Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Understanding Complex Networks in Membranes and Glyco/Sphingolipid Homeostasis |
| Discussion Leaders: Walter Holleran (VA Medical Center / University of California, San Francisco, USA) and Yasuyuki Igarashi (Hokkaido University, Japan) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:15 pm | Yusuf Hannun (Stony Brook University, USA) "Neutral Sphingomyelinase in the DNA Damage Response" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Giulio Superti-Furga (Center for Molecular Medicine, Austrian Academy of Sciences, Austria) "The Circular Network of Coregulated Lipids in Cellular Signaling and Drug Action" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Auxiliadora Aguilera Romero (University of Geneva, Switzerland) "Cross-Talk Between Sphingolipids and Glycerophospholipids" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Per Haberkant (Leiden Institute of Chemistry, The Netherlands) "A Quantitative Map of Cellular Sphingolipid-Protein Complexes Revealed by Large-Scale Systematic Profiling" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Enzymology and Regulation of Glycolipids and Sphingolipids |
| Discussion Leaders: Liana Silva (University of Lisbon, Portugal) and Teresa Dunn (Uniformed Services University of the Health Sciences, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Joost Holthuis (Osnabrück University, Germany) "Molecular Dissection of Ceramide-Mediated Apoptosis Using Bifunctional Ceramides and Switchable Ceramide Transfer Proteins" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Akio Kihara (Hokkaido University, Japan) "Identification of Genes Involved in Epidermal Acylceramide Production" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Tomas Blom (University of Helsinki, Finland) "LAPTM4B Interacts with Ceramide and Regulates Its Subcellular Distribution" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Toshihide Kobayashi (RIKEN, Japan) "Cellular Localization of Sphingomyelin Clusters" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Antonella Chiapparino (European Molecular Biology Laboratory, Germany) "Systematic Isolation and Identification of In Vivo Formed Protein-Lipid Complexes in Eukaryotes" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Florian Froehlich (University of Osnabrück, Germany) "Maintenance of Sphingolipid Homeostasis: A Crucial Role of Endosomal Vesicular Recycling" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Manuel Leonetti (University of California, San Francisco, USA) "Systematic Approaches in Human Cells to Study Sphingolipid Regulation by ORM Proteins" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Glycolipid and Sphingolipid Metabolism and Organization |
| This session will cover lipid metabolism and traffic, but also effects of altered sphingolipid metabolism in mutants. |
| Discussion Leaders: Kentaro Hanada (National Institute of Infectious Diseases, Japan) and Antonella De Matteis (Telethon Institute of Genetics and Medicine, Italy) |
6:00 pm - 6:05 pm | Introduction by Discussion Leader |
6:05 pm - 6:25 pm | Anthony Futerman (Weizmann Institute of Science, Israel) "Simple Sphingolipids in Complex Human Diseases" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:45 pm | Nils Faergeman (University of Southern Denmark, Denmark) "Novel Mode of Activation of Ceramide Synthases by Acyl-CoA Binding Protein" |
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Pietro De Camilli (Yale University, USA) "Membrane Contact Sites in the Regulation of Lipid Dynamics" |
7:15 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Mary Kraft (University of Illinois at Urbana-Champaign, USA) "Sphingolipid Organization in the Plasma Membrane and Its Determinants" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Glycolipid and Sphingolipids in Infection, Inflammation and Autophagy |
| Discussion Leaders: Tilla Worgall (Columbia University, USA) and Ludger Johannes (Institut Curie, France) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Erich Gulbins (University of Duisburg-Essen, Germany) "Sphingosine and Bacterial Infections" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Urs Greber (University of Zurich, Switzerland) "Lipid-Tuned Viral Infections" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Xueli Guan (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore) "Phosphosphingolipidomics of Trypanosomatids Reveals Lifecycle- and Taxonomic-Dependent Lipid Chemistry" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Maurizio Del Poeta (Stony Brook University, USA) "Fungal Lipids as Regulators of Fungal Pathogenesis and Host Immunity" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Giuseppe Astarita (Waters Corporation, USA) "Unbiased Lipidomics Reveals a Key Role for De Novo Ceramide Biosynthesis in Methamphetamine-Induced Systemic Inflammation" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Rachel Kraut (Biotechnology Center (BIOTEC), TU Dresden, Germany) "The Drosophila Neurodegenerative Autophagy Mutant Blue Cheese Perturbs Sphingolipid Metabolism, Autophagic Clearance, and Stress/MAPK Signaling, and Is Rescued by Increased Ceramide Availability" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Ashish Saroha (Weizmann Institute of Science, Israel) "Short-Term Susceptibility to Lymphocytic Choriomeningitis Virus (LCMV) in Ceramide Synthase 2 (CerS2) Null Mice" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Glycolipid and Sphingolipid Tool Box |
| This session will cover lipidomics and novel technologies that will improve our understanding of the role of lipids. |
| Discussion Leaders: Alfred Merrill (Georgia Institute of Technology, USA) and Roger Sandhoff (German Cancer Research Center, Germany) |
6:00 pm - 6:05 pm | Introduction by Discussion Leader |
6:05 pm - 6:30 pm | Carsten Schultz (European Molecular Biology Laboratory, Heidelberg, Germany) "Sphingosine as a Regulator of Lysosomal Ion Homeostasis
and Autophagy" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Xianlin Han (Sanford-Burnham Medical Research Insitute, USA) "Shotgun Lipidomics and Its Application in Alzheimer's Research" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Berend Snijder (Center for Molecular Medicine, Austria) "Systems-Level Analyses to Reveal the Organizational Principles Underlying Lipid Abundance and Function" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Jonathan Weissman (Howard Hughes Medical Institute / University of California, San Francisco, USA) "CRISPR Technology and Tagging Methods" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Glycolipid and Sphingolipid in Health and Disease |
| Discussion Leaders: James Shayman (University of Michigan, USA) and L. Ashley Cowart (Medical University of South Carolina, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Frances Platt (University of Oxford, United Kingdom) "Sphingolipid Storage Diseases: Unanticipated Links to Common Diseases" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Scott Summers (Baker IDI Heart and Diabetes Institute, Australia) "Effect of Ceramide Depletion on Adipose Remodeling" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | William Holland (University of Texas Southwestern Medical Center, USA) "Interactions of Sphingolipids and Glucagon Critically Link Insulin Resistance to Hyperglycemia" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Annarita Di Lorenzo (Weill Cornell Medical College, USA) "Nogo-B Regulates Sphingolipid Homeostasis to Impact Vascular Functions" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Stephanie Xie (Princess Margaret Cancer Centre, University Health Network, Canada) "Differential Dependence on Sphingolipid Metabolism in the Normal and Leukemic Human Hematopoietic Hierarchy" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | J. Thomas Hannich (Université de Genève, Switzerland) "Deoxydihydroceramides and Anoxia Survival" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Mariana Nikolova-Karakashian (University of Kentucky, USA) "Chronic Elevation of Sphingomyelin Synthase 2 in Hepatic Cells Leads to Cell Senescence Associated with Mitochondrial Dysfunction and Neutral Fat Accumulation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Sphingosine 1P Signaling in Health and Disease |
| Discussion Leaders: Richard Proia (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) and Nigel Pyne (University of Strathclyde, United Kingdom) |
6:00 pm - 6:05 pm | Introduction by Discussion Leader |
6:05 pm - 6:25 pm | Sarah Spiegel (Virginia Commonwealth University, USA) "The Role ORMDL3 in Ceramide Homeostasis and Asthma" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Julie Saba (UCSF Benioff Children's Hospital Oakland, USA) "An Update on Sphingosine Phosphate Lyase" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:35 pm | Timothy Hla (Weill Cornell Medicine, USA) "Sphingosine 1-Phosphate Signaling via Chaperones and Receptors" |
7:35 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Yoshikazu Uchida (University of California, San Francisco, USA) "ER Stress Stimulates Production of Cathelicidin Antimicrobial Peptide by Forming a Stress Specific Novel Intracellular S1P Signaling Complex" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Genetic Disorders of Glycolipids and Sphingolipids / Neurobiology |
| Discussion Leaders: Alessandro Prinetti (University of Milano, Italy) and Thierry Levade (INSERM UMR1037 Cancer Research Center of Toulouse, France) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Yoshio Hirabayashi (Brain Science Institute, RIKEN, Japan) "Critical Roles of Lipid Modification with Glucose in Life: Unexpected Synthesis of Novel Glycolipids in the ER Membrane" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Giovanni D'Angelo (Institute of Protein Biochemistry, National Research Council, Italy) "A Molecular Circuit Controlling Glycosphingolipid Production and Neural Differentiation" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Vittorio Maglione (Neuromed Institute for Neurosciences, Italy) "Sphingolipid Metabolism in Huntington's Disease: New Perspectives into Pathogenesis and Potential Treatment" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Shun-Ichi Nakamura (Kobe University, Japan) "Essential Roles of Sphingosine 1-Phosphate Signaling in the Maturation of Exosomal Multivesicular Endosomes" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Thorsten Hornemann (University Hospital Zürich, Switzerland) "Deoxysphingolipids" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Translational Aspects of Glycolipid and Sphingolipid Biology |
| Discussion Leaders: Lina Obeid (Stony Brook University, USA) and Myles Cabot (Brody School of Medicine, East Carolina University, USA) |
6:00 pm - 6:05 pm | Introduction by Discussion Leader |
6:05 pm - 6:25 pm | Richard Kolesnick (Memorial Sloan-Kettering Cancer Center, USA) "Ceramides and Radiation Therapy" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Leah Siskind (University of Louisville, USA) "Role of Glycosphingolipids in Mesangial Cell Hypertrophy in Diabetic Nephropathy" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:35 pm | Irina Petrache (National Jewish Health, USA) "Metabolo-Genomic Sphingolipid Signatures in Lung Disease Phenotypes Induced by Chronic Cigarette Smoking" |
7:35 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Thomas Loughran (University of Virginia, USA) "Targetting Acid Ceramidase in Acute Myeloid Leukemia" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |