SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Introductory Comments by GRC Site Staff Welcome by Conference Chair, Nigel Mackman (University of North Carolina at Chapel Hill, Chapel Hill, North Carolina) |
7:45 pm - 9:30 pm | Historical Views of Thrombosis and Hemostasis |
| Discussion Leader: David Ginsburg (University of Michigan) |
7:45 pm - 8:15 pm | Ken Mann (University of Vermont) "Discovery of thrombin and its central role in coagulation" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Shaun Coughlin (University of California San Francisco) "Protease-activated receptors: discovery, physiology, and therapy" |
9:00 pm - 9:15 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Platelet Biology |
| Discussion Leader: Jane Freedman (Boston University) |
9:00 am - 9:25 am | Joe Italiano (Harvard Medical School) "Mechanistic insights into how platelets are produced and how they regulate angiogenesis" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Michael Berndt (University College Cork, Ireland) "A novel signaling pathway regulating early events in platelet adhesion" |
10:05 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break / Group Photo |
11:00 am - 11:25 am | Tatiana Byzova (Lerner Research Institute, Cleveland Clinic) "Kindlin as a key component of integrin activation machinery" |
11:25 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Andy Weyrich (University of Utah) "Synthetic Events Mediated by Platelets: Links to Thrombosis and Hemostasis" |
12:05 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Atherothrombosis |
| Discussion Leader: Jose Lopez (Puget Sounds Blood Center) |
7:30 pm - 7:55 pm | Mark Taubman (University of Rochester) "Role of tissue factor in smooth muscle cell biology and thrombosis" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Lisa Jennings (University of Tennessee Health Science Center) "Platelet function in atherothrombosis: critical factors for thrombus stability" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Skip Brass (University of Pennsylvania) "The biology of semaphorins in platelets and their role in atherothrombosis" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Blood Coagulation Factors |
| Discussion Leader: Paula Tracy (University of Vermont) |
9:00 am - 9:25 am | Rodney Camire (University of Pennsylvania) "The molecular basis of factor V procofactor activation" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Jim Huntington (Cambridge for Medical Research, United Kingdom) "NMR studies on thrombin structure and interactions" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Jim Morrissey (University of Illinois at Urbana-Champaign) "Nanoscale studies of protein-membrane interactions" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Alisa Wolberg (University of North Carolina at Chapel Hill) "Plasma and cellular influences on fibrin structure and stability" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Hongmin Sun (University of Missouri) "Exploring the interaction of host hemostatic system and group A streptococcus to generate novel antimicrobial reagents" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Anticoagulants and Cross Talk Between Thrombosis and Inflammation |
| Discussion Leader: Charles Esmon (Oklahoma Medical Research Foundation) |
7:30 pm - 7:55 pm | George Broze (Washington University, St. Louis) "TFPI isoforms" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | John Griffin (The Scripps Research Institute) "Protein C" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Denisa Wagner (Immune Disease Institute and Harvard Medical School) "Links between thrombosis and inflammation" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Platelet Signaling |
| Discussion Leader: Mark Ginsberg (University of California San Diego) |
9:00 am - 9:25 am | Xiaoping Du (University of Illinois) "MAPK signaling in platelets" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Wolfgang Bergmeier (Thomas Jefferson University) "CalDAG-GEFI: At the nexus of calcium-dependent calcium signaling" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Leslie Parise (University of North Carolina at Chapel Hill) "Platelets, leukocytes and RBCs in sickle cell disease" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Steve Watson (University of Birmingham, United Kingdom) "Platelet activation by ITAM and ITAM-like receptors" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Gow Arepally (Duke University) "Immune Pathogenesis of HIT" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Hot Topics |
| Discussion Leader: Sriram Krishnaswarmy (Children’s Hospital of Philadelphia) |
7:30 pm - 7:40 pm | Feng Ye (University of California-San Diego) "Complete Reconstitution of GPIIb-IIIa Activation In Vitro" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Heyu Ni (University of Toronto) "Apolipoprotein A-IV is a ligand of platelet beta3 integrins and an endogenous inhibitor of thrombosis: A novel link between lipoprotein metabolism and platelet function" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Dominic W. Chung (University of Washington) "Regulation of ADAMTS13 by a cofactor from human plasma" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Parvathi Kamath (Children’s Hospital of Philadelphia) "Ligand binding shuttles thrombin along a continuum of zymogen-like and proteinase-like states" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Alastair W. Poole (University of Bristol) "Distinct regulation of calcium signaling by different PKC isoforms in platelets" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Umesh Desai (Virginia Commonwealth University) "Desgined allosteric regulators of coagulation enzymes" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Alec A. Schmaier (University of Pennsylvania) "Platelet vs. thrombocyte function: aggregate formation under shear is unique to platelets" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Mikhail V. Ovanesov (Food and Drug Administration) "Regulation of clot growth by Factor XI through the generation of thrombin inside the clot" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biology of Von Willebrand Factor |
| Discussion Leader: X. Long Zheng (The Children's Hospital of Philadelphia and The University of Pennsylvania Medical Center) |
9:00 am - 9:25 am | Tim Springer (Harvard University) "Structure of the A2 domain of VWF and the cleavage by ADAMTS13" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Zaverio Ruggeri (The Scripps Research Institute) "Von Willebrand factor and thrombin as GPIba ligands: structural aspects and physiopathological consequences" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Shaun Jackson (Monash University, Australia) "Impact of flow disturbances on platelet aggregation and thrombus growth" |
11:15 am - 11:30 | Discussion |
11:30 am 11:55 am | David Motto (University of Iowa) "VWF and ADAMTS13 in mouse models" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Jerry Ware (University of Arkansas) "GP1ba and mouse models" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Microparticles and Anti-Thrombotic Drugs |
| Discussion Leader: Bruce Sullenger (Duke University) |
7:30 pm - 7:55 pm | Alok Khorana (University of Rochester Medical Center)
"Role of tissue factor and microparticles in venous thrombosis in cancer" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Jimmy Tcheng (Duke University) "Antithrombotic Therapies in Coronary Artery Disease: Promises (Partially) Fulfilled" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Jeff Weitz (McMaster University, Canada) "New anticoagulants: Is targeted therapy better therapy" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |