SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | Signaling Strategies in Bacterial and Eucaryotic Chemotaxis |
| Keynote Speaker: Sandy Parkinson, University of Utah
"Bacterial Chemotaxis: Signal Gain Through Receptor Teamwork" |
| Keynote Speaker: Mel Simon, California Institute of Technology
"Signal Transducing Networks in Macrophage: A report from your AFCS" |
9:00 | Chair's Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Photo |
9:00 am - 12:30 pm | Directed Cell Migration in Development I |
| Discussion Leader: Ruth Lehmann, NYU Medical Center
"Multiple Signals Guide Drosophila Germ Cells" |
| Erez Raz, Max Planck Institute for Biophysical Chemistry
"Directed Migration of Primordial Germ Cells in Zebrafish" |
| Alex Kolodkin, Johns Hopkins University School of Medicine
"Semaphorin-mediated neuronal and non-neuronal guidance" |
| Mu-Ming Poo, University of California at Berkeley
"Calcium Signaling in Axon Guidance and Neuronal Migration" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Workshops (Optional/Informal) |
4:00 pm - 6:00 pm | Poster Session A [ pdf file ] |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Directed Cell Migration in Development II |
| Discussion Leader: Denise Montell, Johns Hopkins University
"Developmental Regulation of Border Cell Migration" |
| Pernille Rorth, European Molecular Biology Laboratory
"Gradient sensing and tension sensing in invasive border cell migration" |
| Kees Weijer, University of Dundee
"Chemotaxis and its role in tissue morphogenesis" |
| David Soll, University of Iowa
"Spatial and Temporal Information, Lateral Pseudopod Formation, and Parallel Signal Transduction Pathways in Dictyostelium Chemotaxis" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling Networks in Chemotaxing Cells I |
| Discussion Leader: Henry Bourne, University of California at San Francisco
"Signaling via cytoskeletons" |
| Verena Niggli, University of Bern
"Cytoskeletal reorganization, polarization and migration of neutrophils: roles of Rho/Rho-kinase, PI 3-kinase and lipid microdomains" |
| Richard Firtel, University of California - San Diego
"Signaling pathways controlling leading edge formation" |
| Peter J. van Haastert, University of Groningen
"Contributions of PI(3,4,5)P3 and cGMP to chemotaxis at the front and back of Dictyostelium cells" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Workshops (Optional/Informal) |
4:00 pm - 6:00 pm | Poster Session A [ pdf file ] |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signaling Networks in Chemotaxing Cells II |
| Discussion Leader: Lew Cantley, Harvard Medical School
"Role of PI 3-Kinase in Actin Rearrangement" |
| Tobias Meyer, Stanford University
"Probing mammalian cell signaling networks using RNAi perturbations" |
| Stephen Ward, Bath University
"PI3K and T Lymphocytes: does it have a role in chemotaxis?" |
| Carole Parent, National Cancer Institute, Bethesda
"Signal relay during chemotaxis" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling Networks in Migrating Cells III |
| Discussion Leader: Rick Horwitz, University of Virginia
"Adhesive and protrusive dynamics in migrating cells" |
| Anna Huttenlocher, University of Wisconsin-Madison
"Regulated Proteolysis by Calpain During Neutrophil Chemotaxis" |
| Alan Wells, University of Pittsburgh
"Front-Back Asymmetry During EGF-induced Cell Motility" |
| Gareth Jones, King's College London
"WASP-mediated regulation of podosomes in migrating myeloid cells" |
| Diane Barber, University of California - San Francisco
"H+ efflux at the leading edge: a key determinant in polarity and localized actin polymerization" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Workshops (Optional/Informal) |
4:00 pm - 6:00 pm | Poster Session B [ pdf file ] |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Modeling of Chemotactic Signaling Networks |
| Discussion Leader: Hans Meinhardt, Max Planck Institute for Developmental Biology
"Models for the Orientation of Cell Polarity by Weak Chemotactic Gradients" |
| Pablo Iglesias, Johns Hopkins University
"Modeling gradient sensing in Dictyostelium" |
| Yu-Li Wang, University of Massachusetts Medical School
"Top-Down Stohastic Modeling of Cell Migration and Gradient Guidance" |
| Jason Haugh, North Carolina State University
"PDGF gradient sensing in fibroblasts: the 'absolute' truth" |
| Herbert Levine, University of California, San Diego
"A critical evaluation of gradient-sensing models" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Small GTPases and Directional Responses |
| Discussion Leader: Alan Hall, University College London
"Coordinated polarization of actin and microtubules during directed cell migration" |
| Matthias Peter, Swiss Federal Institute of Technology
"Regulated interactions of the yeast cytoskeleton with the bud cortex" |
| Erfei Bi, University of Pennsylvania School of Medicine
"Coordinated Regulation of Polarized Growth by a Protein Complex Containing Rab GAPs, a Formin, and a Scaffold Protein" |
| Dianqing Wu, University of Connecticut
"Regulation of Directionality by Chemoattractant Signaling Pathways" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Workshops (Optional/Informal) |
4:00 pm - 6:00 pm | Poster Session B [ pdf file ] |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation of the Cytoskeleton |
| Discussion Leader: Anne Ridley, Ludwig Institute for Cancer Research
"Directed migration of leukocytes across endothelial cells" |
| John Condeelis, Albert Einstein College of Medicine
"Sensing, protrusion and polarity during chemotaxis of tumor cells" |
| Guenther Gerisch, Max Plauch Institute, Martinstried
"Dynamics of the actin system in chemotaxis" |
| Richard Klemke, Scripps Research Institute
"Proteomic Analysis of Phosphoprotein Signaling Networks in Cell Chemotaxis" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |