SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Microdomain and Membrane Dynamics |
| Discussion Leaders: Sandro Sonnino (University of Milan, Italy) & Toshihide Kobayashi (Riken, Japan) |
7:40 pm - 7:45 pm | Introduction by Discussion Leaders |
7:45 pm - 8:05 pm | Toyoshi Fujimoto (Nagoya University, Japan)
"Nanoscale observation of membrane lipids by electron microscopy" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:30 pm | Manuel Prieto (IST, Portugal)
"Ceramide platform and microdomain function" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Verana Gobel (Harvard Medical School, USA)
"A role of sphingolipid biosynthesis in membrane polarity in C. elegans" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Alessandro Prinetti (University of Milan, Italy)
"Regulation of caveolin-dependent signaling complexes by gangliosides" |
9:20 pm - 9:30 pm | Discussion and Session Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Hot Topics in Sphingolipid Metabolism |
| Discussion Leaders: Yusuf Hannun (Stony Brook Cancer Center, USA) & Toshiro Okazaki (Kanazawa medical School, Japan) |
9:00 am - 9:10 am | Introduction by Discussion leaders |
9:10 am - 9:30 am | Richard L. Proia and Mari Kono (NIH, USA)
"Imaging S1P1 receptor signaling in vivo"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Francoise Roelants (UC Berkeley, USA)
"A complex protein kinase network regulates sphingolipid-glycerolipid homeostasis" |
10:00 am - 10:10 am | Discussion |
10:10 am | Group Photo / Coffee Break |
10:40 am - 11:00 am | Joost Holthius (Utrecht University, Netherlands)
"Control of mitochondrial apoptosis by a putative ceramide sensor in the ER" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Dimitri Krainc and Joe Mazzulli (Harvard Medical School, USA)
"Glucocerebrosidase and lysosomal diseases" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Felix Wieland (Heidelberg University, Germany)
"Membrane Lipids as Cofactors for Membrane Proteins?"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Roger Sandhoff (German Cancer Research Center, Germany)
"Physiological functions of CerS3 in skin barrier development and spermatogenesis"
|
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Session Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session (Odd-Numbered Posters to be presented) |
5:30 pm - 7:30 pm | Glyco/Sphingo Lipidomics |
| Discussion Leader: James Shayman (University of Michigan, USA) |
5:30 pm - 5:35 pm | Introduction by Discussion Leader |
5:35 pm - 5:55 pm | Al Merrill (Geogia Institute of Technology, USA)
"Welcome to the sphingolipidome, and get ready for more surprises" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:25 pm | John Yu (Academia Sinica, Taiwan)
"Stem Cells and Cancer from the perspective of glycomics analysis" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:55 pm | Yasuroh Shinohara (Hokkaido University, Japan)
"Qualitative cellular glycomics of glycosphingolipids and other classes of complex carbohydrates as cellular descriptors" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:20 pm | Akemi Suzuki (Tokai University, Japan)
"Structural Analysis of Glycosphingolipids by LC-MS"
|
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:30 pm | Session Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Functions of S1P and Application |
| Discussion Leaders: Tim Hla (Medical College Cornell University, USA) & Nigel Pyne (University of Strathclyde, UK) |
9:00 am - 9:10 am | Introduction by Discussion Leaders |
9:10 am - 9:30 am | Sarah Spiegel (Virginia Commonwealth University School of Medicine, USA)
"Sphingosine-1-Phosphate: the TRAFfic regulator of NF-kB" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Masaru Ishii (Osaka University, Japan)
"Roles of S1P in osteoclast regulation and bone physiology" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Jody Rosenblatt (University of Utah, USA)
"S1P signals epithelial cell extrusion to control homeostatic cell numbers" |
10:30 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:00 am - 11:20 am | Tsuyoshi Nishi (Osaka University, Japan)
"Analysis of physiological function of the sphingosine 1-phosphate transporter in mice" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Nigel Pyne (University of Strathclyde, UK)
"Sphingosine 1-phosphate and cancer" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Besim Ogretmen (Medical University of South Carolina, USA)
"Communication between host organism and cancer cells is transduced by systemic sphingosine 1-phosphate to regulate lung metastasis"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Session Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session (Even-Numbered Posters to be presented) |
5:30 pm - 7:30 pm | Novel Glycolipids with Novel Function |
| Discussion Leaders: Akemi Suzuki (Tokai University, Japan) & Yu-Teh Li (Tulane University, USA) |
5:30 pm - 5:35 pm | Introduction by Discussion Leaders |
5:35 pm - 5:55 pm | Yoshio Hirabayashi (Brain Science Institute Riken, Japan)
"A novel bioactive lipid, phosphatidylglucoside: from structure to functions in the developing brain" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:25 pm | Mitchell Kronenberg (La Jolla Institute, USA)
"Novel glycolipid stimulating NKT cells" |
6:25 pm - 6:35 pm | Discussion
|
6:35 pm - 6:50 pm | Yuki Ito (Yamaguchi University, Japan)
"Pathological and immunological functions of cholesteryl alpha-glucosides in Helicobacter pylori-associated inflammation" |
6:50 pm - 6:55 pm | Discussion |
6:55 pm - 7:15 pm | Teymuras Kurzchalia (MaxPlank Institute, Germany)
"Discovery of two novel classes of glycolipids in C.elegans and investigation of their role in the functioning of the organism" |
7:15 pm - 7:30 pm | Discussion and Session Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Sphingolipid Metabolism and Pathology |
| Discussion Leaders: Richard Kolesnick (Sloan-Kettering Cancer Center, USA) & Kentaroh Hanada (National Institute of Infectious Disease, Japan) |
9:00 am - 9:10 am | Introduction by Discussion leaders |
9:10 am - 9:30 am | Tony Futerman (Weizmann Institute, Israel)
"Ceramide synthases in pathology" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Erich Gulbins (University of Duisburg-Essen, Germany)
"Ceramide in cystic fibrosis and Pseudomonas aeruginosa infections" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:50 am | Akio Kihara (Hokkaido University, Japan)
"The complete sphingosine 1-phosphate metabolic pathway involves the Sjögren-Larsson syndrome gene" |
10:50 am - 11:00 am | Discussion
|
11:00 am - 11:15 am | Nathalie Andrieu-Abadie (Cancer Research Center of Toulouse, France)
"Role of sphingosine-1-phosphate in melanoma-stroma interactions" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Mark Kester (Penn State University College of Medicine, USA)
"Sphingolipid-based nanotechnologies for the treatment of acute myeloid leukemias" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Susumu Mitsutake (Hokkaido University, Japan)
"SMS2 is implicated as a novel regulator of lipid microdomain structure and function"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Derek Sieburth (University of Southern California, USA)
"Regulation of synapse structure and function by sphingosine kinase in C. elegans"
|
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Session Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session (All Posters to be open for discussion) |
5:30 pm - 7:30 pm | Diabetes and Metabolic Syndrome |
| Discussion Leader: Konrad Sandhoff (Bonn University, Germany) |
5:30 pm - 5:35 pm | Introduction by Discussion Leader |
5:35 pm - 5:55 pm | Jin-ichi Inokuchi (Tohoku Pharmaceutical University, Japan)
"Ganglioside GM3 participates in the pathogenesis of metabolic syndrome" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:25 pm | Xian-Cheng Jiang (State University of New York, USA)
"Reduced Serine-palmitoyltransferase activity in macrophages alleviates atherosclerosis" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:55 pm | Pingsheng Liu (Chinese Academy of Science, China)
"Proteomics reveals lipid droplets as a conserved multifunctional organelle from bacteria to human" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:20 pm | Linkang Zhou (Tsinghua University, China)
"Cidea Promotes Hepatic Steatosis by Sensing Dietary Fatty Acids"
|
7:20 pm - 7:30 pm | Discussion and Session Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Glycolipid Metabolism and Pathology |
| Discussion Leaders: Hugo Maccioni (Ciudad University, Argentina) & Koichi Furukawa (Nagoya University, Japan) |
9:00 am - 9:10 am | Introduction by Discussion Leaders |
9:10 am - 9:30 am | Sen-tiroh Hakomori (University of Washington, USA)
"Functional role of specific glycosphingolipids in epithelial-mesenchymal transition process defining tumor progression" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Hugo Maccioni (Ciudad University, Argentina)
"Regulation of glycolipid synthesis in Golgi Apparatus" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Rhoderick Brown (University of Minnesota, USA)
"Glycolipid Transfer Protein (GLTP) Superfamily: Emerging New Members and Transcriptional Regulation by Sphingolipid Metabolites" |
10:15 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:40 am - 11:00 am | Johannes Aerts (Academic Medical Center Amsterdam, Netherlands)
"Lipid and protein biomarkers for sphingolipidoses" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Hiroshi Kiyono (University of Tokyo, Japan)
"Role of glycolipid/S1P in the regulation of mucosal immunity" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Massimo Aureli (University of Milan, Italy)
"Plasma membrane associated glycohydrolases"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Julian Prendergast (Johns Hopkins University)
"Ganglioside interacting proteins - bridging the gap between myelin associated glycoprotein (MAG) and RhoA"
|
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Session Discussion |
12:30 pm | Lunch |
1:30 pm - 5:30 pm | Free Time / Optional Excursion |
5:30 pm - 7:30 pm | Model Animals/Plants/Microbes in Sphingolipid Biology |
| Discussion Leader: Makoto Itoh (Kyusyu University, Japan) |
5:30 pm - 5:35 pm | Introduction by Discussion Leader |
5:35 pm - 5:55 pm | Howard Riezman (University of Geneva, Switzerland)
"Lipid homeostasis and function in model systems" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:20 pm | Robert Dickson (University of Kentucky College of Medicine, USA)
"Down-regulation of sphingolipid synthesis in yeast increases chronological lifespan" |
6:20 pm - 6:25 pm | Discussion |
6:25 pm - 6:45 pm | Usha Acharya (University of Massachusetts Medical School, Worcester USA)
"Intersection of sphingolipid and intermediary metabolism - insights from drosophila" |
6:45 pm - 6:55 pm | Discussion |
6:55 pm - 7:15 pm | Lina Obeid (Stony Brook University, USA)
"Bioactive sphingolipids in cancer: lessons from mice" |
7:15 pm - 7:30 pm | Discussion and Session Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |