SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff |
7:40 pm - 7:55 pm | Welcome and Overview (Organizers) |
8:00 pm - 9:30 pm | Thrombosis and Hemostasis: Historical Perspectives |
8:00 pm - 8:05 pm | Discussion Leader: Charles Esmon (OMRF) |
8:05 pm - 8:35 pm | Joel Bennett (University of Pennsylvania)
"Adventures and misadventures in chasing the mechanism of platelet aggregation"
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8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Darrel Stafford (University of North Carolina-Chapel Hill)
"The vitamin K cycle: Retrospective and Prospective"
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9:15 pm - 9:25 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inflammation/Infection and Coagulation |
9:00 am - 9:05 am | Discussion Leader: Susan Smyth (University of Kentucky) |
9:05 am - 9:30 am | Piet Gros (Utrecht University)
"Structural Biology of the Complement System"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Paul Kubes (University of Calgary)
"Imaging the host-pathogen interaction in the vasculature"
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10:10 am - 10:25 am | Discussion |
10:25 am - 11:05 am | Group Photo / Coffee Break |
11:05 am - 11:30 am | Jo Ann Trejo (University of California-San Diego)
"Cytoprotective signaling by activated protein C"
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11:30 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Jerry Ware (University of Arkansas for Medical Sciences)
"The platelet-inflammatory axis in rheumatoid arthritis"
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12:10 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Thrombus Formation and its Dissolution |
7:30 pm - 7:35 pm | Discussion Leader: José Lopez (Puget Sound Blood Center) |
7:35 pm - 8:00 pm | James Whisstock (Monash University)
"The X-ray crystal structure of full length human plasminogen"
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8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | John Weisel (University of Pennsylvania)
"Thrombus Composition and Properties"
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8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:05 pm | Short Talk: Paul Bock (Vanderbilt University)
"Staphylocoagulase shows promiscuity in conformational activation of prothrombin"
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9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Patricia Liaw (McMaster University)
"Cell-free DNA in coagulation, sepsis, and cancer"
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9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Receptors and Signaling |
9:00 am - 9:05 am | Discussion Leader: Skip Brass (University of Pennsylvania) |
9:05 am - 9:30 am | Renhao Li (Emory University)
"Organization and structure of GPIb-IX complex"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Mark Ginsberg (University of California-San Diego)
"Two Modes of Integrin Activation Form A Binary Switch in Adhesion Maturation" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Charles Abrams (University of Pennsylvania)
"Phosphoinositides and platelet biology" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Sergio Grinstein (Hospital for Sick Children, Toronto)
"Tracking immunoreceptors at the single-molecule level: how does receptor mobility affect activation?"
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11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Short Talk: Valder Arruda (Children's Hospital of Philadelphia)
"Zymogen Protein C and Tumor Progression"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Blood/Vessel Wall Interface |
7:30 pm - 7:35 pm | Discussion Leader: Leslie Parise (UNC-Chapel Hill) |
7:35 pm - 8:00 pm | Jaime Grutzendler (Yale University)
"Imaging microvascular occlusion and recanalization"
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8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Robert Flaumenhaft (Harvard)
"Targeting vascular PDI with small molecules"
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8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:05 pm | Short Talk: Rafal Pawlinski (University of North Carolina-Chapel Hill)
"Role of Tissue Factor in the Pathology of Sickle Cell Disease"
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9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Rodger McEver (OMRF)
"Regulation of Cell Adhesion to the Vessel Wall"
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9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Defective Hemostasis |
9:00 am - 9:05 am | Discussion Leader: James Morrissey (University of Illinois, Champaign-Urbana) |
9:05 am - 9:30 am | Rodney Camire (University of Pennsylvania)
"Zymogen-Like Proteases for the Treatment of Coagulation Defects"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Alfica Sehgal (Alnylam Pharmaceuticals)
"RNAi mediated intervention of coagulation pathway for treatment of hemophilia"
|
10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Walter Kahr (Hospital for Sick Children, Toronto)
"Molecular Basis of Platelet Granule Defects"
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11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Bruce Sullenger (Duke University Medical Center)
"Inhibition of thrombosis with aptamers and nucleic acid binding polymers" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Short Talk: Shekhar Kumar (Children's Hospital of Philadelphia)
"Structures of Snake Venom Factor V: Evolution of a Hemostatic Cofactor to a Potent Toxin"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session C |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Hot Topics |
| Discussion Leader: Andrew Weyrich (University of Utah) |
7:30 pm - 7:40 pm | Ying Zheng (University of Washington)
"In vitro microvessels for the study of angiogenesis and thrombosis"
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7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Matthew Bunce (Children's Hospital of Philadelphia)
"Autoinhibitory B-domain fragments reveal the mechanism by which factor V function is suppressed"
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7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Renata Grozovsky (Brigham and Women's Hospital/Harvard Medical School)
"Clearance of desialylated platelets by the hepatic asialoglycoprotein receptor regulates TPO homeostasis in vivo"
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8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Karen De Ceunynck (Catholic University of Leuven)
"Single molecule visualization of ADAMTS13 enzymes on EC-anchored VWF strings"
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8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Yiming Wang (University of Toronto)
"Plasma fibronectin is a supportive factor for hemostasis and a regulator of thrombosis: Evidence for fibrin-dependent and independent pathways"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Sang Min (University of Pennsylvania)
"The regulation of intracellular trafficking of platelet granules by PIKFyve, a phopholipid kinase that synthesizes PtdIns(3,5)P2"
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8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Jonathan Thon (Brigham and Women's Hospital/Harvard Medical School)
"T-granules function as a mediator of innate immunity in platelets"
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9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Yacine Boulaftali (University of North Carolina at Chapel Hill)
"A novel method for the adoptive transfer of platelets into thrombocytopenic mice for studying the specific role of platelets in the maintenance of vascular integrity during inflammation"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of Thrombus Formation |
9:00 am - 9:05 am | Discussion Leader: Barbara Furie (Harvard) |
9:05 am - 9:30 am | Jim Huntington (Cambridge University)
"Structure of prothrombinase from Pseudonaja textilis venom"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Wolfgang Bergmeier (University of North Carolina-Chapel Hill)
"Platelet activation in thrombosis and hemostasis: a RAP-sody in cell biology"
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10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Evan Sadler (Washington University in Saint Louis)
"How ADAMTS13 recognizes von Willebrand factor"
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11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Jorge DiPaola (University of Colorado)
"Genomic approaches to dissect platelet and coagulation disorders"
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11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Short Talk: Timothy Stalker (University of Pennsylvania)
"Hierarchical organization in the hemostatic response and its relationship to the platelet signaling network"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Membranes/Microparticles/Atherothrombosis |
7:30 pm - 7:35 pm | Discussion Leader: Nigel Mackman (University of North Carolina-Chapel Hill) |
7:35 pm - 8:00 pm | Roy Silverstein (Medical College of Wisconsin)
"Platelets and Lipoproteins"
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8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Wolfram Ruf (Scripps)
"Tissue factor, microparticles and the P2X7 receptor"
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8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:05 pm | Short Talk: Jonathan Gibbins (University of Reading)
"Minding the gaps ... and channels in platelet function"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Andrew Kim (University of California-San Francisco)
"TMEM16F Regulates Phosphatidylserine Exposure" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |