| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome: José A. López (Puget Sound Blood Center) |
| 7:40 pm - 9:30 pm | BLOOD COAGULATION - A HISTORICAL VIEW |
| Discussion Leader: Peter Newman (Blood Research Institute) |
| 7:40 pm - 8:25 pm | Aaron Marcus (Cornell University)
"From Thromboplastin to Thromboregulation - Creators and Connections" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:20 pm | Ulla Hedner (University of Lund)
"Background, Development and Clinical Experience of the Use of rFVIIa" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:45 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PLATELET ADHESION |
| Discussion Leader: J. Evan Sadler (Washington University) |
| 9:00 am - 9:20 am | Jorge Di Paola (University of Iowa)
"Searching for Genes that (may) Affect Platelet Adhesion" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Michael C. Berndt (Monash University, Australia)
"Regulation of Platelet Function by Ectodomain Shedding" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:05 am | Zaverio Ruggeri (Scripps Research Institute)
"Transitional and Synergistic Events in the Regulation of Platelet Adhesion and Aggregation" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Andrew S. Weyrich (University of Utah)
"Signal-Dependent Splicing: a New Mechanism of Regulatory Control that Alters Platelet Functional Responses" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Miguel Cruz (Baylor College of Medicine)
"More on the Roles of the A Domains of von Willebrand Factor" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Group Photo / Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session A |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ANTICOAGULATION |
| Discussion Leader: Hartmut Weiler (Blood Research Institute) |
| 7:30 pm - 7:50 pm | Alan Mast (Blood Research Institute)
"Cell Surface Association of TFPI" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Gary E. Gilbert (VAMC Brockton/West Rocksbury)
"Regulated Platelet Phosphatidylserine Exposure in Thrombosis" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Susan Lord (University of North Carolina)
"Fibrinogen and Fibrin: Scaffold Proteins in Hemostasis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | George J. Broze (Washington University)
"Murine Protein Z-Dependent Protease Inhibitor Gene Deletion" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ADAMTS-13 |
| Discussion Leader: David Ginsburg (University of Michigan) |
| 9:00 am - 9:20 am | Toshiyuki Miyata (National Cardiovascular Center Research Institute)
"ADAMTS13 and its Related Issue" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Peter Lenting (University Medical Center Utrecht)
"The Presence of Active VWF Under Various Pathological Conditions" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Jing-fei Dong (Baylor College of Medicine)
"ADAMTS-13: Structure and Function Correlations" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | David Motto (University of Michigan)
"TTP Pathogenesis in ADAMTS13-Deficient Mice " |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Flora Peyvandi (University of Milan)
"Risk Factors for Recurrence of Thrombotic Thrombocytopenic Purpora" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session A (continued) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | COAGULATION |
| Discussion Leader: Paula Tracy (University of Vermont) |
| 7:30 pm - 8:00 pm | Ton Lisman (University Medical Center Utrecht)
"Hypofibrinolysis and the Risk for Venous and Arterial Thrombosis" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | David Gailani (Vanderbilt University)
"Intrinsic Pathway Proteases in Mouse Models of Vascular Thrombosis" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Sriram Krishnaswamy (University of Pennsylvania)
"Enzymic Specificity and Function in Coagulation" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PLATELET SIGNALING |
| Discussion Leader: Lawrence Brass (University of Pennsylvania) |
| 9:00 am - 9:20 am | Leslie V. Parise (University of North Carolina at Chapel Hill)
"CIB1, PAK1 and Platelets" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Athar H. Chishti (University of Illinois at Chicago)
"Regulation of Platelet Signaling by Calpain-1" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Xiao-Ping Du (University of Illinois at Chicago)
"Signaling and Regulation of Platelet GPIb-IX" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Alastair Poole (University of Bristol)
"Platelet Regulation by PKC" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Luigi DeMarco (Oncology Reference Center, Aviano)
"Platelet Calcium Signaling in Flowing Blood: Responses to Different Substrates" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | JoAnn Trejo (University of North Carolina at Chapel Hill)
"Regulation of Protease-Activated Receptor Signaling" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOT TOPICS |
| Discussion Leader: Pudur Jagadeeswaran (University of North Texas) |
| 7:30 pm - 7:40 pm | Jonas Emsley (University of Nottingham)
"Structure of the Factor XI Zymogen Reveals a Transactivation Pathway" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Hongmin Sun (University of Michigan)
"Reduced Factor V Level Increases Host Susceptibility to Group A Streptococcal Infection (GAS) in Transgenic Mice" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Thomas Renne (University Hospital Würzburg)
"Targeting Coagulation Factor XII Provides Protection from Pathological Thrombosis Without Interfering with Hemostasis" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Katherine L. Tucker (University of Reading)
"ILK: In The Link" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:35 pm - 8:45 pm | Marketa Jirouskova (Rockefeller University)
"Integrin αIIbß3 Mediates Platelet Response Depending on the Adsorbed Ligand Density" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:00 pm | Renhao Li (University of Texas Health Science Center at Houston)
"GP Ib-α Forms Disulfide Bonds with two GP Ib-ß Molecules" |
| 9:00 pm - 9:10 pm | Andrew Herr (University of Cincinnati)
"Crystal Structure of the Collagen-Binding Domain of Human GPVI" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Elizabeth Gardiner (Monash University)
"ITAM-Dependent Signaling Induces Shedding of both Glycoprotein VI and FcγRIIa on Human Platelets" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 9:00 am - 12:30 pm | PLATELETS IN INFLAMMATION |
| Discussion Leader: Edward Plow (Cleveland Clinic) |
| 9:00 am - 9:20 am | Daniel Simon (Case Western Reserve)
"Platelet Profiling and the Identification of Novel Predictors of Acute Myocardial Infarction" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Satya Kunapoli (Temple University)
"Regulation of ADP-Induced Thromboxane A2 Generation in Platelets" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Cecile Denis (Institut national de la santé et de la recherche médicale, INSERM)
"Von Willebrand Factor as an Adhesive Surface for Leukocytes: Mechanisms and Potential Implications" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | C. Wayne Smith (Baylor College of Medicine)
"Platelets in Inflammation and Wound Healing" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Barry S. Coller (The Rockefeller University)
"Is There Life After Thrombus Formation?: TGF-Beta1 as a Link Between Platelets and Inflammation" |
| 12:20 pm - 12:30 | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B (continued) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Miscellaneous Fun |
| Discussion Leader: Denisa Wagner (Harvard Medical School) |
| 7:30 pm - 7:50 pm | James H. Morrissey (University of Illinois at Urbana-Champaign)
"Novel Ways to Modulate Blood Clotting and Fibrinolysis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Michael Marsh (Baylor College of Medicine)
"Platelet Ultrastructure as Shown by Electron Cryotomography" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Debra K. Newman (Blood Center of Wisconsin)
"Negative Regulators of Src Family Kinase Activity in Human and Murine Platelets" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Bruce Furie (Harvard Medical School)
"Microparticles and Cancer-Associated Thrombosis" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
