Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Sphingolipids and Glycosphingolipids in Cell Biology and Disease
Session in memory of Lina Obeid.
Discussion Leaders: Maurizio Del Poeta (Stony Brook University, United States) and Yusuf Hannun (Stony Brook University, United States)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:30 pm
Sarah Spiegel (Virginia Commonwealth University, United States)
"Sphingosine-1-Phosphate: From Bench to Clinic"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Hugh Willison (University of Glasgow, United Kingdom)
"Glycosphingolipids in Neuronal Homeostasis and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Measuring and Manipulating Sphingolipids and Glycosphingolipids: Challenges and Solutions
Discussion Leaders: Yusuf Hannun (Stony Brook University, United States) and Maria Fuller (SA Pathology, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Roger Sandhoff (German Cancer Research Center, Germany)
"Chromatography & Mass Spectrometry: Why There Is No All-in-One Solution For Sphingolipidomics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Liana Silva (University of Lisbon, Portugal)
"Fluorescence Methods to Investigate the Biophysical Properties of Sphingolipids"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
Noemi Jimenez-Rojo (University of Geneva, Switzerland)
"Optical Control of Membrane Fluidity Modulates Protein Secretion"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
Joost Holthuis (University of Osnabrueck, Germany)
"Ca2+-Activated Sphingomyelin Scrambling and Turnover Mediate ESCRT-Independent Lysosomal Repair"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Giovanni D'Angelo (École Polytechnique Fédérale de Lausanne, Switzerland)
"Sphingolipids Control Dermal Fibroblast Heterogeneity"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Wing-Kee Lee (Bielefeld University, Germany)
"Interrogating Ceramide Synthase Contribution to Functionalization of Membrane Proteins ABCB1 and Megalin in the Kidney"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Cynthia Tifft (National Human Genome Research Institute, NIH, United States) and Doris Höglinger (Heidelberg University Biochemistry Center, Germany)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ceramide Biology and Pathophysiology
Discussion Leaders: Tony Futerman (Weizmann Institute of Science, Israel) and Gerhild Van Echten-Deckert (Universität Bonn, Germany)
6:00 pm - 6:20 pm
Teresa Dunn (Uniformed Services Univ of the Health Sciences, United States)
"Pathogenic Mutations in Serine Palmitoyltransferase Cause Multiple Neurodegenerative Diseases"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Iris Zelnik (Weizmann Institute of Science, Israel)
"Structure-Function Analysis of Ceramide Synthases"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Alicia Alonso (University of the Basque Country , Spain)
"The Physical Properties of Ceramides and Their Pathophysiological Correlations"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Myles Cabot (Brody School of Medicine, East Carolina University, United States)
"Avenues for Boosting Therapeutic Potential of the 'Ceramide Effect'"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sphingosine and Sphingosine-1-Phosphate Biology and Pathophysiology
Discussion Leaders: Sarah Spiegel (Virginia Commonwealth University, United States) and Timothy Cox (University of Cambridge, United Kingdom)
9:00 am - 9:20 am
Julie Saba (University of California, San Francisco, United States)
"The Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Wiebke Herzog (Friedrich-Alexander-Univ Erlangen-Nuremberg, Germany)
"Interaction of Wnt and S1P Signaling Regulates Brain Angiogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Doris Höglinger (Heidelberg University Biochemistry Center, Germany)
"Sphingosine Exits Lysosomes via Known Cholesterol Transporters NPC1 and LIMP2"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Markus Graeler (Jena University Hospital, Germany)
"Sphingosine 1-phosphate Signaling in Systemic Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Eric Camerer (Paris Cardiovascular Research Center, France)
"S1P Receptor-1 Signaling at the Blood-Brain Barrier"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Shah Alam (Kekulé-Institute Life & Medical Sciences Institute, Germany)
"S1P-Lyase Deficiency in the Brain Increases Glucose Breakdown Evoking a P2Y1 Receptor-Dependent Astrogliosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Youn-Jeong Choi (UCSF, United States)
"The Effects of Gut-Specific S1P Lyase Deficiency on the Intestinal Transcriptome and Microbiome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycosphingolipids: Biosynthesis, Function and Disease
Discussion Leaders: Doris Höglinger (Heidelberg University Biochemistry Center, Germany) and Roger Sandhoff (German Cancer Research Center, Germany)
6:00 pm - 6:20 pm
Maria Antonietta De Matteis (Telethon Institute of Genetics and Medicine, Italy)
"ER-Golgi Contact Sites"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Janet Deane (University of Cambridge, United Kingdom)
"Identifying New Players in Krabbe Disease: How Galactosphingolipids Alter Membrane Protein Abundance"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Cynthia Tifft (National Human Genome Research Institute, NIH, United States)
"Gene Therapy for GM1 Gangliosidosis: A Ten-Year Odyssey"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Robert Engel (German Cancer Research Center (DKFZ), Germany)
"Glycosphingolipid-Protein Interactions and Renoprotective Mechanisms of Globo-Series Glycosphingolipid Depletion"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Julia Beimdiek (Hannover Medical School - MHH, Germany)
"Generation and Examination of Glycosphingolipid-Depleted Human iPSCs and Their Derivatives"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sphingolipids and Glycosphingolipids as Modulators of Membrane Function
Discussion Leaders: Janet Deane (University of Cambridge, United Kingdom) and Hugh Willison (University of Glasgow, United Kingdom)
9:00 am - 9:20 am
Mary Kraft (University of Illinois at Urbana-Champaign, United States)
"Imaging the Cholesterol and Sphingolipid Abundance at the Site of Influenza Virus Assembly"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sandro Sonnino (University of Milan, Italy)
"The Different Approaches to Study the Role of Membrane Gangliosides in Modulating Cell Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Mark Kester (University of Virginia, United States)
"Biophysical Lessons Learned from the Ceramide Nanoliposome Clinical Trial"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
Maria Fazzari (University of Milano, Italy)
"GM1 Oligosaccharide Membrane Signalling: The Switch to Turn on a Neuroprotective Program Acting via Mitochondria Modulation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Giulia Lunghi (University of Milano, Italy)
"Role of ß-glucocerebrosidase Deficiency in the Onset of Neuronal Degeneration: New Findings on the Involvement of a Lysosome-Plasma Membrane Axis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Tsaffrir Zor (Tel-Aviv University, Israel)
"Short Fatty Acid Chain Sulfatides are Endogenous Ligands for TLR4/MD-2"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Sphingolipids and Glycosphingolipids in Cell Growth and Differentiation
Discussion Leaders: James Shayman (University of Michigan, United States) and Julie Saba (University of California, San Francisco, United States)
6:00 pm - 6:20 pm
Alessandra D'Azzo (St. Jude Children's Research Hospital, United States)
"Organellar Membrane Contact Sites in the Synaptogenesis and Synaptopathy of GM1-Gangliosidosis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Erhard Bieberich (University of Kentucky, United States)
"Ceramide-Enriched Exosomes in Alzheimer's Disease: Role in Pathophysiology and Novel Pharmacological Target"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Richard Kolesnick (Memorial Sloan-Kettering Cancer Center, United States)
"Endothelial Cell Apoptosis Determines Intestinal Stem Cell Fate"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Sara Grassi (Università degli Studi di Milano, Italy)
"Sphingolipids Orchestrating the Cross-Talk Between Different Cell Populations in the Repair of Damaged Myelin"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Late-Breaking Topics
Discussion Leaders: Walter Holleran (University of California, San Franciso, United States) and Mylene Huebecker (Federal Institute for Drugs and Medical Devices, Germany)
9:00 am - 9:20 am
Yohann Boutte (French National Centre for Scientific Research, France)
"A Novel Mechanism in Sphingolipid-Mediated Phosphoinositide Homeostasis at Trans-Golgi Network"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Fikadu Tafesse (Oregon Health & Science University, United States)
"The Multifaceted Roles of Sphingolipids in Microbial Infection"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Michela Deleidi (German Ctr for Neurodegenerative, Germany)
"Glucocerebrosidase and Brain Disease: Novel Functions Beyond the Lysosome"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Stefanka Spassieva (University of Kentucky, United States)
"Oral L-serine Prevents Taxane-Induced Neuropathic Behaviors in Mice"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Hans Aerts (Leiden University, The Netherlands)
"Glucosylceramide as Precursor of Glucosylsphingosine and Glucolites"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Leobarda Robles-Martinez (University of Kentucky, United States)
"Hepatic Ceramide Accumulation During Fatty Liver Disease Requires Active Neutral Sphingomyelinase-2 and Drives Insulin Resistance"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Tolulope Sokoya (University of Osnabrueck, Germany)
"Pathogenic Variants of SMS2 Disrupt Lipid Landscapes in the Secretory Pathway"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Sphingolipids and Glycosphingolipids in Non-Mammalian Systems
Discussion Leaders: Teresa Dunn (Uniformed Services Univ of the Health Sciences, United States) and Maurizio Del Poeta (Stony Brook University, United States)
6:00 pm - 6:20 pm
Manuel Muñiz (University of Sevilla, Spain)
"Ceramide Chain Length-Dependent Protein Sorting Into Selective Endoplasmic Reticulum Exit Sites "
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Eric Brown (The Broad Institute of MIT and Harvard, United States)
"Bacterial Sphingolipids Mediate Host-Microbiome Interactions in the Intestine"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Dominic Campopiano (University of Edinburgh, United Kingdom)
"Discovery of Cryptic Bacterial Sphingolipids Reveals a Convergent Evolutionary Biosynthetic Pathway"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Sebastien Mongrand (CNRS, France)
"Multiple Biophysical Approaches To Study the Role of Plant Sphingolipids GIPC in Plasma Membrane Organization"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure