SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Introductory Comments by GRC Site Staff |
| Welcome: Peter Newman (Blood Research Institute, BloodCenter of Wisconsin) |
7:45 pm - 9:30 pm | HISTORICAL VIEWS OF THROMBOSIS AND HEMOSTASIS |
| Discussion Leader: Nigel Mackman (University of North Carolina - Chapel Hill) |
7:45 pm - 8:15 pm | Barry Coller (Rockefeller University) "From the Rivers of Babylon to the Coronary Blood Stream: Vignettes form the αIIbβ3 Story" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Charles Esmon (Oklahoma Medical Research Foundation) "Toward an Understanding of the Physiological Regulation of Blood Coagulation" |
9:00 pm - 9:15 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BIOLOGY OF VON WILLEBRAND FACTOR |
| Discussion Leader: Zaverio Ruggeri (Scripps Research Institute) |
9:00 am - 9:25 am | Robert Montgomery (Blood Research Institute and Medical College of Wisconsin) "The platelet and endothelial cell as targets for drug delivery in hemophilia" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | José Lopez (Puget Sound Blood Center) "Shear Hell: VWF and Oxidative Stress" |
10:05 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break / Group Photo |
11:00 am - 11:25 am | J. Evan Sadler (Washington University, St. Louis) "Assembly, Storage and Structure of von Willebrand Factor" |
11:25 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Karen Vanhoorelbeke (Catholic University of Leuven, Campus Kortrijk) "von Willebrand Factor and its Processing by ADAMTS13" |
12:05 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | BASIC AND CLINICAL DEVELOPMENTS IN ANTI-THROMBOTICS |
| Discussion Leader: Wolfgang Eisert (Boehringer Ingelheim GmbH, Germany) |
7:30 pm - 7:55 pm | J. Anthony Ware (Eli Lilly) "Prasugrel and the Patient Determinants of Drug Response" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Robert Schaub (Archemix Corp) "The Evaluation of an Anti-von Willebrand Factor Therapeutic Aptamer" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Pamela Conley (Portola) "Mechanistic Distinctions of Reversible and Irreversible P2Y12 Antagonists" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BLOOD COAGULATION FACTORS AND HEMOSTASIS |
| Discussion Leader: Sriram Krishnaswamy (University of Pennsylvania) |
9:00 am - 9:25 am | Shannon Meeks (Emory University School of Medicine) "Uncovering the Diversity of Structural and Functional Epitopes on the C2 Domain of Factor VIII" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Susan Lord (University of North Carolina at Chapel Hill) "Defining Residues Critical to Fibrin Clot Structure" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Paula Tracy (University of Vermont) "Physical Modifications and Functional Characteristics Unique to Platelet-Derived Factor Va" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | John McVey (Imperial College London) "The X Factor in Adenovirus Liver Infection" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Jacky Chi Ki Ngo (Beth Israel Deaconess, Harvard) "Crystal Structure of B-Domain Deleted Factor VIII" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ATHEROTHROMBOSIS |
| Discussion Leader: Susan Smyth (University of Kentucky) |
7:30 pm - 7:55 pm | Willem Ouwehand (Cambridge University, United Kingdom) "Genome-wide Association Study Meets Systems Biology" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Susan Smyth (University of Kentucky) "Regulation of platelet function and atherothrombosis by lysophosphatidic acid and autotaxin/lysophospholipase D" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Eugene Podrez (Lerner Research Institute, Cleveland Clinic) "Platelet Scavenger Receptors Class B, Oxidative Stress and Atherothrombosis" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PLATELET SIGNALING - What turns ‘em on, what turns ‘em off |
| Discussion Leader: Sanford Shattil (University of California - San Diego) |
9:00 am - 9:25 am | Lawrence Brass (University of Pennsylvania) "Novel Regulators of Thrombus Growth and Stability" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Jane Freedman (Boston University) "Thrombosis and the Platelet Transcriptome" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10.50 am | Coffee Break |
10:50 am - 11:15 am | Joel Bennett (University of Pennsylvania) "Interactions of Integrin Transmembrane and Cytoplasmic Domains" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Mark Kahn (University of Pennsylvania) "Regulation of Thrombopoiesis and Platelet Function by Collagen Receptors" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Donna Woulfe (Thomas Jefferson University) "The Akt/GSK3 Pathway: Regulating Platelet Responses to Agonist" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | HOT TOPICS |
| Discussion Leader: Edward Plow (Lerner Research Institute, Cleveland Clinic) |
7:30 pm - 7:40 pm | Ty Adams (University of Cambridge) "Crystal structure of thrombin and TM" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Ed Conway (University of Leuven) "Regulation of complement by TM" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Simon De Meyer (Catholic University of Leuven) "Gene therapy for severe VWD" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Karen Fong (University of Pennsylvania) "Microfluidic analysis of mouse platelets" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Guillermina Girardi (Hospital for Special Surgery) "Role of TF:FVIIa-PAR-2 signaling in PMNs" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Stephen Lam (University of Illinois-Chicago) "Activation of integrin alphaIIb/beta3 in platelets" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Toshiyuki Miyata (National Cardiovascular Research Institute, Osaka) "Binding of ADAMTS13 to Lys-plasminogen" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Yan-Quing Ma (Cleveland Clinic) "Kindkin-2 is a cofactor of integrin activation" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOVEL TIES BETWEEN HEMOSTASIS AND INFLAMMATION |
| Discussion Leader: John Griffin (Scripps Research Institute) |
9:00 am - 9:25 am | Mark Ginsberg (University of California - San Diego) "Endogenous Stabilizers of Endothelial Cell-Cell Junctions" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | David Ginsburg (University of Michigan) "Hemostasis in Host Defense from Microbial Pathogens" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Cheryl Hillery (Medical College of Wisconsin) "Sickle Cell Disease as an Inflammatory Disorder" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Wolfram Ruf (Scripps Research Institute) "PAR Signaling in Sepsis" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Anil Chauhan (CBR Institute for Biomedical Research) "ADAMTS13- a New Link Between Thrombosis and Inflammation" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PLATELET POLYMORPHISMS AND PLATELET IMMUNOLOGY |
| Discussion Leader: Gow Arepally (Duke University Medical College) |
7:30 pm - 7:55 pm | Paul Bray (Cardeza and Thomas Jefferson University) "Genetic Variations and Platelet Reactivity" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Morty Poncz (University of Pennsylvania) "New Models/New Thinking on the Pathophysiology of Heparin-induced Thrombocytopenia" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Richard Aster (Blood Research Institute) "Drug-induced Immune Thrombocytopenia: Molecular Mechanisms" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |