| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| Introduction |
| 7:30 pm - 9:30 pm | Microdomain and functions |
| Session Chair: Yoshitaka Nagai (Mitsubishi Life Sci. Inst.) |
| 7:30 pm - 8:00 pm | Sen-itiroh Hakomori (Univ. of Washington)
"Contact inhibitability of WI38 vs. oncogenic transformants VA13 cells
depends on composition and function of GM3-enriched microdomain" |
| 8:00 pm - 8:30 pm | Toshihide Kobayashi (RIKEN)
"A lipid-specific toxin reveals heterogeneity of sphingomyelin-containing
membranes" |
| 8:30 pm - 8:50 pm | Alessandro Prinetti (Univ. of Milano)
"Sphingolipid-enriched membrane domains in neuronal apoptosis" |
| 8:50 pm - 9:10 pm | Jin-ichi Inokuchi (Hokkaido Univ.)
"TNFalfa-induced insulin resistance as a membrane microdomain disorder: Involvement of ganglioside GM3" |
| 9:10 pm - 9:30 pm | Kenichi Suzuki (Nagoya Univ.)
"GPI-anchored proteins reside in small and unstable rafts at the resting state" |
| MONDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | Sphingolipid biosynthesis |
| Session Chair: Robert Dickson (Univ. of Kentucky) |
| 9:00 am - 9:10 am | Introduction |
| 9:10 am - 9:40 am | Lina Obeid (Med. Univ. of South Carolina)
"Regulation of enzymes of sphingolipid metabolism: Biologic implications" |
| 9:40 am - 10:10 am | Joost Holthuis (Utrecht Univ.)
"Identification of a family of animal sphingomyelin synthases" |
| 10:10 am - 10:40 am | Toshiro Okazaki (Kyoto Univ.)
"Biological implication of sphingomyelin synthase in cell growth and death" |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Karsten Meier (Univ. of Basel)
"Sphingolipid synthesis mediates stress induced regulation of translation" |
| 11:20 am - 11:40 am | Lauren A. Cowart (Med. Univ. of South Carolina)
"Substrate supply to serine palmitoyltransferase: Potential mechanisms of heat-mediated regulation" |
| 11:40 am - 12:00 pm | Hiroko Ikusiro (Osaka Med. Coll.)
"Reaction mechanism of serine palmitoyltransfearse proposed on the basis of its crystal structure: Bacterial prototype of the eukaryotic enzyme" |
| 12:00 pm - 12:20 pm | Hiroko Hama (Med. Univ. of South Carolina)
"The human FAH2H gene encodes a fatty acid 2-hydroxylase" |
| 12:20 pm - 12:30 pm | Discussion |
| 1:00 pm | Lunch |
| 2:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | (Glyco)sphingolipid trafficking and metabolism |
| Session Chair: Guido Tettamanti (Univ. of Milan) |
| 7:30 pm - 7:40 pm | Introduction |
| 7:40 pm - 8:10 pm | Yusuf Hannun (Med. Univ. of South Carolina)
"Overview, Sphingolipid metabolism and trafficking: A foundation for function" |
| 8:10 pm - 8:40 pm | Kentaroh Hanada (Nat. Inst. of Infectious Diseases)
"Molecular machinery for non-vesicular trafficking of ceramide in mammalian cells" |
| 8:40 pm - 9:10 pm | Howard Riezman (Univ. of Geneva)
"Synthesis, transport and function of ceramide" |
| 9:10 pm - 9:30 pm | Dan Sillence (Univ. of Oxford)
"Accumulation of GSL and disrupted endosomal transport" |
| TUESDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | Sphingolipids and cell signaling |
| Session Chair: Yasuyuki Igarashi (Hokkaido Univ.) |
| 9:00 am - 9:05 am | Introduction |
| 9:05 am - 9:35 am | Sarah Spiegel (Virginia Comm. Univ.)
"Overview, Sphingosine-1-phosphate : Finally in the big leagues" |
| 9:35 am - 10:05 am | Tim Hla (Univ. of Connecticut)
"Barking up the right vascular tree with sphingosine 1-phosphate" |
| 10:05 am - 10:35 am | Julie Saba (Children's Hosp. Oakland)
"The truth about lyase" |
| 10:35 am - 10:55 am | Coffee Break |
| 10:55 am - 11:25 am | Nigel Pyne (Univ. of Strathelyde)
"S1P receptor-PDGFbeta receptor signaling platforms" |
| 11:25 am - 11:45 am | Paola Bruni (Univ. of Florence)
"Effect of sphingosine 1-phosphate on muscle cell growth and differentiation" |
| 11:45 am - 12:10 pm | Akio Kihara (Hokkaido Univ.)
"Posttranslational modification of the yeast sphingosine kinase, Lcb4p, by palmitoylation and phosphorylation" |
| 12:10 pm - 12:30 pm | Yoh Takuwa (Kanazawa Univ.)
"Receptor subtype-specific S1P signaling and biological activities" |
| 12:30 pm | Photo |
| 1:00 pm | Lunch |
| 2:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Sphingolipids in controlling cell function |
| Session Chair: Alfred Merrill (Georgia Inst. of Tech.) |
| 7:30 pm - 7:40 pm | Introduction |
| 7:40 pm - 8:10 pm | Tony Futerman (Weizmann Inst. of Sci.)
"Overview, The pathogenesis of sphingolipid storage diseases" |
| 8:10 pm - 8:30 pm | Jairaj Acharya (NCI)
"Ceramidase and optical function in Drosophila" |
| 8:30 pm - 8:50 pm | Makoto Ito (Kyusyu Univ.)
"Neutral ceramidase: Localization and functions" |
| 8:50 pm - 9:10 pm | Yasunori Kozutsumi (Kyoto Univ.)
"Regulation of sphingolipid signaling in yeast" |
| 9:10 pm - 9:30 pm | Gabor Tigyi (Univ. of Tennessee)
"Ligand recognition by sphingosine-1-phosphate receptors: computational and mutational analysis" |
| WEDNESDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | Complex glycosphingolipid structure and function |
| Session Chair: Kunihiko Suzuki (Tokai Univ.) |
| 9:00 am - 9:10 am | Introduction |
| 9:10 am - 9:40 am | Koichi Furukawa (Nagoya Univ.)
"Roles of glycosphingolipids in the integrity of the nervous system" |
| 9:40 am - 10:10 am | Gerrit van Meer (Utrecht Univ.)
"Simple glycolipids, sites of synthesis and sites of action" |
| 10:10 am - 10:30 am | Sandro Sonnino (Univ. of Milan)
"Interactions between sphingolipids and proteins within the plasma membrane lipid domains" |
| 10:30 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Iuliana Popa (Edouard Herriot Hospital)
"Gangliosides are present, but with different patterns, in all subcellar fractions of rat liver" |
| 11:10 am - 11:30 am | Tadashi Yamashita (NIH)
"Conditional disruption of glycosphingolipid synthesis in the central nervous system" |
| 11:30 am - 11:50 am | Miki Yokoyama (Tokyo Med. Den. Univ.)
"Glycolipid-dependent signaling in murine splenic B cells upon CD38 ligation" |
| 11:50 am - 12:10 pm | Tatsuro Mutoh (Fujita Health Univ.)
"Abnormal connection of mutant presenilin 1 to glycosphingolipid metabolism" |
| 12:10 pm - 12:30 pm | Roger Sandhoff (German Cancer Res. Cent.)
"Glycosphingolipids in male mouse fertility: Comparison of testis GSLs of infertile and fertile GSL-knockout mouse models" |
| 1:00 pm | Lunch |
| 2:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:00 pm | Poster Session |
| 5:00 pm - 6:00 pm | Business meeting |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | (Glyco)sphingolipid-receptor interactions |
| Session Chair: Robert Yu (Med. Coll. of Georgia) |
| 7:30 pm - 7:40 pm | Introduction |
| 7:40 pm - 8:10 pm | Reiji Kannagi (Aichi Cancer Res. Inst.)
"Regulation of gene expression in carbohydrate-mediated cell-cell interactions" |
| 8:10 pm - 8:30 pm | Katsuhiko Yanagisawa (Nat. Cent. for Geriat. and Gerontol.)
"A pivotal role of gangliosides in accelerated aggregation of amyloid ß-protein in the brain" |
| 8:30 pm - 8:50 pm | Alka Vyas (Johns Hopkins Univ.)
"Gangliosides as recognition molecules in axon regeneration" |
| 8:50 pm - 9:10 pm | Subroto Chatterjee (Johns Hopkins Univ.)
"Role of lactosylceramide in cell adhesion trans-endothelial migration and proliferation" |
| 9:10 pm - 9:30 pm | Soichi Wakatsuki (Structural Biology Center)
"Crystal structure of the human sialidase NEU2" |
| THURSDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | (Glyco)sphingolipids in differentiation and diseases |
| Session Chair: Konrad Sandhoff (Univ. of Bonn) |
| 9:00 am - 9:10 am | Introduction |
| 9:10 am - 9:40 am | Yoshio Hirabayashi (RIKEN)
"Overview: Significance of lipid glycosylation in complex biological systems" |
| 9:40 am - 10:10 am | James Shayman (Univ. of Michigan)
"The development of small molecule inhibitors for Gaucher and Fabry disease" |
| 10:10 am - 10:40 am | Walter Holleran (Unv. of California SF)
"Regulation of sphingolipid production in the epidermis" |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Koichi Honke (Kochi Mid. Sch.)
"Metabolism and physiological function of sulfoglycolipids" |
| 11:20 am - 11:40 am | Pam Fredman (Univ. of Goeteborg)
"Glycosphingolipids and regulation of inflammatory responses" |
| 11:40 am - 12:00 pm | Richard Jennemann (German Cancer Res. Cent.)
"Lox P-flanked glucosylceramide-synthase (GCS) mice - Generation of conditional glycolipid knockouts" |
| 12:00 pm - 12:20 pm | Junko Matsuda (Univ. of Tokushima)
"Mutation in Saposin D domain of sphingolipid activator protein gene causes patterned cerebellar Purkinje cell death with accumulation of hydroxyl fatty acid-ceramide in the mouse" |
| 12:20 pm - 12:30 pm | Discussion |
| 1:00 pm | Lunch |
| 2:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner (Banquet) |
| 7:30 pm - 9:30 pm | (Glyco)sphingolipid biodiversity and the new era of "Sphingolipidomics" |
| Session chair: Roger Laine (Louisiana State Univ.) |
| 7:30 pm - 7:40 pm | Introduction |
| 7:40 pm - 8:10 pm | Peter Seeberger (ETH)
"Automated synthesis of oligosaccharides and GPI anchors: From carbohydrate array to vaccines" |
| 8:10 pm - 8:30 pm | Mark Kester (Penn State Coll. of Med.)
"Innovative nanoscale delivery methodologies for ceramide and other hydrophobic chemotherapeutic agents" |
| 8:30 pm - 8:50 pm | Cameron Sullards (Georgia Inst. of Tch.)
"Sphingolipidomics: New LC-MS/MS methods to elucidate sphingolipid structure, metabolism, and cellular signaling" |
| 8:50 pm - 9:00 pm | Etsuko Yasugi (Res. Inst. Intnatl. Med. Cent. of Japan)
"Glycolipid database in LIPID BANK for Web" |
| 9:00 pm - 9:30 pm | Steven Pfeiffer (Univ. of Connecticut)
"Proteomics approach to ligand induced signal transduction" |
| FRIDAY |
| 8:00 am - 9:00 am | Breakfast |
| 8:30 am | Departure |
