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Hemostasis

Gordon Research Conference

June 28 - July 3, 1998
Chair J. Evan Sadler
Vice Chair Lawrence F. Brass

Conference Program

Sunday evening - June 28 7:30 - 9:45 pm
Welcome Reception 9:45 pm - 12:00 am
Session Title: Toward an integrated model of hemostasis

  • J. Evan Sadler (Discussion Leader)
  • George J. Broze - The coagulation cascade in mouse models
  • Charles T. Esmon - New insights into the regulation of the protein C activation complex on endothelium
  • Sanford J. Shattil - Integrin signaling in hemostasis: the rules of engagement
  • Michael A. Gimbrone - Hemodynamic forces and endothelial gene regulation

Monday morning - June 29 9:00 - 12:15
Session Title: Platelet signaling pathways

  • Lawrence F. Brass (Discussion Leader) - Signaling through protease-activated receptors
  • John H. Hartwig - Signals controlling platelet actin assembly
  • Kenneth Lerea - Control of platelet function by seryl/threonyl phosphatases: Role of beta3 threonine phosphorylation (BRIEF UPDATE - 10 min.)
  • Philip W. Majerus - Intracellular signalling by phosphatidylinositols
  • Satya P. Kunapuli - Molecular basis for ADP-induced platelet activation
  • Hans-Michael Jantzen - Two distinct receptors mediate ADP-dependent platelet aggregation, one P2Y1-like, the other Gi-coupled (BRIEF UPDATE - 10 min.)

Monday evening 7:30 - 9:45 pm
Session Title: Novel gene and protein therapies for hemostatic and vascular disorders

  • Katherine P. Ponder (Discussion Leader) - Retroviral vectors for gene therapy for plasma protein deficiencies
  • Katherine A. High - AAV-mediated gene transfer for hemophilia B
  • Thomas S. Edgington - Delivery of thrombogenic function to selected vascular beds: An approach to solid tumor eradicative therapy
  • Victor Dzau - Inhibition of cellular proliferation in vessel grafts with antisense oligonucleotides to cell cycle transcripts

Tuesday morning - June 30 9:00 - 12:15
Session Title: Integrins and platelet communications

  • Mark Ginsberg (Discussion Leader) - Integrin cytoplasmic domains: the shape of things to come
  • Debbie A. Law - Tyrosine phosphorylation in GP IIb-IIIa signaling
  • Tatiana V. Byzova - Ligand recognition control by activation states of α vß3 (BRIEF UPDATE - 10 min.)
  • Samuel A. Santoro - Ligand recognition by cell surface collagen receptors
  • Joan E. B. Fox - Signaling induced by GPIb-IX and integrins. Involvement of calpain and Rho family members
  • Sacha M. Dopheide - Calpain proteolysis of platelet GPIb/V/IX: a novel mechanism regulating platelet rolling, adhesion and thrombus formation under flow (BRIEF UPDATE - 10 min.)

Tuesday evening - June 30 7:30 - 9:45 pm
Session Title: Genes, development, and hemostasis

  • David Ginsburg (Discussion Leader) - Combined factors V and VIII deficiency due to mutations in a resident protein of the ER-Golgi intermediate compartment
  • Shaun Coughlin - Lessons from protease-activated receptor knockouts
  • John P. Sheehan - The zebrafish as a genetic model for hemostasis (BRIEF UPDATE - 10 min.)
  • Peter Carmeliet - Gene targeting of membrane proteins in the blood clotting and anticoagulant pathways
  • Hartmut Weiler-Guettler - Consequences of a prethrombotic state in mice with APC-deficiency

Wednesday morning - July 1 9:00 - 12:15
Session Title: Cell surfaces and cell-cell interactions

  • Charles T. Esmon (Discussion Leader)
  • Michael P. Lisanti - caveolae, signaling, and cell transformation
  • Peter J. Newman - Adhesive and signaling properties of PECAM-1
  • Denise E. Jackson - Recruitment and activation of the protein-tyrosine phosphatase SHP-1 by PECAM-1 (BRIEF UPDATE - 10 min.)
  • Becky J. Fredrickson - Functional role of glycoprotein V and high shear in modulating von Willebrand factor-platelet glycoprotein Ib-IX-V complex interactions under dynamic conditions (BRIEF UPDATE - 10 min.)
  • Simone M. Schoenwaelder - Platelet glycoprotein Ib/IX: a unique shear-resistant rolling receptor - studies with GPIb/IX-transfected CHO cells (BRIEF UPDATE - 10 min.)
  • Rodger P. McEver - Cell adhesion and signaling through selectins
  • Peter J. Sims - Structure and function of plasma membrane phospholipid scramblase: a protein mediating the cell surface exposure of procoagulant phospholipids

Wednesday evening - July 1 7:30 - 9:45 pm
Session Title: Structure and function of protein domains

  • Edwin L. Madison (Discussion Leader) - Rational design of zymogen-like variants of tissue-type plasminogen activator
  • Glen Spraggon - Crystal structures of fibrinogen fragments
  • Kathleen P. Pratt - Gamma chain dysfibrinogenemias: Molecular structure-function analysis of naturally occurring mutations in the gamma chain of human fibrinogen
  • Zaverio M. Ruggeri - Structural analysis of the von Willebrand factor A1 domain-glycoprotein Ibα interaction
  • R.M. van der Plas - Which residues of the vWF A3 domain are involved in binding to collagen type III? (BRIEF UPDATE - 10 min.)

Thursday morning - July 2 9:00 - 12:15
Session Title: Megakaryocytes and the birth of platelets
  • Kenneth Kaushansky (Discussion Leader) - Molecular mechanisms of megakaryocyte development
  • Ramesh A. Shivdasani - Transcriptional control of platelet biogenesis
  • Katya Ravid - Transcriptional mechanisms responsible for thrombopoietin effects on platelet production
  • Paula B. Tracy - Secretable human platelet-derived factor V originates from the plasma pool (BRIEF UPDATE - 10 min.)

Thursday evening - July 2 8:00 - 9:00 pm
Joint Party with Vascular Biology 9:00 pm - 12:00 am
Keynote address

  • Mario R. Capecchi - How do hox genes specify our body plan?

Contributors

We are grateful to the following companies for their generous financial support:

Astra Hässle
Baxter-Hyland
Berlex Biosciences
Bristol-Myers Squibb
Glaxo-Wellcome
Haematologic Technologies
Hoffman-La Roche
Lilly Research Laboratories
Merck Research Laboratories
Monsanto
Novo-Nordisk

Conference Links

Conference History
Additional Fee Info

Cell Biology of Megakaryocytes and Platelets
March 2 - 7, 2025
Endothelial Cell Phenotypes in Health and Disease
June 30 - July 5, 2024
Hemostasis (GRS)
August 3 - 4, 2024
Vascular Cell Biology
January 12 - 17, 2025


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