Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Regulation of Sphingolipid Metabolism
Discussion Leader: Elena-Raluca Nicoli (National Institutes of Health, United States)
3:15 pm - 3:55 pm
Tony Futerman (Weizmann Institute of Science, Israel)
"Why We Love Sphingolipids"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The Complex Biology of SLs and GSLs
Discussion Leader: Iris Zelnik (Weizmann Institute of Science, Israel)
5:30 pm - 5:45 pm
Denisa Jamecna (Biochemie Zentrum Heidelberg (BZH), Germany)
"STARD3 Transfers Sphingosine at Lysosome-ER Contact Sites"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Henrik Nurmi (Åbo Akademi, Finland)
"In Vivo Effects of Glycolipid Transfer Protein (GLTP) Knockout in HeLa Cells"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Bianca Esch (University of Osnabrück, Germany)
"Spatio-Temporal Control of Sphingolipid Metabolism in Saccharomyces Cerevisiae"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Yuzhe Weng (University of Oxford, United Kingdom)
"Lipid-Mediated Inhibition of Niemann-Pick C1 Protein Contributes to the Pathogenesis of Pathogenic Mycobacteria"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Tamir Dingjan (Weizmann Institute of Science, Israel)
"The Sphingoid Motif: Five Carbon Atoms That Do It All"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Tasha Morrison (NIAMS/NIH, United States)
"Essential Role of Ugcg for Natural Killer Cell Development and Function"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
When Things Go Wrong: Pathobiology of SLs and GSLs
Discussion Leader: Jason Weesner (St. Jude Children's Research Hospital, United States)
9:00 am - 9:15 am
Nivea Pereira de Sa (Stony Brook University, United States)
"Structure and Inhibition of Cryptococcus Neoformans Sterylglucosidase to Develop Antifungal Agents"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Adam Majcher (University Hospital Zurich, Switzerland)
"Sphingosine-1-phosphate (S1P) Lyase Insufficiency Syndrome - SPLIS"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Leobarda Robles-Martinez (University of Kentucky, United States)
"Hepatic Ceramide Accumulation During Fatty Liver Disease Requires Active Neutral Sphingomyelinase-2 and Drives Insulin Resistance"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Tolulope Sokoya (University of Osnabrueck, Germany)
"Perturbation of Sphingomyelin Asymmetry, Cholesterol Organization and Lipid Order by Pathogenic SMS2 Variants"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Maria Fazzari (University of Milano, Italy)
"GM1 Oligosaccharide Membrane Signalling: The Switch to Turn On a Neuroprotective Program Acting via Mitochondria Modulation"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Leigh Fremuth (St. Jude Children's Research Hospital, United States)
"Investigating the Immunomodulatory Role of the Sialidase Neu1 During Neurodegeneration and Neuroinflammation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: What Options Do I Have For My Scientific Career?
Discussion Leader: Janathan Juarez-Altuzar (Heidelberg University, Germany)
1:30 pm - 2:30 pm
Panel Discussion
What Options Do I Have For My Scientific Career?
Timothy Cox (University of Cambridge, United Kingdom)
Doris Höglinger (Heidelberg University Biochemistry Center, Germany)
Frances Platt (University of Oxford, United Kingdom)
Thomas Kirkegaard Jensen (Orphazyme A/S, Denmark)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
