SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Glyco/Sphingolipids in Biology of Infection, Inflammation & Host Defense |
| Discussion Leaders: Yusuf Hannun (Stony Brook Cancer Center, USA) and Yasuyuki Igarashi (Hokkaido University, Japan) |
7:40 pm - 7:55 pm | Yusuf Hannun (Stony Brook Cancer Center, USA) "Introduction: Key Issues & Questions" |
7:55 pm - 8:20 pm | Joanne Engel (University of California San Francisco, USA)
"Chlamydia Co-Opts Host Lipid Transport Systems to Establish an Onsite Sphingomyelin Synthesis Factory"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Assaf Vardi (Weizmann Institute of Science, Israel)
"Chemical Arms Race at Sea: Rewiring Sphingolipid Metabolism by Marine Viruses Regulates the Fate of Algal Blooms in the Ocean"
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8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Al Merrill, Jr. (Georgia Institute of Technology, USA)
"Food for Thought: The Sphingo Snack Shack Circa 2014"
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9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Yasuyuki Igarashi (Hokkaido University, Japan) "Summary: Outstanding Questions" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Membrane Dynamics and Lipid Trafficking |
| Discussion Leaders: Kentaroh Hanada (National Institute of Infectious Disease, Japan) and Toshiro Okazaki (Kanazawa Medical School, Japan) |
9:00 am - 9:10 am | Kentaroh Hanada (National Institute of Infectious Disease, Japan)
"Introduction: Key Issues & Questions" |
9:10 am - 9:30 am | Ludger Johannes (Curie Institute, France)
"Glycosphingolipids in Clathrin-Independent Endocytosis"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Kenichi Suzuki (Kyoto University, Japan)
"The Very First Steps for Raft Formation and Function, Revealed by Single-Molecule Imaging"
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10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Late-Breaking Topic: Anne Kenworthy (Vanderbilt University, USA)
"Microtubules, Dynein, and Dynactin Bend the Plasma Membrane During Clathrin-Independent Endocytosis of Glycolipid Binding Toxins"
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10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Antonella DeMatteis (Telethon Institute of Genetics and Medicine, Italy)
"Vesicular and Non Vesicular Transport Feed Distinct Glycosylation Pathways in the Golgi Complex"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Koichi Furukawa (Nagoya University, Japan)
"Spatio-Temporal Dynamics of the Interaction Between Glycosphingolipids and Membrane Molecules"
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11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Late-Breaking Topic: Liana Silva (University of Lisbon, Portugal)
"Ceramide-Platforms in the Endo/Lysosomal Pathway: A Novel Mechanism by Which Ceramide Activates Intracellular Targets"
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12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Toshiro Okazaki (Kanazawa Medical School, Japan)
"Summary: Outstanding Questions" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (Odd-numbered posters) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Glyco/Sphingolipids in Biology of Autophagy, Apoptosis and Immune Response |
| Discussion Leaders: Nygel Pyne (University of Strathclyde, Scotland) and Sarah Spiegel (Virginia Commonwealth University, USA) |
7:30 pm - 7:40 pm | Nygel Pyne (University of Strathclyde, Scotland)
"Introduction: Key Issues & Questions" |
7:40 pm - 8:00 pm | Hong-Gang Wang (Penn State College of Medicine, USA)
"Sphingolipids: Regulators of the Interplay Between mTOR and Autophagy"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Yoshikazu Uchida (University of California San Francisco, USA)
"Sphingolipid Metabolites Regulate Innate Immunity"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Late-Breaking Topic: Antonella Rella (Stony Brook University, USA)
"Identification of a Novel Sterylglucosidase and Its Role as Essential Regulator of Cryptococcus neoformans Pathogenicity"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Late-Breaking Topic: Tilla Worgall (Columbia University, USA)
"Sphingolipids and Susceptibility to Airway Hyperreactivity"
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9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Sarah Spiegel (Virginia Commonwealth University, USA)
"Summary: Outstanding Questions & Discussion" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Mechanisms & Regulation of Lipid Metabolism |
| Discussion Leaders: Tony Futerman (Weizman Institute of Science, Israel) and Yoshio Hirabayashi (Brain Science Institute Riken, Japan) |
9:00 am - 9:10 am | Tony Futerman (Weizman Institute of Science, Israel)
"Introduction: Key Issues & Questions" |
9:10 am - 9:40 am | Keynote Speaker: Kasey Vickers (Vanderbilt University, USA)
"MicroRNAs: Intercellular Transport and Roles in Lipid Homeostasis and Cardiometabolic Disease" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:20 am | Robbie Loewith (University of Geneva, Switzerland)
"The Intimate Relationship Between Sphingolipids and TORC2 in Yeast" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Manuel Muñiz (University of Sevilla, Spain)
"Regulation and Trafficking of GPI-Anchored Proteins" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Late-Breaking Topic: Per Haberkant (European Molecular Biology Laboratory)
"Bifunctional Sphingosine for Cell-Based Mapping of Protein-Sphingolipid Interactions" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Late-Breaking Topic: Wayne Lencer (Harvard Medical School, USA)
"Unsaturated Glycoceramides as Molecular Carriers for Mucosal Drug Delivery of GLP-1" |
12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Yoshio Hirabayashi (Brain Science Institute Riken, Japan)
"Summary: Outstanding Questions" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (Odd-numbered posters) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Translational Studies and Therapeutics: Sphingosine-1-Phosphate |
| Discussion Leaders: Richard Kolesnick (Sloan-Kettering Cancer Center, USA) and Richard Proia (NIDDK, NIH, USA) |
7:30 pm - 7:40 pm | Richard Kolesnick (Sloan-Kettering Cancer Center, USA)
"Introduction: Key Issues & Questions" |
7:40 pm - 8:00 pm | Andreas Billich (Novartis, Switzerland)
"Second Generation S1P Modulators"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Roger Sabbadini (Lpath Inc., USA)
"Therapeutic Potential of Antibodies to S1P and LPA"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Late-Breaking Topic: Alison McCracken (University of California Irvine, USA)
"Characterization of an FTY720 Analog Lacking S1P1 and S1P3 Activity that Exhibits Enhanced Anti-Leukemic Activity Against BCR-ABL+ Leukemias"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Late-Breaking Topic: Mari Kono (NIDDK/National Institutes of Health, USA)
"Mapping Sphingosine-1-Phosphate Receptor 1 Signaling In Vivo"
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9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Richard Proia (NIDDK, NIH, USA)
"Summary: Outstanding Questions & Discussion" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Sphingolipid Metabolism in Infection, Diabetes, Obesity and Cardiovascular Disease |
| Discussion Leaders: Johannes Aerts (Academic Medical Center Amsterdam, Netherlands) and Mark Kester (University of Virginia, USA)
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9:00 am - 9:10 am | Johannes Aerts (Academic Medical Center Amsterdam, Netherlands)
"Introduction: Key Issues & Questions" |
9:10 am - 9:35 am | Scott Summers (Duke-NUS Medical School, Singapore)
"Ceramides and Metabolic Disease: A Survey of Therapeutic Targets"
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9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Thorsten Hornemann (University of Zurich, Switzerland)
"Atypical Sphingolipids as Biomarkers and Therapeutic Targets in Cardio-Metabolic Diseases"
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10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:15 am | Erich Gulbins (University Duisburg-Essen, FRG)
"Ceramide and Sphingosine in Bacterial Infections and Cystic Fibrosis"
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11:15 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Late-Breaking Topic: William Holland (University of Texas Southwestern, USA)
"Regulation of Hepatic Glucose and Lipid Metabolism via Ceramidase Action in the Adipocyte"
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11:45 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Late-Breaking Topic: Ashley Cowart (Medical University of South Carolina, USA)
"The Distinct Features and Functions of Cardiac Lipid Metabolism in Diabetic Cardiomyopathy"
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12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Mark Kester (University of Virginia, USA)
"Summary: Outstanding Questions" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III (Even-numbered posters) |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Advanced Sphingolipidomics, Imaging and Structural Characterization (In Honor of Prof. Charles C. Sweeley) |
| Discussion Leaders: Al Merrill (Georgia Institute of Technology, USA) and Alessandro Prinetti (University of Milan, Italy) |
7:30 pm - 7:40 pm | Al Merrill (Georgia Institute of Technology, USA)
"Introduction & Retrospective on Scientific Contributions of Charles C. Sweeley" |
7:40 pm - 8:00 pm | Cameron Sullards (Georgia Institute of Technology, USA)
"Complex Glyco/Sphingolipidomics"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Masaru Ishii (Osaka University, Japan)
"S1P-Mediated Control of Bone Cell Dynamics Visualized by Intra-Vital Microscopy"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Late-Breaking Topic: Richard Drake (Medical University of South Carolina, USA)
"An On-Tissue Profiling Workflow for Ceramides Using High Resolution MALDI-Imaging Mass Spectrometry"
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8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Late-Breaking Topic: Xueli Guan (Swiss Tropical & Public Health Institute, SWI)
"Sphingolipidomics and Genomics of Medically Relevant Pathogens - A Novel Pathway and Biomarker Discovery Tool For Infectious Diseases"
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9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Alessandro Prinetti (University of Milan, Italy)
"Summary: Outstanding Questions & Discussion" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Late-Breaking Topics and Young Investigators: Cancer, Cell Regulation, & Metabolism: (In Honor of Prof. Norman S. Radin) |
| Discussion Leaders: Lina Obeid (Stony Brook University, USA) and Besim Ogretmen (Medical University of South Carolina, USA) |
9:00 am - 9:10 am | James Shayman (University of Michigan, USA)
"Retrospective on Scientific Contributions from Norman S. Radin" |
9:10 am - 9:20 am | Lina Obeid (Stony Brook University, USA)
"Introduction: Key Issues & Questions" |
9:20 am - 9:35 am | Late-Breaking Topic: Stefka Spassieva (Medical University of South Carolina, USA)
"A Role of Deoxysphingolipids in Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Late-Breaking Topic: Simone Filosto (University of California Davis, USA)
"Paradigm Shift for nSMase2-Derived Ceramide in the Lung: From Injury to Cancer and Fibrosis" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Late-Breaking Topic: Toshiyuki Yamaji (National Institute of Infectious Disease, Japan)
"TALEN-Mediated Disruption of Several Sphingolipid-Related Genes in a HeLa Cell Line"
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10:25 am - 10:35 am | Discussion |
10:35 am | Coffee Break |
11:00 am - 11:15 am | Late-Breaking Topic: Jonathan Markham (University of Nebraska-Lincoln, USA)
"Role of Unsaturated VLCFA in Sphingolipids and Plant's Response to Low Temperature Stress"
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11:15 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Late-Breaking Topic: Akio Kihara (Hokkaido University, Japan)
"The Fatty Acid Elongase ELOVL1 and the P450 Family Member CYP4F22 are Involved in the Production of Epidermal Acylceramide"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Late-Breaking Topic: Jin-Ichi Inokuchi (Tohoku Pharmaceutical University, Japan)
"GM3 and Diabetes"
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12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Besim Ogretmen (Medical University of South Carolina, USA)
"Summary: Outstanding Questions & Discussion" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session IV (Even-numbered posters) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Glycolipids and Sphingolipids in Neurologic Disorders |
| Discussion Leaders: Thierry Levade (INSERM & Center of Research on Cancer of Toulouse, France) and Ed Schuchman (Mt. Sinai School of Medicine, USA) |
7:30 pm - 7:40 pm | Thierry Levade (INSERM & Center of Research on Cancer of Toulouse, France)
"Introduction: Key Issues" |
7:40 pm - 8:00 pm | Johannes Kornhuber (University of Erlangen-Nuremberg, FRG)
"Acid Sphingomeylinase-Ceramide Mediates Effects of Antidepressant Drugs"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Silke Walter (Saarland University, FRG)
"The Role of Acid Sphingomyelinase in Multiple Sclerosis"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Late-Breaking Topic: Einat Vitner (Weizmann Institute of Science, Israel)
"RIPK3 as a Novel Potential Therapeutic Target for Gaucher Disease"
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8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Marco Presta (University of Brescia, Italy)
"Inhibition of Angiogenesis by Beta-GalactoslCeramide Deficiency in Globoid Cell Leukodystrophy (Krabbe's Disease)"
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9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Ed Schuchman (Mt. Sinai School of Medicine, USA)
"Summary: Outstanding Questions & Discussion" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |