| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PLATELETS & MEGAKARYOCYTOPOIESIS |
| Discussion Leader: Morty Poncz (University of Pennsylvania)
|
| 7:30 pm - 8:00 pm | Ramesh Shivdasani (Harvard Medical School)
"Molecular regulation of thrombopoiesis" |
| 8:00 pm - 8:30 pm | Kenneth Kaushansky (UC San Diego)
"The molecular wiring diagram of a megakaryocyte" |
| 8:30 pm - 9:00 pm | Paula Tracy (University of Vermont)
"Human megakaryocytes endocytose and modify plasma-derived factor V to yield a unique platelet-derived cofactor" |
| 9:00 pm - 9:30 pm | George Dale (University of Oklahoma)
"Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PLATELET RECEPTOR SIGNALING |
| Discussion Leader: Michael Berndt (Baker Medical Research Institute)
|
| 9:00 am - 9:35 am | Skip Brass (University of Pennsylvania)
"Signaling through Eph kinases and ephrins in the later stages of platelet activation" |
| 9:35 am - 10:10 am | David Phillips (Millennium Pharmaceuticals, Inc.)
"Functional activities of platelet CD40L" |
| 10:10 am - 10:45 am | Coffee Break and Conference Photo |
| 10:45 am - 11:20 am | Gilbert White (University of North Carolina, Chapel Hill, NC)
"Rap1b deficient mice" |
| 11:20 am - 11:55 am | Leslie Parise (University of North Carolina)
"Collagen receptor signaling and integrin activation" |
| 11:55 am - 12:30 pm | Shaun Jackson (Australian Centre for Blood Diseases)
"Signaling mechanisms regulating platelet adhesion on VWF" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session A |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HEMOSTASIS AND THE VESSEL WALL |
| Discussion Leader: Tom Deuel (The Scripps Research Institute) |
| 7:30 pm - 8:05 pm | Denisa Wagner (Harvard Medical School)
"Double agents of inflammation and hemostasis" |
| 8:05 pm - 8:40 pm | Charles Esmon (Oklahoma Medical Research Foundation)
"Novel structural aspects of the endothelial cell protein C receptor provide insights into its complex biology" |
| 8:40 pm - 9:15 pm | Tatiana Byzova (Cleveland Clinic)
"Molecular mechanisms of angiogenesis" |
| 9:15 pm - 9:30 pm | Thrombosis Program/NHLBI update:
Ahmed Hasan ( NHLBI/ NIH)
|
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | VWF and TTP |
| Discussion Leader: Robert Montgomery (Medical College of Wisconsin)
|
| 9:00 am - 9:35 am | J. Evan Sadler (Washington University)
"Biochemical and clinical studies of ADAMTS13 and TTP" |
| 9:35 am - 10:10 am | Bernhard Lämmle (Inselspital/University Hospital, Bern, Switzerland)
"Pathophysiology, diagnosis and treatment of thrombotic thrombocytopenic purpura" |
| 10:10 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Han-Mau Tsai (Montefiore Medical Center, Bronx, NY)
"von Willebrand factor, ADAMTS-13, and thrombotic microangiopathies" |
| 11:20 am - 11:55 am | José López (Baylor College of Medicine, Houston, TX)
"Unusual von Willebrand factor conformations and TTP" |
| 11:55 am - 12:30 pm | Zaverio Ruggeri (The Scripps Research Institute)
"Dynamic platelet adhesion and aggregation in normal and pathological flow conditions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session A |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | COAGULATION PROTEIN BIOSYNTHESIS & FUNCTION |
| Discussion Leader: Aaron Marcus (NY VA/Cornell Medical College)
|
| 7:30 pm - 8:00 pm | Randal Kaufman (University of Michigan)
"Regulation of Factor VIII expression and activity" |
| 8:00 pm - 8:30 pm | Barbara Furie (Beth Israel Deaconess Medical Center, Boston, MA)
"Initiation of thrombus formation: a crossroads of blood coagulation and selectins" |
| 8:30 pm - 9:00 pm | Kenneth Mann (University of Vermont, Burlington, VT)
"Numerical analyses of thrombin production" |
| 9:00 pm - 9:30 pm | Wolfram Ruf (The Scripps Research Institute)
"Specificity of protease signaling" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | OF MICE AND MEN |
| Discussion Leader: Bruce Furie (Beth Israel Deaconess Medical Center)
|
| 9:00 am - 9:35 am | Shaun Coughlin (UC, San Francisco)
"Protease-activated receptors" |
| 9:35 am - 10:10 am | Hartmut Weiler (Blood Center of Southeastern Wisconsin)
"The protein C pathway and early pregnancy maintenance" |
| 10:10 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Victoria Ploplis (Notre Dame)
"The fibrinolytic system in tumor growth, dissemination, and angiogenesis" |
| 11:20 am - 11:55 am | Pamela Conley (Millennium Pharmaceuticals)
"P2Y12-Insights from patients and knock-out mice" |
| 11:55 am - 12:30 pm | Nigel Mackman (The Scripps Research Institute)
"Hemostasis and thrombosis in low tissue factor mice" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | LATE-BREAKING TOPICS AND SELECTED ABSTRACT PRESENTATIONS |
| Discussion Leader: Edward Plow (Cleveland Clinic Foundation) |
| 7:30 pm - 7:45 pm | Toshiyuki Miyata (National Cardiovascular Center Research Institute, Osaka)
"Mutation and common polymorphism in the ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity" |
| 7:45 pm - 8:00 pm | S. Betty Yan (Eli Lilly & Co.)
"factor V Leiden mutation in severe sepsis in the PROWESS study with Drotrecogin alfa (activated)" |
| 8:00 pm - 8:15 pm | Renhao Li (University of Pennsylvania)
"Activation of the platelet integrin αIIbß3 by thermodynamic modulation of transmembrane helix associations" |
| 8:15 pm - 8:30 pm | Elaine L. Bearer (Brown University)
"How actin polymerizes during platelet activation: Requirement for the Arp2/3 complex" |
| 8:30 pm - 8:45 pm | Michael Cunningham (University of Michigan)
"Both specific N-linked oligosaccharide structures and protein-protein associations mediate the Interaction of coagulation factor VIII with ERGIC-53" |
| 8:45 pm - 9:00 pm | Jonas Emsley (University of Leicester)
"Structure of the N-terminal domain of GPIbα" |
| 9:00 pm - 9:15 pm | David Farrell (Oregon Health & Science University)
"Antisense oligomer to integrin αv inhibits retinopathy of prematurity in mice" |
| 9:15 pm - 9:30 pm | Yuki Kimura (Mount Sinai Hospital, Toronto)
"Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PLATELET RECEPTORS AND SIGNALING II |
| Discussion Leader: Joel Bennett (University of Pennsylvania)
|
| 9:00 am - 9:35 am | Mark Ginsberg (The Scripps Research Institute)
"Mechanisms of integrin activation" |
| 9:35 am - 10:10 am | Sanford Shattil (The Scripps Research Institute, La Jolla, CA)
"The initiation and propagation of integrin signaling in platelets" |
| 10:10 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Joan Fox (Cleveland Clinic Foundation)
"Regulation of signaling across αIIbß3: role of 14-3-3 and calpain" |
| 11:20 am - 11:55 am | Peter Newman (Blood Center of Southeastern Wisconsin)
"Anoikis extended: Inhibition of Bax-mediated apoptosis by PECAM-1" |
| 11:55 am - 12:30 pm | Mark Kahn (University of Pennsylvania, Philadelphia, PA)
"New vascular roles for immune receptor signaling" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENOMICS AND NEW APPROACHES TO THERAPY |
| Discussion Leader: Richard Hynes (MIT) |
| 7:30 pm - 8:00 pm | Luanne Peters (The Jackson Laboratory)
"A large scale strain characterization and mutagenesis program to detect variation in heart, lung, blood, and sleep phenotypes in the mouse" |
| 8:00pm - 8:30 pm | Robert Flaumenhaft (Harvard, Boston)
"Discovery of intracellular platelet molecules that mediate thrombosis using high throughput technology" |
| 8:30 pm - 9:00 pm | Mark Kay (Stanford University School of Medicine)
"Gene transfer approaches for genetic and acquired diseases" |
| 9:00 pm - 9:30 pm | Robert Handin (Harvard Medical School)
"Assessing thrombocyte development and function in zebrafish: insights from genetic screens and transgenic fish" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
