| 9:00 pm - 9:30 pm | Discussion: Sandro Sonnino
University of Milan |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | (Glyco)sphingolipid biosynthesis, trafficking and turnover |
| Session Chair: Konrad Sandhoff Bonn University |
| 9:00 am - 9:15 am | Chair's Overview |
| 9:15 am - 9:45 am | Ken Hanada National Institute of Infectious Diseases (Tokyo)
Molecular organization of mammalian serine palmitoyltransferase and de novo sphingolipid biosynthesis |
| 9:45 am - 10:00 am | Soh Osuka RIKEN Brain Science Institute
Physiological roles of sphingolipids in thymocyte revealed by conditional gene targeting |
| 10:00 am - 10:45 am | Photo and Coffee Break |
| 10:45 am - 11:15 am | Garth Nicholson
ANZAC Med. Research Inst., University of Sydney at Concord Hospital
Serine palmitoyltransferase mutations in hereditary sensory neuropathy |
| 11:15 am - 11:30 am | Rhoderick Brown
Hormel Institute, University of Minnesotta
In vitro and in vivo insights into Sphingolipid Transfer Proteins |
| 11:30 am - 11:45 am | Akio Kihara Hokkaido University
Topological analysis of sphingoid base 1-phosphate phosphatases and identification of transporter protein responsible for resistance to sphingoid bases in yeast |
| 11:45 am - 12:00 am | Alessandro Prinetti University of Milan
Sphingolipid turnover and exchange with the extracellular enviroment |
| 12:00 pm - 12:30 pm | Discussion: Gerrit van Meer
University of Amsterdam |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | (Glyco)sphingolipid biosynthesis, trafficking and metabolism |
| Session Chair: Lina Obeid
Medical University of South Carolina |
| 7:30 pm - 7:45 pm | Chair's Overview |
| 7:45 pm - 8:15 pm | Richard Pagano
Mayo Clinic and Foundation
Endosomal sorting and cholesterol-sensitive, rab-dependent transport of sphingolipids |
| 8:15 pm - 8:45 pm | Ira Tabas Columbia University
The Ying and Yang of Acid Sphigomyelinase in Atherogenesis: Distinct Roles of S-SMase and L-SMase in Cellular Cholesterol Metabolism and Trafficking |
| 8:45 pm - 9:00 pm | David Priestman University of Oxford
Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice |
| 9:00 pm - 9:15 pm | Mariana Nikolova-Karakashian University of Kentucky
Ceramide-enriched Low-Density Lipoproteins (LDL): metabolism and role in the development of atherosclerosis |
| 9:15 pm - 9:30 pm | Discussion: Stephan Ladisch
Children's National Medical Center |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Sphingolipids and cell signaling |
| Session Chair: Sarah Spiegel
Medical College of Virginia |
| 9:00 am - 9:15 am | Chair's Overview |
| 9:15 am - 9:45 am | Mathew Vadas Inst. Med. & Vet. Sci. / Hanson Inst.
Sphingosine kinase and the endothelium |
| 9:45 am - 10:00 am | Farida Safadi-Chamberlain Colorado State University
The effect of membrane targeted sphingosine kinase on 3T3-L1 cell proliferation |
| 10:00 am | Coffee Break |
| 10:30 am - 10:45 am | Kevin Lynch University of Virginia
Structure activity relationships of psychosine and other lyso(glyco)sphingolipid ligands |
| 10:45 am - 11:00 am | Wayne Bowen NIDDK, NIH
Sigma-2 receptors, sphingolipid signaling, and a novel pathway to apoptosis |
| 11:00 am - 11:30 am | Brent Polk Vanderbilt University
KSR as a ceramide regulated protein in intestinal inflammation |
| 11:30 am - 11:45 am | David Brindley University of Alberta
Tumor necrosis factor-a induces stress fiber formation and division in fibroblasts through ceramide production |
| 11:45 am - 12:00 am | Rick Dobrowsky University of Kansas
Ceramide may inhibit adipogenesis by regulating the nuclear levels and transcriptional activity of C/EBPb |
| 12:00 pm - 12:30 pm | Discussion: Richard Kolesnick
Memorial Sloan Kettering |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Sphingolipids in controlling cell growth and apoptosis with implications for the etiology, prevention and treatment of disease |
| Session Chair: Thierry Levade
INSERM (Toulouse) |
| 7:30 pm - 7:45 pm | Chair's Overview |
| 7:45 pm - 8:15 pm | Mark Kester
Penn State College of Medicine
Therapeutic implications of ceramide signaling cascades |
| 8:15 pm - 8:45 pm | Eva Schmelz
Wayne State University
Suppression of colonic neoplasia by sphingolipids in vitro and in vivo |
| 8:45 pm - 9:00 pm | J. Gelineau-van Waes
University of Nebraska Medical Center
Fumonisin B1-induced neural tube defects: Disription of membrane sphingolipids and folate transport |
| 9:00 pm - 9:30 pm | Discussion: Jim Shayman
University of Michigan |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Complex glycosphingolipid structure and function |
| Session Chair: Ron Schnaar
Johns Hopkins University |
| 9:00 am - 9:15 am | Chair's Overview |
| 9:15 am - 9:45 am | Gerhild VanEchten-Deckert
Bonn University
(Glyco)sphingolipid signaling in neuronal cells |
| 9:45 am - 10:00 am | Joan Boggs
Hospital for Sick Children (Toronto)
Liposomal glycosphingolipids and polyvalent galactose cause transmembrane signaling to the cytoskeleton in oligodendrocytes |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Rick Proia
NIH
Life without gangliosides |
| 11:00 am - 11:15 am | Roger Sandhoff
German Cancer Research Center Heidelberg
Sulfatide SM2a is degraded by the action of Hex S and Hex A in collaboration with GM2-activator protein |
| 11:15 am - 11:30 am | Yasuhiro Hashimoto
RIKEN Institute
A six-amino acids sequence of the natural killer cell receptor,
Siglec-7, is responsible for the unique specificity for GD3: a comparison
with Siglec-9. |
| 11:30 am - 11:45 am | Masaru Taniguchi
RIKEN RCAI and Chiba University
Molecular interaction of a-GalCer with CD1d for NKT lymphocyte activation |
| 11:45 am - 12:00 am | Zvi Fuks
Memorial Sloan Kettering
Sphingolipid targets in radiation therapy |
| 12:00 pm - 12:30 pm | Discussion: Laura Riboni
University of Milan |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 6:00 pm | Business meeting
|
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | (Glyco)sphingolipid-receptor interactions: cellular and extracellular
ligands |
| Session Chair: Cliff Lingwood
Hospital for Sick Children (Toronto) |
| 7:30 pm - 7:45 pm | Chair's Overview |
| 7:45 pm - 8:15 pm | Robert Blumenthal
NCI (Frederick)
The role of glycosphingolipids in entry of HIV-1 into cells |
| 8:15 pm - 8:45 pm | Mary Vinson
Neurology CEDD, GSK
GT1b is a potential myelin associated-glycoprotein receptor,
mediating inhibition of neurite outgrowth |
| 8:45 pm - 9:00 pm | Erich Gulbins
University of Essen
Ceramide enriched membrane platforms for P. aeruginosa infections and
might be a paradigm for many other host pathogen interactions |
| 9:00 pm - 9:30 pm | Discussion: Sen Hakomori
Pacific Northwest Research Institute |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | (Glyco)sphingolipids in cell differentiation, development and function |
| Session Chair: Reiji Kannagi
Aichi Cancer Center |
| 9:00 am - 9:15 am | Chair's Overview
|
| 9:15 am - 9:45 am | Rashmi Bansal
University of Connecticut Medical School
Role of glycosphingolipids in oligodendrocyte differentiation
and myelin biogenesis |
| 9:45 am - 10:00 am | Alka Vyas
Johns Hopkins University
Gangliosides are functional nerve cell surface ligands for MAG, an inhibitor of axon regeneration |
| 10:00 am - 10:15 am | Gregory Fredericks
Johns Hopkins University
Ganglioside-mediated signal transduction via RhoA inhibits nerve regeneration |
| 10:15 am | Coffee Break |
| 10:45 am - 11:00 am | Scott Summers
Colorado State University
Regulation of insulin action by ceramide: Dual mechanisms for the inhibition of the serine/threonine kinase Akt/PKB |
| 11:00 am-11:15 am | Yoshikazu Uchida
UCSF & V.A. Med Center, San Francisco
Regulation of glucosylceramide synthase expression via SP1-mediated promoter activation in epidermal keratinocytes. |
| 11:15 am-11:30 am | Julie Saba
Children's Hospital Oakland Research Institute
Altered sphingolipid metabolism leads to muscle developmental defects in Drosophila melanogaster |
| 11:30 am-11:45 am | Irina Y. Dobrosotskaya
University of Texas Southwestern Medical Center
Regulation and Function of Drosophila SREBP: Role of Sphingo- and Phospholipids |
| 11:45 am-12:00 am | Open |
| 12:00 pm - 12:30 pm | Discussion: Yoshio Hirabayashi
RIKEN Brain Science Institute |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | (Glyco)sphingolipid Biodiversity and the New Era of "Sphingolipidomics" |
| Session Chair: Yusuf Hannun
Medical University of South Carolina |
| 7:30 pm - 7:45 pm | Chair's Overview |
| 7:45 pm - 8:15 pm | Ernst Heinz
Institut fuer Allgemeine Botanik, University of Hamburg
Functions of ceramide glucosides in plants, fungi and other
eukaryotic organisms: cloning of desaturases, glycosyltransferases and other biosynthetic enzymes as first steps for a reverse genetics approach |
| 8:15 pm - 8:45 pm | Robert Yu
Medical College of Georgia
Application of genomics-type technologies to understand sphingolipid metabolism and function |
| 8:45 pm - 9:15 pm | Discussion: Steven Pfeiffer
University of Connecticut Medical School |
| 9:15 pm - 9:30 pm | Closing comments: Akemi Suzuki
RIKEN Frontier Research System |
| FRIDAY |
| 7:30 am - 8:30 pm | Breakfast |
| 9:00 am | Departure |
