SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff |
7:40 pm - 7:50 pm | Welcome Overview, and Highlights of the GRS by Andrew S. Weyrich (GRC Chair, University of Utah) |
7:50 pm - 9:30 pm | The Vessel Wall in Thrombosis and Coagulation |
7:50 pm - 7:55 pm | Discussion Leader: Karen Hoffmeister (Harvard Medical School)
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7:55 pm - 8:20 pm | Jose Lopez (Puget Sound Blood Center Research Institute)
"Regulation of VWF Reactivity: More Than Just ADAMTS13"
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8:20 pm - 8:35 pm | Discussion |
8:35 pm - 8:50 pm | Ulhas Naik (University of Delaware)
"Identification of a Novel Small Molecule Against ASK1 as a Potent Anti-Thrombotic Agent"
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8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Karen Vanhoorelbeke (KU Leuven, Belgium)
"Unwinding Von Willebrand Factor at the Vessel Wall"
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9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Thrombosis and Coagulation During Infection |
9:00 am - 9:05 am | Discussion Leader: Jane Freedman (University of Massachusetts)
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9:05 am - 9:30 am | Nigel Mackman (University of North Carolina)
"Viral Infection and the Clotting Cascade" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Craig Morrell (University of Rochester)
"Understanding Roles for Platelets in Malaria Infection" |
10:10 am - 10:25 am | Discussion |
10:25 am - 11:05 am | Group Photo / Coffee Break |
11:05 am - 11:30 am | Mark Looney (University of California, San Francisco)
"Platelet-Neutrophil Interactions in Lung Inflammation and Injury" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Ed Pryzdial (University of British Columbia)
"Interactions Between Dengue and Platelets" |
12:10 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Platelets and Coagulation Factors in Development and Disease |
7:30 pm - 7:35 pm | Discussion Leader: Keith Neeves (Colorado School of Mines)
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7:35 pm - 8:00 pm | Mark Kahn (University of Pennsylvania)
"New Roles for CLEC2 in Hemostasis" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Katerina Akassoglou (University of California, San Francisco)
"Fibrinogen in Neurologic Diseases" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | David Gailani (Vanderbilt University)
"Factor XI in Thrombosis and Inflammation" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Crosstalk in the Vascular Milieu |
9:00 am - 9:05 am | Discussion Leader: Paul Bray (Thomas Jefferson University)
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9:05 am - 9:30 am | Patrick Provost (Quebec Research Center)
"Transfer of Platelet microRNAs" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Alan Mast (Blood Center of Wisconsin)
"A Newly-Recognized, TF-Independent Anticoagulant Activity of TFPI" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Stephanie Smith (University of Illinois)
"Polyphosphate as a Modulator of Hemostasis and Inflammation" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Chuck Esmon (Oklahoma Research Medical Foundation)
"Molecular Circuits in Thrombosis and Inflammation" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Jim Huntington (University of Cambridge)
"Identification and Characterization of a Novel Anti-Thrombin Antibody"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Links Between Thrombosis, Coagulation, and Inflammation |
7:30 pm - 7:35 pm | Discussion Leader: Pete Lollar (Emory University) |
7:35 pm - 8:00 pm | Eric Boilard (Quebec University)
"Platelets Release Microparticle Subtypes that Mediate Distinct Roles in Sterile Inflammation"
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8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Alisa Wolberg (University of North Carolina)
"Fibrinogen, Factor XIII and Red Blood Cells in Venous Thrombosis"
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8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Xiaoping Du (University of Illinois at Chicago)
"Integrin Signaling and a New Concept in Anti-Thrombotic Development"
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9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Coagulation and Platelets in Disease |
9:00 am - 9:05 am | Discussion Leader: Martha Sola-Visner (Children's Hospital Boston) |
9:05 am - 9:30 am | Owen McCarty (Oregon Health and Science University)
"Platelets and Coagulation Pathways in Vascular Disease"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | David Corry (Baylor College of Medicine)
"Fibrinogenolysis Links Coagulation and Immunity"
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10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Desmond Fitzgerald (University College Dublin)
"Proteomic Signatures of Platelet Drug Response"
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11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Jay Degen (University of Cincinnati)
"Thrombin and Thrombin Targets in Sickle Cell Disease in Mice"
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11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | John Kulman (Biogen Idec Hematology)
"Orthogonal Approaches for Assessing Structure-Activity Relationships in Factor FVIII"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Late-Breaking Topics |
| Discussion Leaders: Co-Vice Chairs Jorge DiPaola (University of Colorado) and Jim Morrissey (University of Illinois) |
7:30 pm - 7:40 pm | Eric Mullins (Cincinnati Children's Research)
"Plasmin(ogen) Exacerbates Inflammation, Demyelination, and Paralysis in a Murine Model of Multiple Sclerosis"
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7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Debra Pittman (Pfizer)
"A Novel Factor Xa Variant for Control of Acute Bleeding"
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7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Dallas Shi (University of Utah)
"Proteasome Function Is Required for Platelet Formation"
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8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Brian Storrie (University of Arkansas for Medicine)
"Platelet α-Granules Are Structurally Homogenous as Revealed by a Combination of Thin, Semi-Thick, and Thick Electron Microscopy"
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8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Peter Gross (McMaster University)
"Point of Care Whole Blood Thrombin Generation"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Kimberly Martinod (Harvard Medical School)
"NET-Deficiency Does Not Impact Mortality in Polymicrobial Sepsis but Ameliorates Endotoxemic Shock"
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8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Matthew Flick (Cincinnati Children's Hospital)
"Transglutaminase Factor XIII Promotes Arthritis Through Mechanisms Linked to Inflammation and Bone Erosion"
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9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Yacine Boulaftali (University of North Carolina)
"The Calcium-Binding Protein S100A1 Negatively Regulates Collagen-Dependent Platelet Activation and Thrombosis in Mice"
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9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Defective Hemostasis |
9:00 am - 9:05 am | Discussion Leader: Paula Tracy (University of Vermont) |
9:05 am - 9:30 am | Barry Coller (Rockefeller University)
"New Insights into Integrin αIIbβ3 in Hemostasis"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | David Lillicrap (Queen's University)
"Clearance of FVIII and VWF: Many Answers to a Simple Question"
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10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Paula Tracy/Beth Bouchard (University of Vermont)
"Processes Defining Megakaryocyte Formation of the Platelet-Derived Factor V/Va Pool"
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11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Sriram Krishnaswamy (University of Pennsylvania)
"Transitioning from Pro-Thrombin to Thrombin"
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11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Gary Gilbert (VA Boston Healthcare System)
"Platelet Fibrin-Related Binding Site and Function of Factor VIII"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: The Impact of Mouse and Human Genetics on Thrombosis and Hemostasis |
7:30 pm - 7:35 pm | Discussion Leader: Jorge DiPaola (GRC Vice Chair, University of Colorado) |
7:35 pm - 8:10 pm | Keynote: David Ginsburg (University of Michigan)
"What the Mouse Can Teach Us About Human Hemostasis: Past and Future"
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8:10 pm - 8:25 pm | Discussion |
8:25 pm - 9:00 pm | Keynote: Frits Rosendaal (Leiden University Medical Center)
"How Human Genetics Has Impacted Hemostasis Research and Clinical Practice"
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9:00 pm - 9:15 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |