Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Session in Memory of Mark Kester: Sphingolipids and Glycosphingolipids in Physiology and Disease
Discussion Leader: Charles Chalfant (University of Virginia-School of Medicine, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Todd Fox (University of Virginia, United States)
"Ceramide in the Clinic"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Julie Saba (University of California, San Francisco, United States)
"S1P Lyase: From Gene Discovery to Gene Therapy and Beyond"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Analysis of Sphingolipids and Glycosphingolipids: Problems and Solutions
Discussion Leaders: Alfred Merrill (Georgia Institute of Technology, United States) and Liana Silva (University of Lisbon, Portugal)
9:00 am - 9:20 am
Michal Holcapek (University of Pardubice, Czech Republic)
"Dysregulation of (Glyco)sphingolipids in Pancreatic Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Rosário Domingues (University of Aveiro, Portugal)
"Unlocking the Diversity of Glycolipids Using Lipidomic Tools: From Bacteria, to Plants and Mammals"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Anthony Don (The University of Sydney, Australia)
"Stable Isotope Mass Spectrometry to Follow Brain Lipid Synthesis and Turnover in vivo "
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
RICHARD PROIA (NIDDK/NIH, United States)
"CRISPR-Mediated Advancements in Sphingolipid Metabolism Disorders: Disease Modeling and Therapeutic Innovations"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Liana Silva (University of Lisbon, Portugal) and Frances Platt (University of Oxford, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biosynthesis of Sphingolipids and Glycosphingolipids
Discussion Leaders: Kentaro Hanada (National Institute of Infectious Diseases, Japan) and Annarita Di Lorenzo (Weill Cornell Medicine, United States)
7:30 pm - 7:50 pm
Alessandro Prinetti (University of Milan, Italy)
"Cross Talk Between Different Cell Populations in Myelin Repair: Sphingolipids Conduct the Orchestra"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Mariana Nikolova-Karakashian (University of Kentucky, United States)
"Neutral Sphingomyelinase Activity is Present in Hepatic Lipid Droplets and has a Role in Droplet Biogenesis and Metabolism"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Tilla Worgall (Columbia University, United States)
"Sphingolipids and Asthma"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Metabolism and Trafficking of Sphingolipids and Glycosphingolipids
Discussion Leaders: Hans Aerts (Leiden University, The Netherlands) and Sarah Spiegel (Virginia Commonwealth University, United States)
9:00 am - 9:20 am
Long Nguyen (National University of Singapore, Singapore)
"Mechanistic Insights into Lysolipid Transport in the Lysosomes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Maria Antonietta De Matteis (Telethon Institute of Genetics and Medicine, Italy)
"ER-Golgi Contact Sites: Regulators and Targets of Sphingolipids"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Leah Siskind (University of Louisville, United States)
"Role of Sphingolipids in Acute Kidney Injury and Progression to Chronic Kidney Disease"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
L. Ashley Cowart (Virginia Commonwealth University, United States)
"SPTLC3 and Unusual Sphingolipids as Inducible Metabolic Modulators"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Function of Sphingolipids and Glycosphingolipids
Discussion Leaders: L. Ashley Cowart (Virginia Commonwealth University, United States) and Yusuf Hannun (Stony Brook University, United States)
7:30 pm - 7:50 pm
Annarita Di Lorenzo (Weill Cornell Medicine, United States)
"Rewiring Sphingolipid Signaling in Cardiometabolic Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Saranna Fanning (Harvard Medical School and Brigham & Women's Hospital, United States)
"Lipid Dysregulation Pinpoints Candidate Therapeutic Targets for Parkinson’s Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Emery Bresnick (University of Wisconsin School of Medicine and Public Health, United States)
"Transcriptional Network Governing Ceramide Homeostasis Establishes a Cytokine-Dependent Developmental Process"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sphingolipids and Diseases
Discussion Leaders: Richard Kolesnick (Memorial Sloan-Kettering Cancer Center, United States) and Sara Grassi (Università degli Studi di Milano, Italy)
9:00 am - 9:20 am
Besim Ogretmen (02/26/2018, United States)
"Roles of Sphingolipid Metabolism in the Regulation of Anti-Tumor Functions of T-cells and Immunotherapy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Daniela Salvemini (Saint Louis University, United States)
"Sphingolipids in Chemotherapy-Induced Neurotoxicity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Simonetta Sipione (University of Alberta, Canada)
"Brain Gangliosides: Old Dogs with new Tricks"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Christian Metallo (The Salk Institute for Biological Studies, United States)
"Measuring Sphingolipid Fluxes and the Impacts of Substrate Diversity on Metabolic Disease Co-Morbidities"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycosphingolipids and Diseases
Discussion Leader: Michela Deleidi (Imagine Institute, France)
7:30 pm - 7:50 pm
Frances Platt (University of Oxford, United Kingdom)
"The Complexity of Secondary Sphingolipid Storage Disorders: Insights from Niemann-Pick Disease Type C"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Yoshikazu Uchida (Hallym University, South Korea)
"Positive and Negative Roles of Ceramide and its Metabolites as Lipid Mediators in Skin"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Silke Nuber (ARCND, Brigham and Women's Hospital-Harvard Medical School, United States)
"Targeting Lipid Saturation as a new Treatment-Strategy in GBA1 and a-Synuclein Mutant Mouse Models of Gaucher’s and Parkinson’s Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Latest Discoveries in Glycolipid and Sphingolipid Biology: New Insights and Implications
Discussion Leaders: Giovanni D'Angelo (École Polytechnique Fédérale de Lausanne, Switzerland) and Gerhild Van Echten-Deckert (Universität Bonn, Germany)
9:00 am - 9:10 am
Giovanni D'Angelo (École Polytechnique Fédérale de Lausanne, Switzerland)
"Late Breaking Topic Introduction"
9:10 am - 9:15 am
Discussion
9:15 am - 9:30 am
Late-Breaking Topic
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Late-Breaking Topic
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:50 am
Late-Breaking Topic
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
Late-Breaking Topic
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Late-Breaking Topic
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Gerhild Van Echten-Deckert (Universität Bonn, Germany)
"Late Breaking Topic Conclusions"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sphingolipids and Glycosphingolipids in Yeasts, Bacteria and Parasites
Discussion Leaders: Eric Klein (Rutgers University-Camden, United States) and Takashi Watanabe (Kawasaki Medical School, Japan)
7:30 pm - 7:50 pm
Fumika Mi-ichi ( Institute of Tropical Medicine (NEKKEN), Nagasaki University,, Japan)
"Unique Features of Entamoeba Sphingolipid Metabolism; Very Long Chain Dihydroceramides Confer Dormancy to Entamoeba Parasites"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Mary Ellen Davey (Forsyth, United States)
"Sphingolipid Synthesis and the Pathophysiology of Porphyromonas Gingivalis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Kai Zhang (Texas Tech University, United States)
"Sphingolipid Metabolism in the Protozoan Parasite Leishmania"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure